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Items: 48

1.

The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice.

Moquin-Beaudry G, Colas C, Li Y, Bazin R, Guimond JV, Haddad E, Beauséjour C.

J Immunol. 2019 Nov 15;203(10):2735-2745. doi: 10.4049/jimmunol.1900807. Epub 2019 Oct 2.

PMID:
31578272
2.

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Aug;572(7767):E5. doi: 10.1038/s41586-019-1350-9.

PMID:
31296937
3.

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.

Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJ.

J Exp Clin Cancer Res. 2019 Jun 13;38(1):251. doi: 10.1186/s13046-019-1242-8.

4.

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.

Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C.

Aging Cell. 2019 Aug;18(4):e12971. doi: 10.1111/acel.12971. Epub 2019 May 31.

5.

L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. Erratum in: Nature. 2019 Aug;572(7767):E5.

6.

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.

Le O, Palacio L, Bernier G, Batinic-Haberle I, Hickson G, Beauséjour C.

Stem Cell Reports. 2018 Jun 5;10(6):1721-1733. doi: 10.1016/j.stemcr.2018.03.025. Epub 2018 Apr 26.

7.

A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues.

Galbiati A, Beauséjour C, d'Adda di Fagagna F.

Aging Cell. 2017 Apr;16(2):422-427. doi: 10.1111/acel.12573. Epub 2017 Jan 26.

8.

Sustained p16INK4a expression is required to prevent IR-induced tumorigenesis in mice.

Palacio L, Krishnan V, Le NL, Sharpless NE, Beauséjour CM.

Oncogene. 2017 Mar 2;36(9):1309-1314. doi: 10.1038/onc.2016.298. Epub 2016 Aug 29.

9.

Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming.

Selleri S, Bifsha P, Civini S, Pacelli C, Dieng MM, Lemieux W, Jin P, Bazin R, Patey N, Marincola FM, Moldovan F, Zaouter C, Trudeau LE, Benabdhalla B, Louis I, Beauséjour C, Stroncek D, Le Deist F, Haddad E.

Oncotarget. 2016 May 24;7(21):30193-210. doi: 10.18632/oncotarget.8623.

10.

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F Jr, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S.

Nat Med. 2014 Oct;20(10):1165-73. doi: 10.1038/nm.3669. Epub 2014 Sep 14.

PMID:
25216639
11.

Heterotopic bone formation derived from multipotent stromal cells is not inhibited in aged mice.

Carbonneau CL, Despars G, Beaudry GM, Benabdallah B, Bouhanik S, Dépôt J, Moreau A, Beauséjour CM.

Cytotherapy. 2014 Aug;16(8):1073-9. doi: 10.1016/j.jcyt.2014.03.004. Epub 2014 Jun 13.

PMID:
24934305
12.

Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study.

Marcoux S, Le ON, Langlois-Pelletier C, Laverdière C, Hatami A, Robaey P, Beauséjour CM.

Radiat Oncol. 2013 Oct 31;8:252. doi: 10.1186/1748-717X-8-252.

13.

Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.

Despars G, Carbonneau CL, Bardeau P, Coutu DL, Beauséjour CM.

PLoS One. 2013 Aug 29;8(8):e73206. doi: 10.1371/journal.pone.0073206. eCollection 2013.

14.

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.

Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J.

J Cell Biol. 2013 May 13;201(4):613-29. doi: 10.1083/jcb.201206006. Epub 2013 May 6.

15.

Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation.

Benabdallah BF, Duval A, Rousseau J, Chapdelaine P, Holmes MC, Haddad E, Tremblay JP, Beauséjour CM.

Mol Ther Nucleic Acids. 2013 Jan 29;2:e68. doi: 10.1038/mtna.2012.55.

16.

A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoietic cell homing and reconstitution in mice.

Fortin A, Benabdallah B, Palacio L, Carbonneau CL, Le ON, Haddad E, Beauséjour CM.

Stem Cells Dev. 2013 Mar 15;22(6):975-84. doi: 10.1089/scd.2012.0438. Epub 2013 Jan 11.

17.

Cord-blood-derived mesenchymal stromal cells downmodulate CD4+ T-cell activation by inducing IL-10-producing Th1 cells.

Selleri S, Dieng MM, Nicoletti S, Louis I, Beausejour C, Le Deist F, Haddad E.

Stem Cells Dev. 2013 Apr 1;22(7):1063-75. doi: 10.1089/scd.2012.0315. Epub 2013 Jan 4.

18.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.

Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F.

Nat Cell Biol. 2012 Mar 18;14(4):355-65. doi: 10.1038/ncb2466. Erratum in: Nat Cell Biol. 2012 May;14(5):555.

19.

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.

Carbonneau CL, Despars G, Rojas-Sutterlin S, Fortin A, Le O, Hoang T, Beauséjour CM.

Blood. 2012 Jan 19;119(3):717-26. doi: 10.1182/blood-2011-06-361626. Epub 2011 Nov 18.

PMID:
22101896
20.

Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graft-versus-host disease in a xenogenic mouse model.

Gregoire-Gauthier J, Selleri S, Fontaine F, Dieng MM, Patey N, Despars G, Beauséjour CM, Haddad E.

Stem Cells Dev. 2012 Jul 1;21(10):1616-26. doi: 10.1089/scd.2011.0413. Epub 2011 Oct 21.

PMID:
21910645
21.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P.

Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589. Epub 2011 Feb 25.

22.

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.

Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J.

J Cell Sci. 2011 Jan 1;124(Pt 1):68-81. doi: 10.1242/jcs.071340. Epub 2010 Nov 30.

23.

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.

Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM.

Aging Cell. 2010 Jun;9(3):398-409. doi: 10.1111/j.1474-9726.2010.00567.x. Epub 2010 Mar 13.

24.

Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform.

Benabdallah BF, Allard E, Yao S, Friedman G, Gregory PD, Eliopoulos N, Fradette J, Spees JL, Haddad E, Holmes MC, Beauséjour CM.

Cytotherapy. 2010 May;12(3):394-9. doi: 10.3109/14653240903583803.

PMID:
20331411
25.

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J.

PLoS One. 2010 Feb 12;5(2):e9188. doi: 10.1371/journal.pone.0009188.

26.

Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation.

Landry Y, Lê O, Mace KA, Restivo TE, Beauséjour CM.

J Cell Mol Med. 2010 Jun;14(6B):1594-604. doi: 10.1111/j.1582-4934.2009.00887.x. Epub 2009 Sep 1.

27.

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.

Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S.

Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5.

PMID:
18836459
28.

Blockade of sensory abnormalities and kinin B(1) receptor expression by N-acetyl-L-cysteine and ramipril in a rat model of insulin resistance.

Ismael MA, Talbot S, Carbonneau CL, Beauséjour CM, Couture R.

Eur J Pharmacol. 2008 Jul 28;589(1-3):66-72. doi: 10.1016/j.ejphar.2008.05.006. Epub 2008 May 16.

PMID:
18555989
29.

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.

Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J.

J Cell Biol. 2008 May 5;181(3):447-60. doi: 10.1083/jcb.200710028. Epub 2008 Apr 28.

30.

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery.

Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L.

Nat Biotechnol. 2007 Nov;25(11):1298-306. Epub 2007 Oct 28.

PMID:
17965707
31.

An improved zinc-finger nuclease architecture for highly specific genome editing.

Miller JC, Holmes MC, Wang J, Guschin DY, Lee YL, Rupniewski I, Beausejour CM, Waite AJ, Wang NS, Kim KA, Gregory PD, Pabo CO, Rebar EJ.

Nat Biotechnol. 2007 Jul;25(7):778-85. Epub 2007 Jul 1.

PMID:
17603475
32.

Bone marrow-derived cells: the influence of aging and cellular senescence.

Beauséjour C.

Handb Exp Pharmacol. 2007;(180):67-88. Review.

PMID:
17554505
33.

Ageing: balancing regeneration and cancer.

Beausejour CM, Campisi J.

Nature. 2006 Sep 28;443(7110):404-5. No abstract available.

PMID:
16957734
34.

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence.

Coppé JP, Kauser K, Campisi J, Beauséjour CM.

J Biol Chem. 2006 Oct 6;281(40):29568-74. Epub 2006 Jul 31.

35.

Age-dependent acceleration of ischemic injury in endothelial nitric oxide synthase-deficient mice: potential role of impaired VEGF receptor 2 expression.

Qian HS, de Resende MM, Beausejour C, Huw LY, Liu P, Rubanyi GM, Kauser K.

J Cardiovasc Pharmacol. 2006 Apr;47(4):587-93.

PMID:
16680073
36.

Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, Jamieson AC, Porteus MH, Gregory PD, Holmes MC.

Nature. 2005 Jun 2;435(7042):646-51. Epub 2005 Apr 3.

37.

TIN2 mediates functions of TRF2 at human telomeres.

Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J.

J Biol Chem. 2004 Oct 15;279(42):43799-804. Epub 2004 Aug 3.

38.

Reversal of human cellular senescence: roles of the p53 and p16 pathways.

Beauséjour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J.

EMBO J. 2003 Aug 15;22(16):4212-22.

39.

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.

Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP.

Mol Cell Biol. 2003 Jan;23(1):389-401.

40.

Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene.

Beauséjour CM, Gagnon J, Primeau M, Momparler RL.

Biochem Biophys Res Commun. 2002 May 24;293(5):1478-84.

PMID:
12054682
41.

Human cytidine deaminase as an ex vivo drug selectable marker in gene-modified primary bone marrow stromal cells.

Eliopoulos N, Al-Khaldi A, Beauséjour CM, Momparler RL, Momparler LF, Galipeau J.

Gene Ther. 2002 Apr;9(7):452-62.

42.

Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene.

Beauséjour CM, Eliopoulos N, Momparler L, Le NL, Momparler RL.

Cancer Gene Ther. 2001 Sep;8(9):669-76.

43.

Potential of ribozymes against deoxycytidine kinase to confer drug resistance to cytosine nucleoside analogs.

Beauséjour CM, Tremblay G, Momparler RL.

Biochem Biophys Res Commun. 2000 Nov 30;278(3):569-75.

PMID:
11095951
44.
45.

Chemoprotection against cytosine nucleoside analogs using the human cytidine deaminase gene.

Eliopoulos N, Beauséjour C, Momparler RL.

Prog Exp Tumor Res. 1999;36:124-42. Review. No abstract available.

PMID:
10386070
47.
48.

Transfection of murine fibroblast cells with human cytidine deaminase cDNA confers resistance to cytosine arabinoside.

Momparler RL, Laliberté J, Eliopoulos N, Beauséjour C, Cournoyer D.

Anticancer Drugs. 1996 May;7(3):266-74.

PMID:
8791999

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