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Items: 42


TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells.

Wu B, Blot FG, Wong AB, Osório C, Adolfs Y, Pasterkamp RJ, Hartmann J, Becker EB, Boele HJ, De Zeeuw CI, Schonewille M.

Elife. 2019 Sep 5;8. pii: e45590. doi: 10.7554/eLife.45590.


A gene expression signature in developing Purkinje cells predicts autism and intellectual disability co-morbidity status.

Clifford H, Dulneva A, Ponting CP, Haerty W, Becker EBE.

Sci Rep. 2019 Jan 24;9(1):485. doi: 10.1038/s41598-018-37284-1.


The Use of Stem Cell-Derived Neurons for Understanding Development and Disease of the Cerebellum.

Nayler SP, Becker EBE.

Front Neurosci. 2018 Sep 26;12:646. doi: 10.3389/fnins.2018.00646. eCollection 2018.


Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Wong MMK, Hoekstra SD, Vowles J, Watson LM, Fuller G, Németh AH, Cowley SA, Ansorge O, Talbot K, Becker EBE.

Acta Neuropathol Commun. 2018 Sep 24;6(1):99. doi: 10.1186/s40478-018-0600-7.


Cerebellar involvement in autism and ADHD.

Bruchhage MMK, Bucci MP, Becker EBE.

Handb Clin Neurol. 2018;155:61-72. doi: 10.1016/B978-0-444-64189-2.00004-4. Review.


Genotype-phenotype correlations, dystonia and disease progression in spinocerebellar ataxia type 14.

Chelban V, Wiethoff S, Fabian-Jessing BK, Haridy NA, Khan A, Efthymiou S, Becker EBE, O'Connor E, Hersheson J, Newland K, Hojland AT, Gregersen PA, Lindquist SG, Petersen MB, Nielsen JE, Nielsen M, Wood NW, Giunti P, Houlden H.

Mov Disord. 2018 Jul;33(7):1119-1129. doi: 10.1002/mds.27334. Epub 2018 Mar 30.


A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.

Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE.

Cerebellum. 2018 Aug;17(4):419-427. doi: 10.1007/s12311-017-0913-2.


Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Lickiss J, Jayawant S, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.

Am J Hum Genet. 2017 Nov 2;101(5):866. doi: 10.1016/j.ajhg.2017.10.008. No abstract available.


Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Jayawant S, Lickiss J, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.

Am J Hum Genet. 2017 Oct 5;101(4):638. doi: 10.1016/j.ajhg.2017.09.006. No abstract available.


Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.

Watson LM, Bamber E, Schnekenberg RP, Williams J, Bettencourt C, Lickiss J, Jayawant S, Fawcett K, Clokie S, Wallis Y, Clouston P, Sims D, Houlden H, Becker EBE, Németh AH.

Am J Hum Genet. 2017 Sep 7;101(3):451-458. doi: 10.1016/j.ajhg.2017.08.005. Erratum in: Am J Hum Genet. 2017 Oct 5;101(4):638. Am J Hum Genet. 2017 Nov 2;101(5):866.


Recent advances in modelling of cerebellar ataxia using induced pluripotent stem cells.

Wong MMK, Watson LM, Becker EBE.

J Neurol Neuromedicine. 2017 Jul 10;2(7):11-15.


Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.

Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD.

J Physiol. 2017 Aug 15;595(16):5525-5544. doi: 10.1113/JP274659. Epub 2017 Jul 20.


A Transient Translaminar GABAergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal Somatosensory Cortex.

Marques-Smith A, Lyngholm D, Kaufmann AK, Stacey JA, Hoerder-Suabedissen A, Becker EB, Wilson MC, Molnár Z, Butt SJ.

Neuron. 2016 Feb 3;89(3):536-49. doi: 10.1016/j.neuron.2016.01.015.


Consensus Paper: Cerebellar Development.

Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R.

Cerebellum. 2016 Dec;15(6):789-828. Review.


Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.

Wei WC, Jacobs B, Becker EB, Glitsch MD.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10738-43. doi: 10.1073/pnas.1506085112. Epub 2015 Aug 10.


Induced pluripotent stem cell technology for modelling and therapy of cerebellar ataxia.

Watson LM, Wong MM, Becker EB.

Open Biol. 2015 Jul;5(7):150056. doi: 10.1098/rsob.150056. Review.


Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.

Hanson SM, Sansom MS, Becker EB.

Biochemistry. 2015 Jul 7;54(26):4033-41. doi: 10.1021/acs.biochem.5b00235. Epub 2015 Jun 26.


The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.

Dulneva A, Lee S, Oliver PL, Di Gleria K, Kessler BM, Davies KE, Becker EB.

Hum Mol Genet. 2015 Jul 15;24(14):4114-25. doi: 10.1093/hmg/ddv150. Epub 2015 Apr 23.


From Mice to Men: TRPC3 in Cerebellar Ataxia.

Becker EBE.

Cerebellum. 2017 Dec;16(5-6):877-879. doi: 10.1007/s12311-015-0663-y.


Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?

Fogel BL, Hanson SM, Becker EB.

Mov Disord. 2015 Feb;30(2):284-6. doi: 10.1002/mds.26096. Epub 2014 Dec 5. No abstract available.


The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.

Becker EB.

Cerebellum. 2014 Oct;13(5):628-36. doi: 10.1007/s12311-014-0564-5. Review.


Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

Sekerková G, Kim JA, Nigro MJ, Becker EB, Hartmann J, Birnbaumer L, Mugnaini E, Martina M.

J Neurosci. 2013 Dec 11;33(50):19689-94. doi: 10.1523/JNEUROSCI.2294-13.2013.


Autism spectrum disorder and the cerebellum.

Becker EB, Stoodley CJ.

Int Rev Neurobiol. 2013;113:1-34. doi: 10.1016/B978-0-12-418700-9.00001-0. Review.


Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model.

Németh AH, Kwasniewska AC, Lise S, Parolin Schnekenberg R, Becker EB, Bera KD, Shanks ME, Gregory L, Buck D, Zameel Cader M, Talbot K, de Silva R, Fletcher N, Hastings R, Jayawant S, Morrison PJ, Worth P, Taylor M, Tolmie J, O'Regan M; UK Ataxia Consortium, Valentine R, Packham E, Evans J, Seller A, Ragoussis J.

Brain. 2013 Oct;136(Pt 10):3106-18. doi: 10.1093/brain/awt236. Epub 2013 Sep 11.


Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia.

Becker EB, Zuliani L, Pettingill R, Lang B, Waters P, Dulneva A, Sobott F, Wardle M, Graus F, Bataller L, Robertson NP, Vincent A.

J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):437-40. doi: 10.1136/jnnp-2011-301506. Epub 2012 Feb 15.


Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.

Oliver PL, Finelli MJ, Edwards B, Bitoun E, Butts DL, Becker EB, Cheeseman MT, Davies B, Davies KE.

PLoS Genet. 2011 Oct;7(10):e1002338. doi: 10.1371/journal.pgen.1002338. Epub 2011 Oct 20.


Candidate screening of the TRPC3 gene in cerebellar ataxia.

Becker EB, Fogel BL, Rajakulendran S, Dulneva A, Hanna MG, Perlman SL, Geschwind DH, Davies KE.

Cerebellum. 2011 Jun;10(2):296-9. doi: 10.1007/s12311-011-0253-6.


A JIP3-regulated GSK3β/DCX signaling pathway restricts axon branching.

Bilimoria PM, de la Torre-Ubieta L, Ikeuchi Y, Becker EB, Reiner O, Bonni A.

J Neurosci. 2010 Dec 15;30(50):16766-76. doi: 10.1523/JNEUROSCI.1362-10.2010.


A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.

Becker EB, Oliver PL, Glitsch MD, Banks GT, Achilli F, Hardy A, Nolan PM, Fisher EM, Davies KE.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6706-11. doi: 10.1073/pnas.0810599106. Epub 2009 Apr 7.


Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.

Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A.

Science. 2008 Mar 21;319(5870):1665-8. doi: 10.1126/science.1152337.


Pin1 in neuronal apoptosis.

Becker EB, Bonni A.

Cell Cycle. 2007 Jun 1;6(11):1332-5. Epub 2007 Jun 20.


p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65.

Cai B, Chang SH, Becker EB, Bonni A, Xia Z.

J Biol Chem. 2006 Sep 1;281(35):25215-22. Epub 2006 Jul 3.


A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.

Cell. 2006 Jun 2;125(5):987-1001.


Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS.

Mol Cell Biol. 2005 Jun;25(11):4591-601.


Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

Becker EB, Howell J, Kodama Y, Barker PA, Bonni A.

J Neurosci. 2004 Oct 6;24(40):8762-70. Erratum in: J Neurosci. 2004 Oct 27;24(43):1 p following 9722.


Cell cycle regulation of neuronal apoptosis in development and disease.

Becker EB, Bonni A.

Prog Neurobiol. 2004 Jan;72(1):1-25. Review.


Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.

Bhakar AL, Howell JL, Paul CE, Salehi AH, Becker EB, Said F, Bonni A, Barker PA.

J Neurosci. 2003 Dec 10;23(36):11373-81.


JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery.

Donovan N, Becker EB, Konishi Y, Bonni A.

J Biol Chem. 2002 Oct 25;277(43):40944-9. Epub 2002 Aug 19.


In re Hofbauer: may parents choose unorthodox medical care for their child?

Becker EB.

Spec Law Dig Health Care (Mon). 1981 Jan;2(11):5-35. No abstract available.


Giant hypertrophy of the jejunal circular rugae associated with recurrent intussusception.


Am J Pathol. 1954 Jul-Aug;30(4):787-97. No abstract available.

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