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Items: 1 to 50 of 183

1.

Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis.

Shi C, Pan FC, Kim JN, Washington MK, Padmanabhan C, Meyer CT, Kopp JL, Sander M, Gannon M, Beauchamp RD, Wright CV, Means AL.

Cell Mol Gastroenterol Hepatol. 2019 Jul 13. pii: S2352-345X(19)30088-8. doi: 10.1016/j.jcmgh.2019.07.001. [Epub ahead of print]

2.

Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W.

Gastroenterology. 2019 Feb;156(3):662-675.e7. doi: 10.1053/j.gastro.2018.10.030. Epub 2018 Oct 17.

PMID:
30342037
3.

Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.

Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD.

Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):257-276. doi: 10.1016/j.jcmgh.2018.05.006. eCollection 2018.

4.

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.

Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E.

Dev Cell. 2018 Mar 12;44(5):566-581.e8. doi: 10.1016/j.devcel.2018.02.013.

5.

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition.

Padmanabhan C, Rellinger EJ, Zhu J, An H, Woodbury LG, Chung DH, Waterson AG, Lindsley CW, Means AL, Beauchamp RD.

Oncotarget. 2017 Jul 25;8(60):101072-101086. doi: 10.18632/oncotarget.19557. eCollection 2017 Nov 24.

6.

Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma.

Rellinger EJ, Padmanabhan C, Qiao J, Craig BT, An H, Zhu J, Correa H, Waterson AG, Lindsley CW, Beauchamp RD, Chung DH.

Oncotarget. 2017 Jul 20;8(53):91040-91051. doi: 10.18632/oncotarget.19406. eCollection 2017 Oct 31.

7.

Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma.

Idrees K, Padmanabhan C, Liu E, Guo Y, Gonzalez RS, Berlin J, Dahlman KB, Beauchamp RD, Shi C.

J Surg Oncol. 2018 Feb;117(2):284-289. doi: 10.1002/jso.24834. Epub 2017 Sep 20.

PMID:
28940307
8.

ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand.

Rellinger EJ, Padmanabhan C, Qiao J, Appert A, Waterson AG, Lindsley CW, Beauchamp RD, Chung DH.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):463-468. doi: 10.1016/j.bbrc.2017.07.050. Epub 2017 Jul 14.

9.

Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.

Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C.

Histopathology. 2017 Jan;70(2):223-231. doi: 10.1111/his.13068. Epub 2016 Oct 28.

10.

The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.

Ma Y, Wang L, Neitzel LR, Loganathan SN, Tang N, Qin L, Crispi EE, Guo Y, Knapp S, Beauchamp RD, Lee E, Wang J.

Clin Cancer Res. 2017 Apr 15;23(8):2027-2037. doi: 10.1158/1078-0432.CCR-16-0453. Epub 2016 Sep 27.

11.

Evaluation of frozen tissue-derived prognostic gene expression signatures in FFPE colorectal cancer samples.

Zhu J, Deane NG, Lewis KB, Padmanabhan C, Washington MK, Ciombor KK, Timmers C, Goldberg RM, Beauchamp RD, Chen X.

Sci Rep. 2016 Sep 14;6:33273. doi: 10.1038/srep33273.

12.

Comparison of Nanostring nCounter® Data on FFPE Colon Cancer Samples and Affymetrix Microarray Data on Matched Frozen Tissues.

Chen X, Deane NG, Lewis KB, Li J, Zhu J, Washington MK, Beauchamp RD.

PLoS One. 2016 May 13;11(5):e0153784. doi: 10.1371/journal.pone.0153784. eCollection 2016.

13.

Optimization of a small molecule probe that restores e-cadherin expression.

Brogan JT, Stoops SL, Brady S, An H, Weaver C, Daniels JS, Beauchamp RD, Lindsley CW, Waterson AG.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4260-4. doi: 10.1016/j.bmcl.2015.07.104. Epub 2015 Aug 6.

14.

Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness.

French CL, Ye F, Revetta F, Zhang B, Coffey RJ, Washington MK, Deane NG, Beauchamp RD, Weaver AM.

F1000Res. 2015 Apr 24;4:99. doi: 10.12688/f1000research.6388.1. eCollection 2015.

15.

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition.

An H, Stoops SL, Deane NG, Zhu J, Zi J, Weaver C, Waterson AG, Zijlstra A, Lindsley CW, Beauchamp RD.

Oncotarget. 2015 Sep 8;6(26):22934-48.

16.

Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.

Gonzalez RS, Cates JM, Washington MK, Beauchamp RD, Coffey RJ, Shi C.

Histopathology. 2016 Jan;68(2):183-90. doi: 10.1111/his.12725. Epub 2015 Jun 4.

17.

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis.

Bhat AA, Pope JL, Smith JJ, Ahmad R, Chen X, Washington MK, Beauchamp RD, Singh AB, Dhawan P.

Oncogene. 2015 Aug 27;34(35):4570-80. doi: 10.1038/onc.2014.385. Epub 2014 Dec 15.

18.

Minority Underrepresentation in Academia: Factors Impacting Careers of Surgery Residents.

Julien JS, Lang R, Brown TN, Aldrich MC, Deppen SA, Wu H, Feurer ID, Tarpley M, Hill G, Tarpley J, Beauchamp RD, Grogan EL.

J Racial Ethn Health Disparities. 2014 Dec 1;1(4):238-246.

19.

Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer.

Tripathi MK, Deane NG, Zhu J, An H, Mima S, Wang X, Padmanabhan S, Shi Z, Prodduturi N, Ciombor KK, Chen X, Washington MK, Zhang B, Beauchamp RD.

Cancer Res. 2014 Dec 1;74(23):6947-57. doi: 10.1158/0008-5472.CAN-14-1592. Epub 2014 Oct 15.

20.

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL.

Lab Invest. 2014 Apr;94(4):409-21. doi: 10.1038/labinvest.2014.10. Epub 2014 Feb 17.

21.

Deciphering genomic alterations in colorectal cancer through transcriptional subtype-based network analysis.

Zhu J, Wang J, Shi Z, Franklin JL, Deane NG, Coffey RJ, Beauchamp RD, Zhang B.

PLoS One. 2013 Nov 15;8(11):e79282. doi: 10.1371/journal.pone.0079282. eCollection 2013.

22.

Classification of midfoot break using multi-segment foot kinematics and pedobarography.

Maurer JD, Ward V, Mayson TA, Davies KR, Alvarez CM, Beauchamp RD, Black AH.

Gait Posture. 2014 Jan;39(1):1-6. doi: 10.1016/j.gaitpost.2013.08.015. Epub 2013 Aug 19. Erratum in: Gait Posture. 2014 Apr;39(4):1162.

PMID:
24001869
23.

Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma.

Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD.

PLoS One. 2013 Jul 29;8(7):e69660. doi: 10.1371/journal.pone.0069660. Print 2013.

24.

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.

Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P.

Gut. 2014 Apr;63(4):622-34. doi: 10.1136/gutjnl-2012-304241. Epub 2013 Jun 13.

25.

Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome.

Hansen AG, Freeman TJ, Arnold SA, Starchenko A, Jones-Paris CR, Gilger MA, Washington MK, Fan KH, Shyr Y, Beauchamp RD, Zijlstra A.

Cancer Res. 2013 May 15;73(10):2955-64. doi: 10.1158/0008-5472.CAN-12-2052. Epub 2013 Mar 28.

26.

A kinematic description of dynamic midfoot break in children using a multi-segment foot model.

Maurer JD, Ward V, Mayson TA, Davies KR, Alvarez CM, Beauchamp RD, Black AH.

Gait Posture. 2013 Jun;38(2):287-92. doi: 10.1016/j.gaitpost.2012.12.002. Epub 2012 Dec 28.

PMID:
23273965
27.

Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS.

PLoS One. 2012;7(12):e51205. doi: 10.1371/journal.pone.0051205. Epub 2012 Dec 12.

28.

A network-based gene expression signature informs prognosis and treatment for colorectal cancer patients.

Shi M, Beauchamp RD, Zhang B.

PLoS One. 2012;7(7):e41292. doi: 10.1371/journal.pone.0041292. Epub 2012 Jul 23.

29.

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E.

Mol Cell. 2012 Mar 9;45(5):619-28. doi: 10.1016/j.molcel.2011.12.032. Epub 2012 Feb 1.

30.

Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of ╬▓-catenin.

Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD.

Gastroenterology. 2012 Mar;142(3):562-571.e2. doi: 10.1053/j.gastro.2011.11.026. Epub 2011 Nov 22.

31.

Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer.

Oh SC, Park YY, Park ES, Lim JY, Kim SM, Kim SB, Kim J, Kim SC, Chu IS, Smith JJ, Beauchamp RD, Yeatman TJ, Kopetz S, Lee JS.

Gut. 2012 Sep;61(9):1291-8. doi: 10.1136/gutjnl-2011-300812. Epub 2011 Oct 13.

32.

BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma.

Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS.

J Clin Invest. 2011 Oct;121(10):4056-69. doi: 10.1172/JCI44228. Epub 2011 Sep 12.

33.

Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells.

Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P.

Gastroenterology. 2011 Dec;141(6):2140-53. doi: 10.1053/j.gastro.2011.08.038. Epub 2011 Aug 28.

34.

Inter-observer and intra-observer agreement in the radiographic diagnosis of avascular necrosis of the femoral head following slipped capital femoral epiphysis.

Davidson D, Ghag A, Beauchamp RD, Tredwell SJ, Mulpuri K.

J Child Orthop. 2010 Aug;4(4):327-30. doi: 10.1007/s11832-010-0273-7. Epub 2010 Jun 24.

35.

The use of a multidisciplinary morbidity and mortality conference to incorporate ACGME general competencies.

Kauffmann RM, Landman MP, Shelton J, Dmochowski RR, Bledsoe SH, Hickson GB, Beauchamp RD, Dattilo JB.

J Surg Educ. 2011 Jul-Aug;68(4):303-8. doi: 10.1016/j.jsurg.2011.02.002. Epub 2011 Mar 25.

36.

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.

Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB.

Oncogene. 2011 Jul 21;30(29):3234-47. doi: 10.1038/onc.2011.43. Epub 2011 Mar 7.

37.

Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.

Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR.

Cytoskeleton (Hoboken). 2011 Feb;68(2):97-111. doi: 10.1002/cm.20497. Epub 2011 Jan 3.

38.

Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells.

Stoops SL, Pearson AS, Weaver C, Waterson AG, Days E, Farmer C, Brady S, Weaver CD, Beauchamp RD, Lindsley CW.

ACS Chem Biol. 2011 May 20;6(5):452-65. doi: 10.1021/cb100305h. Epub 2011 Feb 9.

39.

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines.

Rachakonda G, Sekhar KR, Jowhar D, Samson PC, Wikswo JP, Beauchamp RD, Datta PK, Freeman ML.

Oncogene. 2010 Jun 24;29(25):3703-14. doi: 10.1038/onc.2010.118. Epub 2010 May 3.

40.

Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.

Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR.

J Clin Invest. 2010 Mar;120(3):840-9. doi: 10.1172/JCI40728. Epub 2010 Feb 8.

41.

Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, Eschrich S, Kis C, Levy S, Washington MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD.

Gastroenterology. 2010 Mar;138(3):958-68. doi: 10.1053/j.gastro.2009.11.005. Epub 2009 Nov 13.

42.

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability.

Krishnan M, Singh AB, Smith JJ, Sharma A, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD, Dhawan P.

Oncogene. 2010 Jan 14;29(2):305-12. doi: 10.1038/onc.2009.324. Epub 2009 Nov 2.

43.

Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS.

Xu BJ, Li J, Beauchamp RD, Shyr Y, Li M, Washington MK, Yeatman TJ, Whitehead RH, Coffey RJ, Caprioli RM.

Mol Cell Proteomics. 2009 May;8(5):936-45. doi: 10.1074/mcp.M800345-MCP200. Epub 2009 Jan 21.

44.

Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology.

Smith JJ, Deane NG, Dhawan P, Beauchamp RD.

Surgery. 2008 Sep;144(3):353-66. doi: 10.1016/j.surg.2008.05.007. Epub 2008 Jul 25. Review. No abstract available.

45.

Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition.

Kanies CL, Smith JJ, Kis C, Schmidt C, Levy S, Khabar KS, Morrow J, Deane N, Dixon DA, Beauchamp RD.

Mol Cancer Res. 2008 Jul;6(7):1124-36. doi: 10.1158/1541-7786.MCR-07-2095.

46.

A quality assessment of randomized clinical trials in pediatric orthopaedics.

Dulai SK, Slobogean BL, Beauchamp RD, Mulpuri K.

J Pediatr Orthop. 2007 Jul-Aug;27(5):573-81.

PMID:
17585270
47.

Variability of in situ proteomic profiling and implications for study design in colorectal tumors.

Li JQ, Xu BJ, Shakhtour B, Deane N, Merchant N, Heslin MJ, Washington K, Coffey RJ, Beauchamp RD, Shyr Y, Billheimer D.

Int J Oncol. 2007 Jul;31(1):103-11.

PMID:
17549410
48.

Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells.

Shiou SR, Singh AB, Moorthy K, Datta PK, Washington MK, Beauchamp RD, Dhawan P.

Cancer Res. 2007 Feb 15;67(4):1571-9.

49.

Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer.

Kim DW, Blanke CD, Wu H, Shyr Y, Berlin J, Beauchamp RD, Chakravarthy B.

Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):397-404. Epub 2006 Nov 9.

PMID:
17097833
50.

Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia.

Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB.

Clin Gastroenterol Hepatol. 2006 Nov;4(11):1358-65. Epub 2006 Sep 25.

PMID:
16996805

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