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Items: 20


Attenuation of RNA viruses by redirecting their evolution in sequence space.

Moratorio G, Henningsson R, Barbezange C, Carrau L, Bordería AV, Blanc H, Beaucourt S, Poirier EZ, Vallet T, Boussier J, Mounce BC, Fontes M, Vignuzzi M.

Nat Microbiol. 2017 Jun 5;2:17088. doi: 10.1038/nmicrobiol.2017.88.


Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.

Abdelnabi R, Morais ATS, Leyssen P, Imbert I, Beaucourt S, Blanc H, Froeyen M, Vignuzzi M, Canard B, Neyts J, Delang L.

J Virol. 2017 May 26;91(12). pii: e00487-17. doi: 10.1128/JVI.00487-17. Print 2017 Jun 15.


Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo.

McDonald S, Block A, Beaucourt S, Moratorio G, Vignuzzi M, Peersen OB.

J Biol Chem. 2016 Jul 1;291(27):13999-4011. doi: 10.1074/jbc.M116.726596. Epub 2016 May 2.


Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.

Campagnola G, McDonald S, Beaucourt S, Vignuzzi M, Peersen OB.

J Virol. 2015 Jan;89(1):275-86. doi: 10.1128/JVI.01574-14. Epub 2014 Oct 15.


Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential.

Stapleford KA, Coffey LL, Lay S, Bordería AV, Duong V, Isakov O, Rozen-Gagnon K, Arias-Goeta C, Blanc H, Beaucourt S, Haliloğlu T, Schmitt C, Bonne I, Ben-Tal N, Shomron N, Failloux AB, Buchy P, Vignuzzi M.

Cell Host Microbe. 2014 Jun 11;15(6):706-16. doi: 10.1016/j.chom.2014.05.008.


Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance.

Beaucourt S, Vignuzzi M.

Curr Opin Virol. 2014 Oct;8:10-5. doi: 10.1016/j.coviro.2014.04.011. Epub 2014 May 19. Review.


Coxsackievirus B3 mutator strains are attenuated in vivo.

Gnädig NF, Beaucourt S, Campagnola G, Bordería AV, Sanz-Ramos M, Gong P, Blanc H, Peersen OB, Vignuzzi M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2294-303. doi: 10.1073/pnas.1204022109. Epub 2012 Aug 1.


Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency.

Beaucourt S, Bordería AV, Coffey LL, Gnädig NF, Sanz-Ramos M, Beeharry Y, Vignuzzi M.

J Vis Exp. 2011 Jun 16;(52). pii: 2953. doi: 10.3791/2953.


Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.

Levi LI, Gnädig NF, Beaucourt S, McPherson MJ, Baron B, Arnold JJ, Vignuzzi M.

PLoS Pathog. 2010 Oct 28;6(10):e1001163. doi: 10.1371/journal.ppat.1001163.


NO-cGMP mediated galanin expression in NGF-deprived or axotomized sensory neurons.

Thippeswamy T, Haddley K, Corness JD, Howard MR, McKay JS, Beaucourt SM, Pope MD, Murphy D, Morris R, Hökfelt T, Quinn JP.

J Neurochem. 2007 Feb;100(3):790-801.


Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users.

Morice Y, Cantaloube JF, Beaucourt S, Barbotte L, De Gendt S, Goncales FL, Butterworth L, Cooksley G, Gish RG, Beaugrand M, Fay F, Fay O, Gonzalez JE, Martins RM, Dhumeaux D, Vanderborght B, Stuyver L, Sablon E, de Lamballerie X, Pawlotsky JM.

J Med Virol. 2006 Oct;78(10):1296-303.


Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function.

Mundell SJ, Jones ML, Hardy AR, Barton JF, Beaucourt SM, Conley PB, Poole AW.

Mol Pharmacol. 2006 Sep;70(3):1132-42. Epub 2006 Jun 27.


Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene.

Castino R, Davies J, Beaucourt S, Isidoro C, Murphy D.

FASEB J. 2005 Jun;19(8):1021-3. Epub 2005 Mar 21.


Manipulating sorting signals to generate co-expression of somatostatin and eGFP in the regulated secretory pathway from a monocistronic construct.

Davies JS, Holter JL, Knight D, Beaucourt SM, Murphy D, Carter DA, Wells T.

J Mol Endocrinol. 2004 Oct;33(2):523-32.


Translationally controlled tumor protein is a target of tumor reversion.

Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, Moras D, Amson R, Telerman A.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15364-9. Epub 2004 Oct 15.


Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.

Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Géant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3510-5. Epub 2004 Feb 25.


Deciphering the mechanisms of homeostatic plasticity in the hypothalamo-neurohypophyseal system--genomic and gene transfer strategies.

Sharman G, Ghorbel M, Leroux M, Beaucourt S, Wong LF, Murphy D.

Prog Biophys Mol Biol. 2004 Feb-Apr;84(2-3):151-82. Review.


Genomic organization and expression of mouse Tpt1 gene.

Fiucci G, Lespagnol A, Stumptner-Cuvelette P, Beaucourt S, Duflaut D, Susini L, Amson R, Telerman A.

Genomics. 2003 Jun;81(6):570-8.


Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication.

Bouvier-Alias M, Patel K, Dahari H, Beaucourt S, Larderie P, Blatt L, Hezode C, Picchio G, Dhumeaux D, Neumann AU, McHutchison JG, Pawlotsky JM.

Hepatology. 2002 Jul;36(1):211-8.


[Management of unilateral vocal cord paralysis].

Lecoq M, Arias C, Calas M, Beaucourt S.

Rev Laryngol Otol Rhinol (Bord). 1991;112(4):373-5. French.


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