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Antisense inhibition of lpxB gene expression in Acinetobacter baumannii by peptide-PNA conjugates and synergy with colistin.

Martínez-Guitián M, Vázquez-Ucha JC, Álvarez-Fraga L, Conde-Pérez K, Bou G, Poza M, Beceiro A.

J Antimicrob Chemother. 2019 Oct 5. pii: dkz409. doi: 10.1093/jac/dkz409. [Epub ahead of print]


Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection.

Martínez-Guitián M, Vázquez-Ucha JC, Álvarez-Fraga L, Conde-Pérez K, Lasarte-Monterrubio C, Vallejo JA, Bou G, Poza M, Beceiro A.

Front Cell Infect Microbiol. 2019 Aug 29;9:310. doi: 10.3389/fcimb.2019.00310. eCollection 2019.


Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii.

Vázquez-Ucha JC, Martínez-Guitián M, Maneiro M, Conde-Pérez K, Álvarez-Fraga L, Torrens G, Oliver A, Buynak JD, Bonomo RA, Bou G, González-Bello C, Poza M, Beceiro A.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01092-19. doi: 10.1128/AAC.01092-19. Print 2019 Oct.


Challenging Antimicrobial Susceptibility and Evolution of Resistance (OXA-681) during Treatment of a Long-Term Nosocomial Infection Caused by a Pseudomonas aeruginosa ST175 Clone.

Arca-Suárez J, Fraile-Ribot P, Vázquez-Ucha JC, Cabot G, Martínez-Guitián M, Lence E, González-Bello C, Beceiro A, Rodríguez-Iglesias M, Galán-Sánchez F, Bou G, Oliver A.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01110-19. doi: 10.1128/AAC.01110-19. Print 2019 Oct.


Draft Genome Sequences of Two Epidemic OXA-48-Producing Klebsiella pneumoniae Clinical Strains Isolated during a Large Outbreak in Spain.

Gato E, Álvarez-Fraga L, Vallejo JA, Rumbo-Feal S, Martínez-Guitián M, Beceiro A, Poza M, Bou G, Pérez A.

Genome Announc. 2018 Mar 29;6(13). pii: e00026-18. doi: 10.1128/genomeA.00026-18.


Pneumonia infection in mice reveals the involvement of the feoA gene in the pathogenesis of Acinetobacter baumannii.

Álvarez-Fraga L, Vázquez-Ucha JC, Martínez-Guitián M, Vallejo JA, Bou G, Beceiro A, Poza M.

Virulence. 2018 Jan 1;9(1):496-509. doi: 10.1080/21505594.2017.1420451.


Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii.

Vázquez-Ucha JC, Maneiro M, Martínez-Guitián M, Buynak J, Bethel CR, Bonomo RA, Bou G, Poza M, González-Bello C, Beceiro A.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01172-17. doi: 10.1128/AAC.01172-17. Print 2017 Nov.


Global assessment of small RNAs reveals a non-coding transcript involved in biofilm formation and attachment in Acinetobacter baumannii ATCC 17978.

Álvarez-Fraga L, Rumbo-Feal S, Pérez A, Gómez MJ, Gayoso C, Vallejo JA, Ohneck EJ, Valle J, Actis LA, Beceiro A, Bou G, Poza M.

PLoS One. 2017 Aug 1;12(8):e0182084. doi: 10.1371/journal.pone.0182084. eCollection 2017.


Increased Antimicrobial Resistance in a Novel CMY-54 AmpC-Type Enzyme with a GluLeu217-218 Insertion in the Ω-Loop.

Pérez-Llarena FJ, Vázquez-Ucha JC, Kerff F, Zamorano L, Miró E, Cabral MP, Fleites A, Lantero M, Martínez-Martínez L, Oliver A, Galleni M, Navarro F, Beceiro A, Bou G.

Microb Drug Resist. 2018 Jun;24(5):527-533. doi: 10.1089/mdr.2017.0017. Epub 2017 Jun 30.


Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy.

Cabral MP, García P, Beceiro A, Rumbo C, Pérez A, Moscoso M, Bou G.

Nat Commun. 2017 May 26;8:15480. doi: 10.1038/ncomms15480.


Contribution of the A. baumannii A1S_0114 Gene to the Interaction with Eukaryotic Cells and Virulence.

Rumbo-Feal S, Pérez A, Ramelot TA, Álvarez-Fraga L, Vallejo JA, Beceiro A, Ohneck EJ, Arivett BA, Merino M, Fiester SE, Kennedy MA, Actis LA, Bou G, Poza M.

Front Cell Infect Microbiol. 2017 Apr 3;7:108. doi: 10.3389/fcimb.2017.00108. eCollection 2017.


The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain.

Pérez A, Merino M, Rumbo-Feal S, Álvarez-Fraga L, Vallejo JA, Beceiro A, Ohneck EJ, Mateos J, Fernández-Puente P, Actis LA, Poza M, Bou G.

Virulence. 2017 Aug 18;8(6):959-974. doi: 10.1080/21505594.2016.1262313. Epub 2016 Nov 18.


Assessment of antivirulence activity of several d-amino acids against Acinetobacter baumannii and Pseudomonas aeruginosa.

Rumbo C, Vallejo JA, Cabral MP, Martínez-Guitián M, Pérez A, Beceiro A, Bou G.

J Antimicrob Chemother. 2016 Dec;71(12):3473-3481. Epub 2016 Sep 7.


Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme.

Prado V, Lence E, Maneiro M, Vázquez-Ucha JC, Beceiro A, Thompson P, Hawkins AR, González-Bello C.

J Med Chem. 2016 Jun 9;59(11):5471-87. doi: 10.1021/acs.jmedchem.6b00483. Epub 2016 May 18.


Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.

Martínez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4375-9. doi: 10.1128/AAC.00510-16. Print 2016 Jul.


LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Vallejo JA, Martínez-Guitián M, Vázquez-Ucha JC, González-Bello C, Poza M, Buynak JD, Bethel CR, Bonomo RA, Bou G, Beceiro A.

J Antimicrob Chemother. 2016 Aug;71(8):2171-80. doi: 10.1093/jac/dkw105. Epub 2016 Apr 28.


Analysis of the role of the LH92_11085 gene of a biofilm hyper-producing Acinetobacter baumannii strain on biofilm formation and attachment to eukaryotic cells.

Álvarez-Fraga L, Pérez A, Rumbo-Feal S, Merino M, Vallejo JA, Ohneck EJ, Edelmann RE, Beceiro A, Vázquez-Ucha JC, Valle J, Actis LA, Bou G, Poza M.

Virulence. 2016 May 18;7(4):443-55. doi: 10.1080/21505594.2016.1145335. Epub 2016 Feb 8.


Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Prado V, Lence E, Vallejo JA, Beceiro A, Thompson P, Hawkins AR, González-Bello C.

Chemistry. 2016 Feb 18;22(8):2758-68. doi: 10.1002/chem.201504438. Epub 2016 Jan 21.


Optimisation of the Caenorhabditis elegans model for studying the pathogenesis of opportunistic Acinetobacter baumannii.

Vallejo JA, Beceiro A, Rumbo-Feal S, Rodríguez-Palero MJ, Russo TA, Bou G.

Int J Antimicrob Agents. 2015 Jul 9. pii: S0924-8579(15)00241-1. doi: 10.1016/j.ijantimicag.2015.05.021. [Epub ahead of print]


Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

González-Bello C, Tizón L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AR.

J Am Chem Soc. 2015 Jul 29;137(29):9333-43. doi: 10.1021/jacs.5b04080. Epub 2015 Jul 16.


Quantitative proteomic analysis of host--pathogen interactions: a study of Acinetobacter baumannii responses to host airways.

Méndez JA, Mateos J, Beceiro A, Lopez M, Tomás M, Poza M, Bou G.

BMC Genomics. 2015 May 30;16:422. doi: 10.1186/s12864-015-1608-z.


The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells.

Rumbo C, Tomás M, Fernández Moreira E, Soares NC, Carvajal M, Santillana E, Beceiro A, Romero A, Bou G.

Infect Immun. 2014 Nov;82(11):4666-80. doi: 10.1128/IAI.02034-14. Epub 2014 Aug 25.


Genetic and kinetic characterization of the novel AmpC β-lactamases DHA-6 and DHA-7.

Pérez-Llarena FJ, Zamorano L, Kerff F, Beceiro A, García P, Miró E, Larrosa N, Gómez-Bertomeu F, Méndez JA, González-López JJ, Oliver A, Galleni M, Navarro F, Bou G.

Antimicrob Agents Chemother. 2014 Nov;58(11):6544-9. doi: 10.1128/AAC.03144-14. Epub 2014 Aug 18.


New mutations in ADC-type β-lactamases from Acinetobacter spp. affect cefoxitin and ceftazidime hydrolysis.

Pérez A, Pérez-Llarena FJ, García P, Kerff F, Beceiro A, Galleni M, Bou G.

J Antimicrob Chemother. 2014 Sep;69(9):2407-11. doi: 10.1093/jac/dku163. Epub 2014 May 20.


Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii.

Beceiro A, Moreno A, Fernández N, Vallejo JA, Aranda J, Adler B, Harper M, Boyce JD, Bou G.

Antimicrob Agents Chemother. 2014;58(1):518-26. doi: 10.1128/AAC.01597-13. Epub 2013 Nov 4.


Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Beceiro A, Tomás M, Bou G.

Clin Microbiol Rev. 2013 Apr;26(2):185-230. doi: 10.1128/CMR.00059-12. Review.


Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities.

Moyá B, Beceiro A, Cabot G, Juan C, Zamorano L, Alberti S, Oliver A.

Antimicrob Agents Chemother. 2012 Sep;56(9):4771-8. doi: 10.1128/AAC.00680-12. Epub 2012 Jun 25.


Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.

Pérez-Llarena FJ, Fernández A, Zamorano L, Kerff F, Beceiro A, Aracil B, Cercenado E, Miro E, Oliver A, Oteo J, Navarro F, Bou G.

Antimicrob Agents Chemother. 2012 Aug;56(8):4540-3. doi: 10.1128/AAC.00776-12. Epub 2012 Jun 5.


[Antimicrobial resistance and virulence: a beneficial relationship for the microbial world?].

Beceiro A, Tomás M, Bou G.

Enferm Infecc Microbiol Clin. 2012 Oct;30(8):492-9. doi: 10.1016/j.eimc.2012.01.011. Epub 2012 Mar 2. Review. Spanish.


False extended-spectrum {beta}-lactamase phenotype in clinical isolates of Escherichia coli associated with increased expression of OXA-1 or TEM-1 penicillinases and loss of porins.

Beceiro A, Maharjan S, Gaulton T, Doumith M, Soares NC, Dhanji H, Warner M, Doyle M, Hickey M, Downie G, Bou G, Livermore DM, Woodford N.

J Antimicrob Chemother. 2011 Sep;66(9):2006-10. doi: 10.1093/jac/dkr265. Epub 2011 Jul 8.


Acinetobacter baumannii RecA protein in repair of DNA damage, antimicrobial resistance, general stress response, and virulence.

Aranda J, Bardina C, Beceiro A, Rumbo S, Cabral MP, Barbé J, Bou G.

J Bacteriol. 2011 Aug;193(15):3740-7. doi: 10.1128/JB.00389-11. Epub 2011 Jun 3.


Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system.

Beceiro A, Llobet E, Aranda J, Bengoechea JA, Doumith M, Hornsey M, Dhanji H, Chart H, Bou G, Livermore DM, Woodford N.

Antimicrob Agents Chemother. 2011 Jul;55(7):3370-9. doi: 10.1128/AAC.00079-11. Epub 2011 May 16.


Clinical features of infections and colonization by Acinetobacter genospecies 3.

Molina J, Cisneros JM, Fernández-Cuenca F, Rodríguez-Baño J, Ribera A, Beceiro A, Martínez-Martínez L, Pascual Á, Bou G, Vila J, Pachón J; Spanish Group for Nosocomial Infection (GEIH).

J Clin Microbiol. 2010 Dec;48(12):4623-6. doi: 10.1128/JCM.01216-10. Epub 2010 Oct 13.


Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.

Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD.

J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z.


Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-beta-lactamases.

Merino M, Pérez-Llarena FJ, Kerff F, Poza M, Mallo S, Rumbo-Feal S, Beceiro A, Juan C, Oliver A, Bou G.

J Antimicrob Chemother. 2010 Sep;65(9):1950-4. doi: 10.1093/jac/dkq259. Epub 2010 Jul 11.


OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak.

Merino M, Acosta J, Poza M, Sanz F, Beceiro A, Chaves F, Bou G.

Antimicrob Agents Chemother. 2010 Jun;54(6):2724-7. doi: 10.1128/AAC.01674-09. Epub 2010 Apr 12.


Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Tomás M, Doumith M, Warner M, Turton JF, Beceiro A, Bou G, Livermore DM, Woodford N.

Antimicrob Agents Chemother. 2010 May;54(5):2219-24. doi: 10.1128/AAC.00816-09. Epub 2010 Mar 1.


In vitro activity and in vivo efficacy of clavulanic acid against Acinetobacter baumannii.

Beceiro A, López-Rojas R, Domínguez-Herrera J, Docobo-Pérez F, Bou G, Pachón J; Spanish Network for Research in Infectious Diseases (REIPI).

Antimicrob Agents Chemother. 2009 Oct;53(10):4298-304. doi: 10.1128/AAC.00320-09. Epub 2009 Jul 27.


Genetic variability among ampC genes from acinetobacter genomic species 3.

Beceiro A, Pérez A, Fernández-Cuenca F, Martínez-Martínez L, Pascual A, Vila J, Rodríguez-Baño J, Cisneros JM, Pachón J, Bou G; Spanish Group for Nosocomial Infection (GEIH).

Antimicrob Agents Chemother. 2009 Mar;53(3):1177-84. doi: 10.1128/AAC.00485-08. Epub 2008 Nov 24.


Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.

Juan C, Beceiro A, Gutiérrez O, Albertí S, Garau M, Pérez JL, Bou G, Oliver A.

Antimicrob Agents Chemother. 2008 Oct;52(10):3589-96. doi: 10.1128/AAC.00465-08. Epub 2008 Jul 21.


Structure-function studies of arginine at position 276 in CTX-M beta-lactamases.

Pérez-Llarena FJ, Cartelle M, Mallo S, Beceiro A, Pérez A, Villanueva R, Romero A, Bonnet R, Bou G.

J Antimicrob Chemother. 2008 Apr;61(4):792-7. doi: 10.1093/jac/dkn031. Epub 2008 Feb 14.


False extended-spectrum beta-lactamase detection in Acinetobacter spp. due to intrinsic susceptibility to clavulanic acid.

Beceiro A, Fernández-Cuenca F, Ribera A, Martínez-Martínez L, Pascual A, Vila J, Rodríguez-Baño J, Cisneros JM, Pachón J, Bou G; Spanish Group for Nosocomial Infection (GEIH).

J Antimicrob Chemother. 2008 Feb;61(2):301-8. Epub 2007 Dec 8.


Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate.

Pérez A, Canle D, Latasa C, Poza M, Beceiro A, Tomás Mdel M, Fernández A, Mallo S, Pérez S, Molina F, Villanueva R, Lasa I, Bou G.

Antimicrob Agents Chemother. 2007 Sep;51(9):3247-53. Epub 2007 Jul 16.


Molecular characterization of the gene encoding a new AmpC beta-lactamase in Acinetobacter baylyi.

Beceiro A, Pérez-Llarena FJ, Pérez A, Tomás Mdel M, Fernández A, Mallo S, Villanueva R, Bou G.

J Antimicrob Chemother. 2007 May;59(5):996-1000. Epub 2007 Apr 2.


Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis.

Santillana E, Beceiro A, Bou G, Romero A.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5354-9. Epub 2007 Mar 20.


Interspecies spread of CTX-M-32 extended-spectrum beta-lactamase and the role of the insertion sequence IS1 in down-regulating bla CTX-M gene expression.

Fernández A, Gil E, Cartelle M, Pérez A, Beceiro A, Mallo S, Tomás MM, Pérez-Llarena FJ, Villanueva R, Bou G.

J Antimicrob Chemother. 2007 May;59(5):841-7. Epub 2007 Mar 1.


Cloning and functional analysis of the gene encoding the 33- to 36-kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii.

del Mar Tomás M, Beceiro A, Pérez A, Velasco D, Moure R, Villanueva R, Martínez-Beltrán J, Bou G.

Antimicrob Agents Chemother. 2005 Dec;49(12):5172-5.


Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection.

del Mar Tomas M, Cartelle M, Pertega S, Beceiro A, Llinares P, Canle D, Molina F, Villanueva R, Cisneros JM, Bou G.

Clin Microbiol Infect. 2005 Jul;11(7):540-6.


Evaluation of different methods for detecting methicillin (oxacillin) resistance in Staphylococcus aureus.

Velasco D, del Mar Tomas M, Cartelle M, Beceiro A, Perez A, Molina F, Moure R, Villanueva R, Bou G.

J Antimicrob Chemother. 2005 Mar;55(3):379-82. Epub 2005 Feb 18.


Risk factors for colonization and infection in a hospital outbreak caused by a strain of Klebsiella pneumoniae with reduced susceptibility to expanded-spectrum cephalosporins.

Cartelle M, del Mar Tomas M, Pertega S, Beceiro A, Dominguez MA, Velasco D, Molina F, Villanueva R, Bou G.

J Clin Microbiol. 2004 Sep;42(9):4242-9.

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