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Items: 1 to 50 of 64

1.

An Improved Strategy for the Chemical Synthesis of 3',5'-Cyclic Diguanylic Acid.

Grajkowski A, Takahashi M, Kaczyński T, Srivastava SC, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2019 Jun;77(1):e84. doi: 10.1002/cpnc.84. Epub 2019 Apr 10.

PMID:
30970180
2.

Synthesis, Characterization, and Function of an RNA-Based Transfection Reagent.

Jain HV, Boehler JF, Nagaraju K, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2018 Mar;72(1):4.81.1-4.81.29. doi: 10.1002/cpnc.51.

3.

Trans-acting oligodeoxythymidine phosphorothioate triester reagents for transient transfection optimized and facilitated by a high-throughput microbioreactor system.

Hsu CJ, Jain HV, Williams A, Wang J, Lute SC, Beaucage SL, Brorson KA.

Biotechnol Appl Biochem. 2018 May;65(3):467-475. doi: 10.1002/bab.1620. Epub 2017 Dec 26.

PMID:
29023997
4.

An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes.

Jain HV, Boehler JF, Verthelyi D, Nagaraju K, Beaucage SL.

RSC Adv. 2017;7:42519-42528. doi: 10.1039/C7RA04247G. Epub 2017 Sep 4.

5.

A High-Throughput Process for the Solid-Phase Purification of Synthetic DNA Sequences.

Grajkowski A, Cieślak J, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2017 Jun 19;69:10.17.1-10.17.30. doi: 10.1002/cpnc.31.

6.

Structural evaluation of an amyloid fibril model using small-angle x-ray scattering.

Dahal E, Choi M, Alam N, Bhirde AA, Beaucage SL, Badano A.

Phys Biol. 2017 Jun 29;14(4):046001. doi: 10.1088/1478-3975/aa776a.

PMID:
28585521
7.

Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions.

Bhirde AA, Sindiri S, Calco GN, Aronova MA, Beaucage SL.

Nanoscale. 2017 Feb 9;9(6):2291-2300. doi: 10.1039/c6nr08579b.

PMID:
28127597
8.

An amphipathic trans-acting phosphorothioate DNA element delivers uncharged PNA and PMO nucleic acid sequences in mammalian cells.

Jain HV, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2016;64:4.69.1-4.69.22. Epub 2016 Mar 1.

9.

Solid-Phase Purification of Synthetic DNA Sequences.

Grajkowski A, Cieslak J, Beaucage SL.

J Org Chem. 2016 Aug 5;81(15):6165-75. doi: 10.1021/acs.joc.6b01020. Epub 2016 Jul 25.

PMID:
27382974
10.

2'-Hydroxy protection of ribonucleosides as 2-cyano-2,2-dimethylethanimine-N-oxymethyl ethers in solid-phase synthesis of RNA sequences.

Cieślak J, Ausín C, Grajkowski A, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2013 Oct 8;54:Unit 3.22.. doi: 10.1002/0471142700.nc0322s54.

PMID:
24510797
11.

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.

Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C.

EMBO Rep. 2013 Oct;14(10):900-6. doi: 10.1038/embor.2013.132. Epub 2013 Sep 6.

12.

Assessment of the cellular internalization of thermolytic phosphorothioate DNA oligonucleotide prodrugs.

Jain HV, Takeda K, Tami C, Verthelyi D, Beaucage SL.

Bioorg Med Chem. 2013 Oct 15;21(20):6224-32. doi: 10.1016/j.bmc.2013.04.071. Epub 2013 May 7.

PMID:
23755885
13.

Biotinylation of a propargylated cyclic (3'-5') diguanylic acid and of its mono-6-thioated analog under "click" conditions.

Grajkowski A, Cieślak J, Schindler C, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2013 Mar;Chapter 14:Unit 14.9. doi: 10.1002/0471142700.nc1409s52.

PMID:
23512694
14.

The 2-cyano-2,2-dimethylethanimine-N-oxymethyl group for the 2'-hydroxyl protection of ribonucleosides in the solid-phase synthesis of RNA sequences.

Cieślak J, Ausín C, Grajkowski A, Beaucage SL.

Chemistry. 2013 Apr 2;19(14):4623-32. doi: 10.1002/chem.201204235. Epub 2013 Feb 18.

PMID:
23417977
15.

A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest.

Xu L, Elkahloun AG, Candotti F, Grajkowski A, Beaucage SL, Petricoin EF, Calvert V, Juhl H, Mills F, Mason K, Shastri N, Chik J, Xu C, Rosenberg AS.

J Virol. 2013 Jan;87(1):25-36. doi: 10.1128/JVI.01648-12. Epub 2012 Oct 24.

16.

Convenient and efficient approach to the permanent or reversible conjugation of RNA and DNA sequences with functional groups.

Cieślak J, Ausín C, Grajkowski A, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2012 Sep;Chapter 4:Unit4.52. doi: 10.1002/0471142700.nc0452s50.

PMID:
22956458
17.

Permanent or reversible conjugation of 2'-O- or 5'-O-aminooxymethylated nucleosides with functional groups as a convenient and efficient approach to the modification of RNA and DNA sequences.

Cieslak J, Grajkowski A, Ausín C, Gapeev A, Beaucage SL.

Nucleic Acids Res. 2012 Mar;40(5):2312-29. doi: 10.1093/nar/gkr896. Epub 2011 Nov 8.

18.

The overlapping host responses to bacterial cyclic dinucleotides.

Abdul-Sater AA, Grajkowski A, Erdjument-Bromage H, Plumlee C, Levi A, Schreiber MT, Lee C, Shuman H, Beaucage SL, Schindler C.

Microbes Infect. 2012 Feb;14(2):188-97. doi: 10.1016/j.micinf.2011.09.002. Epub 2011 Sep 10.

19.

Time-dependent thermocontrol of the hydrophilic and lipophilic properties of DNA oligonucleotide prodrugs.

Ausín C, Grajkowski A, Cieślak J, Gapeev A, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2010 Dec;Chapter 4:Unit 4.42.. doi: 10.1002/0471142700.nc0442s43.

PMID:
21154531
20.

Convenient synthesis of a propargylated cyclic (3'-5') diguanylic acid and its "click" conjugation to a biotinylated azide.

Grajkowski A, Cieślak J, Gapeev A, Schindler C, Beaucage SL.

Bioconjug Chem. 2010 Nov 17;21(11):2147-52. doi: 10.1021/bc1003857. Epub 2010 Oct 13.

21.

Recent advances in the chemical synthesis of RNA.

Beaucage SL, Reese CB.

Curr Protoc Nucleic Acid Chem. 2009 Sep;Chapter 2:Unit 2.16 1-31. doi: 10.1002/0471142700.nc0216s38.

PMID:
19746354
22.

Release of DNA oligonucleotides and their conjugates from controlled-pore glass under thermolytic conditions.

Grajkowski A, Cieślak J, Norris S, Freedberg DI, Kauffman JS, Duff RJ, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2008 Dec;Chapter 3:Unit 3.17. doi: 10.1002/0471142700.nc0317s35.

PMID:
19085983
23.

Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.

Grajkowski A, Cieślak J, Kauffman JS, Duff RJ, Norris S, Freedberg DI, Beaucage SL.

Bioconjug Chem. 2008 Aug;19(8):1696-706. doi: 10.1021/bc800189e. Epub 2008 Jul 23.

PMID:
18646834
24.

Chemical phosphorylation of deoxyribonucleosides and thermolytic DNA oligonucleotides.

Ausín C, Grajkowski A, Cieślak J, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2006 Oct;Chapter 13:Unit 13.6. doi: 10.1002/0471142700.nc1306s26.

PMID:
18428949
25.

The 4-methylthio-1-butyl group for phosphate/thiophosphate protection in oligodeoxyribonucleotide synthesis.

Cieślak J, Grajkowski A, Livengood V, Beaucage SL.

Curr Protoc Nucleic Acid Chem. 2004 Dec;Chapter 3:Unit 3.11. doi: 10.1002/0471142700.nc0311s19.

PMID:
18428926
26.

3-(N-tert-butylcarboxamido)-1-propyl and 4-oxopentyl groups for phosphate/thiophosphate protection in oligodeoxyribonucleotide synthesis.

Wilk A, Chmielewski MK, Grajkowski A, Beaucage SL, Phillips LR.

Curr Protoc Nucleic Acid Chem. 2003 Feb;Chapter 3:Unit 3.9. doi: 10.1002/0471142700.nc0309s11.

PMID:
18428905
27.

Synthetic strategies and parameters involved in the synthesis of oligodeoxyribonucleotides according to the phosphoramidite method.

Beaucage SL, Caruthers MH.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 3:Unit 3.3. doi: 10.1002/0471142700.nc0303s00.

PMID:
18428844
28.

Deoxyribonucleoside phosphoramidites.

Wilk A, Grajkowski A, Chmielewski MK, Beaucage SL, Phillips LR.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 2:Unit 2.7. doi: 10.1002/0471142700.nc0207s04.

PMID:
18428840
29.

The 4-(N-dichloroacetyl-N-methylamino)benzyloxymethyl group for 2'-hydroxyl protection of ribonucleosides in the solid-phase synthesis of oligoribonucleotides.

Cieślak J, Grajkowski A, Kauffman JS, Duff RJ, Beaucage SL.

J Org Chem. 2008 Apr 4;73(7):2774-83. doi: 10.1021/jo702717g. Epub 2008 Mar 8.

PMID:
18327953
30.

Solid-phase synthesis of siRNA oligonucleotides.

Beaucage SL.

Curr Opin Drug Discov Devel. 2008 Mar;11(2):203-16. Review.

PMID:
18283608
31.

Assessment of 4-nitrogenated benzyloxymethyl groups for 2'-hydroxyl protection in solid-phase RNA synthesis.

Cieślak J, Kauffman JS, Kolodziejski MJ, Lloyd JR, Beaucage SL.

Org Lett. 2007 Feb 15;9(4):671-4. Epub 2007 Jan 26.

PMID:
17256869
32.

Solid-phase synthesis of thermolytic DNA oligonucleotides functionalized with a single 4-hydroxy-1-butyl or 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group.

Grajkowski A, Ausín C, Kauffman JS, Snyder J, Hess S, Lloyd JR, Beaucage SL.

J Org Chem. 2007 Feb 2;72(3):805-15.

PMID:
17253799
33.

Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates.

Puig M, Grajkowski A, Boczkowska M, Ausín C, Beaucage SL, Verthelyi D.

Nucleic Acids Res. 2006;34(22):6488-95. Epub 2006 Nov 27.

34.

Design and development of thermolytic DNA oligonucleotide prodrugs.

Grajkowski A, Pedras-Vasconcelos J, Ausín C, Verthelyi D, Beaucage SL.

Ann N Y Acad Sci. 2005 Nov;1058:26-38.

PMID:
16394123
35.

An efficient reagent for the phosphorylation of deoxyribonucleosides, DNA oligonucleotides, and their thermolytic analogues.

Ausín C, Grajkowski A, Cieślak J, Beaucage SL.

Org Lett. 2005 Sep 15;7(19):4201-4.

PMID:
16146387
36.

Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs.

Grajkowski A, Pedras-Vasconcelos J, Wang V, Ausín C, Hess S, Verthelyi D, Beaucage SL.

Nucleic Acids Res. 2005 Jun 21;33(11):3550-60. Print 2005.

37.

Novel multiple 5'-amino-modified primer for DNA microarrays.

Han J, Lee H, Nguyen NY, Beaucage SL, Puri RK.

Genomics. 2005 Aug;86(2):252-8.

PMID:
15949917
38.

31P NMR study of the desulfurization of oligonucleoside phosphorothioates effected by "aged" trichloroacetic acid solutions.

Cieślak J, Ausín C, Chmielewski MK, Kauffman JS, Snyder J, Del-Grosso A, Beaucage SL.

J Org Chem. 2005 Apr 15;70(8):3303-6.

PMID:
15823001
39.
40.

Thermolytic 4-methylthio-1-butyl group for phosphate/thiophosphate protection in solid-phase synthesis of DNA oligonucleotides.

Cieślak J, Grajkowski A, Livengood V, Beaucage SL.

J Org Chem. 2004 Apr 2;69(7):2509-15.

PMID:
15049652
41.

Conceptual "Heat-Driven" approach to the synthesis of DNA oligonucleotides on microarrays.

Grajkowski A, Cieślak J, Chmielewski MK, Marchán V, Phillips LR, Wilk A, Beaucage SL.

Ann N Y Acad Sci. 2003 Dec;1002:1-11.

PMID:
14751818
43.

Thermolytic carbonates for potential 5'-hydroxyl protection of deoxyribonucleosides.

Chmielewski MK, Marchán V, Cieślak J, Grajkowski A, Livengood V, Münch U, Wilk A, Beaucage SL.

J Org Chem. 2003 Dec 26;68(26):10003-12.

PMID:
14682694
44.

The 3-(N-tert-butylcarboxamido)-1-propyl group as an attractive phosphate/thiophosphate protecting group for solid-phase oligodeoxyribonucleotide synthesis.

Wilk A, Chmielewski MK, Grajkowski A, Phillips LR, Beaucage SL.

J Org Chem. 2002 Sep 6;67(18):6430-8.

PMID:
12201764
45.
46.
47.

Strategies in the preparation of DNA oligonucleotide arrays for diagnostic applications.

Beaucage SL.

Curr Med Chem. 2001 Aug;8(10):1213-44. Review.

PMID:
11472237
48.

The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis.

Grajkowski A, Wilk A, Chmielewski MK, Phillips LR, Beaucage SL.

Org Lett. 2001 May 3;3(9):1287-90.

PMID:
11348216
49.

Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.

Boal JH, Wilk A, Harindranath N, Max EE, Kempe T, Beaucage SL.

Nucleic Acids Res. 1996 Aug 1;24(15):3115-7.

50.

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM.

Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2879-83.

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