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Items: 1 to 50 of 266

1.

Loss of miR-451a enhances SPARC production during myogenesis.

Munk R, Martindale JL, Yang X, Yang JH, Grammatikakis I, Di Germanio C, Mitchell SJ, de Cabo R, Lehrmann E, Zhang Y, Becker KG, Raz V, Gorospe M, Abdelmohsen K, Panda AC.

PLoS One. 2019 Mar 29;14(3):e0214301. doi: 10.1371/journal.pone.0214301. eCollection 2019.

2.

Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism.

González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM.

FASEB J. 2019 May;33(5):5850-5863. doi: 10.1096/fj.201801145R. Epub 2019 Feb 6.

PMID:
30726112
3.

Misregulation of the IgH Locus in Thymocytes.

Kumari G, Gerasimova T, Du H, De S, Wood WH 3rd, Becker KG, Sen R.

Front Immunol. 2018 Nov 13;9:2426. doi: 10.3389/fimmu.2018.02426. eCollection 2018.

4.

Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila.

Lee SK, Xue Y, Shen W, Zhang Y, Joo Y, Ahmad M, Chinen M, Ding Y, Ku WL, De S, Lehrmann E, Becker KG, Lei EP, Zhao K, Zou S, Sharov A, Wang W.

Nat Commun. 2018 Nov 23;9(1):4946. doi: 10.1038/s41467-018-07101-4.

5.

Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells.

Bodogai M, O'Connell J, Kim K, Kim Y, Moritoh K, Chen C, Gusev F, Vaughan K, Shulzhenko N, Mattison JA, Lee-Chang C, Chen W, Carlson O, Becker KG, Gurung M, Morgun A, White J, Meade T, Perdue K, Mack M, Ferrucci L, Trinchieri G, de Cabo R, Rogaev E, Egan J, Wu J, Biragyn A.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaat4271. doi: 10.1126/scitranslmed.aat4271.

6.

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation.

Zhao M, Joy J, Zhou W, De S, Wood WH 3rd, Becker KG, Ji H, Sen R.

PLoS Biol. 2018 Sep 10;16(9):e2006347. doi: 10.1371/journal.pbio.2006347. eCollection 2018 Sep.

7.

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs.

Sun Q, Tripathi V, Yoon JH, Singh DK, Hao Q, Min KW, Davila S, Zealy RW, Li XL, Polycarpou-Schwarz M, Lehrmann E, Zhang Y, Becker KG, Freier SM, Zhu Y, Diederichs S, Prasanth SG, Lal A, Gorospe M, Prasanth KV.

Nucleic Acids Res. 2018 Nov 2;46(19):10405-10416. doi: 10.1093/nar/gky696.

8.

Extracellular RNA profiles with human age.

Dluzen DF, Noren Hooten N, De S, Wood WH 3rd, Zhang Y, Becker KG, Zonderman AB, Tanaka T, Ferrucci L, Evans MK.

Aging Cell. 2018 Aug;17(4):e12785. doi: 10.1111/acel.12785. Epub 2018 May 24.

9.

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes.

Freeman DW, Noren Hooten N, Eitan E, Green J, Mode NA, Bodogai M, Zhang Y, Lehrmann E, Zonderman AB, Biragyn A, Egan J, Becker KG, Mattson MP, Ejiogu N, Evans MK.

Diabetes. 2018 Nov;67(11):2377-2388. doi: 10.2337/db17-1308. Epub 2018 May 2.

10.

Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus.

Qiu X, Kumari G, Gerasimova T, Du H, Labaran L, Singh A, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Sen R.

Mol Cell. 2018 Apr 5;70(1):21-33.e6. doi: 10.1016/j.molcel.2018.02.020. Epub 2018 Mar 22.

11.

Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets.

González-Mariscal I, Montoro RA, Doyle ME, Liu QR, Rouse M, O'Connell JF, Santa-Cruz Calvo S, Krzysik-Walker SM, Ghosh S, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Chia CW, Ghosh P, Egan JM.

Diabetologia. 2018 Jun;61(6):1470-1483. doi: 10.1007/s00125-018-4576-4. Epub 2018 Mar 1.

12.

Elongator and codon bias regulate protein levels in mammalian peripheral neurons.

Goffena J, Lefcort F, Zhang Y, Lehrmann E, Chaverra M, Felig J, Walters J, Buksch R, Becker KG, George L.

Nat Commun. 2018 Mar 1;9(1):889. doi: 10.1038/s41467-018-03221-z.

13.

Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Marosi K, Moehl K, Navas-Enamorado I, Mitchell SJ, Zhang Y, Lehrmann E, Aon MA, Cortassa S, Becker KG, Mattson MP.

FASEB J. 2018 Jul;32(7):3844-3858. doi: 10.1096/fj.201701378RR. Epub 2018 Feb 27.

PMID:
29485903
14.

Autism and Socioeconomic Status-An Immune Link?

Becker KG.

Am J Public Health. 2018 Mar;108(3):e16. doi: 10.2105/AJPH.2017.304271. No abstract available.

15.

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging.

Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12725. Epub 2018 Jan 21.

16.

Transcriptome States Reflect Imaging of Aging States.

Eckley DM, Coletta CE, Orlov NV, Wilson MA, Iser W, Bastian P, Lehrmann E, Zhang Y, Becker KG, Goldberg IG.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):893-901. doi: 10.1093/gerona/glx236.

17.

A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study.

Tanaka T, Milaneschi Y, Zhang Y, Becker KG, Zukley L, Ferrucci L.

PLoS One. 2017 Aug 7;12(8):e0181100. doi: 10.1371/journal.pone.0181100. eCollection 2017.

18.

Sarcopenia, Aging and Prospective Interventional Strategies.

Waltz TB, Fivenson EM, Morevati M, Li C, Becker KG, Bohr VA, Fang EF.

Curr Med Chem. 2018;25(40):5588-5596. doi: 10.2174/0929867324666170801095850. Review.

19.

MicroRNAs Modulate Oxidative Stress in Hypertension through PARP-1 Regulation.

Dluzen DF, Kim Y, Bastian P, Zhang Y, Lehrmann E, Becker KG, Noren Hooten N, Evans MK.

Oxid Med Cell Longev. 2017;2017:3984280. doi: 10.1155/2017/3984280. Epub 2017 Jun 4.

20.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.

21.

Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.

Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK, Gao P.

J Allergy Clin Immunol. 2018 Jan;141(1):350-364.e8. doi: 10.1016/j.jaci.2017.04.049. Epub 2017 Jun 17.

22.

Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats.

Balivada S, Ganta CK, Zhang Y, Pawar HN, Ortiz RJ, Becker KG, Khan AM, Kenney MJ.

Physiol Genomics. 2017 Aug 1;49(8):400-415. doi: 10.1152/physiolgenomics.00131.2016. Epub 2017 Jun 16.

23.

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.

Martin B, Wang R, Cong WN, Daimon CM, Wu WW, Ni B, Becker KG, Lehrmann E, Wood WH 3rd, Zhang Y, Etienne H, van Gastel J, Azmi A, Janssens J, Maudsley S.

J Biol Chem. 2017 Jul 7;292(27):11508-11530. doi: 10.1074/jbc.M116.773820. Epub 2017 May 18.

24.

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG.

Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208.

25.

Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.

Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S.

Aging (Albany NY). 2017 Mar 4;9(3):706-740. doi: 10.18632/aging.101185.

26.

Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes.

Illuzzi JL, McNeill DR, Bastian P, Brenerman B, Wersto R, Russell HR, Bunz F, McKinnon PJ, Becker KG, Wilson DM 3rd.

Environ Mol Mutagen. 2017 Mar;58(2):84-98. doi: 10.1002/em.22074. Epub 2017 Feb 9.

27.

Cocaine promotes primary human astrocyte proliferation via JNK-dependent up-regulation of cyclin A2.

Lee CT, Boeshore KL, Wu C, Becker KG, Errico SL, Mash DC, Freed WJ.

Restor Neurol Neurosci. 2016 Nov 22;34(6):965-976.

28.

miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets.

Dahiya N, Sarachana T, Kulkarni S, Wood WH III, Zhang Y, Becker KG, Wang BD, Atreya CD.

Platelets. 2017 Jan;28(1):74-81. doi: 10.1080/09537104.2016.1203405. Epub 2016 Aug 25.

29.

Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Sep 8;537(7619):254. doi: 10.1038/nature18939. Epub 2016 Jul 6. No abstract available.

PMID:
27383789
30.

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.

31.

RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF.

Tsuchiya M, Kalurupalle S, Kumar P, Ghoshal S, Zhang Y, Lehrmann E, Becker KG, Gorospe M, Biswas R.

RNA Biol. 2016 Sep;13(9):837-47. doi: 10.1080/15476286.2016.1197484. Epub 2016 Jun 10.

32.

Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.

Tweedie D, Fukui K, Li Y, Yu QS, Barak S, Tamargo IA, Rubovitch V, Holloway HW, Lehrmann E, Wood WH 3rd, Zhang Y, Becker KG, Perez E, Van Praag H, Luo Y, Hoffer BJ, Becker RE, Pick CG, Greig NH.

PLoS One. 2016 Jun 2;11(6):e0156493. doi: 10.1371/journal.pone.0156493. eCollection 2016.

33.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT.

Nature. 2016 Apr 14;532(7598):250-4. doi: 10.1038/nature17392. Epub 2016 Apr 4.

34.

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.

Noren Hooten N, Martin-Montalvo A, Dluzen DF, Zhang Y, Bernier M, Zonderman AB, Becker KG, Gorospe M, de Cabo R, Evans MK.

Aging Cell. 2016 Jun;15(3):572-81. doi: 10.1111/acel.12469. Epub 2016 Mar 17.

35.

Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.

Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH.

J Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016/j.jneumeth.2016.02.003. Epub 2016 Feb 8.

36.

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

Martin B, Chadwick W, Janssens J, Premont RT, Schmalzigaug R, Becker KG, Lehrmann E, Wood WH, Zhang Y, Siddiqui S, Park SS, Cong WN, Daimon CM, Maudsley S.

Front Endocrinol (Lausanne). 2016 Jan 18;6:191. doi: 10.3389/fendo.2015.00191. eCollection 2015.

37.

Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.

Panda AC, Abdelmohsen K, Martindale JL, Di Germanio C, Yang X, Grammatikakis I, Noh JH, Zhang Y, Lehrmann E, Dudekula DB, De S, Becker KG, White EJ, Wilson GM, de Cabo R, Gorospe M.

Nucleic Acids Res. 2016 Mar 18;44(5):2393-408. doi: 10.1093/nar/gkw023. Epub 2016 Jan 26.

38.

Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire.

Montefiori L, Wuerffel R, Roqueiro D, Lajoie B, Guo C, Gerasimova T, De S, Wood W, Becker KG, Dekker J, Liang J, Sen R, Kenter AL.

Cell Rep. 2016 Feb 2;14(4):896-906. doi: 10.1016/j.celrep.2015.12.083. Epub 2016 Jan 21.

39.

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.

Daimon CM, Jasien JM, Wood WH 3rd, Zhang Y, Becker KG, Silverman JL, Crawley JN, Martin B, Maudsley S.

Front Physiol. 2015 Nov 24;6:324. doi: 10.3389/fphys.2015.00324. eCollection 2015.

40.

Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.

Zhang P, Abdelmohsen K, Liu Y, Tominaga-Yamanaka K, Yoon JH, Ioannis G, Martindale JL, Zhang Y, Becker KG, Yang IH, Gorospe M, Mattson MP.

Nat Commun. 2015 Nov 20;6:8888. doi: 10.1038/ncomms9888.

41.

Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.

Dai B, Chen AY, Corkum CP, Peroutka RJ, Landon A, Houng S, Muniandy PA, Zhang Y, Lehrmann E, Mazan-Mamczarz K, Steinhardt J, Shlyak M, Chen QC, Becker KG, Livak F, Michalak TI, Talwani R, Gartenhaus RB.

Oncogene. 2016 Jun 9;35(23):2979-90. doi: 10.1038/onc.2015.364. Epub 2015 Oct 5.

42.

TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition.

Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP.

J Leukoc Biol. 2016 Mar;99(3):505-13. doi: 10.1189/jlb.6A0215-071RR. Epub 2015 Sep 22.

43.

Platelet MicroRNAs: An Overview.

Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH 3rd, Zhang Y, Atreya CD.

Transfus Med Rev. 2015 Oct;29(4):215-9. doi: 10.1016/j.tmrv.2015.08.002. Epub 2015 Aug 10. Review.

44.

Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4.

Tweedie D, Rachmany L, Rubovitch V, Li Y, Holloway HW, Lehrmann E, Zhang Y, Becker KG, Perez E, Hoffer BJ, Pick CG, Greig NH.

Alzheimers Dement. 2016 Jan;12(1):34-48. doi: 10.1016/j.jalz.2015.07.489. Epub 2015 Aug 29.

45.

Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging.

Sewal AS, Patzke H, Perez EJ, Park P, Lehrmann E, Zhang Y, Becker KG, Fletcher BR, Long JM, Rapp PR.

J Neurosci. 2015 Aug 19;35(33):11729-42. doi: 10.1523/JNEUROSCI.4339-14.2015.

46.

AUF1 promotes let-7b loading on Argonaute 2.

Yoon JH, Jo MH, White EJ, De S, Hafner M, Zucconi BE, Abdelmohsen K, Martindale JL, Yang X, Wood WH 3rd, Shin YM, Song JJ, Tuschl T, Becker KG, Wilson GM, Hohng S, Gorospe M.

Genes Dev. 2015 Aug 1;29(15):1599-604. doi: 10.1101/gad.263749.115.

47.

Postnatal TLR2 activation impairs learning and memory in adulthood.

Madar R, Rotter A, Waldman Ben-Asher H, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun E.

Brain Behav Immun. 2015 Aug;48:301-12. doi: 10.1016/j.bbi.2015.04.020. Epub 2015 May 27.

48.

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation.

Liu D, Zhang Y, Gharavi R, Park HR, Lee J, Siddiqui S, Telljohann R, Nassar MR, Cutler RG, Becker KG, Mattson MP.

J Neurochem. 2015 Aug;134(4):677-92. doi: 10.1111/jnc.13176. Epub 2015 Jun 19.

49.

Divergence of transcriptional landscape occurs early in B cell activation.

Fowler T, Garruss AS, Ghosh A, De S, Becker KG, Wood WH, Weirauch MT, Smale ST, Aronow B, Sen R, Roy AL.

Epigenetics Chromatin. 2015 May 14;8:20. doi: 10.1186/s13072-015-0012-x. eCollection 2015.

50.

Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes.

Ohta N, Ishiguro S, Kawabata A, Uppalapati D, Pyle M, Troyer D, De S, Zhang Y, Becker KG, Tamura M.

PLoS One. 2015 May 5;10(5):e0123756. doi: 10.1371/journal.pone.0123756. eCollection 2015.

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