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Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.

Beck SC, Wilding T, Buka RJ, Baretto RL, Huissoon AP, Krishna MT.

Front Immunol. 2019 Apr 5;10:494. doi: 10.3389/fimmu.2019.00494. eCollection 2019. Review.


A retinal model of cerebral malaria.

Paquet-Durand F, Beck SC, Das S, Huber G, Le Chang, Schubert T, Tanimoto N, Garcia-Garrido M, Mühlfriedel R, Bolz S, Hoffmann W, Schraermeyer U, Mordmüller B, Seeliger MW.

Sci Rep. 2019 Mar 5;9(1):3470. doi: 10.1038/s41598-019-39143-z.


Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.


Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina.

Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T.

Sci Rep. 2018 Apr 13;8(1):5970. doi: 10.1038/s41598-018-24476-y.


Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]


GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.

Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ, Rangwala SM.

Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28.


The concordance between component tests and clinical history in British adults with suspected pollen-food syndrome to peanut and hazelnut.

Beck SC, Huissoon AP, Collins D, Richter AG, Krishna MT.

J Clin Pathol. 2018 Mar;71(3):239-245. doi: 10.1136/jclinpath-2017-204573. Epub 2017 Aug 5.


A critical analysis of the utility of component tests in the diagnosis of pollen-related peanut and hazelnut allergy in the context of the BSACI guideline.

Beck SC, Huissoon AP, Baretto RL, Krishna MT.

Clin Exp Allergy. 2017 Sep;47(9):1223-1224. doi: 10.1111/cea.12991. No abstract available.


AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S.

Front Neurosci. 2017 May 24;11:292. doi: 10.3389/fnins.2017.00292. eCollection 2017.


Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease.

Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW.

PLoS One. 2017 Jun 2;12(6):e0178753. doi: 10.1371/journal.pone.0178753. eCollection 2017.


Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells.

Mitsuuchi Y, Benetatos CA, Deng Y, Haimowitz T, Beck SC, Arnone MR, Kapoor GS, Seipel ME, Chunduru SK, McKinlay MA, Begley CG, Condon SM.

Cell Death Discov. 2017 Jan 16;3:16046. doi: 10.1038/cddiscovery.2016.46. eCollection 2017.


Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.

Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):318-328. doi: 10.1167/iovs.16-20419.


Point-of-Care Ultrasound in the Evaluation of Pyogenic Flexor Tenosynovitis.

Cohen SG, Beck SC.

Pediatr Emerg Care. 2015 Nov;31(11):805-7. doi: 10.1097/PEC.0000000000000604.


Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F.

Hum Mol Genet. 2015 Oct 1;24(19):5486-99. doi: 10.1093/hmg/ddv275. Epub 2015 Jul 17.


Scale Adjustments to Facilitate Two-Dimensional Measurements in OCT Images.

Garcia Garrido M, Mühlfriedel RL, Beck SC, Wallrapp C, Seeliger MW.

PLoS One. 2015 Jun 25;10(6):e0131154. doi: 10.1371/journal.pone.0131154. eCollection 2015.


Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH.

Nat Genet. 2015 Jul;47(7):757-65. doi: 10.1038/ng.3319. Epub 2015 Jun 1.


VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

Antes R, Salomon-Zimri S, Beck SC, Garcia Garrido M, Livnat T, Maharshak I, Kadar T, Seeliger M, Weinberger D, Michaelson DM.

Curr Alzheimer Res. 2015;12(4):323-34.


Highly efficient star formation in NGC 5253 possibly from stream-fed accretion.

Turner JL, Beck SC, Benford DJ, Consiglio SM, Ho PT, Kovács A, Meier DS, Zhao JH.

Nature. 2015 Mar 19;519(7543):331-3. doi: 10.1038/nature14218.


Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses.

Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2312-24. doi: 10.1167/iovs.15-16654.


Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory.

Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R.

J Biol Chem. 2015 Apr 17;290(16):10242-55. doi: 10.1074/jbc.M114.611921. Epub 2015 Mar 4.


Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A.

PLoS One. 2014 Sep 9;9(9):e107048. doi: 10.1371/journal.pone.0107048. eCollection 2014.


Uncertainty of measurement: an immunology laboratory perspective.

Beck SC, Lock RJ.

Ann Clin Biochem. 2015 Jan;52(Pt 1):7-17. doi: 10.1177/0004563214551066. Epub 2014 Aug 26. Review.


Tuberculosis screening in a dialysis unit: detecting latent tuberculosis infection is only half the problem.

Brij SO, Beck SC, Kleemann F, Jack AL, Wilkinson C, Enoch DA.

J Hosp Infect. 2014 Aug;87(4):241-4. doi: 10.1016/j.jhin.2014.05.008. Epub 2014 Jun 24.


Towards a quantitative OCT image analysis.

Garcia Garrido M, Beck SC, Mühlfriedel R, Julien S, Schraermeyer U, Seeliger MW.

PLoS One. 2014 Jun 13;9(6):e100080. doi: 10.1371/journal.pone.0100080. eCollection 2014.


Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Michalakis S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, Biel M.

Adv Exp Med Biol. 2014;801:733-9. doi: 10.1007/978-1-4614-3209-8_92.


Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

Alves CH, Pellissier LP, Vos RM, Garcia Garrido M, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 1;23(13):3384-401. doi: 10.1093/hmg/ddu048. Epub 2014 Feb 2.


Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DM, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J.

PLoS Genet. 2013;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.


Making sense of serotype-specific pneumococcal antibody measurements.

Beck SC.

Ann Clin Biochem. 2013 Nov;50(Pt 6):517-9. doi: 10.1177/0004563213500241. Epub 2013 Sep 17. No abstract available.


Alterations of the tunica vasculosa lentis in the rat model of retinopathy of prematurity.

Favazza TL, Tanimoto N, Munro RJ, Beck SC, Garcia Garrido M, Seide C, Sothilingam V, Hansen RM, Fulton AB, Seeliger MW, Akula JD.

Doc Ophthalmol. 2013 Aug;127(1):3-11. doi: 10.1007/s10633-013-9392-z. Epub 2013 Jun 8.


Successful subretinal delivery and monitoring of MicroBeads in mice.

Fischer MD, Goldmann T, Wallrapp C, Mühlfriedel R, Beck SC, Stern-Schneider G, Ueffing M, Wolfrum U, Seeliger MW.

PLoS One. 2013;8(1):e55173. doi: 10.1371/journal.pone.0055173. Epub 2013 Jan 28.


Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2013 Jan 1;22(1):35-50. doi: 10.1093/hmg/dds398. Epub 2012 Sep 21.


Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Biel M, Mühlfriedel R, Michalakis S.

Hum Mol Genet. 2012 Oct 15;21(20):4486-96. Epub 2012 Jul 16.


Relevance of exocytotic glutamate release from retinal glia.

Slezak M, Grosche A, Niemiec A, Tanimoto N, Pannicke T, Münch TA, Crocker B, Isope P, Härtig W, Beck SC, Huber G, Ferracci G, Perraut M, Reber M, Miehe M, Demais V, Lévêque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Pfrieger FW.

Neuron. 2012 May 10;74(3):504-16. doi: 10.1016/j.neuron.2012.03.027.


Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.

Dudkin VY, Wang C, Arrington KL, Fraley ME, Hartman GD, Stirdivant SM, Drakas RA, Rickert K, Walsh ES, Hamilton K, Buser CA, Hardwick J, Tao W, Beck SC, Mao X, Lobell RB, Sepp-Lorenzino L.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2613-9. doi: 10.1016/j.bmcl.2012.01.120. Epub 2012 Feb 7.


Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia.

Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Schmidt J, Zong X, Gollisch T, Biel M, Seeliger MW.

Adv Exp Med Biol. 2012;723:183-9. doi: 10.1007/978-1-4614-0631-0_25. No abstract available.


PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW, Wijnholds J.

J Neurosci. 2011 Nov 23;31(47):17230-41. doi: 10.1523/JNEUROSCI.4430-11.2011.


Degeneration of the mouse retina upon dysregulated activity of serum response factor.

Sandström J, Heiduschka P, Beck SC, Philippar U, Seeliger MW, Schraermeyer U, Nordheim A.

Mol Vis. 2011 Apr 29;17:1110-27.


Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape.

Bartz R, Fan H, Zhang J, Innocent N, Cherrin C, Beck SC, Pei Y, Momose A, Jadhav V, Tellers DM, Meng F, Crocker LS, Sepp-Lorenzino L, Barnett SF.

Biochem J. 2011 Apr 15;435(2):475-87. doi: 10.1042/BJ20101021.


Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

Alfano G, Conte I, Caramico T, Avellino R, Arnò B, Pizzo MT, Tanimoto N, Beck SC, Huber G, Dollé P, Seeliger MW, Banfi S.

Development. 2011 Jan;138(2):261-71. doi: 10.1242/dev.051037. Epub 2010 Dec 9.


Novel rodent models for macular research.

Huber G, Heynen S, Imsand C, vom Hagen F, Muehlfriedel R, Tanimoto N, Feng Y, Hammes HP, Grimm C, Peichl L, Seeliger MW, Beck SC.

PLoS One. 2010 Oct 15;5(10):e13403. doi: 10.1371/journal.pone.0013403.


Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function.

Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW.

Mol Ther. 2010 Dec;18(12):2057-63. doi: 10.1038/mt.2010.149. Epub 2010 Jul 13.


Cone loss is delayed relative to rod loss during induced retinal degeneration in the diurnal cone-rich rodent Arvicanthis ansorgei.

Boudard DL, Tanimoto N, Huber G, Beck SC, Seeliger MW, Hicks D.

Neuroscience. 2010 Sep 15;169(4):1815-30. doi: 10.1016/j.neuroscience.2010.06.037. Epub 2010 Jun 22.


Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice.

Schaeferhoff K, Michalakis S, Tanimoto N, Fischer MD, Becirovic E, Beck SC, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Seeliger MW, Bonin M.

Cell Mol Life Sci. 2010 Sep;67(18):3173-86. doi: 10.1007/s00018-010-0376-9. Epub 2010 May 14.


In vivo assessment of retinal vascular wall dimensions.

Fischer MD, Huber G, Feng Y, Tanimoto N, Mühlfriedel R, Beck SC, Tröger E, Kernstock C, Preising MN, Lorenz B, Hammes HP, Seeliger MW.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5254-9. doi: 10.1167/iovs.09-5139. Epub 2010 May 5.


Structural and functional phenotyping in the cone-specific photoreceptor function loss 1 (cpfl1) mouse mutant - a model of cone dystrophies.

Fischer MD, Tanimoto N, Beck SC, Huber G, Schaeferhoff K, Michalakis S, Riess O, Wissinger B, Biel M, Bonin M, Seeliger MW.

Adv Exp Med Biol. 2010;664:593-9. doi: 10.1007/978-1-4419-1399-9_68.


Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.

Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW.

PLoS One. 2009 Oct 19;4(10):e7507. doi: 10.1371/journal.pone.0007507.


In vivo analysis of cone survival in mice.

Beck SC, Schaeferhoff K, Michalakis S, Fischer MD, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Bonin M, Seeliger MW, Tanimoto N.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):493-7. doi: 10.1167/iovs.09-4003. Epub 2009 Sep 8.


Spectral domain optical coherence tomography in mouse models of retinal degeneration.

Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz A, Paquet-Durand F, Wenzel A, Humphries P, Redmond TM, Seeliger MW, Fischer MD.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5888-95. doi: 10.1167/iovs.09-3724. Epub 2009 Aug 6.


Study of gene-targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP).

Bujakowska K, Maubaret C, Chakarova CF, Tanimoto N, Beck SC, Fahl E, Humphries MM, Kenna PF, Makarov E, Makarova O, Paquet-Durand F, Ekström PA, van Veen T, Leveillard T, Humphries P, Seeliger MW, Bhattacharya SS.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5927-33. doi: 10.1167/iovs.08-3275. Epub 2009 Jul 2.


Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.

Converso A, Hartingh T, Garbaccio RM, Tasber E, Rickert K, Fraley ME, Yan Y, Kreatsoulas C, Stirdivant S, Drakas B, Walsh ES, Hamilton K, Buser CA, Mao X, Abrams MT, Beck SC, Tao W, Lobell R, Sepp-Lorenzino L, Zugay-Murphy J, Sardana V, Munshi SK, Jezequel-Sur SM, Zuck PD, Hartman GD.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1240-4. doi: 10.1016/j.bmcl.2008.12.076. Epub 2008 Dec 24.


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