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Items: 1 to 50 of 60

1.

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.

Ge X, Yang H, Bednarek MA, Galon-Tilleman H, Chen P, Chen M, Lichtman JS, Wang Y, Dalmas O, Yin Y, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.

Cell Metab. 2018 Feb 6;27(2):461-469.e6. doi: 10.1016/j.cmet.2017.10.016. Epub 2017 Dec 7.

2.

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.

J Biol Chem. 2017 Feb 3;292(5):1925-1933. doi: 10.1074/jbc.M116.748103. Epub 2016 Dec 19.

3.

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.

Furukawa A, Townsend CE, Schwochert J, Pye CR, Bednarek MA, Lokey RS.

J Med Chem. 2016 Oct 27;59(20):9503-9512. Epub 2016 Oct 11.

PMID:
27690434
4.

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates.

Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, Jansson-Löfmark R, Naylor J, Rossi A, Bednarek MA, Bhagroo N, Salari H, Will S, Oldham S, Hansen G, Feigh M, Klein T, Grimsby J, Maguire S, Jermutus L, Rondinone CM, Coghlan MP.

Diabetes Obes Metab. 2016 Dec;18(12):1176-1190. doi: 10.1111/dom.12735. Epub 2016 Aug 15.

5.

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS.

J Med Chem. 2015 Sep 24;58(18):7409-18. doi: 10.1021/acs.jmedchem.5b00919. Epub 2015 Sep 2.

PMID:
26308180
6.

Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.

Revell JD, Lund PE, Linley JE, Metcalfe J, Burmeister N, Sridharan S, Jones C, Jermutus L, Bednarek MA.

Peptides. 2013 Jun;44:40-6. doi: 10.1016/j.peptides.2013.03.011. Epub 2013 Mar 19.

PMID:
23523779
7.

Potent and selective peptide agonists for human melanocortin receptor 5.

Bednarek MA, MacNeil T, Tang R, Cabello MA, Maroto M, Teran A.

Adv Exp Med Biol. 2009;611:95-6. No abstract available.

PMID:
19400109
8.

MCH receptor peptide agonists and antagonists.

MacNeil DJ, Bednarek MA.

Peptides. 2009 Nov;30(11):2008-13. doi: 10.1016/j.peptides.2009.04.009. Epub 2009 May 4.

PMID:
19397944
9.

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

Ito M, Gomori A, Suzuki J, Tsujioka S, Sasaki M, Matsuda M, Bednarek MA, Ito M, Ishihara A, Iwaasa H, Macneil DJ, Kanatani A.

J Endocrinol. 2008 Aug;198(2):309-15. doi: 10.1677/JOE-08-0087. Epub 2008 Jun 3.

PMID:
18523032
10.

Cyclic analogs of alpha-melanocyte-stimulating hormone (alphaMSH) with high agonist potency and selectivity at human melanocortin receptor 1b.

Bednarek MA, MacNeil T, Tang R, Fong TM, Cabello MA, Maroto M, Teran A.

Peptides. 2008 Jun;29(6):1010-7. doi: 10.1016/j.peptides.2008.02.008. Epub 2008 Feb 19.

PMID:
18378043
11.

Analogs of alpha-melanocyte stimulating hormone with high agonist potency and selectivity at human melanocortin receptor 1b: the role of Trp(9) in molecular recognition.

Bednarek MA, Macneil T, Tang R, Fong TM, Angeles Cabello M, Maroto M, Teran A.

Biopolymers. 2008 May;89(5):401-8.

PMID:
17926329
12.

Peptide ligands for the melanin-concentrating hormone (MCH) receptor 1.

Bednarek MA.

Curr Top Med Chem. 2007;7(15):1425-32.

PMID:
17897029
13.

Potent and selective peptide agonists of alpha-melanocyte stimulating hormone (alphaMSH) action at human melanocortin receptor 5; their synthesis and biological evaluation in vitro.

Bednarek MA, MacNeil T, Tang R, Fong TM, Angeles Cabello M, Maroto M, Teran A.

Chem Biol Drug Des. 2007 May;69(5):350-5.

PMID:
17539827
14.

Blockade of MCH1 receptor signalling ameliorates obesity and related hepatic steatosis in ovariectomized mice.

Gomori A, Ishihara A, Ito M, Matsushita H, Ito M, Mashiko S, Iwaasa H, Matsuda M, Bednarek MA, Qian S, Macneil DJ, Kanatani A.

Br J Pharmacol. 2007 Jul;151(6):900-8. Epub 2007 May 21.

15.

Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.

Bednarek MA, MacNeil T, Tang R, Fong TM, Cabello MA, Maroto M, Teran A.

J Med Chem. 2007 May 17;50(10):2520-6. Epub 2007 Apr 25.

PMID:
17455928
16.

Potent and selective agonists of alpha-melanotropin (alphaMSH) action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.

Bednarek MA, MacNeil T, Tang R, Fong TM, Cabello MA, Maroto M, Teran A.

Peptides. 2007 May;28(5):1020-8. Epub 2007 Feb 17.

PMID:
17376561
17.

Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.

Felix JP, Liu J, Schmalhofer WA, Bailey T, Bednarek MA, Kinkel S, Weinglass AB, Kohler M, Kaczorowski GJ, Priest BT, Garcia ML.

Biochemistry. 2006 Aug 22;45(33):10129-39.

PMID:
16906771
18.

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

Mashiko S, Ishihara A, Gomori A, Moriya R, Ito M, Iwaasa H, Matsuda M, Feng Y, Shen Z, Marsh DJ, Bednarek MA, MacNeil DJ, Kanatani A.

Endocrinology. 2005 Jul;146(7):3080-6. Epub 2005 Apr 7.

PMID:
15817671
19.

The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.

Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ.

J Neurosci. 2005 Mar 16;25(11):2933-40.

20.

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Shearman LP, Camacho RE, Sloan Stribling D, Zhou D, Bednarek MA, Hreniuk DL, Feighner SD, Tan CP, Howard AD, Van der Ploeg LH, MacIntyre DE, Hickey GJ, Strack AM.

Eur J Pharmacol. 2003 Aug 15;475(1-3):37-47.

PMID:
12954357
21.

1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).

Victoria Silva Elipe M, Mosley RT, Bednarek MA, Arison BH.

Biopolymers. 2003 Apr;68(4):512-27.

PMID:
12666176
22.

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH.

Eur J Pharmacol. 2002 Aug 16;450(1):93-109. Review.

PMID:
12176114
23.

Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LH, Howard AD, Feighner SD.

Biochemistry. 2002 May 21;41(20):6383-90.

PMID:
12009900
24.

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ, Chen HY, Shen CP, Chen AS, Rosenblum CI, MacNeil T, Tota M, MacIntyre ED, Van der Ploeg LH.

Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. Review. Corrected and republished in: Eur J Pharmacol. 2002 Aug 16;450(1):93-109.

PMID:
12007532
25.

Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD.

J Biol Chem. 2002 Apr 19;277(16):13821-6. Epub 2002 Feb 11.

26.

1H NMR structural analysis of human ghrelin and its six truncated analogs.

Silva Elipe MV, Bednarek MA, Gao YD.

Biopolymers. 2001 Dec;59(7):489-501.

PMID:
11745115
27.

Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.

Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH.

J Med Chem. 2001 Oct 25;44(22):3665-72.

PMID:
11606131
28.

Potent and selective peptide agonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.

Bednarek MA, MacNeil T, Tang R, Kalyani RN, Van der Ploeg LH, Weinberg DH.

Biochem Biophys Res Commun. 2001 Aug 24;286(3):641-5.

PMID:
11511108
29.

Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.

Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH.

Biochemistry. 2001 Aug 7;40(31):9379-86.

PMID:
11478907
30.

Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.

Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV.

J Med Chem. 2000 Nov 16;43(23):4370-6.

PMID:
11087562
31.

Analogs of lactam derivatives of alpha-melanotropin with basic and acidic residues.

Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH.

Biochem Biophys Res Commun. 2000 May 27;272(1):23-8.

PMID:
10872798
32.

Mimicry of erythropoietin by a nonpeptide molecule.

Qureshi SA, Kim RM, Konteatis Z, Biazzo DE, Motamedi H, Rodrigues R, Boice JA, Calaycay JR, Bednarek MA, Griffin P, Gao YD, Chapman K, Mark DF.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12156-61.

33.

Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin.

Bednarek MA, Silva MV, Arison B, MacNeil T, Kalyani RN, Huang RR, Weinberg DH.

Peptides. 1999;20(3):401-9.

PMID:
10447101
34.

Analogs of MTII, lactam derivatives of alpha-melanotropin, modified at the N-terminus, and their selectivity at human melanocortin receptors 3, 4, and 5.

Bednarek MA, Macneil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH.

Biochem Biophys Res Commun. 1999 Jul 22;261(1):209-13.

PMID:
10405347
35.

Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4.

Nare B, Allocco JJ, Kuningas R, Galuska S, Myers RW, Bednarek MA, Schmatz DM.

Anal Biochem. 1999 Feb 15;267(2):390-6.

PMID:
10036146
36.

Amino acids with aryl-keto function in their side chains.

Bednarek MA.

J Pept Res. 1998 Sep;52(3):195-200.

PMID:
9774232
37.

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ, Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, Dombrowski AW, Polishook JD, Schmatz DM.

Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.

38.

Observation of noncovalent complexes between margatoxin and the Kv1.3 peptide ligands: A model investigation using ion-spray mass spectrometry.

Bakhtiarcor R, Bednarek MA.

J Am Soc Mass Spectrom. 1996 Oct;7(10):1075-80. doi: 10.1016/1044-0305(96)00108-0.

PMID:
24202889
40.

Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes.

Bednarek MA, Bugianesi RM, Leonard RJ, Felix JP.

Biochem Biophys Res Commun. 1994 Jan 28;198(2):619-25.

PMID:
8297371
41.
42.

Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza A virus matrix protein.

Sauma SY, Gammon MC, Bednarek MA, Cunningham B, Biddison WE, Hermes JD, Porter G, Tamhankar S, Hawkins JC, Bush BL, et al.

Hum Immunol. 1993 Aug;37(4):252-8.

PMID:
8300410
43.

Reactions of C-terminal omega-amino acid residues in liquid hydrogen fluoride.

Bednarek MA, Springer JP, Cunningham BR, Bernick AM, Bodanszky M.

Int J Pept Protein Res. 1993 Jul;42(1):10-3.

PMID:
8370637
44.

Cyclic V3-loop-related HIV-1 conjugate vaccines. Synthesis, conformation and immunological properties.

Tolman RL, Bednarek MA, Johnson BA, Leanza WJ, Marburg S, Underwood DJ, Emini EA, Conley AJ.

Int J Pept Protein Res. 1993 May;41(5):455-66.

PMID:
8320039
45.

Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2.

Parker KC, Bednarek MA, Hull LK, Utz U, Cunningham B, Zweerink HJ, Biddison WE, Coligan JE.

J Immunol. 1992 Dec 1;149(11):3580-7.

PMID:
1331239
46.

Endogenous loading of HLA-A2 molecules with an analog of the influenza virus matrix protein-derived peptide and its inhibition by an exogenous peptide antagonist.

Gammon MC, Bednarek MA, Biddison WE, Bondy SS, Hermes JD, Mark GE, Williamson AR, Zweerink HJ.

J Immunol. 1992 Jan 1;148(1):7-12.

PMID:
1727876
47.

The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2.

Bednarek MA, Sauma SY, Gammon MC, Porter G, Tamhankar S, Williamson AR, Zweerink HJ.

J Immunol. 1991 Dec 15;147(12):4047-53.

PMID:
1721637
48.

Soluble HLA-A2.1 restricted peptides that are recognized by influenza virus specific cytotoxic T lymphocytes.

Bednarek MA, Engl SA, Gammon MC, Lindquist JA, Porter G, Williamson AR, Zweerink HJ.

J Immunol Methods. 1991 May 17;139(1):41-7.

PMID:
1904085
49.

Detection of factor X activation in humans.

Bauer KA, Kass BL, ten Cate H, Bednarek MA, Hawiger JJ, Rosenberg RD.

Blood. 1989 Nov 1;74(6):2007-15.

PMID:
2804345
50.

Active esters in solid-phase peptide synthesis.

Bodanszky M, Bednarek MA.

J Protein Chem. 1989 Aug;8(4):461-9. Review.

PMID:
2679654

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