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Items: 28


Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.

Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ, James LK, Sutton BJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8707-E8716. doi: 10.1073/pnas.1806840115. Epub 2018 Aug 27.


Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.

Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM.

Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4.


IgE Trimers Drive SPE-7 Cytokinergic Activity.

Bax HJ, Bowen H, Beavil RL, Chung R, Ward M, Davies AM, Dodev TS, McDonnell JM, Beavil AJ, Sutton BJ, Gould HJ.

Sci Rep. 2017 Aug 15;7(1):8164. doi: 10.1038/s41598-017-08212-6.


The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.

Terali K, Beavil RL, Pickersgill RW, van der Giezen M.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):235-40. doi: 10.1016/j.bbrc.2013.09.039. Epub 2013 Sep 14.


A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition.

Hunt J, Keeble AH, Dale RE, Corbett MK, Beavil RL, Levitt J, Swann MJ, Suhling K, Ameer-Beg S, Sutton BJ, Beavil AJ.

J Biol Chem. 2012 May 18;287(21):17459-70. doi: 10.1074/jbc.M111.331967. Epub 2012 Mar 22.


Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies.

Gilbert AE, Karagiannis P, Dodev T, Koers A, Lacy K, Josephs DH, Takhar P, Geh JL, Healy C, Harries M, Acland KM, Rudman SM, Beavil RL, Blower PJ, Beavil AJ, Gould HJ, Spicer J, Nestle FO, Karagiannis SN.

PLoS One. 2011 Apr 29;6(4):e19330. doi: 10.1371/journal.pone.0019330.


The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

Bergeron JR, Huthoff H, Veselkov DA, Beavil RL, Simpson PJ, Matthews SJ, Malim MH, Sanderson MR.

PLoS Pathog. 2010 Jun 3;6(6):e1000925. doi: 10.1371/journal.ppat.1000925.


Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.

Hands-Taylor KL, Martino L, Tata R, Babon JJ, Bui TT, Drake AF, Beavil RL, Pruijn GJ, Brown PR, Conte MR.

Nucleic Acids Res. 2010 Jul;38(12):4052-66. doi: 10.1093/nar/gkq141. Epub 2010 Mar 9.


A monomeric chicken IgY receptor binds IgY with 2:1 stoichiometry.

Taylor AI, Beavil RL, Sutton BJ, Calvert RA.

J Biol Chem. 2009 Sep 4;284(36):24168-75. doi: 10.1074/jbc.M109.020263. Epub 2009 Jul 10.


IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F, Moore RJ, Dombrowicz DD, Balkwill FR, Gould HJ.

J Immunol. 2007 Sep 1;179(5):2832-43.


Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.

Karagiannis SN, Bracher MG, Beavil RL, Beavil AJ, Hunt J, McCloskey N, Thompson RG, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill FR, Gould HJ.

Cancer Immunol Immunother. 2008 Feb;57(2):247-63. Epub 2007 Jul 27.


Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells.

McCloskey N, Hunt J, Beavil RL, Jutton MR, Grundy GJ, Girardi E, Fabiane SM, Fear DJ, Conrad DH, Sutton BJ, Gould HJ.

J Biol Chem. 2007 Aug 17;282(33):24083-91. Epub 2007 Jun 18.


l-Methionine sulfoximine, but not phosphinothricin, is a substrate for an acetyltransferase (gene PA4866) from Pseudomonas aeruginosa: structural and functional studies.

Davies AM, Tata R, Beavil RL, Sutton BJ, Brown PR.

Biochemistry. 2007 Feb 20;46(7):1829-39. Epub 2007 Jan 25.


Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.

Yiu CP, Beavil RL, Chan HY.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):311-8. Epub 2006 Mar 6.


The structure of human CD23 and its interactions with IgE and CD21.

Hibbert RG, Teriete P, Grundy GJ, Beavil RL, Reljic R, Holers VM, Hannan JP, Sutton BJ, Gould HJ, McDonnell JM.

J Exp Med. 2005 Sep 19;202(6):751-60.


Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI.

Hunt J, Beavil RL, Calvert RA, Gould HJ, Sutton BJ, Beavil AJ.

J Biol Chem. 2005 Apr 29;280(17):16808-14. Epub 2005 Mar 2.


The biology of IGE and the basis of allergic disease.

Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA, Fear D, Smurthwaite L.

Annu Rev Immunol. 2003;21:579-628. Epub 2001 Dec 19. Review.


The crystal structure of IgE Fc reveals an asymmetrically bent conformation.

Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ.

Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17.


Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding.

Mackay GA, Hulett MD, Cook JP, Trist HM, Henry AJ, McDonnell JM, Beavil AJ, Beavil RL, Sutton BJ, Hogarth PM, Gould HJ.

J Immunol. 2002 Feb 15;168(4):1787-95.


Regulation of IgE production requires oligomerization of CD23.

Kilmon MA, Ghirlando R, Strub MP, Beavil RL, Gould HJ, Conrad DH.

J Immunol. 2001 Sep 15;167(6):3139-45.


Inhibition of IgE-receptor interactions.

Sutton BJ, Beavil RL, Beavil AJ.

Br Med Bull. 2000;56(4):1004-18. Review.


IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation.

Gould HJ, Beavil RL, Vercelli D.

Br Med Bull. 2000;56(4):908-24. Review.


The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.

McDonnell JM, Calvert R, Beavil RL, Beavil AJ, Henry AJ, Sutton BJ, Gould HJ, Cowburn D.

Nat Struct Biol. 2001 May;8(5):437-41.


Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23.

Schulz O, Sutton BJ, Beavil RL, Shi J, Sewell HF, Gould HJ, Laing P, Shakib F.

Eur J Immunol. 1997 Mar;27(3):584-8.


Interaction of the low-affinity receptor CD23/Fc epsilonRII lectin domain with the Fc epsilon3-4 fragment of human immunoglobulin E.

Shi J, Ghirlando R, Beavil RL, Beavil AJ, Keown MB, Young RJ, Owens RJ, Sutton BJ, Gould HJ.

Biochemistry. 1997 Feb 25;36(8):2112-22.


CD23/Fc epsilon RII and its soluble fragments can form oligomers on the cell surface and in solution.

Beavil RL, Graber P, Aubonney N, Bonnefoy JY, Gould HJ.

Immunology. 1995 Feb;84(2):202-6.


Structural basis of the IgE-Fc epsilon RI interaction.

Beavil AJ, Beavil RL, Chan CM, Cook JP, Gould HJ, Henry AJ, Owens RJ, Shi J, Sutton BJ, Young RJ.

Biochem Soc Trans. 1993 Nov;21(4):968-72. Review. No abstract available.


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