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Items: 1 to 50 of 98

1.

Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy.

Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE.

Circulation. 2019 Sep 19. doi: 10.1161/CIRCULATIONAHA.119.040676. [Epub ahead of print]

PMID:
31533459
2.

Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.

Agrimi J, Spalletti C, Baroni C, Keceli G, Zhu G, Caragnano A, Matteucci M, Chelko S, Ramirez-Correa GA, Bedja D, Casieri V, Di Lascio N, Scalco A, Beltrami AP, Paolocci N, Caleo M, Lionetti V.

EBioMedicine. 2019 Sep;47:384-401. doi: 10.1016/j.ebiom.2019.08.042. Epub 2019 Sep 3.

3.

Cardiac regeneration using human-induced pluripotent stem cell-derived biomaterial-free 3D-bioprinted cardiac patch in vivo.

Yeung E, Fukunishi T, Bai Y, Bedja D, Pitaktong I, Mattson G, Jeyaram A, Lui C, Ong CS, Inoue T, Matsushita H, Abdollahi S, Jay SM, Hibino N.

J Tissue Eng Regen Med. 2019 Aug 13. doi: 10.1002/term.2954. [Epub ahead of print]

PMID:
31408915
4.

Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.

Kim DH, Beckett JD, Nagpal V, Seman-Senderos MA, Gould RA, Creamer TJ, MacFarlane EG, Chen Y, Bedja D, Butcher JT, Mitzner W, Rouf R, Hata S, Warren DS, Dietz HC.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaau2814. doi: 10.1126/scitranslmed.aau2814.

PMID:
31316008
5.

Regenerative and durable small-diameter graft as an arterial conduit.

Elliott MB, Ginn B, Fukunishi T, Bedja D, Suresh A, Chen T, Inoue T, Dietz HC, Santhanam L, Mao HQ, Hibino N, Gerecht S.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12710-12719. doi: 10.1073/pnas.1905966116. Epub 2019 Jun 10.

PMID:
31182572
6.

Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome.

Habashi JP, MacFarlane EG, Bagirzadeh R, Bowen C, Huso N, Chen Y, Bedja D, Creamer TJ, Rykiel G, Manning M, Huso D, Dietz HC.

Sci Transl Med. 2019 May 1;11(490). pii: eaat4822. doi: 10.1126/scitranslmed.aat4822.

PMID:
31043570
7.

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.

Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. doi: 10.1073/pnas.1815354116. Epub 2019 Apr 26.

PMID:
31028142
8.

Inorganic arsenic exposure induces sex-disparate effects and exacerbates ischemia-reperfusion injury in the female heart.

Veenema R, Casin KM, Sinha P, Kabir R, Mackowski N, Taube N, Bedja D, Chen R, Rule A, Kohr MJ.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1053-H1064. doi: 10.1152/ajpheart.00364.2018. Epub 2019 Mar 1.

PMID:
30822117
9.

Chronic Atrial and Ventricular Pacing in the Mouse.

Ståhlberg M, Nakagawa R, Bedja D, Zhu G, Lin BL, Saberi A, Lee DI, Kass DA.

Circ Heart Fail. 2019 Feb;12(2):e005655. doi: 10.1161/CIRCHEARTFAILURE.118.005655.

PMID:
30764638
10.

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.

Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA.

Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30.

11.

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome.

MacFarlane EG, Parker SJ, Shin JY, Kang BE, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC.

J Clin Invest. 2019 Feb 1;129(2):659-675. doi: 10.1172/JCI123547. Epub 2019 Jan 7.

12.

S-Nitrosoglutathione Reductase Is Essential for Protecting the Female Heart From Ischemia-Reperfusion Injury.

Casin KM, Fallica J, Mackowski N, Veenema RJ, Chan A, St Paul A, Zhu G, Bedja D, Biswal S, Kohr MJ.

Circ Res. 2018 Nov 9;123(11):1232-1243. doi: 10.1161/CIRCRESAHA.118.313956.

PMID:
30571462
13.

ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.

Gould RA, Aziz H, Woods CE, Seman-Senderos MA, Sparks E, Preuss C, Wünnemann F, Bedja D, Moats CR, McClymont SA, Rose R, Sobreira N, Ling H, MacCarrick G, Kumar AA, Luyckx I, Cannaerts E, Verstraeten A, Björk HM, Lehsau AC, Jaskula-Ranga V, Lauridsen H, Shah AA, Bennett CL, Ellinor PT, Lin H, Isselbacher EM, Lino Cardenas CL, Butcher JT, Hughes GC, Lindsay ME; Baylor-Hopkins Center for Mendelian Genomics; MIBAVA Leducq Consortium, Mertens L, Franco-Cereceda A, Verhagen JMA, Wessels M, Mohamed SA, Eriksson P, Mital S, Van Laer L, Loeys BL, Andelfinger G, McCallion AS, Dietz HC.

Nat Genet. 2019 Jan;51(1):42-50. doi: 10.1038/s41588-018-0265-y. Epub 2018 Nov 19.

14.

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.

Kokkonen-Simon KM, Saberi A, Nakamura T, Ranek MJ, Zhu G, Bedja D, Kuhn M, Halushka MK, Lee DI, Kass DA.

JCI Insight. 2018 Aug 9;3(15). pii: 121739. doi: 10.1172/jci.insight.121739. eCollection 2018 Aug 9.

15.

Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE-/- mice fed western diet.

Bedja D, Yan W, Lad V, Iocco D, Sivakumar N, Bandaru VVR, Chatterjee S.

Sci Rep. 2018 Jul 30;8(1):11463. doi: 10.1038/s41598-018-28663-9.

16.

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy.

Chung HS, Kim GE, Holewinski RJ, Venkatraman V, Zhu G, Bedja D, Kass DA, Van Eyk JE.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10763-E10771. doi: 10.1073/pnas.1712623114. Epub 2017 Nov 29.

17.

Regulation of autoimmune myocarditis by host responses to the microbiome.

Barin JG, Talor MV, Diny NL, Ong S, Schaub JA, Gebremariam E, Bedja D, Chen G, Choi HS, Hou X, Wu L, Cardamone AB, Peterson DA, Rose NR, Čiháková D.

Exp Mol Pathol. 2017 Oct;103(2):141-152. doi: 10.1016/j.yexmp.2017.08.003. Epub 2017 Aug 16.

18.

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice.

Rouf R, MacFarlane EG, Takimoto E, Chaudhary R, Nagpal V, Rainer PP, Bindman JG, Gerber EE, Bedja D, Schiefer C, Miller KL, Zhu G, Myers L, Amat-Alarcon N, Lee DI, Koitabashi N, Judge DP, Kass DA, Dietz HC.

JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. eCollection 2017 Aug 3.

19.

Moderately Elevated Homocysteine Does Not Contribute to Thoracic Aortic Aneurysm in Mice.

Roohi J, Kang B, Bernard D, Bedja D, Dietz HC, Brody LC.

J Nutr. 2017 Jul;147(7):1290-1295. doi: 10.3945/jn.117.251173. Epub 2017 May 24.

20.

Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy.

Diny NL, Baldeviano GC, Talor MV, Barin JG, Ong S, Bedja D, Hays AG, Gilotra NA, Coppens I, Rose NR, Čiháková D.

J Exp Med. 2017 Apr 3;214(4):943-957. doi: 10.1084/jem.20161702. Epub 2017 Mar 16.

21.

Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets.

Das S, Kohr M, Dunkerly-Eyring B, Lee DI, Bedja D, Kent OA, Leung AK, Henao-Mejia J, Flavell RA, Steenbergen C.

J Am Heart Assoc. 2017 Feb 27;6(3). pii: e004694. doi: 10.1161/JAHA.116.004694.

22.

Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2.

Sørensen LL, Bedja D, Sysa-Shah P, Liu H, Maxwell A, Yi X, Pozios I, Olsen NT, Abraham TP, Abraham R, Gabrielson K.

Comp Med. 2016;66(4):268-77.

23.

Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP.

JCI Insight. 2016 Apr 21;1(5). pii: 85923. doi: 10.1172/jci.insight.85923.

24.

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling.

Hashimoto T, Sivakumaran V, Carnicer R, Zhu G, Hahn VS, Bedja D, Recalde A, Duglan D, Channon KM, Casadei B, Kass DA.

J Am Heart Assoc. 2016 Mar 21;5(3):e003208. doi: 10.1161/JAHA.116.003208.

25.

Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.

Sysa-Shah P, Tocchetti CG, Gupta M, Rainer PP, Shen X, Kang BH, Belmonte F, Li J, Xu Y, Guo X, Bedja D, Gao WD, Paolocci N, Rath R, Sawyer DB, Naga Prasad SV, Gabrielson K.

Cardiovasc Res. 2016 Mar 1;109(3):358-73. doi: 10.1093/cvr/cvv274. Epub 2015 Dec 21.

26.

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome.

Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F, Myers L, Huso N, Bachir S, Squires O, Rusholme B, Ehsan H, Huso D, Thomas CJ, Caulfield MJ, Van Eyk JE, Judge DP, Dietz HC; GenTAC Registry Consortium; MIBAVA Leducq Consortium.

Elife. 2015 Oct 27;4. pii: e08648. doi: 10.7554/eLife.08648.

27.

Prevention of cardiac hypertrophy by the use of a glycosphingolipid synthesis inhibitor in ApoE-/- mice.

Mishra S, Bedja D, Amuzie C, Avolio A, Chatterjee S.

Biochem Biophys Res Commun. 2015 Sep 11;465(1):159-64. doi: 10.1016/j.bbrc.2015.07.159. Epub 2015 Aug 4.

28.

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies.

Burks TN, Marx R, Powell L, Rucker J, Bedja D, Heacock E, Smith BJ, Foster DB, Kass D, O'Rourke B, Walston JD, Abadir PM.

Oncotarget. 2015 May 20;6(14):11979-93.

29.

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

Tocchetti CG, Stanley BA, Sivakumaran V, Bedja D, O'Rourke B, Paolocci N, Cortassa S, Aon MA.

Clin Sci (Lond). 2015 Oct;129(7):561-74. doi: 10.1042/CS20150204. Epub 2015 Jun 11.

30.

Improved intervention of atherosclerosis and cardiac hypertrophy through biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor.

Mishra S, Bedja D, Amuzie C, Foss CA, Pomper MG, Bhattacharya R, Yarema KJ, Chatterjee S.

Biomaterials. 2015 Sep;64:125-135. doi: 10.1016/j.biomaterials.2015.06.001. Epub 2015 Jun 3.

31.

Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome.

Busnadiego O, Gorbenko Del Blanco D, González-Santamaría J, Habashi JP, Calderon JF, Sandoval P, Bedja D, Guinea-Viniegra J, Lopez-Cabrera M, Rosell-Garcia T, Snabel JM, Hanemaaijer R, Forteza A, Dietz HC, Egea G, Rodriguez-Pascual F.

J Mol Cell Cardiol. 2015 Aug;85:48-57. doi: 10.1016/j.yjmcc.2015.05.008. Epub 2015 May 16.

32.

Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA.

Foss CA, Bedja D, Mease RC, Wang H, Kass DA, Chatterjee S, Pomper MG.

Biochem Biophys Res Commun. 2015 May 22;461(1):70-5. doi: 10.1016/j.bbrc.2015.03.171. Epub 2015 Apr 6.

33.

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA.

Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.

34.

Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H.

EMBO J. 2014 Dec 1;33(23):2798-813. doi: 10.15252/embj.201488658. Epub 2014 Oct 27.

35.

Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity.

Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM.

J Appl Physiol (1985). 2015 Jan 15;118(2):212-23. doi: 10.1152/japplphysiol.00463.2014. Epub 2014 Oct 16.

36.

Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura Y, Rose NR, Ciháková D.

J Exp Med. 2014 Jun 30;211(7):1449-64. doi: 10.1084/jem.20132126. Epub 2014 Jun 16.

37.

PDE5 inhibitor efficacy is estrogen dependent in female heart disease.

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.

J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16.

38.

miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo.

Das S, Bedja D, Campbell N, Dunkerly B, Chenna V, Maitra A, Steenbergen C.

PLoS One. 2014 May 8;9(5):e96820. doi: 10.1371/journal.pone.0096820. eCollection 2014.

39.

Geranylgeranylacetone blocks doxorubicin-induced cardiac toxicity and reduces cancer cell growth and invasion through RHO pathway inhibition.

Sysa-Shah P, Xu Y, Guo X, Pin S, Bedja D, Bartock R, Tsao A, Hsieh A, Wolin MS, Moens A, Raman V, Orita H, Gabrielson KL.

Mol Cancer Ther. 2014 Jul;13(7):1717-28. doi: 10.1158/1535-7163.MCT-13-0965. Epub 2014 Apr 15.

40.

Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet.

Chatterjee S, Bedja D, Mishra S, Amuzie C, Avolio A, Kass DA, Berkowitz D, Renehan M.

Circulation. 2014 Jun 10;129(23):2403-13. doi: 10.1161/CIRCULATIONAHA.113.007559. Epub 2014 Apr 7.

41.

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL.

J Am Heart Assoc. 2014 Apr 2;3(2):e000874. doi: 10.1161/JAHA.114.000874.

42.

Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse.

Auer DR, Sysa-Shah P, Bedja D, Simmers JL, Pak E, Dutra A, Cohn R, Gabrielson KL, Chakravarti A, Kapoor A.

Biotechnol Lett. 2014 Jun;36(6):1179-85. doi: 10.1007/s10529-014-1473-x. Epub 2014 Feb 22.

43.

Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.

Seo K, Rainer PP, Lee DI, Hao S, Bedja D, Birnbaumer L, Cingolani OH, Kass DA.

Circ Res. 2014 Feb 28;114(5):823-32. doi: 10.1161/CIRCRESAHA.114.302614. Epub 2014 Jan 21.

44.

Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.

Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC.

J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.

45.

A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.

Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T.

J Am Soc Nephrol. 2014 Jan;25(1):81-91. doi: 10.1681/ASN.2012050486. Epub 2013 Sep 26.

46.

Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Fairweather D, Bedja D, Stickel NR, Fontes JA, Cardamone AB, Zheng D, Gabrielson KL, Rose NR, Ciháková D.

J Immunol. 2013 Oct 15;191(8):4038-47. doi: 10.4049/jimmunol.1301282. Epub 2013 Sep 18.

47.

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.

Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA.

J Mol Cell Cardiol. 2013 Sep;62:8-17. doi: 10.1016/j.yjmcc.2013.04.025. Epub 2013 May 2.

48.

Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.

Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N.

Antioxid Redox Signal. 2014 Jan 10;20(2):267-80. doi: 10.1089/ars.2012.4616. Epub 2013 May 22.

49.

Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.

AlGhatrif M, Watts VL, Niu X, Halushka M, Miller KL, Vandegaer K, Bedja D, Fox-Talbot K, Bielawska A, Gabrielson KL, Barouch LA.

J Cardiovasc Transl Res. 2013 Jun;6(3):436-45. doi: 10.1007/s12265-013-9453-4. Epub 2013 Mar 2.

PMID:
23456569
50.

TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4.

Abston ED, Coronado MJ, Bucek A, Onyimba JA, Brandt JE, Frisancho JA, Kim E, Bedja D, Sung YK, Radtke AJ, Gabrielson KL, Mitzner W, Fairweather D.

Am J Physiol Regul Integr Comp Physiol. 2013 Feb 15;304(4):R267-77. doi: 10.1152/ajpregu.00516.2011. Epub 2012 Dec 19.

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