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Items: 25


Multiplexed Phosphoproteomic Profiling Using Titanium Dioxide and Immunoaffinity Enrichments Reveals Complementary Phosphorylation Events.

Possemato AP, Paulo JA, Mulhern D, Guo A, Gygi SP, Beausoleil SA.

J Proteome Res. 2017 Apr 7;16(4):1506-1514. doi: 10.1021/acs.jproteome.6b00905. Epub 2017 Feb 24.


Neutral Loss Is a Very Common Occurrence in Phosphotyrosine-Containing Peptides Labeled with Isobaric Tags.

Everley RA, Huttlin EL, Erickson AR, Beausoleil SA, Gygi SP.

J Proteome Res. 2017 Feb 3;16(2):1069-1076. doi: 10.1021/acs.jproteome.6b00487. Epub 2016 Dec 30.


Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.

Rose CM, Isasa M, Ordureau A, Prado MA, Beausoleil SA, Jedrychowski MP, Finley DJ, Harper JW, Gygi SP.

Cell Syst. 2016 Oct 26;3(4):395-403.e4. doi: 10.1016/j.cels.2016.08.009. Epub 2016 Sep 22.


Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine.

Visconte V, Nawrocki ST, Espitia CM, Kelly KR, Possemato A, Beausoleil SA, Han Y, Carraway HE, Nazha A, Advani AS, Maciejewski JP, Sekeres MA, Carew JS.

Leukemia. 2016 May;30(5):1190-4. doi: 10.1038/leu.2015.250. Epub 2015 Sep 15. No abstract available.


Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.

Costa C, Ebi H, Martini M, Beausoleil SA, Faber AC, Jakubik CT, Huang A, Wang Y, Nishtala M, Hall B, Rikova K, Zhao J, Hirsch E, Benes CH, Engelman JA.

Cancer Cell. 2015 Jan 12;27(1):97-108. doi: 10.1016/j.ccell.2014.11.007. Epub 2014 Dec 24.


Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW.

Mol Cell. 2014 Nov 6;56(3):360-75. doi: 10.1016/j.molcel.2014.09.007. Epub 2014 Oct 2. Erratum in: Mol Cell. 2014 Nov 6;56(3):462.


Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.

Paulo JA, McAllister FE, Everley RA, Beausoleil SA, Banks AS, Gygi SP.

Proteomics. 2015 Jan;15(2-3):462-73. doi: 10.1002/pmic.201400154. Epub 2014 Oct 18.


Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ.

Mol Cell Proteomics. 2014 Jan;13(1):372-87. doi: 10.1074/mcp.O113.027870. Epub 2013 Oct 15.


Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer.

Nawrocki ST, Kelly KR, Smith PG, Espitia CM, Possemato A, Beausoleil SA, Milhollen M, Blakemore S, Thomas M, Berger A, Carew JS.

Clin Cancer Res. 2013 Jul 1;19(13):3577-90. doi: 10.1158/1078-0432.CCR-12-3212. Epub 2013 Apr 30.


Proteomics-directed cloning of circulating antiviral human monoclonal antibodies.

Sato S, Beausoleil SA, Popova L, Beaudet JG, Ramenani RK, Zhang X, Wieler JS, Schieferl SM, Cheung WC, Polakiewicz RD.

Nat Biotechnol. 2012 Nov;30(11):1039-43. doi: 10.1038/nbt.2406. No abstract available.


A proteomics approach for the identification and cloning of monoclonal antibodies from serum.

Cheung WC, Beausoleil SA, Zhang X, Sato S, Schieferl SM, Wieler JS, Beaudet JG, Ramenani RK, Popova L, Comb MJ, Rush J, Polakiewicz RD.

Nat Biotechnol. 2012 Mar 25;30(5):447-52. doi: 10.1038/nbt.2167.


A tissue-specific atlas of mouse protein phosphorylation and expression.

Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP.

Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001.


Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets.

Aguiar M, Haas W, Beausoleil SA, Rush J, Gygi SP.

J Proteome Res. 2010 Jun 4;9(6):3103-7. doi: 10.1021/pr1000225.


Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis.

Villén J, Beausoleil SA, Gygi SP.

Proteomics. 2008 Nov;8(21):4444-52. doi: 10.1002/pmic.200800283.


A quantitative atlas of mitotic phosphorylation.

Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.


Phosphoproteome analysis of Drosophila melanogaster embryos.

Zhai B, Villén J, Beausoleil SA, Mintseris J, Gygi SP.

J Proteome Res. 2008 Apr;7(4):1675-82. doi: 10.1021/pr700696a. Epub 2008 Mar 8.


Profiling of UV-induced ATM/ATR signaling pathways.

Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60. Epub 2007 Dec 6.


Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.

Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villén J, Elias JE, Gygi SP.

J Proteome Res. 2007 Mar;6(3):1190-7.


Large-scale phosphorylation analysis of mouse liver.

Villén J, Beausoleil SA, Gerber SA, Gygi SP.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1488-93. Epub 2007 Jan 22.


A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP.

Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10.


Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.

Everley PA, Bakalarski CE, Elias JE, Waghorne CG, Beausoleil SA, Gerber SA, Faherty BK, Zetter BR, Gygi SP.

J Proteome Res. 2006 May;5(5):1224-31.


Optimization and use of peptide mass measurement accuracy in shotgun proteomics.

Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villén J, Gygi SP.

Mol Cell Proteomics. 2006 Jul;5(7):1326-37. Epub 2006 Apr 23.


Characterization of mouse spleen cells by subtractive proteomics.

Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP.

Mol Cell Proteomics. 2005 Oct;4(10):1459-70. Epub 2005 Jul 21.


Phosphoproteomic analysis of the developing mouse brain.

Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP.

Mol Cell Proteomics. 2004 Nov;3(11):1093-101. Epub 2004 Sep 2.


Large-scale characterization of HeLa cell nuclear phosphoproteins.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9.

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