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Items: 1 to 50 of 385

1.

Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy.

Du J, Yan L, Torres R, Gong X, Bian H, Marugán C, Boehnke K, Baquero C, Hui YH, Chapman SC, Yang Y, Zeng Y, Bogner SM, Foreman RT, Capen A, Donoho GP, Van Horn RD, Barnard DS, Dempsey JA, Beckmann RP, Marshall MS, Chio LC, Qian Y, Webster YW, Aggarwal A, Chu S, Bhattachar S, Stancato LF, Dowless MS, Iversen PW, Manro JR, Walgren JL, Halstead BW, Dieter MZ, Martinez R, Bhagwat SV, Kreklau EL, Lallena MJ, Ye XS, Patel BKR, Reinhard C, Plowman GD, Barda DA, Henry JR, Buchanan SG, Campbell RM.

Mol Cancer Ther. 2019 Sep 17. pii: molcanther.0529.2018. doi: 10.1158/1535-7163.MCT-18-0529. [Epub ahead of print]

PMID:
31530649
2.

Partially inserted nascent chain unzips the lateral gate of the Sec translocon.

Kater L, Frieg B, Berninghausen O, Gohlke H, Beckmann R, Kedrov A.

EMBO Rep. 2019 Oct 4;20(10):e48191. doi: 10.15252/embr.201948191. Epub 2019 Aug 5.

3.

Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.

Cheng J, Baßler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E.

Mol Cell. 2019 Sep 19;75(6):1256-1269.e7. doi: 10.1016/j.molcel.2019.06.032. Epub 2019 Aug 1.

PMID:
31378463
4.

Structural and mutational analysis of the ribosome-arresting human XBP1u.

Shanmuganathan V, Schiller N, Magoulopoulou A, Cheng J, Braunger K, Cymer F, Berninghausen O, Beatrix B, Kohno K, von Heijne G, Beckmann R.

Elife. 2019 Jun 27;8. pii: e46267. doi: 10.7554/eLife.46267.

5.

Publisher Correction: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jul;571(7764):E4. doi: 10.1038/s41586-019-1360-7.

PMID:
31235950
6.

Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.

Su T, Izawa T, Thoms M, Yamashita Y, Cheng J, Berninghausen O, Hartl FU, Inada T, Neupert W, Beckmann R.

Nature. 2019 Jun;570(7762):538-542. doi: 10.1038/s41586-019-1307-z. Epub 2019 Jun 12. Erratum in: Nature. 2019 Jun 25;:.

PMID:
31189955
7.

Structure of the 80S ribosome-Xrn1 nuclease complex.

Tesina P, Heckel E, Cheng J, Fromont-Racine M, Buschauer R, Kater L, Beatrix B, Berninghausen O, Jacquier A, Becker T, Beckmann R.

Nat Struct Mol Biol. 2019 Apr;26(4):275-280. doi: 10.1038/s41594-019-0202-5. Epub 2019 Mar 25.

PMID:
30911188
8.

Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.

Wild K, Juaire KD, Soni K, Shanmuganathan V, Hendricks A, Segnitz B, Beckmann R, Sinning I.

Nucleic Acids Res. 2019 Apr 8;47(6):3184-3196. doi: 10.1093/nar/gky1324.

9.

Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.

Ikeuchi K, Tesina P, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R, Inada T.

EMBO J. 2019 Mar 1;38(5). pii: e100276. doi: 10.15252/embj.2018100276. Epub 2019 Jan 4.

PMID:
30609991
10.

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.

Lowery CD, Dowless M, Renschler M, Blosser W, VanWye AB, Stephens JR, Iversen PW, Lin AB, Beckmann RP, Krytska K, Cole KA, Maris JM, Hawkins DS, Rubin BP, Kurmasheva RT, Houghton PJ, Gorlick R, Kolb EA, Kang MH, Reynolds CP, Erickson SW, Teicher BA, Smith MA, Stancato LF.

Clin Cancer Res. 2019 Apr 1;25(7):2278-2289. doi: 10.1158/1078-0432.CCR-18-2728. Epub 2018 Dec 18.

PMID:
30563935
11.

Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.

Knorr AG, Schmidt C, Tesina P, Berninghausen O, Becker T, Beatrix B, Beckmann R.

Nat Struct Mol Biol. 2019 Jan;26(1):35-39. doi: 10.1038/s41594-018-0165-y. Epub 2018 Dec 17.

PMID:
30559462
12.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V.

Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087.

13.

Folding pathway of an Ig domain is conserved on and off the ribosome.

Tian P, Steward A, Kudva R, Su T, Shilling PJ, Nickson AA, Hollins JJ, Beckmann R, von Heijne G, Clarke J, Best RB.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11284-E11293. doi: 10.1073/pnas.1810523115. Epub 2018 Nov 9.

14.

Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.

Thoms M, Mitterer V, Kater L, Falquet L, Beckmann R, Kressler D, Hurt E.

Nat Commun. 2018 Oct 5;9(1):4094. doi: 10.1038/s41467-018-06660-w.

15.

Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.

Beckert B, Turk M, Czech A, Berninghausen O, Beckmann R, Ignatova Z, Plitzko JM, Wilson DN.

Nat Microbiol. 2018 Oct;3(10):1115-1121. doi: 10.1038/s41564-018-0237-0. Epub 2018 Sep 3.

PMID:
30177741
16.

Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study.

Kim ES, Kelly K, Paz-Ares LG, Garrido P, Jalal S, Mahadevan D, Gutierrez M, Provencio M, Schaefer E, Shaheen M, Johnston EL, Turner PK, Kambhampati SRP, Beckmann R, Hossain A, John WJ, Goldman JW.

Clin Cancer Res. 2018 Nov 15;24(22):5543-5551. doi: 10.1158/1078-0432.CCR-18-0651. Epub 2018 Aug 6.

PMID:
30082474
17.

Spectrum and functional validation of PSMB5 mutations in multiple myeloma.

Barrio S, Stühmer T, Da-Viá M, Barrio-Garcia C, Lehners N, Besse A, Cuenca I, Garitano-Trojaola A, Fink S, Leich E, Chatterjee M, Driessen C, Martinez-Lopez J, Rosenwald A, Beckmann R, Bargou RC, Braggio E, Stewart AK, Raab MS, Einsele H, Kortüm KM.

Leukemia. 2019 Feb;33(2):447-456. doi: 10.1038/s41375-018-0216-8. Epub 2018 Jul 19.

PMID:
30026573
18.

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Ensfelder TT, Kurz MQ, Iwan K, Geiger S, Matheisl S, Müller M, Beckmann R, Carell T.

Chem Commun (Camb). 2018 Aug 11;54(62):8591-8593. doi: 10.1039/c8cc03980a. Epub 2018 Jul 16.

PMID:
30010678
19.

Visualizing late states of human 40S ribosomal subunit maturation.

Ameismeier M, Cheng J, Berninghausen O, Beckmann R.

Nature. 2018 Jun;558(7709):249-253. doi: 10.1038/s41586-018-0193-0. Epub 2018 Jun 6.

PMID:
29875412
20.

Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.

Hong DS, Moore K, Patel M, Grant SC, Burris HA 3rd, William WN Jr, Jones S, Meric-Bernstam F, Infante J, Golden L, Zhang W, Martinez R, Wijayawardana S, Beckmann R, Lin AB, Eng C, Bendell J.

Clin Cancer Res. 2018 Jul 15;24(14):3263-3272. doi: 10.1158/1078-0432.CCR-17-3347. Epub 2018 Apr 11.

21.

Reconstitution of Isotopically Labeled Ribosomal Protein L29 in the 50S Large Ribosomal Subunit for Solution-State and Solid-State NMR.

Barbet-Massin E, van der Sluis E, Musial J, Beckmann R, Reif B.

Methods Mol Biol. 2018;1764:87-100. doi: 10.1007/978-1-4939-7759-8_6.

PMID:
29605910
22.

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.

Schaer DA, Beckmann RP, Dempsey JA, Huber L, Forest A, Amaladas N, Li Y, Wang YC, Rasmussen ER, Chin D, Capen A, Carpenito C, Staschke KA, Chung LA, Litchfield LM, Merzoug FF, Gong X, Iversen PW, Buchanan S, de Dios A, Novosiadly RD, Kalos M.

Cell Rep. 2018 Mar 13;22(11):2978-2994. doi: 10.1016/j.celrep.2018.02.053.

23.

Expansion of functional personalized cells with specific transgene combinations.

Lipps C, Klein F, Wahlicht T, Seiffert V, Butueva M, Zauers J, Truschel T, Luckner M, Köster M, MacLeod R, Pezoldt J, Hühn J, Yuan Q, Müller PP, Kempf H, Zweigerdt R, Dittrich-Breiholz O, Pufe T, Beckmann R, Drescher W, Riancho J, Sañudo C, Korff T, Opalka B, Rebmann V, Göthert JR, Alves PM, Ott M, Schucht R, Hauser H, Wirth D, May T.

Nat Commun. 2018 Mar 8;9(1):994. doi: 10.1038/s41467-018-03408-4.

24.

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.

Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.

Science. 2018 Apr 13;360(6385):215-219. doi: 10.1126/science.aar7899. Epub 2018 Mar 8.

25.

Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer.

O'Brien N, Conklin D, Beckmann R, Luo T, Chau K, Thomas J, Mc Nulty A, Marchal C, Kalous O, von Euw E, Hurvitz S, Mockbee C, Slamon DJ.

Mol Cancer Ther. 2018 May;17(5):897-907. doi: 10.1158/1535-7163.MCT-17-0290. Epub 2018 Feb 26.

26.

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.

Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E.

Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4.

27.

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.

Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039.

28.

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.

Gong X, Litchfield LM, Webster Y, Chio LC, Wong SS, Stewart TR, Dowless M, Dempsey J, Zeng Y, Torres R, Boehnke K, Mur C, Marugán C, Baquero C, Yu C, Bray SM, Wulur IH, Bi C, Chu S, Qian HR, Iversen PW, Merzoug FF, Ye XS, Reinhard C, De Dios A, Du J, Caldwell CW, Lallena MJ, Beckmann RP, Buchanan SG.

Cancer Cell. 2017 Dec 11;32(6):761-776.e6. doi: 10.1016/j.ccell.2017.11.006.

29.

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.

Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.

Elife. 2017 Nov 20;6. pii: e30189. doi: 10.7554/eLife.30189.

30.

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.

Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.

Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014.

31.

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.

Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495. Epub 2017 Oct 30.

PMID:
29083413
32.

RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1.

Chen SH, Gong X, Zhang Y, Van Horn RD, Yin T, Huber L, Burke TF, Manro J, Iversen PW, Wu W, Bhagwat SV, Beckmann RP, Tiu RV, Buchanan SG, Peng SB.

Oncogene. 2018 Feb 8;37(6):821-832. doi: 10.1038/onc.2017.384. Epub 2017 Oct 23.

PMID:
29059158
33.

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer.

Torres-Guzmán R, Calsina B, Hermoso A, Baquero C, Alvarez B, Amat J, McNulty AM, Gong X, Boehnke K, Du J, de Dios A, Beckmann RP, Buchanan S, Lallena MJ.

Oncotarget. 2017 May 10;8(41):69493-69507. doi: 10.18632/oncotarget.17778. eCollection 2017 Sep 19.

34.

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.

Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R.

Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476. Epub 2017 Oct 2.

PMID:
28967883
35.

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T.

Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1.

36.

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.

Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.

Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439. Epub 2017 Jul 24.

37.

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R.

Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642.

38.

Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.

EMBO J. 2017 Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3.

39.

Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2.

Yamashita Y, Takamatsu S, Glasbrenner M, Becker T, Naito S, Beckmann R.

FEBS Lett. 2017 May;591(9):1266-1277. doi: 10.1002/1873-3468.12634. Epub 2017 Apr 10.

40.

Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.

Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.

Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3.

PMID:
28368393
41.

Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair.

Lin AB, McNeely SC, Beckmann RP.

Clin Cancer Res. 2017 Jul 1;23(13):3232-3240. doi: 10.1158/1078-0432.CCR-16-0083. Epub 2017 Mar 22. Review.

42.

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.

Lowery CD, VanWye AB, Dowless M, Blosser W, Falcon BL, Stewart J, Stephens J, Beckmann RP, Bence Lin A, Stancato LF.

Clin Cancer Res. 2017 Aug 1;23(15):4354-4363. doi: 10.1158/1078-0432.CCR-16-2876. Epub 2017 Mar 7.

43.

Cotranslational folding of spectrin domains via partially structured states.

Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J.

Nat Struct Mol Biol. 2017 Mar;24(3):221-225. doi: 10.1038/nsmb.3355. Epub 2017 Jan 23.

PMID:
28112730
44.

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.

Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.

Science. 2016 Dec 16;354(6318):1431-1433.

PMID:
27980209
45.

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.

Kedrov A, Wickles S, Crevenna AH, van der Sluis EO, Buschauer R, Berninghausen O, Lamb DC, Beckmann R.

Cell Rep. 2016 Dec 13;17(11):2943-2954. doi: 10.1016/j.celrep.2016.11.059.

46.

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.

Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.

Nature. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1.

PMID:
27906161
47.

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.

Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Nürenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R.

Nat Commun. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248.

48.

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.

Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24.

PMID:
27775710
49.

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.

Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.

Cell. 2016 Jul 14;166(2):380-393. doi: 10.1016/j.cell.2016.06.014.

50.

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.

Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN.

Nat Commun. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026.

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