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Items: 9


PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.

Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov VB, Church CD, Rodeheffer MS, Cline GW, Geisler JG, Bhanot S, Samuel VT.

Endocrinology. 2019 Jan 1;160(1):205-219. doi: 10.1210/en.2018-00630.


Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E89-100. doi: 10.1152/ajpendo.00573.2012. Epub 2013 May 7.


Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.

Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT.

Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19.


Hepatic glucose production pathways after three days of a high-fat diet.

Jin ES, Beddow SA, Malloy CR, Samuel VT.

Metabolism. 2013 Jan;62(1):152-62. doi: 10.1016/j.metabol.2012.07.012. Epub 2012 Sep 12.


Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes.

Beddow SA, Samuel VT.

Dis Model Mech. 2012 Sep;5(5):681-5. doi: 10.1242/dmm.009035. Epub 2012 Aug 3.


Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.

Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16381-5. doi: 10.1073/pnas.1113359108. Epub 2011 Sep 19.


FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ.

Science. 2011 Mar 25;331(6024):1621-4. doi: 10.1126/science.1198363.


Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.

Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12121-6. doi: 10.1073/pnas.0812547106. Epub 2009 Jul 8.


Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI.

J Clin Invest. 2007 Mar;117(3):739-45. Epub 2007 Feb 22.

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