Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 50

1.

Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.

Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ, James LK, Sutton BJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8707-E8716. doi: 10.1073/pnas.1806840115. Epub 2018 Aug 27.

2.

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.

Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM.

Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4.

3.

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network.

Randall TS, Yip YY, Wallock-Richards DJ, Pfisterer K, Sanger A, Ficek W, Steiner RA, Beavil AJ, Parsons M, Dodding MP.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743. doi: 10.1073/pnas.1715115115. Epub 2017 Dec 11.

4.

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

Ilieva KM, Fazekas-Singer J, Achkova DY, Dodev TS, Mele S, Crescioli S, Bax HJ, Cheung A, Karagiannis P, Correa I, Figini M, Marlow R, Josephs DH, Beavil AJ, Maher J, Spicer JF, Jensen-Jarolim E, Tutt AN, Karagiannis SN.

Front Immunol. 2017 Sep 11;8:1112. doi: 10.3389/fimmu.2017.01112. eCollection 2017.

5.

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

Doré KA, Davies AM, Drinkwater N, Beavil AJ, McDonnell JM, Sutton BJ.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1336-1347. doi: 10.1016/j.bbapap.2017.08.005. Epub 2017 Aug 24.

6.

IgE Trimers Drive SPE-7 Cytokinergic Activity.

Bax HJ, Bowen H, Beavil RL, Chung R, Ward M, Davies AM, Dodev TS, McDonnell JM, Beavil AJ, Sutton BJ, Gould HJ.

Sci Rep. 2017 Aug 15;7(1):8164. doi: 10.1038/s41598-017-08212-6.

7.

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies AM, Allan EG, Keeble AH, Delgado J, Cossins BP, Mitropoulou AN, Pang MOY, Ceska T, Beavil AJ, Craggs G, Westwood M, Henry AJ, McDonnell JM, Sutton BJ.

J Biol Chem. 2017 Jun 16;292(24):9975-9987. doi: 10.1074/jbc.M117.776476. Epub 2017 Apr 24.

8.

IgE binds asymmetrically to its B cell receptor CD23.

Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ.

Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533.

9.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P, Cheung A, Herraiz C, Ilieva KM, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S, Chiaruttini G, Gilbert AE, Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan CJ, Beavil AJ, Nestle FO, Jones PS, Gould HJ, Sanz-Moreno V, Blower PJ, Spicer JF, Karagiannis SN.

Cancer Res. 2017 Mar 1;77(5):1127-1141. doi: 10.1158/0008-5472.CAN-16-1829. Epub 2017 Jan 17.

10.

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class.

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ, Gould HJ, James LK.

Allergy. 2015 Jun;70(6):720-4. doi: 10.1111/all.12607. Epub 2015 Mar 28.

11.

A tool kit for rapid cloning and expression of recombinant antibodies.

Dodev TS, Karagiannis P, Gilbert AE, Josephs DH, Bowen H, James LK, Bax HJ, Beavil R, Pang MO, Gould HJ, Karagiannis SN, Beavil AJ.

Sci Rep. 2014 Jul 30;4:5885. doi: 10.1038/srep05885.

12.

Human immunoglobulin E flexes between acutely bent and extended conformations.

Drinkwater N, Cossins B, Keeble AH, Wright M, Cain K, Hailu H, Oxbrow A, Delgado J, Shuttleworth LK, Kao MW, McDonnell JM, Beavil AJ, Henry AJ, Sutton BJ.

Nat Struct Mol Biol. 2014 Apr;21(4):397-404. doi: 10.1038/nsmb.2795. Epub 2014 Mar 16.

13.

A range of Cℇ3-Cℇ4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Beavil AJ, Sutton BJ.

Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):305-9. doi: 10.1107/S2053230X14003355. Epub 2014 Feb 20.

14.

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ.

Mol Immunol. 2013 Dec;56(4):693-7. doi: 10.1016/j.molimm.2013.07.005. Epub 2013 Aug 7.

15.

Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.

Yuan D, Keeble AH, Hibbert RG, Fabiane S, Gould HJ, McDonnell JM, Beavil AJ, Sutton BJ, Dhaliwal B.

J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.

16.

Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction.

Borthakur S, Hibbert RG, Pang MO, Yahya N, Bax HJ, Kao MW, Cooper AM, Beavil AJ, Sutton BJ, Gould HJ, McDonnell JM.

J Biol Chem. 2012 Sep 7;287(37):31457-61. doi: 10.1074/jbc.C112.397059. Epub 2012 Jul 19.

17.

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI.

Dhaliwal B, Yuan D, Pang MO, Henry AJ, Cain K, Oxbrow A, Fabiane SM, Beavil AJ, McDonnell JM, Gould HJ, Sutton BJ.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12686-91. doi: 10.1073/pnas.1207278109. Epub 2012 Jul 16.

18.

Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

James LK, Bowen H, Calvert RA, Dodev TS, Shamji MH, Beavil AJ, McDonnell JM, Durham SR, Gould HJ.

J Allergy Clin Immunol. 2012 Sep;130(3):663-670.e3. doi: 10.1016/j.jaci.2012.04.006. Epub 2012 May 13.

PMID:
22583928
19.

A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition.

Hunt J, Keeble AH, Dale RE, Corbett MK, Beavil RL, Levitt J, Swann MJ, Suhling K, Ameer-Beg S, Sutton BJ, Beavil AJ.

J Biol Chem. 2012 May 18;287(21):17459-70. doi: 10.1074/jbc.M111.331967. Epub 2012 Mar 22.

20.

Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

Offermann DA, McKendrick JE, Sejberg JJ, Mo B, Holdom MD, Helm BA, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Spivey AC.

J Org Chem. 2012 Apr 6;77(7):3197-214. doi: 10.1021/jo202604q. Epub 2012 Mar 7.

PMID:
22397517
21.

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Cooper AM, Hobson PS, Jutton MR, Kao MW, Drung B, Schmidt B, Fear DJ, Beavil AJ, McDonnell JM, Sutton BJ, Gould HJ.

J Immunol. 2012 Apr 1;188(7):3199-207. doi: 10.4049/jimmunol.1102689. Epub 2012 Mar 5.

22.

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.

Karagiannis SN, Josephs DH, Karagiannis P, Gilbert AE, Saul L, Rudman SM, Dodev T, Koers A, Blower PJ, Corrigan C, Beavil AJ, Spicer JF, Nestle FO, Gould HJ.

Cancer Immunol Immunother. 2012 Sep;61(9):1547-64. doi: 10.1007/s00262-011-1162-8. Epub 2011 Dec 3. Review.

PMID:
22139135
23.

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution.

Carr JL, Sejberg JJ, Saab F, Holdom MD, Davies AM, White AJ, Leatherbarrow RJ, Beavil AJ, Sutton BJ, Lindell SD, Spivey AC.

Org Biomol Chem. 2011 Oct 7;9(19):6814-24. doi: 10.1039/c1ob05862b. Epub 2011 Aug 15.

24.

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.

Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN.

Clin Exp Allergy. 2011 Oct;41(10):1400-13. doi: 10.1111/j.1365-2222.2011.03770.x. Epub 2011 May 16.

PMID:
21569129
25.

Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies.

Gilbert AE, Karagiannis P, Dodev T, Koers A, Lacy K, Josephs DH, Takhar P, Geh JL, Healy C, Harries M, Acland KM, Rudman SM, Beavil RL, Blower PJ, Beavil AJ, Gould HJ, Spicer J, Nestle FO, Karagiannis SN.

PLoS One. 2011 Apr 29;6(4):e19330. doi: 10.1371/journal.pone.0019330.

26.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ.

Nat Struct Mol Biol. 2011 May;18(5):571-6. doi: 10.1038/nsmb.2044. Epub 2011 Apr 24.

27.

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether.

Carr JL, Offermann DA, Holdom MD, Dusart P, White AJ, Beavil AJ, Leatherbarrow RJ, Lindell SD, Sutton BJ, Spivey AC.

Chem Commun (Camb). 2010 Mar 21;46(11):1824-6. doi: 10.1039/b923528k. Epub 2009 Dec 23.

28.

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells.

Karagiannis P, Singer J, Hunt J, Gan SK, Rudman SM, Mechtcheriakova D, Knittelfelder R, Daniels TR, Hobson PS, Beavil AJ, Spicer J, Nestle FO, Penichet ML, Gould HJ, Jensen-Jarolim E, Karagiannis SN.

Cancer Immunol Immunother. 2009 Jun;58(6):915-30. doi: 10.1007/s00262-008-0607-1. Epub 2008 Oct 22.

29.

The crystal structure of rabbit IgG-Fc.

Girardi E, Holdom MD, Davies AM, Sutton BJ, Beavil AJ.

Biochem J. 2009 Jan 1;417(1):77-83. doi: 10.1042/BJ20081355.

PMID:
18764781
30.

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo.

Hunt J, Bracher MG, Shi J, Fleury S, Dombrowicz D, Gould HJ, Sutton BJ, Beavil AJ.

J Biol Chem. 2008 Oct 31;283(44):29882-7. doi: 10.1074/jbc.M804742200. Epub 2008 Aug 13.

31.

IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F, Moore RJ, Dombrowicz DD, Balkwill FR, Gould HJ.

J Immunol. 2007 Sep 1;179(5):2832-43.

32.

Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.

Karagiannis SN, Bracher MG, Beavil RL, Beavil AJ, Hunt J, McCloskey N, Thompson RG, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill FR, Gould HJ.

Cancer Immunol Immunother. 2008 Feb;57(2):247-63. Epub 2007 Jul 27.

PMID:
17657488
33.

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

Prag S, Parsons M, Keppler MD, Ameer-Beg SM, Barber P, Hunt J, Beavil AJ, Calvert R, Arpin M, Vojnovic B, Ng T.

Mol Biol Cell. 2007 Aug;18(8):2935-48. Epub 2007 May 30.

34.

Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI.

Hunt J, Beavil RL, Calvert RA, Gould HJ, Sutton BJ, Beavil AJ.

J Biol Chem. 2005 Apr 29;280(17):16808-14. Epub 2005 Mar 2.

35.

The biology of IGE and the basis of allergic disease.

Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA, Fear D, Smurthwaite L.

Annu Rev Immunol. 2003;21:579-628. Epub 2001 Dec 19. Review.

PMID:
12500981
36.

The crystal structure of IgE Fc reveals an asymmetrically bent conformation.

Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ.

Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17.

PMID:
12068291
37.

Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding.

Mackay GA, Hulett MD, Cook JP, Trist HM, Henry AJ, McDonnell JM, Beavil AJ, Beavil RL, Sutton BJ, Hogarth PM, Gould HJ.

J Immunol. 2002 Feb 15;168(4):1787-95.

38.

Inhibition of IgE-receptor interactions.

Sutton BJ, Beavil RL, Beavil AJ.

Br Med Bull. 2000;56(4):1004-18. Review.

PMID:
11359634
39.

The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.

McDonnell JM, Calvert R, Beavil RL, Beavil AJ, Henry AJ, Sutton BJ, Gould HJ, Cowburn D.

Nat Struct Biol. 2001 May;8(5):437-41.

PMID:
11323720
40.

Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis.

Shimizu TS, Le Novère N, Levin MD, Beavil AJ, Sutton BJ, Bray D.

Nat Cell Biol. 2000 Nov;2(11):792-6.

PMID:
11056533
41.

Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein.

Kirby I, Davison E, Beavil AJ, Soh CP, Wickham TJ, Roelvink PW, Kovesdi I, Sutton BJ, Santis G.

J Virol. 2000 Mar;74(6):2804-13.

42.

Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.

Kirby I, Davison E, Beavil AJ, Soh CP, Wickham TJ, Roelvink PW, Kovesdi I, Sutton BJ, Santis G.

J Virol. 1999 Nov;73(11):9508-14.

43.

Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI.

McDonnell JM, Beavil AJ, Mackay GA, Henry AJ, Cook JP, Gould HJ, Sutton BJ.

Biochem Soc Trans. 1997 May;25(2):387-92. Review. No abstract available.

PMID:
9191123
44.

Interaction of the low-affinity receptor CD23/Fc epsilonRII lectin domain with the Fc epsilon3-4 fragment of human immunoglobulin E.

Shi J, Ghirlando R, Beavil RL, Beavil AJ, Keown MB, Young RJ, Owens RJ, Sutton BJ, Gould HJ.

Biochemistry. 1997 Feb 25;36(8):2112-22.

PMID:
9047310
46.

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor.

McDonnell JM, Beavil AJ, Mackay GA, Jameson BA, Korngold R, Gould HJ, Sutton BJ.

Nat Struct Biol. 1996 May;3(5):419-26.

PMID:
8612071
47.
48.

Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the Fc epsilon RI alpha chain.

Keown MB, Ghirlando R, Young RJ, Beavil AJ, Owens RJ, Perkins SJ, Sutton BJ, Gould HJ.

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1841-5.

49.

Structural basis of the IgE-Fc epsilon RI interaction.

Beavil AJ, Beavil RL, Chan CM, Cook JP, Gould HJ, Henry AJ, Owens RJ, Shi J, Sutton BJ, Young RJ.

Biochem Soc Trans. 1993 Nov;21(4):968-72. Review. No abstract available.

PMID:
8132102
50.

Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins.

Beavil AJ, Edmeades RL, Gould HJ, Sutton BJ.

Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):753-7.

Supplemental Content

Loading ...
Support Center