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Items: 1 to 50 of 126

1.

Directional Genomic Hybridization (dGH) for Detection of Intrachromosomal Rearrangements.

Robinson E, McKenna MJ, Bedford JS, Goodwin EH, Cornforth MN, Bailey SM, Ray FA.

Methods Mol Biol. 2019;1984:107-116. doi: 10.1007/978-1-4939-9432-8_13.

PMID:
31267426
2.

Persistence of Gamma-H2AX Foci in Bronchial Cells Correlates with Susceptibility to Radiation Associated Lung Cancer in Mice.

Ochola DO, Sharif R, Bedford JS, Keefe TJ, Kato TA, Fallgren CM, Demant P, Costes SV, Weil MM.

Radiat Res. 2019 Jan;191(1):67-75. doi: 10.1667/RR14979.1. Epub 2018 Nov 6.

PMID:
30398394
3.

Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells.

Cornforth MN, Anur P, Wang N, Robinson E, Ray FA, Bedford JS, Loucas BD, Williams ES, Peto M, Spellman P, Kollipara R, Kittler R, Gray JW, Bailey SM.

Radiat Res. 2018 Jul;190(1):88-97. doi: 10.1667/RR15053.1. Epub 2018 May 11.

4.

Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells.

Nagasawa H, Lin YF, Kato TA, Brogan JR, Shih HY, Kurimasa A, Bedford JS, Chen BP, Little JB.

Radiat Res. 2017 Feb;187(2):259-267. doi: 10.1667/RR14679.1. Epub 2017 Jan 24.

5.

Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.

Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF Jr, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP.

PLoS One. 2014 Apr 8;9(4):e93579. doi: 10.1371/journal.pone.0093579. eCollection 2014.

6.

Directional genomic hybridization: inversions as a potential biodosimeter for retrospective radiation exposure.

Ray FA, Robinson E, McKenna M, Hada M, George K, Cucinotta F, Goodwin EH, Bedford JS, Bailey SM, Cornforth MN.

Radiat Environ Biophys. 2014 May;53(2):255-63. doi: 10.1007/s00411-014-0513-1. Epub 2014 Jan 30.

PMID:
24477407
7.

From DNA damage to chromosome aberrations: joining the break.

Durante M, Bedford JS, Chen DJ, Conrad S, Cornforth MN, Natarajan AT, van Gent DC, Obe G.

Mutat Res. 2013 Aug 30;756(1-2):5-13. doi: 10.1016/j.mrgentox.2013.05.014. Epub 2013 May 23.

PMID:
23707699
8.

Directional genomic hybridization for chromosomal inversion discovery and detection.

Ray FA, Zimmerman E, Robinson B, Cornforth MN, Bedford JS, Goodwin EH, Bailey SM.

Chromosome Res. 2013 Apr;21(2):165-74. doi: 10.1007/s10577-013-9345-0. Epub 2013 Apr 10.

9.

Genetic susceptibility: radiation effects relevant to space travel.

Peng Y, Nagasawa H, Warner C, Bedford JS.

Health Phys. 2012 Nov;103(5):607-20. doi: 10.1097/HP.0b013e31826945b9.

PMID:
23032891
10.

Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation.

Steffen LS, Bacher JW, Peng Y, Le PN, Ding LH, Genik PC, Ray FA, Bedford JS, Fallgren CM, Bailey SM, Ullrich RL, Weil MM, Story MD.

Mutagenesis. 2013 Jan;28(1):71-9. doi: 10.1093/mutage/ges055. Epub 2012 Sep 17.

11.

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.

Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'Sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, Thorburn A, Jimeno A, Raben D, Bedford JS, Li CY.

Nat Med. 2011 Jul 3;17(7):860-6. doi: 10.1038/nm.2385.

12.

Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo.

Li W, Li F, Huang Q, Shen J, Wolf F, He Y, Liu X, Hu YA, Bedford JS, Li CY.

Cancer Res. 2011 Jun 15;71(12):4130-7. doi: 10.1158/0008-5472.CAN-10-2540. Epub 2011 Apr 28.

13.

Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.

Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS, Chen BP.

Radiat Res. 2011 Jan;175(1):83-9. doi: 10.1667/RR2092.1. Epub 2010 Nov 17.

14.

Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining.

Nagasawa H, Brogan JR, Peng Y, Little JB, Bedford JS.

Mutat Res. 2010 Aug 14;701(1):12-22. doi: 10.1016/j.mrgentox.2010.03.003. Epub 2010 Mar 16. Review.

PMID:
20298803
15.

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.

Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY.

Sci Signal. 2010 Feb 23;3(110):ra13. doi: 10.1126/scisignal.2000634.

16.

G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls.

Wilson PF, Nagasawa H, Fitzek MM, Little JB, Bedford JS.

Radiat Res. 2010 Jan;173(1):62-70. doi: 10.1667/RR1943.1.

17.

Variations in radiosensitivity among individuals: a potential impact on risk assessment?

Kato TA, Wilson PF, Nagasaw H, Peng Y, Weil MM, Little JB, Bedford JS.

Health Phys. 2009 Nov;97(5):470-80. doi: 10.1097/HP.0b013e3181b08eee. Review.

PMID:
19820456
18.

Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions.

Weil MM, Bedford JS, Bielefeldt-Ohmann H, Ray FA, Genik PC, Ehrhart EJ, Fallgren CM, Hailu F, Battaglia CL, Charles B, Callan MA, Ullrich RL.

Radiat Res. 2009 Aug;172(2):213-9. doi: 10.1667/RR1648.1.

PMID:
19630525
19.

Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel.

Lin YF, Nagasawa H, Peng Y, Chuang EY, Bedford JS.

Radiat Res. 2009 Jun;171(6):708-15. doi: 10.1667/RR1554.1.

PMID:
19580477
21.

Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations.

Peng Y, Brown N, Finnon R, Warner CL, Liu X, Genik PC, Callan MA, Ray FA, Borak TB, Badie C, Bouffler SD, Ullrich RL, Bedford JS, Weil MM.

Radiat Res. 2009 Apr;171(4):474-83. doi: 10.1667/RR1547.1.

PMID:
19397448
22.

Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis.

Kato TA, Okayasu R, Bedford JS.

J Cell Physiol. 2009 Jun;219(3):760-5. doi: 10.1002/jcp.21726.

PMID:
19206160
23.
24.

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination.

Nagasawa H, Wilson PF, Chen DJ, Thompson LH, Bedford JS, Little JB.

DNA Repair (Amst). 2008 Mar 1;7(3):515-22. doi: 10.1016/j.dnarep.2007.11.014. Epub 2008 Jan 7.

PMID:
18182331
25.

Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells.

Kato TA, Okayasu R, Bedford JS.

Mutat Res. 2008 Mar 1;639(1-2):108-12. doi: 10.1016/j.mrfmmm.2007.11.006. Epub 2007 Nov 29.

PMID:
18179804
26.
27.

A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans.

Kato TA, Wilson PF, Nagasawa H, Fitzek MM, Weil MM, Little JB, Bedford JS.

DNA Repair (Amst). 2007 Jun 1;6(6):818-29. Epub 2007 Mar 6.

PMID:
17339135
29.

Studies on chromosome aberration induction: what can they tell us about DNA repair?

Bailey SM, Bedford JS.

DNA Repair (Amst). 2006 Sep 8;5(9-10):1171-81. Epub 2006 Jun 30. Review.

PMID:
16814619
30.

gamma-H2AX foci after low-dose-rate irradiation reveal atm haploinsufficiency in mice.

Kato TA, Nagasawa H, Weil MM, Genik PC, Little JB, Bedford JS.

Radiat Res. 2006 Jul;166(1 Pt 1):47-54.

PMID:
16808619
31.

Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.

Chuang EY, Chen X, Tsai MH, Yan H, Li CY, Mitchell JB, Nagasawa H, Wilson PF, Peng Y, Fitzek MM, Bedford JS, Little JB.

Cancer Res. 2006 Apr 1;66(7):3428-33.

32.

Repression of mutagenesis by Rad51D-mediated homologous recombination.

Hinz JM, Tebbs RS, Wilson PF, Nham PB, Salazar EP, Nagasawa H, Urbin SS, Bedford JS, Thompson LH.

Nucleic Acids Res. 2006 Mar 6;34(5):1358-68. Print 2006.

33.

A unique role of the DNA fragmentation factor in maintaining genomic stability.

Yan B, Wang H, Peng Y, Hu Y, Wang H, Zhang X, Chen Q, Bedford JS, Dewhirst MW, Li CY.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1504-9. Epub 2006 Jan 23.

34.

Suppression of DNA-PK by RNAi has different quantitative effects on telomere dysfunction and mutagenesis in human lymphoblasts treated with gamma rays or HZE particles.

Zhang Q, Williams ES, Askin KF, Peng Y, Bedford JS, Liber HL, Bailey SM.

Radiat Res. 2005 Oct;164(4 Pt 2):497-504.

PMID:
16187756
35.

Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations.

Nagasawa H, Peng Y, Wilson PF, Lio YC, Chen DJ, Bedford JS, Little JB.

Radiat Res. 2005 Aug;164(2):141-7.

PMID:
16038585
36.

Polymerase chain reaction-based suppression of repetitive sequences in whole chromosome painting probes for FISH.

Dugan LC, Pattee MS, Williams J, Eklund M, Sorensen K, Bedford JS, Christian AT.

Chromosome Res. 2005;13(1):27-32.

PMID:
15791409
37.

Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.

Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS.

Cancer Res. 2005 Mar 1;65(5):1670-7.

38.
39.
40.

Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003.

Coleman CN, Stone HB, Alexander GA, Barcellos-Hoff MH, Bedford JS, Bristow RG, Dynlacht JR, Fuks Z, Gorelic LS, Hill RP, Joiner MC, Liu FF, McBride WH, McKenna WG, Powell SN, Robbins ME, Rockwell S, Schiff PB, Shaw EG, Siemann DW, Travis EL, Wallner PE, Wong RS, Zeman EM.

Radiat Res. 2003 Dec;160(6):729-37.

PMID:
14640790
41.
42.
43.

Environmental biodosimetry: a biologically relevant tool for ecological risk assessment and biomonitoring.

Ulsh B, Hinton TG, Congdon JD, Dugan LC, Whicker FW, Bedford JS.

J Environ Radioact. 2003;66(1-2):121-39.

PMID:
12590073
44.

Induction of DNA double strand breaks by arsenite: comparative studies with DNA breaks induced by X-rays.

Okayasu R, Takahashi S, Sato H, Kubota Y, Scolavino S, Bedford JS.

DNA Repair (Amst). 2003 Mar 1;2(3):309-14.

PMID:
12547393
46.

Inhibition of DNA-double strand break repair by antimony compounds.

Takahashi S, Sato H, Kubota Y, Utsumi H, Bedford JS, Okayasu R.

Toxicology. 2002 Dec 2;180(3):249-56.

PMID:
12393294
48.
49.

Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.

Lin JY, Pollack JR, Chou FL, Rees CA, Christian AT, Bedford JS, Brown PO, Ginsberg MH.

Genome Biol. 2002;3(6):RESEARCH0026. Epub 2002 May 14.

50.

Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells.

Jha MN, Bamburg JR, Bernstein BW, Bedford JS.

Radiat Res. 2002 Jan;157(1):26-31.

PMID:
11754638

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