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J Immunol. 2018 Jun 1;200(11):3681-3689. doi: 10.4049/jimmunol.1701713.

Links between Immunologic Memory and Metabolic Cycling.

Author information

1
Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232.
2
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
3
Faculty of Medicine, American University of Beirut, Beirut, Lebanon; and.
4
Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232; alyssa.hasty@vanderbilt.edu.
5
Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232.

Abstract

Treatments for metabolic diseases, such as diet and therapeutics, often provide short-term therapy for metabolic stressors, but relapse is common. Repeated bouts of exposure to, and relief from, metabolic stimuli results in a phenomenon we call "metabolic cycling." Recent human and rodent data suggest metabolic cycling promotes an exaggerated response and ultimately worsened metabolic health. This is particularly evident with cycling of body weight and hypertension. The innate and adaptive immune systems have a profound impact on development of metabolic disease, and current data suggest that immunologic memory may partially explain this association, especially in the context of metabolic cycling. In this Brief Review, we highlight recent work in this field and discuss potential immunologic mechanisms for worsened disease prognosis in individuals who experience metabolic cycling.

PMID:
29784764
PMCID:
PMC5973550
DOI:
10.4049/jimmunol.1701713
[Indexed for MEDLINE]
Free PMC Article

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