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Items: 16

1.

ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.

Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller JA, Krantz ID, Carstens RP, Epstein DJ.

Dev Cell. 2017 Nov 6;43(3):318-331.e5. doi: 10.1016/j.devcel.2017.09.026. Epub 2017 Oct 26.

2.

A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.

Comiskey DF Jr, Jacob AG, Sanford BL, Montes M, Goodwin AK, Steiner H, Matsa E, Tapia-Santos AS, Bebee TW, Grieves J, La Perle K, Boyaka P, Chandler DS.

Oncogene. 2018 Jan 4;37(1):95-106. doi: 10.1038/onc.2017.282. Epub 2017 Sep 11.

3.

Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number.

Bebee TW, Sims-Lucas S, Park JW, Bushnell D, Cieply B, Xing Y, Bates CM, Carstens RP.

Dev Dyn. 2016 Oct;245(10):991-1000. doi: 10.1002/dvdy.24431. Epub 2016 Jul 28.

4.

Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins.

Cieply B, Park JW, Nakauka-Ddamba A, Bebee TW, Guo Y, Shang X, Lengner CJ, Xing Y, Carstens RP.

Cell Rep. 2016 Apr 12;15(2):247-55. doi: 10.1016/j.celrep.2016.03.025. Epub 2016 Mar 31.

5.

Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition.

Yang Y, Park JW, Bebee TW, Warzecha CC, Guo Y, Shang X, Xing Y, Carstens RP.

Mol Cell Biol. 2016 May 16;36(11):1704-19. doi: 10.1128/MCB.00019-16. Print 2016 Jun 1.

6.

ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.

Bhate A, Parker DJ, Bebee TW, Ahn J, Arif W, Rashan EH, Chorghade S, Chau A, Lee JH, Anakk S, Carstens RP, Xiao X, Kalsotra A.

Nat Commun. 2015 Nov 4;6:8768. doi: 10.1038/ncomms9768.

7.

The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.

Bebee TW, Park JW, Sheridan KI, Warzecha CC, Cieply BW, Rohacek AM, Xing Y, Carstens RP.

Elife. 2015 Sep 15;4. doi: 10.7554/eLife.08954.

8.

Genome-wide activities of RNA binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT).

Bebee TW, Cieply BW, Carstens RP.

Adv Exp Med Biol. 2014;825:267-302. doi: 10.1007/978-1-4939-1221-6_8. Review.

PMID:
25201109
9.

Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways.

Jacob AG, Singh RK, Comiskey DF Jr, Rouhier MF, Mohammad F, Bebee TW, Chandler DS.

PLoS One. 2014 Aug 8;9(8):e104444. doi: 10.1371/journal.pone.0104444. eCollection 2014.

10.

The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.

Jacob AG, Singh RK, Mohammad F, Bebee TW, Chandler DS.

J Biol Chem. 2014 Jun 20;289(25):17350-64. doi: 10.1074/jbc.M114.554717. Epub 2014 May 5.

11.

Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.

Bebee TW, Dominguez CE, Samadzadeh-Tarighat S, Akehurst KL, Chandler DS.

Hum Mol Genet. 2012 Oct 1;21(19):4301-13. doi: 10.1093/hmg/dds263. Epub 2012 Jul 3.

12.

Mouse models of SMA: tools for disease characterization and therapeutic development.

Bebee TW, Dominguez CE, Chandler DS.

Hum Genet. 2012 Aug;131(8):1277-93. doi: 10.1007/s00439-012-1171-5. Epub 2012 Apr 29. Review.

PMID:
22543872
13.

Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement.

Bebee TW, Gladman JT, Chandler DS.

Genesis. 2011 Dec;49(12):927-34. doi: 10.1002/dvg.20764. Epub 2011 Aug 24.

PMID:
21538807
14.

A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.

Gladman JT, Bebee TW, Edwards C, Wang X, Sahenk Z, Rich MM, Chandler DS.

Hum Mol Genet. 2010 Nov 1;19(21):4239-52. doi: 10.1093/hmg/ddq343. Epub 2010 Aug 12.

15.

Splicing of the Survival Motor Neuron genes and implications for treatment of SMA

Bebee TW, Gladman JT, Chandler DS.

Front Biosci (Landmark Ed). 2010 Jun 1;15:1191-1204. Review.

16.

Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.

Singh RK, Tapia-Santos A, Bebee TW, Chandler DS.

Exp Cell Res. 2009 Nov 15;315(19):3419-32. doi: 10.1016/j.yexcr.2009.07.017. Epub 2009 Jul 21.

PMID:
19631207

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