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Proceedings from the 8th Annual University of Calgary Leaders in Medicine Research Symposium.

Logan LM, Jensen SK, Singh N, Peplowski MA, Rabi D, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2019 Jan 30;41(4):E165-E185. doi: 10.25011/cim.v41i4.32220.


Macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition CD25+ T cells to suppress colitis.

Reyes JL, Lopes F, Leung G, Jayme TS, Matisz CE, Shute A, Burkhard R, Carneiro M, Workentine ML, Wang A, Petri B, Beck PL, Geuking MB, McKay DM.

FASEB J. 2019 Apr;33(4):5676-5689. doi: 10.1096/fj.201802160R. Epub 2019 Jan 22.


Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient.

Fang X, Monk JM, Nurk S, Akseshina M, Zhu Q, Gemmell C, Gianetto-Hill C, Leung N, Szubin R, Sanders J, Beck PL, Li W, Sandborn WJ, Gray-Owen SD, Knight R, Allen-Vercoe E, Palsson BO, Smarr L.

Front Microbiol. 2018 Oct 30;9:2559. doi: 10.3389/fmicb.2018.02559. eCollection 2018.


Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.

Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA.

Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071.


The Need for an Executive Leadership Curriculum in Scientist-Clinician Training Programs.

Barton KI, Capozzi LC, Aker G, Yipp BG, Hollenberg MD, Rabi DM, Beck PL.

Clin Invest Med. 2018 Sep 30;41(3):E144-E147. doi: 10.25011/cim.v41i3.30855.


Inhibition of Intestinal Epithelial Wound Healing through Protease-Activated Receptor-2 Activation in Caco2 Cells.

Fernando EH, Gordon MH, Beck PL, MacNaughton WK.

J Pharmacol Exp Ther. 2018 Nov;367(2):382-392. doi: 10.1124/jpet.118.249524. Epub 2018 Sep 6.


An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.

Flannigan KL, Taylor MR, Pereira SK, Rodriguez-Arguello J, Moffat AW, Alston L, Wang X, Poon KK, Beck PL, Rioux KP, Jonnalagadda M, Chelikani PK, Galipeau HJ, Lewis IA, Workentine ML, Greenway SC, Hirota SA.

J Heart Lung Transplant. 2018 Sep;37(9):1047-1059. doi: 10.1016/j.healun.2018.05.002. Epub 2018 May 23.


Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium.

Sharkey KA, Beck PL, McKay DM.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):765-784. doi: 10.1038/s41575-018-0051-4. Review.


Proceedings from the 7th Annual University of Calgary Leaders in Medicine Research Symposium.

Frolkis A, Beatty J, Peplowski M, Singh N, Beers C, Beck EM, Hollenberg M, Yipp B, Beck PL.

Clin Invest Med. 2018 Jun 30;41(2):E55-E126. doi: 10.25011/cim.v41i2.29916.


Combining the Love of Art, Science, Business and Medicine to Innovate and Enhance Patient Health. Highlights from the 7th Annual Leaders in Medicine Symposium of the Cummings School of Medicine, Calgary, AB.

Beatty J, Peplowski M, Singh N, Beers C, Beck EM, Hollenberg M, Yipp B, Beck PL.

Clin Invest Med. 2018 Jun 30;41(2):E51-E54. doi: 10.25011/cim.v41i2.29915.


Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemée A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA.

J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.


Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease.

Motta JP, Allain T, Green-Harrison LE, Groves RA, Feener T, Ramay H, Beck PL, Lewis IA, Wallace JL, Buret AG.

Inflamm Bowel Dis. 2018 Jun 8;24(7):1493-1502. doi: 10.1093/ibd/izy116.


Neutralization of IL-15 abrogates experimental immune-mediated cholangitis in diet-induced obese mice.

Reyes JL, Vannan DT, Vo T, Gulamhusein A, Beck PL, Reimer RA, Eksteen B.

Sci Rep. 2018 Feb 15;8(1):3127. doi: 10.1038/s41598-018-21112-7.


Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

Komada T, Chung H, Lau A, Platnich JM, Beck PL, Benediktsson H, Duff HJ, Jenne CN, Muruve DA.

J Am Soc Nephrol. 2018 Apr;29(4):1165-1181. doi: 10.1681/ASN.2017080863. Epub 2018 Feb 9.


Not Your Ordinary Ulcer: A Cautionary Tale of an Uncommon Condition.

Nguyen HH, Beck PL.

Gastroenterology. 2017 Dec;153(6):1484-1485. doi: 10.1053/j.gastro.2017.04.013. Epub 2017 Nov 2. No abstract available.


Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription.

Peplowski MA, Vegso AJ, Iablokov V, Dicay M, Zaheer RS, Renaux B, Proud D, Hollenberg MD, Beck PL, MacNaughton WK.

Physiol Rep. 2017 Oct;5(19). pii: e13451. doi: 10.14814/phy2.13451. Epub 2017 Oct 16.


The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study.

Kuenzig ME, Yim J, Coward S, Eksteen B, Seow CH, Barnabe C, Barkema HW, Silverberg MS, Lakatos PL, Beck PL, Fedorak R, Dieleman LA, Madsen K, Panaccione R, Ghosh S, Kaplan GG.

EBioMedicine. 2017 Jul;21:188-196. doi: 10.1016/j.ebiom.2017.06.012. Epub 2017 Jun 16. Review.


Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria.

Li J, Yan Y, Meng Z, Liu S, Beck PL, Ghosh S, Qian J, Gui X.

Dig Dis Sci. 2017 Oct;62(10):2755-2767. doi: 10.1007/s10620-017-4636-5. Epub 2017 Jun 9.


Crossover Subsets of CD4+ T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn's Disease and Ulcerative Colitis.

Li J, Ueno A, Iacucci M, Fort Gasia M, Jijon HB, Panaccione R, Kaplan GG, Beck PL, Luider J, Barkema HW, Qian J, Gui X, Ghosh S.

Dig Dis Sci. 2017 Sep;62(9):2357-2368. doi: 10.1007/s10620-017-4596-9. Epub 2017 Jun 1.


Career and research outcomes of the physician-scientist training program at the University of Calgary: a retrospective cohort study.

Bau JT, Frolkis AD, Nathoo N, Yipp BG, Hollenberg MD, Beck PL.

CMAJ Open. 2017 May 15;5(2):E395-E401. doi: 10.9778/cmajo.20160103. Epub 2017 May 15.


The effects of pregnancy on the pharmacokinetics of infliximab and adalimumab in inflammatory bowel disease.

Seow CH, Leung Y, Vande Casteele N, Ehteshami Afshar E, Tanyingoh D, Bindra G, Stewart MJ, Beck PL, Kaplan GG, Ghosh S, Panaccione R.

Aliment Pharmacol Ther. 2017 May;45(10):1329-1338. doi: 10.1111/apt.14040. Epub 2017 Mar 20.


Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms.

Beatty JK, Akierman SV, Motta JP, Muise S, Workentine ML, Harrison JJ, Bhargava A, Beck PL, Rioux KP, McKnight GW, Wallace JL, Buret AG.

Int J Parasitol. 2017 May;47(6):311-326. doi: 10.1016/j.ijpara.2016.11.010. Epub 2017 Feb 22.


Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.

Hirota SA, Ueno A, Tulk SE, Becker HM, Schenck LP, Potentier MS, Li Y, Ghosh S, Muruve DA, MacDonald JA, Beck PL.

Mediators Inflamm. 2016;2016:5637685. doi: 10.1155/2016/5637685. Epub 2016 Aug 17.


Novel CD8+ T-Cell Subsets Demonstrating Plasticity in Patients with Inflammatory Bowel Disease.

Tom MR, Li J, Ueno A, Fort Gasia M, Chan R, Hung DY, Chenoo S, Iacucci M, Jijon HB, Kaplan GG, Beck PL, Panaccione R, Barkema HW, Buret AG, Yajnik V, Ghosh S.

Inflamm Bowel Dis. 2016 Jul;22(7):1596-608. doi: 10.1097/MIB.0000000000000848.


Profiles of Lamina Propria T Helper Cell Subsets Discriminate Between Ulcerative Colitis and Crohn's Disease.

Li J, Ueno A, Fort Gasia M, Luider J, Wang T, Hirota C, Jijon HB, Deane M, Tom M, Chan R, Barkema HW, Beck PL, Kaplan GG, Panaccione R, Qian J, Iacucci M, Gui X, Ghosh S.

Inflamm Bowel Dis. 2016 Aug;22(8):1779-92. doi: 10.1097/MIB.0000000000000811.


Ulcerative Colitis Patients With Clostridium difficile are at Increased Risk of Death, Colectomy, and Postoperative Complications: A Population-Based Inception Cohort Study.

Negrón ME, Rezaie A, Barkema HW, Rioux K, De Buck J, Checkley S, Beck PL, Carroll M, Fedorak RN, Dieleman L, Panaccione R, Ghosh S, Kaplan GG.

Am J Gastroenterol. 2016 May;111(5):691-704. doi: 10.1038/ajg.2016.106. Epub 2016 Apr 19.


Unique microbial-derived volatile organic compounds in portal venous circulation in murine non-alcoholic fatty liver disease.

Reid DT, McDonald B, Khalid T, Vo T, Schenck LP, Surette MG, Beck PL, Reimer RA, Probert CS, Rioux KP, Eksteen B.

Biochim Biophys Acta. 2016 Jul;1862(7):1337-44. doi: 10.1016/j.bbadis.2016.04.005. Epub 2016 Apr 13.


Lost: Young Canadian physician-scientists need a map.

Lewinson RT, Keough MB, Beck PL, Hollenberg MD, Yipp BG.

Sci Transl Med. 2016 Mar 9;8(329):329fs6. doi: 10.1126/scitranslmed.aad4355. Review.


NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.

Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi-Simpson A, Platnich JM, Bracey NA, French MC, Beck PL, Chun J, Vallance BA, Muruve DA.

Cell Death Differ. 2016 Aug;23(8):1331-46. doi: 10.1038/cdd.2016.14. Epub 2016 Feb 19.


Proceedings from the 6th Annual University of Calgary Leaders in Medicine Research Symposium.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E318-50.


Highlights from the 6th Annual University of Calgary Leaders in Medicine Research Symposium and the Keynote Address by Dr. Danuta Skowronski.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E314-7.


Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection.

Schenck LP, Beck PL, MacDonald JA.

World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):169-80. doi: 10.4291/wjgp.v6.i4.169. Review.


Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA.

Gastroenterology. 2015 Aug;149(2):445-55.e3. doi: 10.1053/j.gastro.2015.04.007. Epub 2015 Apr 9.


Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography.

Frydman GH, Davis N, Beck PL, Fox JG.

Helicobacter. 2015 Aug;20(4):239-51. doi: 10.1111/hel.12200. Epub 2015 Mar 1. Review.


Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells.

Tulk SE, Liao KC, Muruve DA, Li Y, Beck PL, MacDonald JA.

J Cell Biochem. 2015 May;116(5):711-20. doi: 10.1002/jcb.24985.


Predictors of mortality among patients undergoing colectomy for ischemic colitis: A population-based United States study.

Sadler MD, Ravindran NC, Hubbard J, Myers RP, Ghosh S, Beck PL, Dixon E, Ball C, Prusinkiewicz C, Heitman SJ, Kaplan GG.

Can J Gastroenterol Hepatol. 2014 Dec;28(11):600-4.


Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue.

Cotton JA, Motta JP, Schenck LP, Hirota SA, Beck PL, Buret AG.

PLoS One. 2014 Oct 7;9(10):e109087. doi: 10.1371/journal.pone.0109087. eCollection 2014.


A prescription that addresses the decline of basic science education in medical school.

Miller D, Thornton CS, Keough MB, Roberts JI, Yipp B, Hollenberg M, Bau JT, Peplowski MA, Beck PL.

Clin Invest Med. 2014 Oct 4;37(5):E284-91.


Inflammatory bowel disease cause-specific mortality: a primer for clinicians.

Kassam Z, Belga S, Roifman I, Hirota S, Jijon H, Kaplan GG, Ghosh S, Beck PL.

Inflamm Bowel Dis. 2014 Dec;20(12):2483-92. doi: 10.1097/MIB.0000000000000173. Review.


Clostridium difficile infection worsens the prognosis of ulcerative colitis.

Negrón ME, Barkema HW, Rioux K, De Buck J, Checkley S, Proulx MC, Frolkis A, Beck PL, Dieleman LA, Panaccione R, Ghosh S, Kaplan GG.

Can J Gastroenterol Hepatol. 2014 Jul-Aug;28(7):373-80.


Invasive amoebiasis: a review of Entamoeba infections highlighted with case reports.

Skappak C, Akierman S, Belga S, Novak K, Chadee K, Urbanski SJ, Church D, Beck PL.

Can J Gastroenterol Hepatol. 2014 Jul-Aug;28(7):355-9. Review.


Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM.

Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14.


Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.


Giardia duodenalis cathepsin B proteases degrade intestinal epithelial interleukin-8 and attenuate interleukin-8-induced neutrophil chemotaxis.

Cotton JA, Bhargava A, Ferraz JG, Yates RM, Beck PL, Buret AG.

Infect Immun. 2014 Jul;82(7):2772-87. doi: 10.1128/IAI.01771-14. Epub 2014 Apr 14.


Opposing effects of smoking in ulcerative colitis and Crohn's disease may be explained by differential effects on dendritic cells.

Ueno A, Jijon H, Traves S, Chan R, Ford K, Beck PL, Iacucci M, Fort Gasia M, Barkema HW, Panaccione R, Kaplan GG, Proud D, Ghosh S.

Inflamm Bowel Dis. 2014 May;20(5):800-10. doi: 10.1097/MIB.0000000000000018.


The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.

Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA.

PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013.


Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients.

Ueno A, Jijon H, Chan R, Ford K, Hirota C, Kaplan GG, Beck PL, Iacucci M, Fort Gasia M, Barkema HW, Panaccione R, Ghosh S.

Inflamm Bowel Dis. 2013 Nov;19(12):2522-34. doi: 10.1097/MIB.0b013e3182a85709.


Effects of nitric oxide and reactive oxygen species on HIF-1α stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line.

Lee JY, Hirota SA, Glover LE, Armstrong GD, Beck PL, MacDonald JA.

Cell Physiol Biochem. 2013;32(2):417-30. doi: 10.1159/000354448. Epub 2013 Aug 27.


The association between celiac disease and eosinophilic esophagitis in children and adults.

Stewart MJ, Shaffer E, Urbanski SJ, Beck PL, Storr MA.

BMC Gastroenterol. 2013 May 30;13:96. doi: 10.1186/1471-230X-13-96.


Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4.

Dey I, Beck PL, Chadee K.

PLoS One. 2013 Apr 17;8(4):e61891. doi: 10.1371/journal.pone.0061891. Print 2013.

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