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Items: 1 to 50 of 94

1.

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.

Kaminski AM, Chiruvella KK, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2019 Sep 26;47(17):9410-9422. doi: 10.1093/nar/gkz680.

2.

The correlation between serum E-selectin levels and soluble interleukin-2 receptors with relation to disease activity in localized scleroderma.

Wodok-Wieczorek K, Salwowska N, Syguła E, Wodok A, Wcisło-Dziadecka D, Bebenek K, Bergler-Czop B, Brzezińska-Wcisło L.

Postepy Dermatol Alergol. 2018 Dec;35(6):614-619. doi: 10.5114/ada.2018.77613. Epub 2018 Nov 13.

3.

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, Pedersen LC, Bebenek K.

Nat Commun. 2018 Jul 6;9(1):2642. doi: 10.1038/s41467-018-05024-8.

4.

Newer treatments of psoriasis regarding IL-23 inhibitors, phosphodiesterase 4 inhibitors, and Janus kinase inhibitors.

Wcisło-Dziadecka D, Zbiciak-Nylec M, Brzezińska-Wcisło L, Bebenek K, Kaźmierczak A.

Dermatol Ther. 2017 Nov;30(6). doi: 10.1111/dth.12555. Epub 2017 Oct 10. Review.

PMID:
28994166
5.

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nucleic Acids Res. 2017 Sep 6;45(15):9138-9148. doi: 10.1093/nar/gkx527.

6.

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.

Jamsen JA, Beard WA, Pedersen LC, Shock DD, Moon AF, Krahn JM, Bebenek K, Kunkel TA, Wilson SH.

Nat Commun. 2017 Aug 15;8(1):253. doi: 10.1038/s41467-017-00271-7.

7.

Physiochemical properties and application of hyaluronic acid: a systematic review.

Salwowska NM, Bebenek KA, Żądło DA, Wcisło-Dziadecka DL.

J Cosmet Dermatol. 2016 Dec;15(4):520-526. doi: 10.1111/jocd.12237. Epub 2016 Jun 21. Review.

PMID:
27324942
8.

Creative template-dependent synthesis by human polymerase mu.

Moon AF, Gosavi RA, Kunkel TA, Pedersen LC, Bebenek K.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4530-6. doi: 10.1073/pnas.1505798112. Epub 2015 Aug 3.

9.

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol.

Martínez-Jiménez MI, García-Gómez S, Bebenek K, Sastre-Moreno G, Calvo PA, Díaz-Talavera A, Kunkel TA, Blanco L.

DNA Repair (Amst). 2015 May;29:127-38. doi: 10.1016/j.dnarep.2015.02.013. Epub 2015 Feb 23.

10.

Structure-function studies of DNA polymerase λ.

Bebenek K, Pedersen LC, Kunkel TA.

Biochemistry. 2014 May 6;53(17):2781-92. doi: 10.1021/bi4017236. Epub 2014 Apr 23. Review.

11.

Structures of the Leishmania infantum polymerase beta.

Mejia E, Burak M, Alonso A, Larraga V, Kunkel TA, Bebenek K, Garcia-Diaz M.

DNA Repair (Amst). 2014 Jun;18:1-9. doi: 10.1016/j.dnarep.2014.03.001. Epub 2014 Mar 22.

12.

Sustained active site rigidity during synthesis by human DNA polymerase μ.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC.

Nat Struct Mol Biol. 2014 Mar;21(3):253-60. doi: 10.1038/nsmb.2766. Epub 2014 Feb 2.

13.

DNA polymerase λ inactivation by oxidized abasic sites.

Stevens AJ, Guan L, Bebenek K, Kunkel TA, Greenberg MM.

Biochemistry. 2013 Feb 5;52(5):975-83. doi: 10.1021/bi301592x. Epub 2013 Jan 18.

14.

The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ.

Gosavi RA, Moon AF, Kunkel TA, Pedersen LC, Bebenek K.

Nucleic Acids Res. 2012 Aug;40(15):7518-27. doi: 10.1093/nar/gks413. Epub 2012 May 14.

15.

Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.

Daly J, Bebenek K, Watt DL, Richter K, Jiang C, Zhao ML, Ray M, McGregor WG, Kunkel TA, Diaz M.

J Immunol. 2012 Jun 1;188(11):5528-37. doi: 10.4049/jimmunol.1102629. Epub 2012 Apr 30.

16.

Replication infidelity via a mismatch with Watson-Crick geometry.

Bebenek K, Pedersen LC, Kunkel TA.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1862-7. doi: 10.1073/pnas.1012825108. Epub 2011 Jan 13.

17.

Inhibition of short patch and long patch base excision repair by an oxidized abasic site.

Guan L, Bebenek K, Kunkel TA, Greenberg MM.

Biochemistry. 2010 Nov 16;49(45):9904-10. doi: 10.1021/bi101533a. Epub 2010 Oct 20.

18.

Loop 1 modulates the fidelity of DNA polymerase lambda.

Bebenek K, Garcia-Diaz M, Zhou RZ, Povirk LF, Kunkel TA.

Nucleic Acids Res. 2010 Sep;38(16):5419-31. doi: 10.1093/nar/gkq261. Epub 2010 Apr 30.

19.

Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

Terrados G, Capp JP, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsocq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L.

PLoS One. 2009 Oct 6;4(10):e7290. doi: 10.1371/journal.pone.0007290.

20.

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

Garcia-Diaz M, Bebenek K, Larrea AA, Havener JM, Perera L, Krahn JM, Pedersen LC, Ramsden DA, Kunkel TA.

Nat Struct Mol Biol. 2009 Sep;16(9):967-72. doi: 10.1038/nsmb.1654. Epub 2009 Aug 23.

21.

Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies.

Cisneros GA, Perera L, García-Díaz M, Bebenek K, Kunkel TA, Pedersen LG.

DNA Repair (Amst). 2008 Nov 1;7(11):1824-34. doi: 10.1016/j.dnarep.2008.07.007. Epub 2008 Aug 30.

22.

Multiple functions of DNA polymerases.

Garcia-Diaz M, Bebenek K.

CRC Crit Rev Plant Sci. 2007 Mar;26(2):105-122.

23.

Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.

Zhou RZ, Blanco L, Garcia-Diaz M, Bebenek K, Kunkel TA, Povirk LF.

Nucleic Acids Res. 2008 May;36(9):2895-905. doi: 10.1093/nar/gkn126. Epub 2008 Apr 1.

24.

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.

Bebenek K, Garcia-Diaz M, Foley MC, Pedersen LC, Schlick T, Kunkel TA.

EMBO Rep. 2008 May;9(5):459-64. doi: 10.1038/embor.2008.33. Epub 2008 Mar 28.

25.

The X family portrait: structural insights into biological functions of X family polymerases.

Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, Pedersen LC.

DNA Repair (Amst). 2007 Dec 1;6(12):1709-25. Epub 2007 Jul 12. Review.

26.

Role of the catalytic metal during polymerization by DNA polymerase lambda.

Garcia-Diaz M, Bebenek K, Krahn JM, Pedersen LC, Kunkel TA.

DNA Repair (Amst). 2007 Sep 1;6(9):1333-40. Epub 2007 May 1.

27.

RNA-templated DNA repair.

Storici F, Bebenek K, Kunkel TA, Gordenin DA, Resnick MA.

Nature. 2007 May 17;447(7142):338-41. Epub 2007 Apr 11. Erratum in: Nature. 2007 Aug 30;448(7157):1076.

28.

Structural insight into the substrate specificity of DNA Polymerase mu.

Moon AF, Garcia-Diaz M, Bebenek K, Davis BJ, Zhong X, Ramsden DA, Kunkel TA, Pedersen LC.

Nat Struct Mol Biol. 2007 Jan;14(1):45-53. Epub 2006 Dec 10. Erratum in: Nat Struct Mol Biol. 2007 Jul;14(7):680.

PMID:
17159995
29.

Promiscuous mismatch extension by human DNA polymerase lambda.

Picher AJ, García-Díaz M, Bebenek K, Pedersen LC, Kunkel TA, Blanco L.

Nucleic Acids Res. 2006 Jun 28;34(11):3259-66. Print 2006.

30.

Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase.

Garcia-Diaz M, Bebenek K, Krahn JM, Pedersen LC, Kunkel TA.

Cell. 2006 Jan 27;124(2):331-42.

31.

A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.

Brieba LG, Kokoska RJ, Bebenek K, Kunkel TA, Ellenberger T.

Structure. 2005 Nov;13(11):1653-9.

32.

Structure-function studies of DNA polymerase lambda.

Garcia-Diaz M, Bebenek K, Gao G, Pedersen LC, London RE, Kunkel TA.

DNA Repair (Amst). 2005 Dec 8;4(12):1358-67. Epub 2005 Oct 4. Review.

PMID:
16213194
33.

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juárez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA.

Mol Cell. 2005 Aug 5;19(3):357-66.

34.

Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV.

Bebenek K, Garcia-Diaz M, Patishall SR, Kunkel TA.

J Biol Chem. 2005 May 20;280(20):20051-8. Epub 2005 Mar 17.

35.

A closed conformation for the Pol lambda catalytic cycle.

Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC.

Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19.

PMID:
15608652
36.

Functions of DNA polymerases.

Bebenek K, Kunkel TA.

Adv Protein Chem. 2004;69:137-65. Review. No abstract available.

PMID:
15588842
37.

Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.

Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M.

Cancer Res. 2004 Mar 15;64(6):1924-31.

38.

A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.

Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, Pedersen LC.

Mol Cell. 2004 Feb 27;13(4):561-72.

39.

Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

Lee JW, Blanco L, Zhou T, Garcia-Diaz M, Bebenek K, Kunkel TA, Wang Z, Povirk LF.

J Biol Chem. 2004 Jan 2;279(1):805-11. Epub 2003 Oct 15.

40.

Solution structure of the lyase domain of human DNA polymerase lambda.

DeRose EF, Kirby TW, Mueller GA, Bebenek K, Garcia-Diaz M, Blanco L, Kunkel TA, London RE.

Biochemistry. 2003 Aug 19;42(32):9564-74.

PMID:
12911298
41.

Functions of eukaryotic DNA polymerases.

Shcherbakova PV, Bebenek K, Kunkel TA.

Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3. Review.

PMID:
12844548
42.

The frameshift infidelity of human DNA polymerase lambda. Implications for function.

Bebenek K, Garcia-Diaz M, Blanco L, Kunkel TA.

J Biol Chem. 2003 Sep 5;278(36):34685-90. Epub 2003 Jun 25.

43.

Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

Prasad R, Bebenek K, Hou E, Shock DD, Beard WA, Woodgate R, Kunkel TA, Wilson SH.

J Biol Chem. 2003 Aug 8;278(32):29649-54. Epub 2003 May 29.

44.

32nd annual meeting of European Environmental Mutagen Society. DNA damage and repair fundamental aspects and contribution to human disorders.

Tudek B, Ciesla Z, Janion C, Boiteux S, Bebenek K, Shinagawa H, Bartsch H, Laval J, van Zeeland AA, Mullenders LF, Szyfter K, Collins A, Kruszewski M.

DNA Repair (Amst). 2003 Jun 11;2(6):765-81. No abstract available.

PMID:
12767355
45.

Streisinger revisited: DNA synthesis errors mediated by substrate misalignments.

Bebenek K, Kunkel TA.

Cold Spring Harb Symp Quant Biol. 2000;65:81-91. Review. No abstract available.

PMID:
12760023
46.

Human DNA polymerase kappa: a novel DNA polymerase of unknown biological function encoded by the DINB1 gene.

Gerlach VL, Feaver WJ, Fischhaber PL, Richardson JA, Aravind L, Koonin EV, Bebenek K, Kunkel TA, Friedberg EC.

Cold Spring Harb Symp Quant Biol. 2000;65:41-9. Review. No abstract available.

PMID:
12760019
47.

The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair.

Matsuda T, Vande Berg BJ, Bebenek K, Osheroff WP, Wilson SH, Kunkel TA.

J Biol Chem. 2003 Jul 11;278(28):25947-51. Epub 2003 May 6.

48.
49.

Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site.

Kokoska RJ, Bebenek K, Boudsocq F, Woodgate R, Kunkel TA.

J Biol Chem. 2002 May 31;277(22):19633-8. Epub 2002 Mar 27.

50.

Family growth: the eukaryotic DNA polymerase revolution.

Bebenek K, Kunkel TA.

Cell Mol Life Sci. 2002 Jan;59(1):54-7. Review. No abstract available.

PMID:
11846034

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