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Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.

Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton BD, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick SL.

Mol Cancer Ther. 2018 Sep;17(9):1902-1916. doi: 10.1158/1535-7163.MCT-18-0373. Epub 2018 Jul 11.


The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics.

Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA.

PLoS One. 2017 Mar 9;12(3):e0171728. doi: 10.1371/journal.pone.0171728. eCollection 2017.


Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.

Piccolo SR, Hoffman LM, Conner T, Shrestha G, Cohen AL, Marks JR, Neumayer LA, Agarwal CA, Beckerle MC, Andrulis IL, Spira AE, Moos PJ, Buys SS, Johnson WE, Bild AH.

Mol Syst Biol. 2016 Mar 10;12(3):860. doi: 10.15252/msb.20156506.


EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.

Fadul J, Bell R, Hoffman LM, Beckerle MC, Engel ME, Lessnick SL.

Genes Cancer. 2015 Mar;6(3-4):129-43.


A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton.

Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HE, Wang S, Beckerle MC, O'Shaughnessy B.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17528-33. doi: 10.1073/pnas.1417686111. Epub 2014 Nov 24.


Teaching corporate in college.

Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser NR.

Sci Transl Med. 2014 Aug 27;6(251):251fs33. doi: 10.1126/scitranslmed.3009450.


Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers.

Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT.

Cell Mol Bioeng. 2014 Mar 1;7(1):73-85.


Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC.

Mol Biol Cell. 2014 Sep 15;25(18):2695-709. doi: 10.1091/mbc.E14-01-0007. Epub 2014 Jul 23.


Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL.

Clin Cancer Res. 2014 Sep 1;20(17):4584-97. doi: 10.1158/1078-0432.CCR-14-0072. Epub 2014 Jun 24.


LIM proteins in actin cytoskeleton mechanoresponse.

Smith MA, Hoffman LM, Beckerle MC.

Trends Cell Biol. 2014 Oct;24(10):575-83. doi: 10.1016/j.tcb.2014.04.009. Epub 2014 Jun 2. Review.


A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma.

Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL.

Mol Cell Biol. 2013 Nov;33(22):4448-60. doi: 10.1128/MCB.00241-13. Epub 2013 Sep 16.


Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.

Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV.

Cell Cycle. 2013 Nov 1;12(21):3377-89. doi: 10.4161/cc.26388. Epub 2013 Sep 13.


LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.

Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC.

PLoS One. 2013 Aug 21;8(8):e69378. doi: 10.1371/journal.pone.0069378. eCollection 2013.


Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.

Pronovost SM, Beckerle MC, Kadrmas JL.

PLoS Genet. 2013 Mar;9(3):e1003406. doi: 10.1371/journal.pgen.1003406. Epub 2013 Mar 28.


Lateral communication between stress fiber sarcomeres facilitates a local remodeling response.

Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC.

Biophys J. 2012 Nov 21;103(10):2082-92. doi: 10.1016/j.bpj.2012.09.038. Epub 2012 Nov 20.


The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.

Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC.

Genes Cancer. 2012 Feb;3(2):102-16. doi: 10.1177/1947601912457024.


A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.

Elias MC, Pronovost SM, Cahill KJ, Beckerle MC, Kadrmas JL.

J Cell Sci. 2012 Jul 1;125(Pt 13):3185-94. doi: 10.1242/jcs.101386. Epub 2012 Mar 30.


Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators.

Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC.

Mol Biol Cell. 2012 May;23(10):1846-59. doi: 10.1091/mbc.E11-12-1057. Epub 2012 Mar 28.


Medical faculty development: a modern-day odyssey.

Beckerle MC, Reed KL, Scott RP, Shafer MA, Towner D, Valantine HA, Zahniser NR.

Sci Transl Med. 2011 Oct 12;3(104):104cm31. doi: 10.1126/scitranslmed.3002763.


Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.

Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank DM.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C373-82. doi: 10.1152/ajpcell.00206.2010. Epub 2011 May 11.


How cell biologists can contribute to improving cancer outcomes.

Beckerle MC.

Mol Biol Cell. 2010 Nov 15;21(22):3788-9. doi: 10.1091/mbc.E10-05-0423. No abstract available.


The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis.

Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle MC.

Genes Cancer. 2010 May 1;1(5):506-515.


A zyxin-mediated mechanism for actin stress fiber maintenance and repair.

Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC.

Dev Cell. 2010 Sep 14;19(3):365-76. doi: 10.1016/j.devcel.2010.08.008.


The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster.

Renfranz PJ, Blankman E, Beckerle MC.

Anat Rec (Hoboken). 2010 Sep;293(9):1455-69. doi: 10.1002/ar.21193.


Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma.

Scaife CL, Shea J, Emerson L, Boucher K, Firpo MA, Beckerle MC, Mulvihill SJ.

HPB (Oxford). 2010 Jun;12(5):352-8. doi: 10.1111/j.1477-2574.2010.00177.x.


Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.

Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle MC.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):694-701. doi: 10.1161/ATVBAHA.109.200741. Epub 2010 Jan 7.


The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.

Han HF, Beckerle MC.

Mol Biol Cell. 2009 May;20(9):2361-70. doi: 10.1091/mbc.E08-06-0584. Epub 2009 Mar 4.


TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.

Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L.

FASEB J. 2009 Mar;23(3):916-28. doi: 10.1096/fj.08-106344. Epub 2008 Nov 18.


alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions.

Hansen MD, Beckerle MC.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):144-8. doi: 10.1016/j.bbrc.2008.04.018. Epub 2008 Apr 14.


The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.

Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R.

J Exp Biol. 2008 Jan;211(Pt 1):15-23.


Characterization of RACK1 function in Drosophila development.

Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC.

Dev Dyn. 2007 Aug;236(8):2207-15.


The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.

Clark KA, Bland JM, Beckerle MC.

J Cell Sci. 2007 Jun 15;120(Pt 12):2066-77. Epub 2007 May 29.


The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation.

Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC.

Mol Biol Cell. 2007 May;18(5):1723-33. Epub 2007 Mar 1.


From the membrane to the nucleus and back again: bifunctional focal adhesion proteins.

Hervy M, Hoffman L, Beckerle MC.

Curr Opin Cell Biol. 2006 Oct;18(5):524-32. Epub 2006 Sep 5. Review.


Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.

Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna EJ.

J Cell Biol. 2006 Jul 31;174(3):447-58.


Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion.

Hansen MD, Beckerle MC.

J Biol Chem. 2006 Jun 9;281(23):16178-88. Epub 2006 Apr 13.


Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling.

Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC.

J Cell Biol. 2006 Feb 27;172(5):771-82.


Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.

McKeown CR, Han HF, Beckerle MC.

Dev Dyn. 2006 Feb;235(2):530-8.


Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement.

Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC.

J Cell Biol. 2005 Oct 24;171(2):209-15.


The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.

Norman KR, Fazzio RT, Mellem JE, Espelt MV, Strange K, Beckerle MC, Maricq AV.

Cell. 2005 Oct 7;123(1):119-32.


The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.

Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle MC.

J Cell Biol. 2004 Dec 20;167(6):1019-24. Epub 2004 Dec 13.


The LIM domain: from the cytoskeleton to the nucleus.

Kadrmas JL, Beckerle MC.

Nat Rev Mol Cell Biol. 2004 Nov;5(11):920-31. Review.


The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.

Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC.

J Biol Chem. 2004 Feb 20;279(8):6824-33. Epub 2003 Nov 21.


LPP, a LIM protein highly expressed in smooth muscle.

Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo AP.

Am J Physiol Cell Physiol. 2003 Sep;285(3):C674-85. Epub 2003 May 21.


Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled.

Renfranz PJ, Siegrist SE, Stronach BE, Macalma T, Beckerle MC.

Gene. 2003 Feb 13;305(1):13-26.


ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes.

Henderson JR, Pomiès P, Auffray C, Beckerle MC.

Cell Motil Cytoskeleton. 2003 Mar;54(3):254-65.


Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.

Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ.

Dev Cell. 2003 Jan;4(1):107-18.


Targeted disruption of the murine zyxin gene.

Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fässler R, Beckerle MC.

Mol Cell Biol. 2003 Jan;23(1):70-9.


Striated muscle cytoarchitecture: an intricate web of form and function.

Clark KA, McElhinny AS, Beckerle MC, Gregorio CC.

Annu Rev Cell Dev Biol. 2002;18:637-706. Epub 2002 Apr 2. Review.


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