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Items: 1 to 50 of 370

1.

Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase 1b Study.

Kim ES, Kelly K, Paz-Ares L, Garrido P, Jalal S, Mahadevan D, Guttierrez MA, Provencio M, Schaefer E, Shaheen M, Johnston EL, Turner PK, Kambhampati SRP, Beckmann R, Hossain A, John WJ, Goldman JW.

Clin Cancer Res. 2018 Aug 6. pii: clincanres.0651.2018. doi: 10.1158/1078-0432.CCR-18-0651. [Epub ahead of print]

PMID:
30082474
2.

Spectrum and functional validation of PSMB5 mutations in multiple myeloma.

Barrio S, Stühmer T, Da-Viá M, Barrio-Garcia C, Lehners N, Besse A, Cuenca I, Garitano-Trojaola A, Fink S, Leich E, Chatterjee M, Driessen C, Martinez-Lopez J, Rosenwald A, Beckmann R, Bargou RC, Braggio E, Stewart AK, Raab MS, Einsele H, Kortüm KM.

Leukemia. 2018 Jul 19. doi: 10.1038/s41375-018-0216-8. [Epub ahead of print]

PMID:
30026573
3.

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Ensfelder TT, Kurz MQ, Iwan K, Geiger S, Matheisl S, Müller M, Beckmann R, Carell T.

Chem Commun (Camb). 2018 Aug 11;54(62):8591-8593. doi: 10.1039/c8cc03980a. Epub 2018 Jul 16.

PMID:
30010678
4.

Visualizing late states of human 40S ribosomal subunit maturation.

Ameismeier M, Cheng J, Berninghausen O, Beckmann R.

Nature. 2018 Jun;558(7709):249-253. doi: 10.1038/s41586-018-0193-0. Epub 2018 Jun 6.

PMID:
29875412
5.

Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.

Hong DS, Moore K, Patel M, Grant SC, Burris HA 3rd, William WN Jr, Jones S, Meric-Bernstam F, Infante J, Golden L, Zhang W, Martinez R, Wijayawardana S, Beckmann R, Lin AB, Eng C, Bendell J.

Clin Cancer Res. 2018 Jul 15;24(14):3263-3272. doi: 10.1158/1078-0432.CCR-17-3347. Epub 2018 Apr 11.

PMID:
29643063
6.

Reconstitution of Isotopically Labeled Ribosomal Protein L29 in the 50S Large Ribosomal Subunit for Solution-State and Solid-State NMR.

Barbet-Massin E, van der Sluis E, Musial J, Beckmann R, Reif B.

Methods Mol Biol. 2018;1764:87-100. doi: 10.1007/978-1-4939-7759-8_6.

PMID:
29605910
7.

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.

Schaer DA, Beckmann RP, Dempsey JA, Huber L, Forest A, Amaladas N, Li Y, Wang YC, Rasmussen ER, Chin D, Capen A, Carpenito C, Staschke KA, Chung LA, Litchfield LM, Merzoug FF, Gong X, Iversen PW, Buchanan S, de Dios A, Novosiadly RD, Kalos M.

Cell Rep. 2018 Mar 13;22(11):2978-2994. doi: 10.1016/j.celrep.2018.02.053.

8.

Expansion of functional personalized cells with specific transgene combinations.

Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T.

Nat Commun. 2018 Mar 8;9(1):994. doi: 10.1038/s41467-018-03408-4.

9.

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.

Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.

Science. 2018 Apr 13;360(6385):215-219. doi: 10.1126/science.aar7899. Epub 2018 Mar 8.

PMID:
29519914
10.

Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer.

O'Brien N, Conklin D, Beckmann R, Luo T, Chau K, Thomas J, Mc Nulty A, Marchal C, Kalous O, von Euw E, Hurvitz S, Mockbee C, Slamon DJ.

Mol Cancer Ther. 2018 May;17(5):897-907. doi: 10.1158/1535-7163.MCT-17-0290. Epub 2018 Feb 26.

PMID:
29483214
11.

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.

Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E.

Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4.

12.

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.

Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039.

13.

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.

Gong X, Litchfield LM, Webster Y, Chio LC, Wong SS, Stewart TR, Dowless M, Dempsey J, Zeng Y, Torres R, Boehnke K, Mur C, Marugán C, Baquero C, Yu C, Bray SM, Wulur IH, Bi C, Chu S, Qian HR, Iversen PW, Merzoug FF, Ye XS, Reinhard C, De Dios A, Du J, Caldwell CW, Lallena MJ, Beckmann RP, Buchanan SG.

Cancer Cell. 2017 Dec 11;32(6):761-776.e6. doi: 10.1016/j.ccell.2017.11.006.

PMID:
29232554
14.

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.

Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.

Elife. 2017 Nov 20;6. pii: e30189. doi: 10.7554/eLife.30189.

15.

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.

Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.

Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014.

PMID:
29100052
16.

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.

Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495. Epub 2017 Oct 30.

PMID:
29083413
17.

RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1.

Chen SH, Gong X, Zhang Y, Van Horn RD, Yin T, Huber L, Burke TF, Manro J, Iversen PW, Wu W, Bhagwat SV, Beckmann RP, Tiu RV, Buchanan SG, Peng SB.

Oncogene. 2018 Feb 8;37(6):821-832. doi: 10.1038/onc.2017.384. Epub 2017 Oct 23.

PMID:
29059158
18.

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer.

Torres-Guzmán R, Calsina B, Hermoso A, Baquero C, Alvarez B, Amat J, McNulty AM, Gong X, Boehnke K, Du J, de Dios A, Beckmann RP, Buchanan S, Lallena MJ.

Oncotarget. 2017 May 10;8(41):69493-69507. doi: 10.18632/oncotarget.17778. eCollection 2017 Sep 19.

19.

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.

Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R.

Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476. Epub 2017 Oct 2.

PMID:
28967883
20.

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T.

Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1.

21.

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.

Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.

Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439. Epub 2017 Jul 24.

22.

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R.

Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642.

23.

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.

EMBO J. 2017 Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3.

24.

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.

Yamashita Y, Takamatsu S, Glasbrenner M, Becker T, Naito S, Beckmann R.

FEBS Lett. 2017 May;591(9):1266-1277. doi: 10.1002/1873-3468.12634. Epub 2017 Apr 10.

25.

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.

Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.

Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3.

PMID:
28368393
26.

Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair.

Lin AB, McNeely SC, Beckmann RP.

Clin Cancer Res. 2017 Jul 1;23(13):3232-3240. doi: 10.1158/1078-0432.CCR-16-0083. Epub 2017 Mar 22. Review.

27.

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.

Lowery CD, VanWye AB, Dowless M, Blosser W, Falcon BL, Stewart J, Stephens J, Beckmann RP, Bence Lin A, Stancato LF.

Clin Cancer Res. 2017 Aug 1;23(15):4354-4363. doi: 10.1158/1078-0432.CCR-16-2876. Epub 2017 Mar 7.

28.

Cotranslational folding of spectrin domains via partially structured states.

Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J.

Nat Struct Mol Biol. 2017 Mar;24(3):221-225. doi: 10.1038/nsmb.3355. Epub 2017 Jan 23.

PMID:
28112730
29.

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.

Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.

Science. 2016 Dec 16;354(6318):1431-1433.

PMID:
27980209
30.

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.

Kedrov A, Wickles S, Crevenna AH, van der Sluis EO, Buschauer R, Berninghausen O, Lamb DC, Beckmann R.

Cell Rep. 2016 Dec 13;17(11):2943-2954. doi: 10.1016/j.celrep.2016.11.059.

31.

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.

Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.

Nature. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1.

PMID:
27906161
32.

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.

Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Nürenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R.

Nat Commun. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248.

33.

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.

Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24.

PMID:
27775710
34.

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.

Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.

Cell. 2016 Jul 14;166(2):380-393. doi: 10.1016/j.cell.2016.06.014.

35.

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.

Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN.

Nat Commun. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026.

36.

Dynamic Behavior of Trigger Factor on the Ribosome.

Deeng J, Chan KY, van der Sluis EO, Berninghausen O, Han W, Gumbart J, Schulten K, Beatrix B, Beckmann R.

J Mol Biol. 2016 Sep 11;428(18):3588-602. doi: 10.1016/j.jmb.2016.06.007. Epub 2016 Jun 16.

PMID:
27320387
37.

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.

Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25.

38.

Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors.

Patnaik A, Rosen LS, Tolaney SM, Tolcher AW, Goldman JW, Gandhi L, Papadopoulos KP, Beeram M, Rasco DW, Hilton JF, Nasir A, Beckmann RP, Schade AE, Fulford AD, Nguyen TS, Martinez R, Kulanthaivel P, Li LQ, Frenzel M, Cronier DM, Chan EM, Flaherty KT, Wen PY, Shapiro GI.

Cancer Discov. 2016 Jul;6(7):740-53. doi: 10.1158/2159-8290.CD-16-0095. Epub 2016 May 23.

39.

In-vitro cell treatment with focused shockwaves-influence of the experimental setup on the sound field and biological reaction.

Dietz-Laursonn K, Beckmann R, Ginter S, Radermacher K, de la Fuente M.

J Ther Ultrasound. 2016 Mar 29;4:10. doi: 10.1186/s40349-016-0053-z. eCollection 2016.

40.

Incidence of pulmonary emboli on chest computed tomography angiography based upon referral patterns.

Meesa IR, Junewick J, Hoff A, Blumer A, Daro R, Linna N, McElliott M, Meeusen C, Beckmann R, Luttenton C.

Emerg Radiol. 2016 Jun;23(3):251-4. doi: 10.1007/s10140-016-1391-4. Epub 2016 Mar 30.

PMID:
27026032
41.

Optimising the combination dosing strategy of abemaciclib and vemurafenib in BRAF-mutated melanoma xenograft tumours.

Tate SC, Burke TF, Hartman D, Kulanthaivel P, Beckmann RP, Cronier DM.

Br J Cancer. 2016 Mar 15;114(6):669-79. doi: 10.1038/bjc.2016.40.

42.

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available.

43.

Small protein domains fold inside the ribosome exit tunnel.

Marino J, von Heijne G, Beckmann R.

FEBS Lett. 2016 Mar;590(5):655-60. doi: 10.1002/1873-3468.12098. Epub 2016 Feb 25.

44.

Translation regulation via nascent polypeptide-mediated ribosome stalling.

Wilson DN, Arenz S, Beckmann R.

Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/j.sbi.2016.01.008. Epub 2016 Feb 7. Review.

PMID:
26859868
45.

Efficacy assessment of three inactivated koi herpes virus antigen preparations against experimental challenge virus infection in common carp.

Schmid T, Gaede L, Böttcher K, Bräuer G, Fichtner D, Beckmann R, Speck S, Becker F, Truyen U.

J Fish Dis. 2016 Aug;39(8):1007-13. doi: 10.1111/jfd.12428. Epub 2016 Jan 13. No abstract available.

PMID:
26765154
46.

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.

Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R.

Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. doi: 10.1093/nar/gkv1517. Epub 2015 Dec 28.

47.

Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.

Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2016 Jan;23(1):37-44. doi: 10.1038/nsmb.3132. Epub 2015 Nov 30.

PMID:
26619264
48.

LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models.

Barnard D, Diaz HB, Burke T, Donoho G, Beckmann R, Jones B, Barda D, King C, Marshall M.

Invest New Drugs. 2016 Feb;34(1):49-60. doi: 10.1007/s10637-015-0310-y. Epub 2015 Nov 27.

PMID:
26612134
49.

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954.

50.

Structure of the native Sec61 protein-conducting channel.

Pfeffer S, Burbaum L, Unverdorben P, Pech M, Chen Y, Zimmermann R, Beckmann R, Förster F.

Nat Commun. 2015 Sep 28;6:8403. doi: 10.1038/ncomms9403.

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