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Items: 43


Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time.

Crosby P, Hamnett R, Putker M, Hoyle NP, Reed M, Karam CJ, Maywood ES, Stangherlin A, Chesham JE, Hayter EA, Rosenbrier-Ribeiro L, Newham P, Clevers H, Bechtold DA, O'Neill JS.

Cell. 2019 May 2;177(4):896-909.e20. doi: 10.1016/j.cell.2019.02.017. Epub 2019 Apr 25.


Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Commun. 2019 Mar 7;10(1):1100. doi: 10.1038/s41467-019-08917-4.


Biological and clinical insights from genetics of insomnia symptoms.

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J; HUNT All In Sleep, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. Epub 2019 Feb 25.


REVERBa couples the circadian clock to hepatic glucocorticoid action.

Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW.

J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4.


The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

Hopwood TW, Hall S, Begley N, Forman R, Brown S, Vonslow R, Saer B, Little MC, Murphy EA, Hurst RJ, Ray DW, MacDonald AS, Brass A, Bechtold DA, Gibbs JE, Loudon AS, Else KJ.

Sci Rep. 2018 Feb 28;8(1):3782. doi: 10.1038/s41598-018-22021-5.


Sleep and cognitive performance: cross-sectional associations in the UK Biobank.

Kyle SD, Sexton CE, Feige B, Luik AI, Lane J, Saxena R, Anderson SG, Bechtold DA, Dixon W, Little MA, Ray D, Riemann D, Espie CA, Rutter MK, Spiegelhalder K.

Sleep Med. 2017 Oct;38:85-91. doi: 10.1016/j.sleep.2017.07.001. Epub 2017 Jul 14.


Misalignment with the external light environment drives metabolic and cardiac dysfunction.

West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA.

Nat Commun. 2017 Sep 12;8(1):417. doi: 10.1038/s41467-017-00462-2.


Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.

Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R.

Nat Genet. 2017 Feb;49(2):274-281. doi: 10.1038/ng.3749. Epub 2016 Dec 19.


The circadian clock regulates inflammatory arthritis.

Hand LE, Hopwood TW, Dickson SH, Walker AL, Loudon AS, Ray DW, Bechtold DA, Gibbs JE.

FASEB J. 2016 Nov;30(11):3759-3770. Epub 2016 Aug 3.


Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.

Cunningham PS, Ahern SA, Smith LC, da Silva Santos CS, Wager TT, Bechtold DA.

Sci Rep. 2016 Jul 21;6:29983. doi: 10.1038/srep29983.


Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.

Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R.

Nat Commun. 2016 Mar 9;7:10889. doi: 10.1038/ncomms10889.


Feeding time.

Piggins HD, Bechtold DA.

Elife. 2015 May 27;4. doi: 10.7554/eLife.08166.


The cost of circadian desynchrony: Evidence, insights and open questions.

West AC, Bechtold DA.

Bioessays. 2015 Jul;37(7):777-88. doi: 10.1002/bies.201400173. Epub 2015 May 22. Review.


Colour as a signal for entraining the mammalian circadian clock.

Walmsley L, Hanna L, Mouland J, Martial F, West A, Smedley AR, Bechtold DA, Webb AR, Lucas RJ, Brown TM.

PLoS Biol. 2015 Apr 17;13(4):e1002127. doi: 10.1371/journal.pbio.1002127. eCollection 2015 Apr.


Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

Church SJ, Begley P, Kureishy N, McHarg S, Bishop PN, Bechtold DA, Unwin RD, Cooper GJ.

Biochem Biophys Res Commun. 2015 May 8;460(3):549-54. doi: 10.1016/j.bbrc.2015.03.067. Epub 2015 Mar 20.


Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit.

Hand LE, Usan P, Cooper GJ, Xu LY, Ammori B, Cunningham PS, Aghamohammadzadeh R, Soran H, Greenstein A, Loudon AS, Bechtold DA, Ray DW.

Diabetes. 2015 Jan;64(1):128-36. doi: 10.2337/db13-1835. Epub 2014 Sep 4.


The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.

Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM.

Cell Metab. 2014 Oct 7;20(4):639-49. doi: 10.1016/j.cmet.2014.07.022. Epub 2014 Aug 28.


A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli.

Pilorz V, Cunningham PS, Jackson A, West AC, Wager TT, Loudon AS, Bechtold DA.

Curr Biol. 2014 Mar 31;24(7):766-73. doi: 10.1016/j.cub.2014.02.027. Epub 2014 Mar 20.


Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock.

Belle MD, Hughes AT, Bechtold DA, Cunningham P, Pierucci M, Burdakov D, Piggins HD.

J Neurosci. 2014 Mar 5;34(10):3607-21. doi: 10.1523/JNEUROSCI.3388-13.2014.


Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.

Hand LE, Saer BR, Hui ST, Jinnah HA, Steinlechner S, Loudon AS, Bechtold DA.

Endocrinology. 2013 Jun;154(6):2081-91. doi: 10.1210/en.2012-2051. Epub 2013 Apr 12.


Hypothalamic clocks and rhythms in feeding behaviour.

Bechtold DA, Loudon AS.

Trends Neurosci. 2013 Feb;36(2):74-82. doi: 10.1016/j.tins.2012.12.007. Epub 2013 Jan 18. Review.


Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting.

Guilding C, Scott F, Bechtold DA, Brown TM, Wegner S, Piggins HD.

J Physiol. 2013 Feb 15;591(4):1063-80. doi: 10.1113/jphysiol.2012.242198. Epub 2012 Dec 3.


A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor.

Bechtold DA, Sidibe A, Saer BR, Li J, Hand LE, Ivanova EA, Darras VM, Dam J, Jockers R, Luckman SM, Loudon AS.

Curr Biol. 2012 Jan 10;22(1):70-7. doi: 10.1016/j.cub.2011.11.043. Epub 2011 Dec 22.


GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.

Li J, Hand LE, Meng QJ, Loudon AS, Bechtold DA.

PLoS One. 2011;6(8):e23725. doi: 10.1371/journal.pone.0023725. Epub 2011 Aug 17.


Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: 10.1073/pnas.1005101107. Epub 2010 Aug 9.


Circadian dysfunction in disease.

Bechtold DA, Gibbs JE, Loudon AS.

Trends Pharmacol Sci. 2010 May;31(5):191-8. doi: 10.1016/ Epub 2010 Feb 18. Review.


PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling.

Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM.

J Neurosci. 2009 Nov 25;29(47):14828-35. doi: 10.1523/JNEUROSCI.1526-09.2009.


Appetite-modifying actions of pro-neuromedin U-derived peptides.

Bechtold DA, Ivanov TR, Luckman SM.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E545-51. doi: 10.1152/ajpendo.00255.2009. Epub 2009 Jun 16.


Energy-responsive timekeeping.

Bechtold DA.

J Genet. 2008 Dec;87(5):447-58. Review.


The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.

Loudon AS, Meng QJ, Maywood ES, Bechtold DA, Boot-Handford RP, Hastings MH.

Cold Spring Harb Symp Quant Biol. 2007;72:261-71. doi: 10.1101/sqb.2007.72.073. Review.


Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.

Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NRJ, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon ASI.

Neuron. 2008 Apr 10;58(1):78-88. doi: 10.1016/j.neuron.2008.01.019.


Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling.

Bechtold DA, Brown TM, Luckman SM, Piggins HD.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R344-51. Epub 2007 Nov 21.


Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse.

Ivanova EA, Bechtold DA, Dupré SM, Brennand J, Barrett P, Luckman SM, Loudon AS.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E176-82. Epub 2007 Oct 23.


Hypothalamic thyroid hormones: mediators of seasonal physiology.

Bechtold DA, Loudon AS.

Endocrinology. 2007 Aug;148(8):3605-7. No abstract available.


Axonal protection achieved in a model of multiple sclerosis using lamotrigine.

Bechtold DA, Miller SJ, Dawson AC, Sun Y, Kapoor R, Berry D, Smith KJ.

J Neurol. 2006 Dec;253(12):1542-51.


The role of RFamide peptides in feeding.

Bechtold DA, Luckman SM.

J Endocrinol. 2007 Jan;192(1):3-15. Review.


Prolactin-releasing Peptide mediates cholecystokinin-induced satiety in mice.

Bechtold DA, Luckman SM.

Endocrinology. 2006 Oct;147(10):4723-9. Epub 2006 Jun 22.


Sodium-mediated axonal degeneration in inflammatory demyelinating disease.

Bechtold DA, Smith KJ.

J Neurol Sci. 2005 Jun 15;233(1-2):27-35. Review.


Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide.

Bechtold DA, Yue X, Evans RM, Davies M, Gregson NA, Smith KJ.

Brain. 2005 Jan;128(Pt 1):18-28. Epub 2004 Oct 27.


Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

Bechtold DA, Kapoor R, Smith KJ.

Ann Neurol. 2004 May;55(5):607-16.


Heat shock proteins Hsp27 and Hsp32 localize to synaptic sites in the rat cerebellum following hyperthermia.

Bechtold DA, Brown IR.

Brain Res Mol Brain Res. 2000 Feb 22;75(2):309-20.


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