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Items: 8

1.

POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients.

Baird RD, van Rossum AGJ, Oliveira M, Beelen K, Gao M, Schrier M, Mandjes IAM, Garcia-Corbacho J, Vallier AL, Dougall G, van Werkhoven E, Linossi C, Kumar S, van Tinteren H, Callari M, Beddowes E, Perez-Garcia JM, Rosing H, Platte E, Nederlof P, Schot M, de Vries Schultink A, Bernards R, Saura C, Gallagher W, Cort├Ęs J, Caldas C, Linn SC.

Clin Cancer Res. 2019 Nov 15;25(22):6598-6605. doi: 10.1158/1078-0432.CCR-19-0508. Epub 2019 Aug 22.

PMID:
31439579
2.

Cancer Treatment in the Genomic Era.

Doherty GJ, Petruzzelli M, Beddowes E, Ahmad SS, Caldas C, Gilbertson RJ.

Annu Rev Biochem. 2019 Jun 20;88:247-280. doi: 10.1146/annurev-biochem-062917-011840. Epub 2019 Mar 22.

PMID:
30901264
3.

Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA.

Gao M, Callari M, Beddowes E, Sammut SJ, Grzelak M, Biggs H, Jones L, Boumertit A, Linn SC, Cortes J, Oliveira M, Baird R, Chin SF, Caldas C.

Genome Med. 2019 Jan 4;11(1):1. doi: 10.1186/s13073-018-0611-9.

4.

Predicting treatment resistance and relapse through circulating DNA.

Beddowes E, Sammut SJ, Gao M, Caldas C.

Breast. 2017 Aug;34 Suppl 1:S31-S35. doi: 10.1016/j.breast.2017.06.024. Epub 2017 Jul 8. Review.

PMID:
28694015
5.

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers.

Beddowes E, Spicer J, Chan PY, Khadeir R, Corbacho JG, Repana D, Steele JP, Schmid P, Szyszko T, Cook G, Diaz M, Feng X, Johnston A, Thomson J, Sheaff M, Wu BW, Bomalaski J, Pacey S, Szlosarek PW.

J Clin Oncol. 2017 Jun 1;35(16):1778-1785. doi: 10.1200/JCO.2016.71.3230. Epub 2017 Apr 7.

6.

IgG4 subclass antibodies impair antitumor immunity in melanoma.

Karagiannis P, Gilbert AE, Josephs DH, Ali N, Dodev T, Saul L, Correa I, Roberts L, Beddowes E, Koers A, Hobbs C, Ferreira S, Geh JL, Healy C, Harries M, Acland KM, Blower PJ, Mitchell T, Fear DJ, Spicer JF, Lacy KE, Nestle FO, Karagiannis SN.

J Clin Invest. 2013 Apr;123(4):1457-74.

7.

The multiple influences of glutathione on bromate genotoxicity: implications for the dose-response relationship.

Chipman JK, Parsons JL, Beddowes EJ.

Toxicology. 2006 Apr 17;221(2-3):187-9. Epub 2006 Feb 7.

PMID:
16464527
8.

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