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Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes.

Makitrynskyy R, Tsypik O, Nuzzo D, Paululat T, Zechel DL, Bechthold A.

Nucleic Acids Res. 2020 Jan 20. pii: gkz1220. doi: 10.1093/nar/gkz1220. [Epub ahead of print]


Development and optimization of an intergeneric conjugation system and analysis of promoter activity in Streptomyces rimosus M527.

Song ZQ, Liao ZJ, Hu YF, Ma Z, Bechthold A, Yu XP.

J Zhejiang Univ Sci B. 2019 Nov.;20(11):891-900. doi: 10.1631/jzus.B1900270.


Insights into the Role of Ketoreductases in the Biosynthesis of Partially Reduced Bacterial Aromatic Polyketides.

Husain SM, Präg A, Linnenbrink A, Bechthold A, Müller M.

Chembiochem. 2019 Sep 10. doi: 10.1002/cbic.201900357. [Epub ahead of print]


Rational Design of Hybrid Natural Products by Utilizing the Promiscuity of an Amide Synthetase.

Zhu J, Zhang S, Zechel DL, Paululat T, Bechthold A.

ACS Chem Biol. 2019 Aug 16;14(8):1793-1801. doi: 10.1021/acschembio.9b00351. Epub 2019 Aug 6.


ToyA, a positive pathway-specific regulator for toyocamycin biosynthesis in Streptomyces diastatochromogenes 1628.

Xu J, Song Z, Xu X, Ma Z, Bechthold A, Yu X.

Appl Microbiol Biotechnol. 2019 Sep;103(17):7071-7084. doi: 10.1007/s00253-019-09959-w. Epub 2019 Jun 29.


Food Groups and Risk of Overweight, Obesity, and Weight Gain: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.

Schlesinger S, Neuenschwander M, Schwedhelm C, Hoffmann G, Bechthold A, Boeing H, Schwingshackl L.

Adv Nutr. 2019 Mar 1;10(2):205-218. doi: 10.1093/advances/nmy092.


A Potential Biocontrol Agent Streptomyces violaceusniger AC12AB for Managing Potato Common Scab.

Sarwar A, Latif Z, Zhang S, Hao J, Bechthold A.

Front Microbiol. 2019 Feb 8;10:202. doi: 10.3389/fmicb.2019.00202. eCollection 2019.


Sequential improvement of rimocidin production in Streptomyces rimosus M527 by introduction of cumulative drug-resistance mutations.

Zhao Y, Song Z, Ma Z, Bechthold A, Yu X.

J Ind Microbiol Biotechnol. 2019 May;46(5):697-708. doi: 10.1007/s10295-019-02146-w. Epub 2019 Jan 29.


Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452.

Zhang S, Klementz D, Zhu J, Makitrynskyy R, Ola Pasternak AR, Günther S, Zechel DL, Bechthold A.

J Biotechnol. 2019 Feb 20;292:23-31. doi: 10.1016/j.jbiotec.2018.12.016. Epub 2019 Jan 11.


Impact of otrA expression on morphological differentiation, actinorhodin production, and resistance to aminoglycosides in Streptomyces coelicolor M145.

Zhao YF, Lu DD, Bechthold A, Ma Z, Yu XP.

J Zhejiang Univ Sci B. 2018 Sept.;19(9):708-717. doi: 10.1631/jzus.B1800046.


Perspective: Food-Based Dietary Guidelines in Europe-Scientific Concepts, Current Status, and Perspectives.

Bechthold A, Boeing H, Tetens I, Schwingshackl L, Nöthlings U.

Adv Nutr. 2018 Sep 1;9(5):544-560. doi: 10.1093/advances/nmy033. Review.


AdpAsd, a Positive Regulator for Morphological Development and Toyocamycin Biosynthesis in Streptomyces diastatochromogenes 1628.

Wang J, Xu J, Luo S, Ma Z, Bechthold A, Yu X.

Curr Microbiol. 2018 Oct;75(10):1345-1351. doi: 10.1007/s00284-018-1529-6. Epub 2018 Jun 19.


Biological Control of Potato Common Scab With Rare Isatropolone C Compound Produced by Plant Growth Promoting Streptomyces A1RT.

Sarwar A, Latif Z, Zhang S, Zhu J, Zechel DL, Bechthold A.

Front Microbiol. 2018 May 30;9:1126. doi: 10.3389/fmicb.2018.01126. eCollection 2018.


Generating the evidence for risk reduction: a contribution to the future of food-based dietary guidelines.

Schwingshackl L, Schlesinger S, Devleesschauwer B, Hoffmann G, Bechthold A, Schwedhelm C, Iqbal K, Knüppel S, Boeing H.

Proc Nutr Soc. 2018 Nov;77(4):432-444. doi: 10.1017/S0029665118000125. Epub 2018 Apr 30. Review.


Biosynthesis of Rishirilide B.

Schwarzer P, Wunsch-Palasis J, Bechthold A, Paululat T.

Antibiotics (Basel). 2018 Mar 7;7(1). pii: E20. doi: 10.3390/antibiotics7010020.


PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates.

Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B.

Biochemistry. 2018 Feb 13;57(6):1003-1011. doi: 10.1021/acs.biochem.7b01219. Epub 2018 Jan 30.


Revised Reference Values for the Intake of Sodium and Chloride.

Strohm D, Bechthold A, Ellinger S, Leschik-Bonnet E, Stehle P, Heseker H; German Nutrition Society (DGE).

Ann Nutr Metab. 2018;72(1):12-17. doi: 10.1159/000484355. Epub 2017 Dec 12.


Food groups and risk of colorectal cancer.

Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Laure Preterre A, Iqbal K, Bechthold A, De Henauw S, Michels N, Devleesschauwer B, Boeing H, Schlesinger S.

Int J Cancer. 2018 May 1;142(9):1748-1758. doi: 10.1002/ijc.31198. Epub 2017 Dec 14.


New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.

Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A.

Chembiochem. 2018 Feb 2;19(3):272-279. doi: 10.1002/cbic.201700428. Epub 2017 Dec 18.


Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.

Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Iqbal K, Andriolo V, Bechthold A, Schlesinger S, Boeing H.

Adv Nutr. 2017 Nov 15;8(6):793-803. doi: 10.3945/an.117.017178. Print 2017 Nov. Review. Erratum in: Adv Nutr. 2018 Mar 1;9(2):163-164.


Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies.

Bechthold A, Boeing H, Schwedhelm C, Hoffmann G, Knüppel S, Iqbal K, De Henauw S, Michels N, Devleesschauwer B, Schlesinger S, Schwingshackl L.

Crit Rev Food Sci Nutr. 2019;59(7):1071-1090. doi: 10.1080/10408398.2017.1392288. Epub 2017 Nov 7.


Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies.

Schwingshackl L, Schwedhelm C, Hoffmann G, Lampousi AM, Knüppel S, Iqbal K, Bechthold A, Schlesinger S, Boeing H.

Am J Clin Nutr. 2017 Jun;105(6):1462-1473. doi: 10.3945/ajcn.117.153148. Epub 2017 Apr 26. Review.


Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies.

Schwingshackl L, Hoffmann G, Lampousi AM, Knüppel S, Iqbal K, Schwedhelm C, Bechthold A, Schlesinger S, Boeing H.

Eur J Epidemiol. 2017 May;32(5):363-375. doi: 10.1007/s10654-017-0246-y. Epub 2017 Apr 10. Review.


Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties.

Greule A, Marolt M, Deubel D, Peintner I, Zhang S, Jessen-Trefzer C, De Ford C, Burschel S, Li SM, Friedrich T, Merfort I, Lüdeke S, Bisel P, Müller M, Paululat T, Bechthold A.

Front Microbiol. 2017 Feb 21;8:221. doi: 10.3389/fmicb.2017.00221. eCollection 2017.


Selection of an efficient promoter and its application in toyocamycin production improvement in Streptomyces diastatochromogenes 1628.

Xu X, Wang J, Bechthold A, Ma Z, Yu X.

World J Microbiol Biotechnol. 2017 Feb;33(2):30. doi: 10.1007/s11274-016-2194-1. Epub 2017 Jan 5.


Food groups and risk of chronic disease: a protocol for a systematic review and network meta-analysis of cohort studies.

Schwingshackl L, Chaimani A, Bechthold A, Iqbal K, Stelmach-Mardas M, Hoffmann G, Schwedhelm C, Schlesinger S, Boeing H.

Syst Rev. 2016 Jul 27;5(1):125. doi: 10.1186/s13643-016-0302-9.


Thailandins A and B, New Polyene Macrolactone Compounds Isolated from Actinokineospora bangkokensis Strain 44EHW(T), Possessing Antifungal Activity against Anthracnose Fungi and Pathogenic Yeasts.

Intra B, Greule A, Bechthold A, Euanorasetr J, Paululat T, Panbangred W.

J Agric Food Chem. 2016 Jun 29;64(25):5171-9. doi: 10.1021/acs.jafc.6b01119. Epub 2016 Jun 15.


An influence of the copy number of biosynthetic gene clusters on the production level of antibiotics in a heterologous host.

Manderscheid N, Bilyk B, Busche T, Kalinowski J, Paululat T, Bechthold A, Petzke L, Luzhetskyy A.

J Biotechnol. 2016 Aug 20;232:110-7. doi: 10.1016/j.jbiotec.2016.05.038. Epub 2016 Jun 2.


Link between Food Energy Density and Body Weight Changes in Obese Adults.

Stelmach-Mardas M, Rodacki T, Dobrowolska-Iwanek J, Brzozowska A, Walkowiak J, Wojtanowska-Krosniak A, Zagrodzki P, Bechthold A, Mardas M, Boeing H.

Nutrients. 2016 Apr 20;8(4):229. doi: 10.3390/nu8040229. Review.


Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628.

Ma Z, Luo S, Xu X, Bechthold A, Yu X.

J Ind Microbiol Biotechnol. 2016 Apr;43(4):463-71. doi: 10.1007/s10295-015-1732-4. Epub 2016 Jan 20.


StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes.

Klementz D, Döring K, Lucas X, Telukunta KK, Erxleben A, Deubel D, Erber A, Santillana I, Thomas OS, Bechthold A, Günther S.

Nucleic Acids Res. 2016 Jan 4;44(D1):D509-14. doi: 10.1093/nar/gkv1319. Epub 2015 Nov 28.


New Simocyclinones: Surprising Evolutionary and Biosynthetic Insights.

Bilyk O, Brötz E, Tokovenko B, Bechthold A, Paululat T, Luzhetskyy A.

ACS Chem Biol. 2016 Jan 15;11(1):241-50. doi: 10.1021/acschembio.5b00669. Epub 2015 Nov 25.


Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2.

Kroeger JK, Hassan K, Vörös A, Simm R, Saidijam M, Bettaney KE, Bechthold A, Paulsen IT, Henderson PJ, Kolstø AB.

Front Microbiol. 2015 Oct 12;6:1063. doi: 10.3389/fmicb.2015.01063. eCollection 2015.


Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases.

Wolfram G, Bechthold A, Boeing H, Ellinger S, Hauner H, Kroke A, Leschik-Bonnet E, Linseisen J, Lorkowski S, Schulze M, Stehle P, Dinter J; German Nutrition Society.

Ann Nutr Metab. 2015;67(3):141-204. doi: 10.1159/000437243. Epub 2015 Sep 29.


Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule.

Zhu XM, Hackl S, Thaker MN, Kalan L, Weber C, Urgast DS, Krupp EM, Brewer A, Vanner S, Szawiola A, Yim G, Feldmann J, Bechthold A, Wright GD, Zechel DL.

Chembiochem. 2015 Nov;16(17):2498-506. doi: 10.1002/cbic.201500402. Epub 2015 Oct 22.


Revised reference values for selenium intake.

Kipp AP, Strohm D, Brigelius-Flohé R, Schomburg L, Bechthold A, Leschik-Bonnet E, Heseker H; German Nutrition Society (DGE).

J Trace Elem Med Biol. 2015 Oct;32:195-9. doi: 10.1016/j.jtemb.2015.07.005. Epub 2015 Jul 17. Review.


Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.


Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains.

Gessner A, Heitzler T, Zhang S, Klaus C, Murillo R, Zhao H, Vanner S, Zechel DL, Bechthold A.

Chembiochem. 2015 Oct 12;16(15):2244-52. doi: 10.1002/cbic.201500297. Epub 2015 Sep 23.


The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces.

Hackl S, Bechthold A.

Arch Pharm (Weinheim). 2015 Jul;348(7):455-62. doi: 10.1002/ardp.201500073. Epub 2015 Apr 27. Review.


Functional characterization of different ORFs including luciferase-like monooxygenase genes from the mensacarcin gene cluster.

Maier S, Heitzler T, Asmus K, Brötz E, Hardter U, Hesselbach K, Paululat T, Bechthold A.

Chembiochem. 2015 May 26;16(8):1175-82. doi: 10.1002/cbic.201500048. Epub 2015 Apr 23.


Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.

Tam HK, Härle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O.

Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2811-5. doi: 10.1002/anie.201409792. Epub 2015 Jan 7.


Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.

Rebets Y, Tokovenko B, Lushchyk I, Rückert C, Zaburannyi N, Bechthold A, Kalinowski J, Luzhetskyy A.

BMC Genomics. 2014 Oct 10;15:885. doi: 10.1186/1471-2164-15-885.


Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8.

Maier S, Pflüger T, Loesgen S, Asmus K, Brötz E, Paululat T, Zeeck A, Andrade S, Bechthold A.

Chembiochem. 2014 Mar 21;15(5):749-56. doi: 10.1002/cbic.201300704. Epub 2014 Feb 19.


Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628.

Ma Z, Tao L, Bechthold A, Shentu X, Bian Y, Yu X.

Appl Microbiol Biotechnol. 2014 Jun;98(11):5051-8. doi: 10.1007/s00253-014-5573-2. Epub 2014 Feb 9.


Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Makitrynskyy R, Ostash B, Tsypik O, Rebets Y, Doud E, Meredith T, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V.

Open Biol. 2013 Oct 23;3(10):130121. doi: 10.1098/rsob.130121.


A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene.

Kalan L, Gessner A, Thaker MN, Waglechner N, Zhu X, Szawiola A, Bechthold A, Wright GD, Zechel DL.

Chem Biol. 2013 Oct 24;20(10):1214-24. doi: 10.1016/j.chembiol.2013.09.006. Epub 2013 Oct 10.


Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production.

Ma Z, Liu J, Bechthold A, Tao L, Shentu X, Bian Y, Yu X.

Curr Microbiol. 2014 Feb;68(2):180-5. doi: 10.1007/s00284-013-0461-z. Epub 2013 Sep 22.


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