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Items: 45


Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues.

Zaric M, Becker PD, Hervouet C, Kalcheva P, Doszpoly A, Blattman N, A O' Neill L, Yus BI, Cocita C, Kwon SY, Baker AH, Lord GM, Klavinskis LS.

Nat Commun. 2019 May 17;10(1):2214. doi: 10.1038/s41467-019-09969-2.


Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.

Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B.

Nat Immunol. 2018 Dec;19(12):1403-1414. doi: 10.1038/s41590-018-0230-z. Epub 2018 Nov 5.


Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

Emmerson A, Trevelin SC, Mongue-Din H, Becker PD, Ortiz C, Smyth LA, Peng Q, Elgueta R, Sawyer G, Ivetic A, Lechler RI, Lombardi G, Shah AM.

J Clin Invest. 2018 Jul 2;128(7):3088-3101. doi: 10.1172/JCI97490. Epub 2018 Jun 11.


Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays.

Zaric M, Becker PD, Hervouet C, Kalcheva P, Ibarzo Yus B, Cocita C, O'Neill LA, Kwon SY, Klavinskis LS.

J Control Release. 2017 Dec 28;268:166-175. doi: 10.1016/j.jconrel.2017.10.026. Epub 2017 Oct 19.


IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses.

Nova-Lamperti E, Fanelli G, Becker PD, Chana P, Elgueta R, Dodd PC, Lord GM, Lombardi G, Hernandez-Fuentes MP.

Sci Rep. 2016 Jan 22;6:20044. doi: 10.1038/srep20044.


Humanized Mice as Preclinical Models in Transplantation.

Safinia N, Becker PD, Vaikunthanathan T, Xiao F, Lechler R, Lombardi G.

Methods Mol Biol. 2016;1371:177-96. doi: 10.1007/978-1-4939-3139-2_11. Review.


Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells.

Scottà C, Fanelli G, Hoong SJ, Romano M, Lamperti EN, Sukthankar M, Guggino G, Fazekasova H, Ratnasothy K, Becker PD, Afzali B, Lechler RI, Lombardi G.

Haematologica. 2016 Jan;101(1):91-100. doi: 10.3324/haematol.2015.128934. Epub 2015 Oct 15.


Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Alhabbab R, Blair P, Elgueta R, Stolarczyk E, Marks E, Becker PD, Ratnasothy K, Smyth L, Safinia N, Sharif-Paghaleh E, O'Connell S, Noelle RJ, Lord GM, Howard JK, Spencer J, Lechler RI, Lombardi G.

Sci Rep. 2015 Jun 25;5:11554. doi: 10.1038/srep11554.


Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory.

Becker PD, Hervouet C, Mason GM, Kwon SY, Klavinskis LS.

Vaccine. 2015 Sep 8;33(37):4691-8. doi: 10.1016/j.vaccine.2015.04.046. Epub 2015 Apr 24.


TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes.

Chowell D, Krishna S, Becker PD, Cocita C, Shu J, Tan X, Greenberg PD, Klavinskis LS, Blattman JN, Anderson KS.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1754-62. doi: 10.1073/pnas.1500973112. Epub 2015 Mar 23.


Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes.

Becker PD, Nörder M, Weissmann S, Ljapoci R, Erfle V, Drexler I, Guzmán CA.

Vaccines (Basel). 2014 Jul 22;2(3):581-600. doi: 10.3390/vaccines2030581.


Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children.

Gismondi MI, Díaz Carrasco JM, Valva P, Becker PD, Guzmán CA, Campos RH, Preciado MV.

Virology. 2013 Dec;447(1-2):187-96. doi: 10.1016/j.virol.2013.09.002. Epub 2013 Oct 1.


Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays.

Bachy V, Hervouet C, Becker PD, Chorro L, Carlin LM, Herath S, Papagatsias T, Barbaroux JB, Oh SJ, Benlahrech A, Athanasopoulos T, Dickson G, Patterson S, Kwon SY, Geissmann F, Klavinskis LS.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3041-6. doi: 10.1073/pnas.1214449110. Epub 2013 Feb 5.


Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8+ T cell immunity in vivo.

Smyth LA, Hervouet C, Hayday T, Becker PD, Ellis R, Lechler RI, Lombardi G, Klavinskis LS.

J Immunol. 2012 Sep 1;189(5):2274-82. doi: 10.4049/jimmunol.1200664. Epub 2012 Jul 20.


Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice.

Waern JM, Yuan Q, Rüdrich U, Becker PD, Schulze K, Strick-Marchand H, Huntington ND, Zacher BJ, Wursthorn K, DiSanto JP, Guzman CA, Manns MP, Ott M, Bock M.

Hepatology. 2012 Oct;56(4):1479-88. doi: 10.1002/hep.25816.


Cyclic di-nucleotides: new era for small molecules as adjuvants.

Libanova R, Becker PD, Guzmán CA.

Microb Biotechnol. 2012 Mar;5(2):168-76. doi: 10.1111/j.1751-7915.2011.00306.x. Epub 2011 Sep 29. Review.


IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. doi: 10.1073/pnas.1019167108. Epub 2011 Mar 28.


Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahR/P(sal)::xylS2 for biotechnological applications.

Becker PD, Royo JL, Guzman CA.

Bioeng Bugs. 2010 Jul-Aug;1(4):244-51. doi: 10.4161/bbug.1.4.11247. Epub 2010 Jan 12. Review.


Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H.

PLoS One. 2010 Oct 4;5(10). pii: e13137. doi: 10.1371/journal.pone.0013137.


Genetic immunization: bacteria as DNA vaccine delivery vehicles.

Becker PD, Noerder M, Guzmán CA.

Hum Vaccin. 2008 May-Jun;4(3):189-202. Epub 2010 May 14. Review.


Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.

Nörder M, Becker PD, Drexler I, Link C, Erfle V, Guzmán CA.

PLoS One. 2010 Jun 30;5(6):e11400. doi: 10.1371/journal.pone.0011400.


Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection.

Cazorla SI, Frank FM, Becker PD, Arnaiz M, Mirkin GA, Corral RS, Guzmán CA, Malchiodi EL.

J Infect Dis. 2010 Jul 1;202(1):136-44. doi: 10.1086/652872.


Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Nörder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M.

Am J Pathol. 2009 Oct;175(4):1483-92. doi: 10.2353/ajpath.2009.090117. Epub 2009 Aug 28.


Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.

Giagulli C, Noerder M, Avolio M, Becker PD, Fiorentini S, Guzman CA, Caruso A.

Int Immunopharmacol. 2009 Nov;9(12):1366-73. doi: 10.1016/j.intimp.2009.08.010. Epub 2009 Aug 25.


Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.


Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers.

Gismondi MI, Becker PD, Díaz Carrasco JM, Guzmán CA, Campos RH, Preciado MV.

J Viral Hepat. 2009 May;16(5):332-9. doi: 10.1111/j.1365-2893.2009.01071.x. Epub 2009 Feb 17.


Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice.

Jordao L, Lengeling A, Bordat Y, Boudou F, Gicquel B, Neyrolles O, Becker PD, Guzman CA, Griffiths G, Anes E.

Microbes Infect. 2008 Oct;10(12-13):1379-86. doi: 10.1016/j.micinf.2008.08.004. Epub 2008 Aug 14.


Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17.

Fiorentini S, Marsico S, Becker PD, Iaria ML, Bruno R, Guzmán CA, Caruso A.

Vaccine. 2008 Aug 26;26(36):4758-65. doi: 10.1016/j.vaccine.2008.06.082. Epub 2008 Jul 9.


Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice.

Mastini C, Becker PD, Iezzi M, Curcio C, Musiani P, Forni G, Cavallo F, Guzmán CA.

Curr Cancer Drug Targets. 2008 May;8(3):230-42.


Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model.

Cazorla SI, Frank FM, Becker PD, Corral RS, Guzmán CA, Malchiodi EL.

Vaccine. 2008 Apr 7;26(16):1999-2009. doi: 10.1016/j.vaccine.2008.02.011. Epub 2008 Feb 22.


HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype.

Fiorentini S, Riboldi E, Facchetti F, Avolio M, Fabbri M, Tosti G, Becker PD, Guzman CA, Sozzani S, Caruso A.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3867-72. doi: 10.1073/pnas.0800370105. Epub 2008 Feb 29.


Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi.

Cazorla SI, Becker PD, Frank FM, Ebensen T, Sartori MJ, Corral RS, Malchiodi EL, Guzmán CA.

Infect Immun. 2008 Jan;76(1):324-33. Epub 2007 Oct 29.


In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit.

Royo JL, Becker PD, Camacho EM, Cebolla A, Link C, Santero E, Guzmán CA.

Nat Methods. 2007 Nov;4(11):937-42. Epub 2007 Oct 7.


Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses.

Fiorentini S, Marconi P, Avolio M, Marini E, Garrafa E, Caracciolo S, Rossi D, Bozac A, Becker PD, Gentili F, Facchetti F, Guzman CA, Manservigi R, Caruso A.

Microbes Infect. 2007 Jul;9(8):988-96. Epub 2007 Apr 10.


Immune modulator adamantylamide dipeptide stimulates efficient major histocompatibility complex class I-restricted responses in mice.

Becker PD, Nörder M, Guzmán CA, Grinstein S.

Clin Vaccine Immunol. 2007 May;14(5):538-43. Epub 2007 Mar 7.


HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.

Fiorentini S, Becker PD, Marini E, Marconi P, Avolio M, Tosti G, Link C, Manservigi R, Guzman CA, Caruso A.

Viral Immunol. 2006 Summer;19(2):177-88.


Phylogenetic analysis of previously nontypeable hepatitis C virus isolates from Argentina.

Gismondi MI, Becker PD, Valva P, Guzmán CA, Preciado MV.

J Clin Microbiol. 2006 Jun;44(6):2229-32.


The HIV-1 matrix protein p17 can be efficiently delivered by intranasal route in mice using the TLR 2/6 agonist MALP-2 as mucosal adjuvant.

Becker PD, Fiorentini S, Link C, Tosti G, Ebensen T, Caruso A, Guzmán CA.

Vaccine. 2006 Jun 19;24(25):5269-76. Epub 2005 Nov 21.


Efficient systemic and mucosal responses against the HIV-1 Tat protein by prime/boost vaccination using the lipopeptide MALP-2 as adjuvant.

Borsutzky S, Ebensen T, Link C, Becker PD, Fiorelli V, Cafaro A, Ensoli B, Guzmán CA.

Vaccine. 2006 Mar 15;24(12):2049-56. Epub 2005 Nov 28.


The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

Borsutzky S, Kretschmer K, Becker PD, Mühlradt PF, Kirschning CJ, Weiss S, Guzmán CA.

J Immunol. 2005 May 15;174(10):6308-13.


Adamantylamide dipeptide as effective immunoadjuvant in rabbits and mice.

Becker PD, Corral RS, Guzmán CA, Grinstein S.

Vaccine. 2001 Sep 14;19(32):4603-9.



Subotnick SI, Becker PD, Sherrill RN.

Phys Sportsmed. 1982 Jun;10(6):15. doi: 10.1080/00913847.1982.11947238. No abstract available.


Granulomas caused by starch powder from surgeons' gloves.

Cutright DE, Becker PD, Bunge JL.

Oral Surg Oral Med Oral Pathol. 1974 May;37(5):699-704. No abstract available.


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