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J Cancer Res Clin Oncol. 2017 Jun;143(6):1103-1106. doi: 10.1007/s00432-017-2357-y. Epub 2017 Feb 28.

Influence of CYP2C19*2/*17 genotype on adverse drug reactions of voriconazole in patients after allo-HSCT: a four-case report.

Author information

1
Department of Clinical Pharmacology, Faculty of Pharmacy, Wrocław Medical University, 211a Borowska St., 50-556, Wrocław, Poland. beata.sienkiewicz@gmail.com.
2
Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wrocław Medical University, 4 Wybrzeże Pasteura St., 50-367, Wrocław, Poland.
3
Department of Clinical Pharmacology, Faculty of Pharmacy, Wrocław Medical University, 211a Borowska St., 50-556, Wrocław, Poland.

Abstract

PURPOSE:

Voriconazole (VCZ) is a new-generation triazol antifungal agent. CYP2C19 mutations have been reported to cause variability in VCZ pharmacokinetics, and thus lead to undesirable effects of pharmacotherapy. We observed four Caucasian patients who underwent allogenic hematopoietic stem cell transplantation, treated with voriconazole for prevention of fungal infections, to establish the impact of CYP2C19*2/*17 genotype on side effect occurrence.

METHODS:

Genetic testing for CYP2C19 allele*2 and*17 was performed using two PCR-RFLP methods established by Goldstein and Blaisdell, and Sim et al. All four patients presented CYP2C19*2/*17 genotype.

RESULTS:

The patients suffered from gastrointestinal, dermatological, neurological, hepatobiliary and renal adverse drug reactions (ADR). ADR could be best described by the use of VCZ. Other drugs potentially causing side effects were also taken into consideration. The presented complications were temporary and did not force dosage regimen adjustments or discontinuation of pharmacotherapy. After 2 months, the patients were discharged from hospital.

CONCLUSIONS:

Drug-drug interactions and ADR may occur even if an agent is used for prophylaxis only. We, therefore, should use any available tools for pharmacotherapy optimization-also genetic testing.

KEYWORDS:

Adverse drug reactions; CYP2C19*2/*17; Genotype; Hematology; Voriconazole

PMID:
28247033
PMCID:
PMC5427156
DOI:
10.1007/s00432-017-2357-y
[Indexed for MEDLINE]
Free PMC Article

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