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Items: 1 to 50 of 159

1.

Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition.

Rajendran P, Johnson GS, Li L, Chen YS, Dashwood WM, Nguyen N, Ulusan AM, Ertem FU, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HE, Lieberman D, Beaver LM, Ho E, Bedford MT, Chang K, Vilar E, Dashwood RH.

Cancer Res. 2019 Jan 14. pii: canres.2003.2018. doi: 10.1158/0008-5472.CAN-18-2003. [Epub ahead of print]

PMID:
30643017
2.

Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo.

Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A.

Sci Signal. 2019 Jan 8;12(563). pii: eaau0240. doi: 10.1126/scisignal.aau0240.

PMID:
30622194
3.

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.

Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M.

Cell. 2018 Dec 13;175(7):1902-1916.e13. doi: 10.1016/j.cell.2018.11.027.

4.

Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1".

Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV.

Biochemistry. 2018 Nov 28. doi: 10.1021/acs.biochem.8b01187. [Epub ahead of print] No abstract available.

PMID:
30485080
5.

CARM1 methylates MED12 to regulate its RNA-binding ability.

Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Treviño LS, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT.

Life Sci Alliance. 2018 Sep 19;1(5):e201800117. doi: 10.26508/lsa.201800117. eCollection 2018 Oct.

6.

Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.

Bao J, Di Lorenzo A, Lin K, Lu Y, Zhong Y, Sebastian MM, Muller WJ, Yang Y, Bedford MT.

Cancer Res. 2019 Jan 1;79(1):21-32. doi: 10.1158/0008-5472.CAN-18-1995. Epub 2018 Oct 23.

PMID:
30352814
7.

Screening for histone codebreakers.

Bedford MT.

J Biol Chem. 2018 Aug 31;293(35):13766-13767. doi: 10.1074/jbc.H118.005132.

8.

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.

Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F.

JCI Insight. 2018 Aug 23;3(16). pii: 99767. doi: 10.1172/jci.insight.99767. [Epub ahead of print]

9.

Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress.

Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.

Diseases. 2018 Jul 13;6(3). pii: E64. doi: 10.3390/diseases6030064.

10.

Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9.

Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T.

J Biol Chem. 2018 Aug 17;293(33):12770-12780. doi: 10.1074/jbc.RA118.002890. Epub 2018 Jun 29.

PMID:
29959229
11.

The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis.

Bao J, Rousseaux S, Shen J, Lin K, Lu Y, Bedford MT.

Nucleic Acids Res. 2018 May 18;46(9):4327-4343. doi: 10.1093/nar/gky240.

12.

Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.

Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV.

Biochemistry. 2018 Apr 10;57(14):2140-2149. doi: 10.1021/acs.biochem.8b00150. Epub 2018 Mar 28.

13.

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes.

Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR.

BMC Genomics. 2018 Feb 20;19(1):150. doi: 10.1186/s12864-018-4533-0.

14.

Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.

Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL.

Genome Res. 2018 Feb;28(2):159-170. doi: 10.1101/gr.226019.117. Epub 2017 Dec 22.

15.

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T.

Cell Rep. 2017 Dec 19;21(12):3390-3397. doi: 10.1016/j.celrep.2017.11.082.

16.

A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.

Bae N, Gao M, Li X, Premkumar T, Sbardella G, Chen J, Bedford MT.

J Biol Chem. 2017 Dec 22;292(51):20808-20817. doi: 10.1074/jbc.M117.814913. Epub 2017 Oct 23.

17.

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.

Carr SM, Munro S, Sagum CA, Fedorov O, Bedford MT, La Thangue NB.

Cell Death Differ. 2017 Dec;24(12):2139-2149. doi: 10.1038/cdd.2017.135. Epub 2017 Aug 25.

18.

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress.

Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN.

J Virol. 2017 Sep 27;91(20). pii: e00812-17. doi: 10.1128/JVI.00812-17. Print 2017 Oct 15.

19.

Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN.

PLoS Pathog. 2017 Jul 19;13(7):e1006519. doi: 10.1371/journal.ppat.1006519. eCollection 2017 Jul.

20.

Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.

Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW.

J Biol Chem. 2017 Sep 1;292(35):14456-14472. doi: 10.1074/jbc.M117.802074. Epub 2017 Jul 17.

21.

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.

Kaushik S, Liu F, Veazey KJ, Gao G, Das P, Neves LF, Lin K, Zhong Y, Lu Y, Giuliani V, Bedford MT, Nimer SD, Santos MA.

Leukemia. 2018 Feb;32(2):499-509. doi: 10.1038/leu.2017.206. Epub 2017 Jun 30.

22.

Developing Spindlin1 small-molecule inhibitors by using protein microarrays.

Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT.

Nat Chem Biol. 2017 Jul;13(7):750-756. doi: 10.1038/nchembio.2377. Epub 2017 May 15.

23.

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.

Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD.

Epigenetics Chromatin. 2017 Mar 14;10:12. doi: 10.1186/s13072-017-0117-5. eCollection 2017.

24.

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

Gao G, Dhar S, Bedford MT.

Nucleic Acids Res. 2017 May 5;45(8):4359-4369. doi: 10.1093/nar/gkw1367.

25.

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.

Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN.

PLoS Pathog. 2017 Jan 11;13(1):e1006132. doi: 10.1371/journal.ppat.1006132. eCollection 2017 Jan. Erratum in: PLoS Pathog. 2017 Jul 19;13(7):e1006519.

26.

PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch.

Espejo AB, Gao G, Black K, Gayatri S, Veland N, Kim J, Chen T, Sudol M, Walker C, Bedford MT.

J Biol Chem. 2017 Feb 10;292(6):2255-2265. doi: 10.1074/jbc.M116.760330. Epub 2016 Dec 28.

27.

Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains.

Barnea M, Olender T, Bedford MT, Elson A.

Biochem Soc Trans. 2016 Oct 15;44(5):1295-1303. Review.

PMID:
27911712
28.

PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud.

Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA.

Development. 2016 Dec 15;143(24):4608-4619. Epub 2016 Nov 8.

29.

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.

Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C.

Sci Adv. 2016 Apr 1;2(4):e1501290. eCollection 2016 Apr.

30.

Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly.

Tsai WC, Gayatri S, Reineke LC, Sbardella G, Bedford MT, Lloyd RE.

J Biol Chem. 2016 Oct 21;291(43):22671-22685. Epub 2016 Sep 6.

31.

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL.

Cell. 2016 Aug 11;166(4):950-962. doi: 10.1016/j.cell.2016.07.005.

32.

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding.

Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.

J Virol. 2016 Sep 29;90(20):9163-71. doi: 10.1128/JVI.01078-16. Print 2016 Oct 15.

33.

Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs.

Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT.

Sci Rep. 2016 Jun 24;6:28718. doi: 10.1038/srep28718.

34.

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X.

Nat Commun. 2016 Mar 10;7:10810. doi: 10.1038/ncomms10810.

35.

Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.

Bao J, Bedford MT.

Reproduction. 2016 May;151(5):R55-70. doi: 10.1530/REP-15-0562. Epub 2016 Feb 5. Review.

36.

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV.

Nat Chem Biol. 2016 Mar;12(3):180-7. doi: 10.1038/nchembio.2007. Epub 2016 Jan 25.

37.

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.

Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R.

Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11.

PMID:
26751641
38.

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression.

Estève PO, Zhang G, Ponnaluri VK, Deepti K, Chin HG, Dai N, Sagum C, Black K, Corrêa IR Jr, Bedford MT, Cheng X, Pradhan S.

Nucleic Acids Res. 2016 Feb 29;44(4):1642-56. doi: 10.1093/nar/gkv1162. Epub 2015 Nov 8.

39.

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.

Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F.

J Invest Dermatol. 2015 Dec;135(12):3133-3143. doi: 10.1038/jid.2015.314. Epub 2015 Aug 19.

40.

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG.

J Biol Chem. 2015 Jul 3;290(27):16723-43. doi: 10.1074/jbc.M115.659433. Epub 2015 May 15.

41.

Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.

Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X.

Mol Cell. 2015 Jun 4;58(5):863-9. doi: 10.1016/j.molcel.2015.03.032. Epub 2015 May 7.

42.

Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility.

Sarker RS, John-Schuster G, Bohla A, Mutze K, Burgstaller G, Bedford MT, Königshoff M, Eickelberg O, Yildirim AÖ.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):769-81. doi: 10.1165/rcmb.2014-0216OC.

43.

Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus.

Hu SB, Xiang JF, Li X, Xu Y, Xue W, Huang M, Wong CC, Sagum CA, Bedford MT, Yang L, Cheng D, Chen LL.

Genes Dev. 2015 Mar 15;29(6):630-45. doi: 10.1101/gad.257048.114.

44.

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.

Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT.

Nat Commun. 2015 Mar 4;6:6428. doi: 10.1038/ncomms7428.

45.

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A.

J Biol Chem. 2014 Dec 26;289(52):36048-58. doi: 10.1074/jbc.M114.603548. Epub 2014 Nov 7.

46.

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11341-6. doi: 10.1073/pnas.1403737111. Epub 2014 Jul 21.

47.

A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator.

Di Lorenzo A, Yang Y, Macaluso M, Bedford MT.

Nucleic Acids Res. 2014 Jul;42(13):8297-309. doi: 10.1093/nar/gku530. Epub 2014 Jun 17.

48.

Readers of histone methylarginine marks.

Gayatri S, Bedford MT.

Biochim Biophys Acta. 2014 Aug;1839(8):702-10. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28. Review.

49.

Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.

Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT.

Mol Cell. 2014 Feb 6;53(3):484-97. doi: 10.1016/j.molcel.2014.01.011.

50.

Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.

Estève PO, Terragni J, Deepti K, Chin HG, Dai N, Espejo A, Corrêa IR Jr, Bedford MT, Pradhan S.

J Biol Chem. 2014 Mar 21;289(12):8277-87. doi: 10.1074/jbc.M113.525279. Epub 2014 Feb 3.

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