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Items: 1 to 50 of 310

1.

The Impact of Adrenomedullin Thr22 on Selectivity within the Calcitonin Receptor-like Receptor/ Receptor Activity-Modifying Protein System.

Fischer JP, Els-Heindl S, Schönauer R, Bierer D, Koebberling J, Riedl B, Beck-Sickinger AG.

ChemMedChem. 2018 Jul 6. doi: 10.1002/cmdc.201800329. [Epub ahead of print]

PMID:
29979487
2.

Different mode of arrestin-3 binding at the human Y1 and Y2 receptor.

Wanka L, Babilon S, Kaiser A, Mörl K, Beck-Sickinger AG.

Cell Signal. 2018 Jun 23;50:58-71. doi: 10.1016/j.cellsig.2018.06.010. [Epub ahead of print]

PMID:
29944985
3.

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B.

Nature. 2018 Apr;556(7702):520-524. doi: 10.1038/s41586-018-0046-x. Epub 2018 Apr 18.

PMID:
29670288
4.

G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor.

Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG.

Mol Pharmacol. 2018 Apr;93(4):387-401. doi: 10.1124/mol.117.110544. Epub 2018 Feb 7.

PMID:
29436493
5.

Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics.

Erak M, Bellmann-Sickert K, Els-Heindl S, Beck-Sickinger AG.

Bioorg Med Chem. 2018 Jun 1;26(10):2759-2765. doi: 10.1016/j.bmc.2018.01.012. Epub 2018 Jan 31.

PMID:
29395804
6.

Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles.

Schmidt P, Bender BJ, Kaiser A, Gulati K, Scheidt HA, Hamm HE, Meiler J, Beck-Sickinger AG, Huster D.

Front Mol Biosci. 2018 Jan 17;4:100. doi: 10.3389/fmolb.2017.00100. eCollection 2017.

7.

The effect of interleukin-8 truncations on its interactions with glycosaminoglycans.

Nordsieck K, Baumann L, Hintze V, Pisabarro MT, Schnabelrauch M, Beck-Sickinger AG, Samsonov SA.

Biopolymers. 2018 Jan 27. doi: 10.1002/bip.23103. [Epub ahead of print]

PMID:
29377072
8.

Time-Resolved Tracking of Separately Internalized Neuropeptide Y2 Receptors by Two-Color Pulse-Chase.

Lotze J, Wolf P, Reinhardt U, Seitz O, Mörl K, Beck-Sickinger AG.

ACS Chem Biol. 2018 Mar 16;13(3):618-627. doi: 10.1021/acschembio.7b00999. Epub 2018 Jan 11.

PMID:
29268018
9.

A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode.

Zitzmann FD, Jahnke HG, Nitschke F, Beck-Sickinger AG, Abel B, Belder D, Robitzki AA.

Lab Chip. 2017 Dec 5;17(24):4294-4302. doi: 10.1039/c7lc00754j.

PMID:
29119176
10.

Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator.

Schubert M, Stichel J, Du Y, Tough IR, Sliwoski G, Meiler J, Cox HM, Weaver CD, Beck-Sickinger AG.

J Med Chem. 2017 Sep 14;60(17):7605-7612. doi: 10.1021/acs.jmedchem.7b00976. Epub 2017 Aug 28.

PMID:
28795803
11.

Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes.

Schrottke S, Kaiser A, Vortmeier G, Els-Heindl S, Worm D, Bosse M, Schmidt P, Scheidt HA, Beck-Sickinger AG, Huster D.

Sci Rep. 2017 Apr 7;7:46128. doi: 10.1038/srep46128.

12.

Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging.

Moldovan RP, Els-Heindl S, Worm DJ, Kniess T, Kluge M, Beck-Sickinger AG, Deuther-Conrad W, Krügel U, Brust P.

Int J Mol Sci. 2017 Apr 5;18(4). pii: E768. doi: 10.3390/ijms18040768.

13.

Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants.

Jouy F, Lohmann N, Wandel E, Ruiz-Gómez G, Pisabarro MT, Beck-Sickinger AG, Schnabelrauch M, Moeller S, Simon JC, Kalkhof S, von Bergen M, Franz S.

Proteomics. 2017 Mar 24. doi: 10.1002/pmic.201700082. [Epub ahead of print]

PMID:
28337837
14.

Adrenomedullin - new perspectives of a potent peptide hormone.

Schönauer R, Els-Heindl S, Beck-Sickinger AG.

J Pept Sci. 2017 Jul;23(7-8):472-485. doi: 10.1002/psc.2953. Epub 2017 Feb 2. Review.

PMID:
28150464
15.

A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists.

Burkert K, Zellmann T, Meier R, Kaiser A, Stichel J, Meiler J, Mittapalli GK, Roberts E, Beck-Sickinger AG.

ChemMedChem. 2017 Jan 5;12(1):75-85. doi: 10.1002/cmdc.201600433. Epub 2016 Nov 30.

PMID:
27874262
16.

C-terminal motif of human neuropeptide Y4 receptor determines internalization and arrestin recruitment.

Wanka L, Babilon S, Burkert K, Mörl K, Gurevich VV, Beck-Sickinger AG.

Cell Signal. 2017 Jan;29:233-239. doi: 10.1016/j.cellsig.2016.11.003. Epub 2016 Nov 3.

17.

High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice.

Thieme V, Jolly N, Madsen AN, Bellmann-Sickert K, Schwartz TW, Holst B, Cox HM, Beck-Sickinger AG.

Br J Pharmacol. 2016 Nov;173(22):3208-3221. doi: 10.1111/bph.13582. Epub 2016 Oct 5.

18.

Corrigendum to "Short-range cytokine gradients to mimic paracrine cell interactions in vitro" [J. Control. Release 224 (2016) 59-68].

Ansorge M, Rastig N, Steinborn R, König T, Baumann L, Möller S, Schnabelrauch M, Cross M, Werner C, Beck-Sickinger AG, Pompe T.

J Control Release. 2016 Nov 10;241:243. doi: 10.1016/j.jconrel.2016.09.001. Epub 2016 Sep 27. No abstract available.

PMID:
27688089
19.

Multifunctional biomaterial coatings: synthetic challenges and biological activity.

Pagel M, Beck-Sickinger AG.

Biol Chem. 2017 Jan 1;398(1):3-22. doi: 10.1515/hsz-2016-0204. Review.

PMID:
27636830
20.

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.

Ratner C, Skov LJ, Raida Z, Bächler T, Bellmann-Sickert K, Le Foll C, Sivertsen B, Dalbøge LS, Hartmann B, Beck-Sickinger AG, Madsen AN, Jelsing J, Holst JJ, Lutz TA, Andrews ZB, Holst B.

Endocrinology. 2016 Sep;157(9):3482-92. doi: 10.1210/en.2016-1329. Epub 2016 Jul 20.

PMID:
27580810
21.

Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential.

Juhl C, Els-Heindl S, Schönauer R, Redlich G, Haaf E, Wunder F, Riedl B, Burkhardt N, Beck-Sickinger AG, Bierer D.

ChemMedChem. 2016 Aug 25. doi: 10.1002/cmdc.201600307. [Epub ahead of print]

PMID:
27558296
22.

The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites.

Panitz N, Theisgen S, Samsonov SA, Gehrcke JP, Baumann L, Bellmann-Sickert K, Köhling S, Pisabarro MT, Rademann J, Huster D, Beck-Sickinger AG.

Glycobiology. 2016 Nov;26(11):1209-1221. doi: 10.1093/glycob/cww059. Epub 2016 Jun 24.

PMID:
27496764
23.

Peptides@mica: from affinity to adhesion mechanism.

Gladytz A, John T, Gladytz T, Hassert R, Pagel M, Risselada HJ, Naumov S, Beck-Sickinger AG, Abel B.

Phys Chem Chem Phys. 2016 Sep 14;18(34):23516-27. doi: 10.1039/c6cp03325c. Epub 2016 Aug 5.

PMID:
27491508
24.

Discovery of Small-Molecule Modulators of the Human Y4 Receptor.

Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J.

PLoS One. 2016 Jun 13;11(6):e0157146. doi: 10.1371/journal.pone.0157146. eCollection 2016.

25.

Adrenomedullin 2.0: Adjusting Key Levers for Metabolic Stability.

Schönauer R, Els-Heindl S, Fischer JP, Köbberling J, Riedl B, Beck-Sickinger AG.

J Med Chem. 2016 Jun 23;59(12):5695-705. doi: 10.1021/acs.jmedchem.6b00126. Epub 2016 Jun 6.

PMID:
27166982
26.

On-resin Diels-Alder reaction with inverse electron demand: an efficient ligation method for complex peptides with a varying spacer to optimize cell adhesion.

Pagel M, Meier R, Braun K, Wiessler M, Beck-Sickinger AG.

Org Biomol Chem. 2016 Jun 7;14(21):4809-16. doi: 10.1039/c6ob00314a. Epub 2016 Apr 27.

PMID:
27117044
27.

Double Methotrexate-Modified Neuropeptide Y Analogues Express Increased Toxicity and Overcome Drug Resistance in Breast Cancer Cells.

Böhme D, Krieghoff J, Beck-Sickinger AG.

J Med Chem. 2016 Apr 14;59(7):3409-17. doi: 10.1021/acs.jmedchem.6b00043. Epub 2016 Apr 6.

PMID:
26985967
28.

Peptide-Mediated Specific Immobilization of Catalytically Active Cytochrome P450 BM3 Variant.

Zernia S, Ott F, Bellmann-Sickert K, Frank R, Klenner M, Jahnke HG, Prager A, Abel B, Robitzki A, Beck-Sickinger AG.

Bioconjug Chem. 2016 Apr 20;27(4):1090-7. doi: 10.1021/acs.bioconjchem.6b00074. Epub 2016 Apr 1.

PMID:
26967204
29.

Peptide-tags for site-specific protein labelling in vitro and in vivo.

Lotze J, Reinhardt U, Seitz O, Beck-Sickinger AG.

Mol Biosyst. 2016 May 24;12(6):1731-45. doi: 10.1039/c6mb00023a. Review.

PMID:
26960991
30.

Multifunctional Coating Improves Cell Adhesion on Titanium by using Cooperatively Acting Peptides.

Pagel M, Hassert R, John T, Braun K, Wießler M, Abel B, Beck-Sickinger AG.

Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4826-30. doi: 10.1002/anie.201511781. Epub 2016 Mar 3.

PMID:
26938787
31.

Peptide mini-scaffold facilitates JNK3 activation in cells.

Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV.

Sci Rep. 2016 Feb 12;6:21025. doi: 10.1038/srep21025.

32.

A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J.

J Biol Chem. 2016 Apr 8;291(15):7809-20. doi: 10.1074/jbc.M115.702282. Epub 2016 Feb 5.

33.

Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear.

Verma D, Hörmer B, Bellmann-Sickert K, Thieme V, Beck-Sickinger AG, Herzog H, Sperk G, Tasan RO.

Br J Pharmacol. 2016 Jun;173(12):1925-38. doi: 10.1111/bph.13456. Epub 2016 May 19.

34.

Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis.

Saalbach A, Tremel J, Herbert D, Schwede K, Wandel E, Schirmer C, Anderegg U, Beck-Sickinger AG, Heiker JT, Schultz S, Magin T, Simon JC.

Am J Pathol. 2016 Mar;186(3):639-51. doi: 10.1016/j.ajpath.2015.10.030. Epub 2016 Jan 11.

PMID:
26783881
35.

Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.

Schönauer R, Kaiser A, Holze C, Babilon S, Köbberling J, Riedl B, Beck-Sickinger AG.

J Pept Sci. 2015 Dec;21(12):905-12. doi: 10.1002/psc.2833.

PMID:
26767744
36.

Short-range cytokine gradients to mimic paracrine cell interactions in vitro.

Ansorge M, Rastig N, Steinborn R, König T, Baumann L, Möller S, Schnabelrauch M, Cross M, Werner C, Beck-Sickinger AG, Pompe T.

J Control Release. 2016 Feb 28;224:59-68. doi: 10.1016/j.jconrel.2015.12.053. Epub 2016 Jan 5. Erratum in: J Control Release. 2016 Nov 10;241:243.

PMID:
26763375
37.

Charge-Compensated Metallacarborane Building Blocks for Conjugation with Peptides.

Frank R, Ahrens VM, Boehnke S, Beck-Sickinger AG, Hey-Hawkins E.

Chembiochem. 2016 Feb 15;17(4):308-17. doi: 10.1002/cbic.201500569. Epub 2016 Jan 15.

PMID:
26662708
38.

Inhibition of Kallikrein-Related Peptidases 7 and 5 by Grafting Serpin Reactive-Center Loop Sequences onto Sunflower Trypsin Inhibitor-1 (SFTI-1).

Jendrny C, Beck-Sickinger AG.

Chembiochem. 2016 Apr 15;17(8):719-26. doi: 10.1002/cbic.201500539. Epub 2015 Dec 22.

PMID:
26574674
39.

C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism.

Els-Heindl S, Bellmann-Sickert K, Beck-Sickinger AG.

Biopolymers. 2016 Jan;106(1):101-8. doi: 10.1002/bip.22768.

PMID:
26566778
40.

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.

Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP.

Chem Biol. 2015 Nov 19;22(11):1431-1436. doi: 10.1016/j.chembiol.2015.09.014. Epub 2015 Nov 5.

41.

Prenatal notch1 receptor blockade by protein delta homolog 1 (DLK1) modulates adipocyte size in vivo.

Kilian TM, Klöting N, Blüher M, Beck-Sickinger AG.

Int J Obes (Lond). 2016 Apr;40(4):698-705. doi: 10.1038/ijo.2015.227. Epub 2015 Aug 26.

PMID:
26499442
42.

Rapid Covalent Fluorescence Labeling of Membrane Proteins on Live Cells via Coiled-Coil Templated Acyl Transfer.

Reinhardt U, Lotze J, Mörl K, Beck-Sickinger AG, Seitz O.

Bioconjug Chem. 2015 Oct 21;26(10):2106-17. doi: 10.1021/acs.bioconjchem.5b00387. Epub 2015 Sep 24.

PMID:
26367072
43.

Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties.

Job F, Settele F, Lorey S, Rundfeldt C, Baumann L, Beck-Sickinger AG, Haupts U, Lilie H, Bosse-Doenecke E.

FEBS Open Bio. 2015 Jul 10;5:579-93. doi: 10.1016/j.fob.2015.07.002. eCollection 2015.

44.

Intracellular Trafficking of Neuropeptide Y Receptors.

Mörl K, Beck-Sickinger AG.

Prog Mol Biol Transl Sci. 2015;132:73-96. doi: 10.1016/bs.pmbts.2015.02.011. Epub 2015 Mar 25. Review.

PMID:
26055055
45.

A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action.

Ahrens VM, Kostelnik KB, Rennert R, Böhme D, Kalkhof S, Kosel D, Weber L, von Bergen M, Beck-Sickinger AG.

J Control Release. 2015 Jul 10;209:170-8. doi: 10.1016/j.jconrel.2015.04.037. Epub 2015 Apr 30.

PMID:
25935706
46.

Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.

Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P.

Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7446-9. doi: 10.1002/anie.201411688. Epub 2015 Apr 29.

47.

Controlling toxicity of Peptide-drug conjugates by different chemical linker structures.

Böhme D, Beck-Sickinger AG.

ChemMedChem. 2015 May;10(5):804-14. doi: 10.1002/cmdc.201402514. Epub 2015 Apr 9.

PMID:
25914147
48.

Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.

Kilian TM, Klöting N, Bergmann R, Els-Heindl S, Babilon S, Clément-Ziza M, Zhang Y, Beck-Sickinger AG, Chollet C.

J Med Chem. 2015 May 28;58(10):4180-93. doi: 10.1021/jm501702q. Epub 2015 May 7.

PMID:
25905598
49.

Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin.

Vortmeier G, DeLuca SH, Els-Heindl S, Chollet C, Scheidt HA, Beck-Sickinger AG, Meiler J, Huster D.

PLoS One. 2015 Mar 24;10(3):e0122444. doi: 10.1371/journal.pone.0122444. eCollection 2015.

50.

Synthesis and in vitro and in vivo evaluation of an (18)F-labeled neuropeptide Y analogue for imaging of breast cancer by PET.

Hofmann S, Maschauer S, Kuwert T, Beck-Sickinger AG, Prante O.

Mol Pharm. 2015 Apr 6;12(4):1121-30. doi: 10.1021/mp500601z. Epub 2015 Mar 13.

PMID:
25748228

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