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Items: 45


Zebrafish: A Pharmacogenetic Model for Anesthesia.

Bedell V, Buglo E, Marcato D, Pylatiuk C, Mikut R, Stegmaier J, Scudder W, Wray M, Züchner S, Strähle U, Peravali R, Dallman JE.

Methods Enzymol. 2018;602:189-209. doi: 10.1016/bs.mie.2018.02.004. Epub 2018 Mar 15.


Correction: RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells (doi:10.1242/jcs.167601).

Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D.

J Cell Sci. 2018 Mar 16;131(6). pii: jcs217604. doi: 10.1242/jcs.217604. No abstract available.


Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.

Herrera AF, Rodig SJ, Song JY, Kim Y, Griffin GK, Yang D, Nikolaenko L, Mei M, Bedell V, Dal Cin P, Pak C, Alyea EP, Budde LE, Chen R, Chen YB, Chan WC, Cutler CS, Ho VT, Koreth J, Krishnan A, Murata-Collins JL, Nikiforow S, Palmer J, Pihan GA, Pillai R, Popplewell L, Rosen ST, Siddiqi T, Sohani AR, Zain J, Kwak LW, Weisenburger DD, Weinstock DM, Soiffer RJ, Antin JH, Forman SJ, Nademanee AP, Armand P.

Biol Blood Marrow Transplant. 2018 Mar;24(3):514-520. doi: 10.1016/j.bbmt.2017.11.023. Epub 2017 Nov 28.


Favorable impact of allogeneic stem cell transplantation in patients with therapy-related myelodysplasia regardless of TP53 mutational status.

Aldoss I, Pham A, Li SM, Gendzekhadze K, Afkhami M, Telatar M, Hong H, Padeganeh A, Bedell V, Cao T, Khaled SK, Malki MMA, Salhotra A, Ali H, Aribi A, Palmer J, Aoun P, Spielberger R, Stein AS, Snyder D, O'Donnell MR, Murata-Collins J, Senitzer D, Weisenburger D, Forman SJ, Pullarkat V, Marcucci G, Pillai R, Nakamura R.

Haematologica. 2017 Dec;102(12):2030-2038. doi: 10.3324/haematol.2017.172544. Epub 2017 Sep 29.


Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation.

Herrera AF, Mei M, Low L, Kim HT, Griffin GK, Song JY, Merryman RW, Bedell V, Pak C, Sun H, Paris T, Stiller T, Brown JR, Budde LE, Chan WC, Chen R, Davids MS, Freedman AS, Fisher DC, Jacobsen ED, Jacobson CA, LaCasce AS, Murata-Collins J, Nademanee AP, Palmer JM, Pihan GA, Pillai R, Popplewell L, Siddiqi T, Sohani AR, Zain J, Rosen ST, Kwak LW, Weinstock DM, Forman SJ, Weisenburger DD, Kim Y, Rodig SJ, Krishnan A, Armand P.

J Clin Oncol. 2017 Jan;35(1):24-31. Epub 2016 Oct 24.


Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.

Portnow J, Synold TW, Badie B, Tirughana R, Lacey SF, D'Apuzzo M, Metz MZ, Najbauer J, Bedell V, Vo T, Gutova M, Frankel P, Chen M, Aboody KS.

Clin Cancer Res. 2017 Jun 15;23(12):2951-2960. doi: 10.1158/1078-0432.CCR-16-1518. Epub 2016 Dec 15.


Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells.

DiGiusto DL, Cannon PM, Holmes MC, Li L, Rao A, Wang J, Lee G, Gregory PD, Kim KA, Hayward SB, Meyer K, Exline C, Lopez E, Henley J, Gonzalez N, Bedell V, Stan R, Zaia JA.

Mol Ther Methods Clin Dev. 2016 Nov 9;3:16067. eCollection 2016.


Cyclin D1 expression in peripheral T-cell lymphomas.

Song JY, Song L, Herrera AF, Venkataraman G, Murata-Collins JL, Bedell VH, Chen YY, Kim YS, Tadros R, Nathwani BN, Weisenburger DD, Feldman AL.

Mod Pathol. 2016 Nov;29(11):1306-1312. doi: 10.1038/modpathol.2016.136. Epub 2016 Jul 29.


Maternal Marijuana Use and Adverse Neonatal Outcomes: A Systematic Review and Meta-analysis.

Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG.

Obstet Gynecol. 2016 Oct;128(4):713-23. doi: 10.1097/AOG.0000000000001649.


Cyclin D1 depletion induces DNA damage in mantle cell lymphoma lines.

Mohanty S, Mohanty A, Sandoval N, Tran T, Bedell V, Wu J, Scuto A, Murata-Collins J, Weisenburger DD, Ngo VN.

Leuk Lymphoma. 2017 Mar;58(3):676-688. doi: 10.1080/10428194.2016.1198958. Epub 2016 Jun 24.


RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.

Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D.

J Cell Sci. 2015 Oct 1;128(19):3556-68. doi: 10.1242/jcs.167601. Epub 2015 Jul 1. Erratum in: J Cell Sci. 2018 Mar 16;131(6):.


Using engineered endonucleases to create knockout and knockin zebrafish models.

Bedell VM, Ekker SC.

Methods Mol Biol. 2015;1239:291-305. doi: 10.1007/978-1-4939-1862-1_17.


Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.

Pullarkat ST, Pullarkat V, Lagoo A, Brynes R, Weiss LM, Bedell V, Chen W, Huang Q, Gaal K, Weisenburger DD, Kim YS.

Leuk Res. 2013 Nov;37(11):1572-5. doi: 10.1016/j.leukres.2013.08.010. Epub 2013 Sep 1.


In vivo genome editing using a high-efficiency TALEN system.

Bedell VM, Wang Y, Campbell JM, Poshusta TL, Starker CG, Krug RG 2nd, Tan W, Penheiter SG, Ma AC, Leung AY, Fahrenkrug SC, Carlson DF, Voytas DF, Clark KJ, Essner JJ, Ekker SC.

Nature. 2012 Nov 1;491(7422):114-8. doi: 10.1038/nature11537. Epub 2012 Sep 23.


2'-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2'-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites.

Lamparska K, Clark J, Babilonia G, Bedell V, Yip W, Smith SS.

Nucleic Acids Res. 2012 Oct;40(19):9788-801. doi: 10.1093/nar/gks706. Epub 2012 Jul 31.


Nervy vasculature.

Bedell VM, Ekker SC.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1546-7. doi: 10.1161/ATVBAHA.112.251272. No abstract available.


Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton.

McNulty MS, Bedell VM, Greenwood TM, Craig TA, Ekker SC, Kumar R.

Gene Expr Patterns. 2012 Aug-Sep;12(7-8):228-35. doi: 10.1016/j.gep.2012.04.003. Epub 2012 May 7.


The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development.

Bedell VM, Person AD, Larson JD, McLoon A, Balciunas D, Clark KJ, Neff KI, Nelson KE, Bill BR, Schimmenti LA, Beiraghi S, Ekker SC.

Development. 2012 Feb;139(4):793-804. doi: 10.1242/dev.071720.


Lessons from morpholino-based screening in zebrafish.

Bedell VM, Westcot SE, Ekker SC.

Brief Funct Genomics. 2011 Jul;10(4):181-8. doi: 10.1093/bfgp/elr021. Epub 2011 Jul 10. Review.


In vivo protein trapping produces a functional expression codex of the vertebrate proteome.

Clark KJ, Balciunas D, Pogoda HM, Ding Y, Westcot SE, Bedell VM, Greenwood TM, Urban MD, Skuster KJ, Petzold AM, Ni J, Nielsen AL, Patowary A, Scaria V, Sivasubbu S, Xu X, Hammerschmidt M, Ekker SC.

Nat Methods. 2011 Jun;8(6):506-15. doi: 10.1038/nmeth.1606. Epub 2011 May 8.


Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma.

Slovak ML, Bedell V, Hsu YH, Estrine DB, Nowak NJ, Delioukina ML, Weiss LM, Smith DD, Forman SJ.

Clin Cancer Res. 2011 May 15;17(10):3443-54. doi: 10.1158/1078-0432.CCR-10-1071. Epub 2011 Mar 8.


Evaluation of chronic lymphocytic leukemia by BAC-based microarray analysis.

Schultz RA, Delioukina M, Gaal K, Bedell V, Smith DD, Forman SJ, McDaniel LD, Ballif BC, Shaffer LG, Slovak ML.

Mol Cytogenet. 2011 Feb 3;4(1):4. doi: 10.1186/1755-8166-4-4.


Assessing karyotype precision by microarray-based comparative genomic hybridization in the myelodysplastic/myeloproliferative syndromes.

Slovak ML, Smith DD, Bedell V, Hsu YH, O'Donnell M, Forman SJ, Gaal K, McDaniel L, Schultz R, Ballif BC, Shaffer LG.

Mol Cytogenet. 2010 Nov 15;3:23. doi: 10.1186/1755-8166-3-23.


SCORE imaging: specimen in a corrected optical rotational enclosure.

Petzold AM, Bedell VM, Boczek NJ, Essner JJ, Balciunas D, Clark KJ, Ekker SC.

Zebrafish. 2010 Jun;7(2):149-54. doi: 10.1089/zeb.2010.0660.


Nicotine response genetics in the zebrafish.

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, Ekker SC.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18662-7. doi: 10.1073/pnas.0908247106. Epub 2009 Oct 26.


Screening for clonal hematopoiesis as a predictive marker for development of therapy-related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012).

Slovak ML, Bedell V, Lew D, Albain KS, Ellis GK, Livingston RB, Martino S, Perez EA, Hortobagyi GN, Sher D, Stock W.

Breast Cancer Res Treat. 2010 Jan;119(2):391-8. doi: 10.1007/s10549-009-0597-5.


Acute leukemia and myelodysplasia after adjuvant chemotherapy for breast cancer: durable remissions after hematopoietic stem cell transplantation.

Pullarkat V, Slovak ML, Dagis A, Bedell V, Somlo G, Nakamura R, Stein AS, O'Donnell MR, Nademanee A, Teotico AL, Bhatia S, Forman SJ.

Ann Oncol. 2009 Dec;20(12):2000-6. doi: 10.1093/annonc/mdp232. Epub 2009 Jun 29.


The ins and outs of VEGF signaling.

Ekker SC, Bedell VM.

Blood. 2009 Mar 5;113(10):2123-4. doi: 10.1182/blood-2008-11-189746. No abstract available.


Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma.

Liu H, Huang J, Wang J, Jiang S, Bailey AS, Goldman DC, Welcker M, Bedell V, Slovak ML, Clurman B, Thayer M, Fleming WH, Epner E.

J Exp Med. 2008 Aug 4;205(8):1843-58. doi: 10.1084/jem.20072102. Epub 2008 Jul 14.


Detection of copy number alterations in metastatic melanoma by a DNA fluorescence in situ hybridization probe panel and array comparative genomic hybridization: a southwest oncology group study (S9431).

Moore SR, Persons DL, Sosman JA, Bobadilla D, Bedell V, Smith DD, Wolman SR, Tuthill RJ, Moon J, Sondak VK, Slovak ML.

Clin Cancer Res. 2008 May 15;14(10):2927-35. doi: 10.1158/1078-0432.CCR-07-4068.


Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia.

Pullarkat ST, Vardiman JW, Slovak ML, Rao DS, Rao NP, Bedell V, Said JW.

Leuk Res. 2008 Nov;32(11):1770-5. doi: 10.1016/j.leukres.2008.02.025. Epub 2008 Apr 15.


A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro.

Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP.

J Cell Sci. 2006 Oct 1;119(Pt 19):4117-26. Epub 2006 Sep 12.


Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone.

Pullarkat V, Bedell V, Kim Y, Bhatia R, Nakamura R, Forman S, Sun J, Senitzer D, Slovak ML.

Leuk Res. 2007 Feb;31(2):261-5. Epub 2006 Jul 28.


Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas.

Chow WA, Bedell V, Gaytan P, Borden E, Goldblum J, Hicks D, Slovak ML.

Cancer Genet Cytogenet. 2006 Apr 15;166(2):95-100.


Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R.

J Biol Chem. 2006 Apr 21;281(16):11347-56. Epub 2006 Feb 15.


Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

Zhu L, Somlo G, Zhou B, Shao J, Bedell V, Slovak ML, Liu X, Luo J, Yen Y.

Mol Cancer Ther. 2005 May;4(5):787-98.


roundabout4 is essential for angiogenesis in vivo.

Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6373-8. Epub 2005 Apr 22.


Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype/genotype fluorescence in situ hybridization.

Slovak ML, Bedell V, Pagel K, Chang KL, Smith D, Somlo G.

Cancer Genet Cytogenet. 2005 Apr 15;158(2):99-109.


Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia.

Arber DA, Chang KL, Lyda MH, Bedell V, Spielberger R, Slovak ML.

Hum Pathol. 2003 Aug;34(8):809-13.


High frequency of pro-B acute lymphoblastic leukemia in adults with secondary leukemia with 11q23 abnormalities.

Ishizawa S, Slovak ML, Popplewell L, Bedell V, Wrede JE, Carter NH, Snyder DS, Arber DA.

Leukemia. 2003 Jun;17(6):1091-5.


Targeting multiple genetic aberrations in isolated tumor cells by spectral fluorescence in situ hybridization.

Slovak ML, Zhang F, Tcheurekdjian L, Bobadilla D, Bedell V, Arber DA, Persons DL, Sosman JA, Murata-Collins JL.

Cancer Detect Prev. 2002;26(3):171-9.


21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop.

Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R.

Genes Chromosomes Cancer. 2002 Apr;33(4):379-94.


Therapy-related acute myeloid leukemia/myelodysplasia with balanced 21q22 translocations.

Arber DA, Slovak ML, Popplewell L, Bedell V, Ikle D, Rowley JD; International Workshop on Leukemia Karyotype and Prior Therapy.

Am J Clin Pathol. 2002 Feb;117(2):306-13.


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