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Items: 44

1.

Combinatorial Treatment Using Umbilical Cord Perivascular Cells and Aβ Clearance Rescues Vascular Function Following Transient Hypertension in a Rat Model of Alzheimer Disease.

Bazzigaluppi P, Beckett TL, Koletar MM, Hill ME, Lai A, Trivedi A, Thomason L, Dorr A, Gallagher D, Librach CL, Joo IL, McLaurin J, Stefanovic B.

Hypertension. 2019 Oct;74(4):1041-1051. doi: 10.1161/HYPERTENSIONAHA.119.13187. Epub 2019 Sep 3.

2.

The db mutation improves memory in younger mice in a model of Alzheimer's disease.

Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2157-2167. doi: 10.1016/j.bbadis.2019.04.013. Epub 2019 Apr 26.

PMID:
31034991
3.

In vivo neurovascular response to focused photoactivation of Channelrhodopsin-2.

Mester JR, Bazzigaluppi P, Weisspapir I, Dorr A, Beckett TL, Koletar MM, Sled JG, Stefanovic B.

Neuroimage. 2019 May 15;192:135-144. doi: 10.1016/j.neuroimage.2019.01.036. Epub 2019 Jan 19.

PMID:
30669007
4.

Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism.

Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B.

Stroke. 2018 Sep;49(9):2173-2181. doi: 10.1161/STROKEAHA.118.020586.

PMID:
30354983
5.

Neurogliovascular dysfunction in a model of repeated traumatic brain injury.

Adams C, Bazzigaluppi P, Beckett TL, Bishay J, Weisspapir I, Dorr A, Mester JR, Steinman J, Hirschler L, Warnking JM, Barbier EL, McLaurin J, Sled JG, Stefanovic B.

Theranostics. 2018 Sep 9;8(17):4824-4836. doi: 10.7150/thno.24747. eCollection 2018.

6.

Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease.

Bazzigaluppi P, Beckett TL, Koletar MM, Lai AY, Joo IL, Brown ME, Carlen PL, McLaurin J, Stefanovic B.

J Neurochem. 2018 Mar;144(5):669-679. doi: 10.1111/jnc.14136. Epub 2017 Oct 10.

7.

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.

Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM.

J Neurosci. 2017 Jun 21;37(25):6132-6148. doi: 10.1523/JNEUROSCI.0877-17.2017. Epub 2017 May 30.

8.

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan.

LeVine H 3rd, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E.

Neurobiol Aging. 2017 Jun;54:163-169. doi: 10.1016/j.neurobiolaging.2017.03.005. Epub 2017 Mar 14.

9.

Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages.

Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E.

Neurobiol Aging. 2017 Jan;49:86-99. doi: 10.1016/j.neurobiolaging.2016.09.007. Epub 2016 Sep 26.

10.

A Novel Small Molecule Modulator of Amyloid Pathology.

Lovell MA, Lynn BC, Fister S, Bradley-Whitman M, Murphy MP, Beckett TL, Norris CM.

J Alzheimers Dis. 2016 May 4;53(1):273-87. doi: 10.3233/JAD-151160.

11.

Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.

Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP.

Neuroscience. 2016 Feb 19;315:162-74. doi: 10.1016/j.neuroscience.2015.12.011. Epub 2015 Dec 14.

12.

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.

Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E.

Neurobiol Aging. 2015 Sep;36(9):2468-74. doi: 10.1016/j.neurobiolaging.2015.05.016. Epub 2015 May 30.

13.

Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's disease.

Sethi M, Joshi SS, Webb RL, Beckett TL, Donohue KD, Murphy MP, O'Hara BF, Duncan MJ.

Neuroscience. 2015 Apr 2;290:80-9. doi: 10.1016/j.neuroscience.2015.01.035. Epub 2015 Jan 28.

14.

Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.

Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP.

J Alzheimers Dis. 2014;42(4):1221-7. doi: 10.3233/JAD-132450.

15.

Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease.

Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E.

J Alzheimers Dis. 2014;42(3):767-75. doi: 10.3233/JAD-140795.

16.

Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.

Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, Hersh LB, Porter NM, Wilcock DM, Murphy MP.

Acta Neuropathol Commun. 2014 Jun 10;2:64. doi: 10.1186/2051-5960-2-64.

17.

Nucleic acid oxidation: an early feature of Alzheimer's disease.

Bradley-Whitman MA, Timmons MD, Beckett TL, Murphy MP, Lynn BC, Lovell MA.

J Neurochem. 2014 Jan;128(2):294-304. doi: 10.1111/jnc.12444. Epub 2013 Oct 21.

18.

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain.

Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA.

Redox Biol. 2013 Jan 30;1:80-5. doi: 10.1016/j.redox.2013.01.002. eCollection 2013.

19.

A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease.

Beckett TL, Studzinski CM, Keller JN, Paul Murphy M, Niedowicz DM.

Brain Res. 2013 Apr 10;1505:61-7. doi: 10.1016/j.brainres.2013.01.046. Epub 2013 Feb 12.

20.

Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.

Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN.

Biochim Biophys Acta. 2013 Sep;1832(9):1456-62. doi: 10.1016/j.bbadis.2013.01.002. Epub 2013 Jan 9.

21.

Leptin regulates amyloid β production via the γ-secretase complex.

Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP.

Biochim Biophys Acta. 2013 Mar;1832(3):439-44. doi: 10.1016/j.bbadis.2012.12.009. Epub 2012 Dec 26.

22.

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM.

J Neurosci. 2012 Nov 14;32(46):16129-40. doi: 10.1523/JNEUROSCI.2323-12.2012.

23.

Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.

Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H 3rd, Keller JN, Murphy MP.

Ann Neurol. 2012 Oct;72(4):564-70. doi: 10.1002/ana.23633.

24.

17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain.

Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ.

Endocrinology. 2012 Nov;153(11):5467-79. doi: 10.1210/en.2012-1464. Epub 2012 Sep 7.

25.

A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease.

Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C.

J Alzheimers Dis. 2012;32(4):1029-42. doi: 10.3233/JAD-2012-120937.

26.

Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H 3rd, Keller JN, Murphy MP.

J Alzheimers Dis. 2012;32(1):127-38.

27.

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.

Duncan MJ, Smith JT, Franklin KM, Beckett TL, Murphy MP, St Clair DK, Donohue KD, Striz M, O'Hara BF.

Exp Neurol. 2012 Aug;236(2):249-58. doi: 10.1016/j.expneurol.2012.05.011. Epub 2012 May 22.

PMID:
22634208
28.

Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O.

J Alzheimers Dis. 2012;30(4):943-61. doi: 10.3233/JAD-2012-111661.

29.

BACE2 expression increases in human neurodegenerative disease.

Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP.

Am J Pathol. 2012 Jan;180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7.

30.

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.

Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H 3rd, Lott IT, Schmitt FA, Butterfield DA, Head E.

Biochim Biophys Acta. 2012 Feb;1822(2):130-8. doi: 10.1016/j.bbadis.2011.10.001. Epub 2011 Oct 8.

31.

RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease.

Weidner AM, Bradley MA, Beckett TL, Niedowicz DM, Dowling AL, Matveev SV, LeVine H 3rd, Lovell MA, Murphy MP.

PLoS One. 2011;6(9):e24930. doi: 10.1371/journal.pone.0024930. Epub 2011 Sep 20.

32.

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.

Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN.

Neurobiol Dis. 2011 Dec;44(3):317-26. doi: 10.1016/j.nbd.2011.07.012. Epub 2011 Jul 28.

33.

Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs.

Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H 3rd, Kryscio RJ, Lin Y, Barrett E, Head E.

J Alzheimers Dis. 2010;22(1):135-50. doi: 10.3233/JAD-2010-100639. Erratum in: J Alzheimers Dis. 2011 Jan 1;24(4):837.

34.

APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.

Niedowicz DM, Beckett TL, Holler CJ, Weidner AM, Murphy MP.

Neurosci Lett. 2010 Sep 20;482(1):57-61. doi: 10.1016/j.neulet.2010.07.006. Epub 2010 Jul 16.

35.

Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle.

Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H 3rd, Murphy MP.

Neurobiol Dis. 2010 Sep;39(3):449-56. doi: 10.1016/j.nbd.2010.05.018. Epub 2010 May 20.

36.

Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.

Aluise CD, Robinson RA, Beckett TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA.

Neurobiol Dis. 2010 Aug;39(2):221-8. doi: 10.1016/j.nbd.2010.04.011. Epub 2010 Apr 23.

37.

Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors.

Webb RL, Findlay KA, Green MA, Beckett TL, Murphy MP.

PLoS One. 2010 Mar 19;5(3):e9799. doi: 10.1371/journal.pone.0009799.

38.

Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.

Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP.

J Alzheimers Dis. 2010;20(2):637-46. doi: 10.3233/JAD-2010-1397.

39.

BACE1 and BACE2 enzymatic activities in Alzheimer's disease.

Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP.

J Neurochem. 2010 Feb;112(4):1045-53. doi: 10.1111/j.1471-4159.2009.06528.x. Epub 2009 Dec 4.

40.

Age-related changes in serum and brain levels of androgens in male Brown Norway rats.

Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike CJ.

Neuroreport. 2009 Nov 25;20(17):1534-7. doi: 10.1097/WNR.0b013e328331f968.

41.

Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H 3rd, Kraner SD, Norris CM.

J Neurosci. 2009 Oct 14;29(41):12957-69. doi: 10.1523/JNEUROSCI.1064-09.2009.

42.

Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.

Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM.

Brain Res. 2008 Aug 21;1226:209-17. doi: 10.1016/j.brainres.2008.06.005. Epub 2008 Jun 11.

PMID:
18582445
43.

In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes.

Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB.

Peptides. 2007 Dec;28(12):2348-55. Epub 2007 Sep 29.

44.

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H 3rd, Keller JN.

Neurobiol Dis. 2007 Sep;27(3):301-11. Epub 2007 Jun 12.

PMID:
17651976

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