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Items: 1 to 50 of 65

1.

Preliminary evaluation of effect of two visual aid devices on navigation in blind dogs.

Bedard KM, Myrna KE, Diehl KA.

J Small Anim Pract. 2020 Feb 20. doi: 10.1111/jsap.13120. [Epub ahead of print]

PMID:
32077502
2.

A potent Lassa virus antiviral targets an arenavirus virulence determinant.

Madu IG, Files M, Gharaibeh DN, Moore AL, Jung KH, Gowen BB, Dai D, Jones KF, Tyavanagimatt SR, Burgeson JR, Korth MJ, Bedard KM, Iadonato SP, Amberg SM.

PLoS Pathog. 2018 Dec 21;14(12):e1007439. doi: 10.1371/journal.ppat.1007439. eCollection 2018 Dec.

3.

Ocular Surface Disease of Rabbits.

Bedard KM.

Vet Clin North Am Exot Anim Pract. 2019 Jan;22(1):1-14. doi: 10.1016/j.cvex.2018.08.003. Review.

PMID:
30454757
4.

Relationship between symptoms and quality of life in fecal incontinence.

Bedard K, Heymen S, Palsson OS, Bharucha AE, Whitehead WE.

Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13241. Epub 2017 Nov 2.

5.

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP Jr, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, Lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Sunaric Megevand G, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega Cueto L, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kasım B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor CC.

Nat Genet. 2017 Jul;49(7):993-1004. doi: 10.1038/ng.3875. Epub 2017 May 29.

6.

Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations.

Obaid NM, Bedard K, Huang WY.

Int J Mol Sci. 2017 Mar 8;18(3). pii: E585. doi: 10.3390/ijms18030585. Review.

7.

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.

Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato SP, Bedard KM.

Vaccine. 2017 Apr 4;35(15):1964-1971. doi: 10.1016/j.vaccine.2017.01.053. Epub 2017 Mar 6.

PMID:
28279563
8.

Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties.

Whitehouse S, Chen PL, Greenshields AL, Nightingale M, Hoskin DW, Bedard K.

Phytomedicine. 2016 Nov 15;23(12):1494-1503. doi: 10.1016/j.phymed.2016.08.011. Epub 2016 Aug 31.

PMID:
27765370
9.

Dual phase-shift Bragg grating silicon photonic modulator operating up to 60 Gb/s.

Bédard K, Simard AD, Filion B, Painchaud Y, Rusch LA, LaRochelle S.

Opt Express. 2016 Feb 8;24(3):2413-9. doi: 10.1364/OE.24.002413.

10.

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, Gale M Jr.

J Virol. 2015 Dec 16;90(5):2372-87. doi: 10.1128/JVI.02202-15.

11.

A Highly Diverse Portrait: Heterogeneity of Neuropsychological Profiles in cblC Defect.

Bellerose J, Neugnot-Cerioli M, Bédard K, Brunel-Guitton C, Mitchell GA, Ospina LH, Beauchamp MH.

JIMD Rep. 2016;29:19-32. Epub 2015 Nov 26.

12.

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Wu Z, Graybill TL, Zeng X, Platchek M, Zhang J, Bodmer VQ, Wisnoski DD, Deng J, Coppo FT, Yao G, Tamburino A, Scavello G, Franklin GJ, Mataruse S, Bedard KL, Ding Y, Chai J, Summerfield J, Centrella PA, Messer JA, Pope AJ, Israel DI.

ACS Comb Sci. 2015 Dec 14;17(12):722-31. doi: 10.1021/acscombsci.5b00124. Epub 2015 Dec 3.

PMID:
26562224
13.

Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics.

Bedard K, Whitehouse S, Jaquet V.

Antioxid Redox Signal. 2015 Aug 10;23(5):355-7. doi: 10.1089/ars.2015.6450.

PMID:
26207329
14.

Eculizumab reduces complement activation, inflammation, endothelial damage, thrombosis, and renal injury markers in aHUS.

Cofiell R, Kukreja A, Bedard K, Yan Y, Mickle AP, Ogawa M, Bedrosian CL, Faas SJ.

Blood. 2015 May 21;125(21):3253-62. doi: 10.1182/blood-2014-09-600411. Epub 2015 Apr 1.

15.

Micro-marketing healthier choices: effects of personalized ordering suggestions on restaurant purchases.

Bedard K, Kuhn P.

J Health Econ. 2015 Jan;39:106-22. doi: 10.1016/j.jhealeco.2014.10.006. Epub 2014 Nov 3.

16.

Germline mutations in MAP3K6 are associated with familial gastric cancer.

Gaston D, Hansford S, Oliveira C, Nightingale M, Pinheiro H, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K.

PLoS Genet. 2014 Oct 23;10(10):e1004669. doi: 10.1371/journal.pgen.1004669. eCollection 2014 Oct.

17.

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia.

Bentley VL, Veinotte CJ, Corkery DP, Pinder JB, LeBlanc MA, Bedard K, Weng AP, Berman JN, Dellaire G.

Haematologica. 2015 Jan;100(1):70-6. doi: 10.3324/haematol.2014.110742. Epub 2014 Oct 3.

18.

Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.

Robitaille JM, Gillett RM, LeBlanc MA, Gaston D, Nightingale M, Mackley MP, Parkash S, Hathaway J, Thomas A, Ells A, Traboulsi EI, Héon E, Roy M, Shalev S, Fernandez CV, MacGillivray C, Wallace K, Fahiminiya S, Majewski J, McMaster CR, Bedard K.

JAMA Ophthalmol. 2014 Dec;132(12):1393-9. doi: 10.1001/jamaophthalmol.2014.2814.

PMID:
25124931
19.

The risks for adolescents of negatively biased self-evaluations of social competence: the mediating role of social support.

Bédard K, Bouffard T, Pansu P.

J Adolesc. 2014 Aug;37(6):787-98. doi: 10.1016/j.adolescence.2014.05.004. Epub 2014 Jun 14.

PMID:
25086456
20.

Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature.

Afroz A, Howlett N, Shukla A, Ahmad F, Batista E, Bedard K, Payne S, Morton B, Mansfield JH, Glendinning JI.

Chem Senses. 2013 Sep;38(7):605-17. doi: 10.1093/chemse/bjt032. Epub 2013 Jul 4.

21.

A novel rearrangement of occludin causes brain calcification and renal dysfunction.

LeBlanc MA, Penney LS, Gaston D, Shi Y, Aberg E, Nightingale M, Jiang H, Gillett RM, Fahiminiya S, Macgillivray C, Wood EP, Acott PD, Khan MN, Samuels ME, Majewski J, Orr A, McMaster CR, Bedard K.

Hum Genet. 2013 Nov;132(11):1223-34. doi: 10.1007/s00439-013-1327-y. Epub 2013 Jun 21.

PMID:
23793442
22.

Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease.

Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW.

Dis Model Mech. 2013 May;6(3):780-92. doi: 10.1242/dmm.010942. Epub 2013 Mar 8.

23.

Novel splice-site mutation in ATP8B1 results in atypical progressive familial intrahepatic cholestasis type 1.

Copeland E, Renault N, Renault M, Dyack S, Bulman DE, Bedard K, Otley A, Magee F, Acott P, Greer WL.

J Gastroenterol Hepatol. 2013 Mar;28(3):560-4. doi: 10.1111/j.1440-1746.2012.07290.x.

PMID:
23033845
24.

Extensive natural variation for cellular hydrogen peroxide release is genetically controlled.

Attar H, Bedard K, Migliavacca E, Gagnebin M, Dupré Y, Descombes P, Borel C, Deutsch S, Prokisch H, Meitinger T, Mehta D, Wichmann E, Delabar JM, Dermitzakis ET, Krause KH, Antonarakis SE.

PLoS One. 2012;7(8):e43566. doi: 10.1371/journal.pone.0043566. Epub 2012 Aug 29.

25.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA.

J Med Chem. 2012 Aug 23;55(16):7061-79. doi: 10.1021/jm300449x. Epub 2012 Aug 14.

PMID:
22891645
26.

Cell-free screening for NOX inhibitors.

Bedard K, Jaquet V.

Chem Biol. 2012 Jun 22;19(6):664-5. doi: 10.1016/j.chembiol.2012.06.002.

27.

Aging and diets regulate the rat anterior pituitary and hypothalamic transcriptome.

Bédard K, Bédard J, Rocheleau G, Ferland G, Gaudreau P.

Neuroendocrinology. 2013;97(2):146-59. doi: 10.1159/000338411. Epub 2012 Oct 12.

PMID:
22538389
28.

Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses.

Bedard KM, Wang ML, Proll SC, Loo YM, Katze MG, Gale M Jr, Iadonato SP.

J Virol. 2012 Jul;86(13):7334-44. doi: 10.1128/JVI.06867-11. Epub 2012 Apr 24.

29.

Effects of aging and caloric restriction on brainstem satiety center signals in rats.

Moyse E, Bédard K, Segura S, Mahaut S, Tardivel C, Ferland G, Lebrun B, Gaudreau P.

Mech Ageing Dev. 2012 Feb-Mar;133(2-3):83-91. doi: 10.1016/j.mad.2012.01.004. Epub 2012 Jan 24.

PMID:
22285292
30.

NOX5: from basic biology to signaling and disease.

Bedard K, Jaquet V, Krause KH.

Free Radic Biol Med. 2012 Feb 15;52(4):725-34. doi: 10.1016/j.freeradbiomed.2011.11.023. Epub 2011 Dec 14. Review.

PMID:
22182486
31.

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.

Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K.

Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x.

32.

The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss.

Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB.

Mol Cancer Ther. 2010 Dec;9(12):3210-20. doi: 10.1158/1535-7163.MCT-10-0572.

33.

Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease.

Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M, Skidmore DL, Benstead T, Samuels ME.

PLoS Genet. 2010 Aug 26;6(8). pii: e1001081. doi: 10.1371/journal.pgen.1001081.

34.

The Canadian Partnership for Tomorrow Project: building a pan-Canadian research platform for disease prevention.

Borugian MJ, Robson P, Fortier I, Parker L, McLaughlin J, Knoppers BM, Bédard K, Gallagher RP, Sinclair S, Ferretti V, Whelan H, Hoskin D, Potter JD.

CMAJ. 2010 Aug 10;182(11):1197-201. doi: 10.1503/cmaj.091540. Epub 2010 Apr 26. No abstract available.

35.

Calnexin deficiency leads to dysmyelination.

Kraus A, Groenendyk J, Bedard K, Baldwin TA, Krause KH, Dubois-Dauphin M, Dyck J, Rosenbaum EE, Korngut L, Colley NJ, Gosgnach S, Zochodne D, Todd K, Agellon LB, Michalak M.

J Biol Chem. 2010 Jun 11;285(24):18928-38. doi: 10.1074/jbc.M110.107201. Epub 2010 Apr 16.

36.

Effects of long-term dietary interventions on pituitary growth hormone-releasing hormone receptor in aging rats and potential mechanisms of action.

Bédard K, Robinette K, Ferland G, Gaudreau P.

Mech Ageing Dev. 2010 Mar;131(3):169-78. doi: 10.1016/j.mad.2010.01.003. Epub 2010 Feb 1.

PMID:
20122951
37.

Current psychological perspectives on adolescent lesbian identity development.

Bedard KK, Marks AK.

J Lesbian Stud. 2010;14(1):16-25. doi: 10.1080/10894160903058857. Review.

PMID:
20077262
38.

Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions.

Akech J, Wixted JJ, Bedard K, van der Deen M, Hussain S, Guise TA, van Wijnen AJ, Stein JL, Languino LR, Altieri DC, Pratap J, Keller E, Stein GS, Lian JB.

Oncogene. 2010 Feb 11;29(6):811-21. doi: 10.1038/onc.2009.389. Epub 2009 Nov 16.

39.

Editorial: Genetic mapping--the path of discovery for novel functions of the NOX NADPH oxidases.

Jaquet V, Bedard K.

J Leukoc Biol. 2009 Sep;86(3):461-3. doi: 10.1189/jlb.0409243. No abstract available.

PMID:
19720613
40.

Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2.

Guernsey DL, Jiang H, Evans SC, Ferguson M, Matsuoka M, Nightingale M, Rideout AL, Provost S, Bedard K, Orr A, Dubé MP, Ludman M, Samuels ME.

Am J Hum Genet. 2009 Jul;85(1):120-9. doi: 10.1016/j.ajhg.2009.06.008. Epub 2009 Jul 2.

41.

Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.

Bedard K, Attar H, Bonnefont J, Jaquet V, Borel C, Plastre O, Stasia MJ, Antonarakis SE, Krause KH.

Hum Mutat. 2009 Jul;30(7):1123-33. doi: 10.1002/humu.21029.

PMID:
19388116
42.

NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle.

Basset O, Deffert C, Foti M, Bedard K, Jaquet V, Ogier-Denis E, Krause KH.

Antioxid Redox Signal. 2009 Oct;11(10):2371-84. doi: 10.1089/ARS.2009.2584.

PMID:
19309260
43.

Prison health care: is contracting out healthy?

Bedard K, Frech HE 3rd.

Health Econ. 2009 Nov;18(11):1248-60. doi: 10.1002/hec.1427.

PMID:
19142875
44.

NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression.

Li B, Bedard K, Sorce S, Hinz B, Dubois-Dauphin M, Krause KH.

J Innate Immun. 2009;1(6):570-81. doi: 10.1159/000235563. Epub 2009 Aug 14.

45.

E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation.

Underbrink MP, Howie HL, Bedard KM, Koop JI, Galloway DA.

J Virol. 2008 Nov;82(21):10408-17. doi: 10.1128/JVI.00902-08. Epub 2008 Aug 20.

46.

NOX enzymes in immuno-inflammatory pathologies.

Krause KH, Bedard K.

Semin Immunopathol. 2008 Jul;30(3):193-4. doi: 10.1007/s00281-008-0127-2. No abstract available.

PMID:
18560833
47.

Endoplasmic reticulum stress in the absence of calnexin.

Coe H, Bedard K, Groenendyk J, Jung J, Michalak M.

Cell Stress Chaperones. 2008 Dec;13(4):497-507. doi: 10.1007/s12192-008-0049-x. Epub 2008 Jun 5.

48.

Effects of a high-glucose environment on the pituitary growth hormone-releasing hormone receptor: type 1 diabetes compared with in vitro glucotoxicity.

Bédard K, Strecko J, Thériault K, Bédard J, Veyrat-Durebex C, Gaudreau P.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E740-51. doi: 10.1152/ajpendo.00141.2007. Epub 2008 Feb 19.

49.

The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes.

Bedard KM, Underbrink MP, Howie HL, Galloway DA.

J Virol. 2008 Apr;82(8):3894-902. doi: 10.1128/JVI.01818-07. Epub 2008 Feb 6.

50.

Regulatory role of UvrY in adaptation of Photorhabdus luminescens growth inside the insect.

Krin E, Derzelle S, Bedard K, Adib-Conquy M, Turlin E, Lenormand P, Hullo MF, Bonne I, Chakroun N, Lacroix C, Danchin A.

Environ Microbiol. 2008 May;10(5):1118-34. doi: 10.1111/j.1462-2920.2007.01528.x. Epub 2008 Jan 31.

PMID:
18248456

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