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Items: 1 to 50 of 61

1.

Altering the Y137-K164-K166 triad of mandelate racemase and its effect on the observed pKa of the Brønsted base catalysts.

Fetter CM, Morrison ZA, Nagar M, Douglas CD, Bearne SL.

Arch Biochem Biophys. 2019 May 15;666:116-126. doi: 10.1016/j.abb.2019.03.011. Epub 2019 Mar 29.

PMID:
30935886
2.

Catalytic properties of the metal ion variants of mandelate racemase reveal alterations in the apparent electrophilicity of the metal cofactor.

Harty ML, Sharma AN, Bearne SL.

Metallomics. 2019 Mar 20;11(3):707-723. doi: 10.1039/c8mt00330k.

PMID:
30843025
3.

Anfractuous assemblies of IMP dehydrogenase and CTP synthase: new twists on regulation?

McCluskey GD, Bearne SL.

FEBS J. 2018 Oct;285(20):3724-3728. doi: 10.1111/febs.14658. Epub 2018 Oct 4.

PMID:
30285320
4.

"Pinching" the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage.

McCluskey GD, Bearne SL.

Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2714-2727. doi: 10.1016/j.bbagen.2018.08.008. Epub 2018 Aug 10.

PMID:
30251661
5.

Changes in quaternary structure cause a kinetic asymmetry of glutamate racemase-catalyzed homocysteic acid racemization.

Mackie J, Kumar H, Bearne SL.

FEBS Lett. 2018 Oct;592(20):3399-3413. doi: 10.1002/1873-3468.13248. Epub 2018 Sep 24.

PMID:
30194685
6.

A platform for chemical modification of mandelate racemase: characterization of the C92S/C264S and γ-thialysine 166 variants.

Nagar M, Kumar H, Bearne SL.

Protein Eng Des Sel. 2018 Apr 1;31(4):135-145. doi: 10.1093/protein/gzy011.

PMID:
29850884
7.

Potent dialkyl substrate-product analogue inhibitors and inactivators of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis by rational design.

Pal M, Easton NM, Yaphe H, Bearne SL.

Bioorg Chem. 2018 Apr;77:640-650. doi: 10.1016/j.bioorg.2018.01.041. Epub 2018 Feb 7.

PMID:
29502025
8.

Biophysical Analysis of Bacterial CTP Synthase Filaments Formed in the Presence of the Chemotherapeutic Metabolite Gemcitabine-5'-triphosphate.

McCluskey GD, Bearne SL.

J Mol Biol. 2018 Apr 13;430(8):1201-1217. doi: 10.1016/j.jmb.2018.02.019. Epub 2018 Mar 1.

PMID:
29501573
9.

A continuous assay for l-talarate/galactarate dehydratase using circular dichroism.

Easton NM, Aboushawareb SAE, Bearne SL.

Anal Biochem. 2018 Mar 1;544:80-86. doi: 10.1016/j.ab.2017.12.015. Epub 2017 Dec 14.

PMID:
29248502
10.

A Paradigm for CH Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase.

Bearne SL, St Maurice M.

Adv Protein Chem Struct Biol. 2017;109:113-160. doi: 10.1016/bs.apcsb.2017.04.007. Epub 2017 Jun 9. Review.

PMID:
28683916
11.

Corrigendum to "The interdigitating loop of the enolase superfamily as a specificity binding determinant or 'flying buttress'" [Biochim. Biophys. Acta] 1865 (2017) 619-630.

Bearne SL.

Biochim Biophys Acta Proteins Proteom. 2017 Oct;1865(10):1287-1289. doi: 10.1016/j.bbapap.2017.06.006. Epub 2017 Jun 15. No abstract available.

PMID:
28627477
12.

The interdigitating loop of the enolase superfamily as a specificity binding determinant or 'flying buttress'.

Bearne SL.

Biochim Biophys Acta Proteins Proteom. 2017 May;1865(5):619-630. doi: 10.1016/j.bbapap.2017.02.006. Epub 2017 Feb 4. Review. Erratum in: Biochim Biophys Acta. 2017 Oct;1865(10 ):1287-1289.

PMID:
28179138
13.

Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5'-Triphosphate.

McCluskey GD, Mohamady S, Taylor SD, Bearne SL.

Chembiochem. 2016 Dec 2;17(23):2240-2249. doi: 10.1002/cbic.201600405. Epub 2016 Nov 16.

PMID:
27643605
14.

Rational design and synthesis of substrate-product analogue inhibitors of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis.

Pal M, Khanal M, Marko R, Thirumalairajan S, Bearne SL.

Chem Commun (Camb). 2016 Feb 14;52(13):2740-3. doi: 10.1039/c5cc08096g.

PMID:
26759836
15.

An additional role for the Brønsted acid-base catalysts of mandelate racemase in transition state stabilization.

Nagar M, Bearne SL.

Biochemistry. 2015 Nov 10;54(44):6743-52. doi: 10.1021/acs.biochem.5b00982. Epub 2015 Nov 2.

PMID:
26480244
16.

Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies.

Nagar M, Wyatt BN, St Maurice M, Bearne SL.

Biochemistry. 2015 May 5;54(17):2747-57. doi: 10.1021/acs.biochem.5b00221. Epub 2015 Apr 20.

PMID:
25844917
17.

Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium.

Pal M, Bearne SL.

Org Biomol Chem. 2014 Dec 28;12(48):9760-3. doi: 10.1039/c4ob02079k.

PMID:
25355071
18.

Inhibition of glutamate racemase by substrate-product analogues.

Pal M, Bearne SL.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1432-6. doi: 10.1016/j.bmcl.2013.12.114. Epub 2014 Jan 8.

PMID:
24507924
19.

Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode.

Nagar M, Lietzan AD, St Maurice M, Bearne SL.

Biochemistry. 2014 Feb 25;53(7):1169-78. doi: 10.1021/bi401703h. Epub 2014 Feb 10.

PMID:
24472022
20.

Inhibition of serine and proline racemases by substrate-product analogues.

Harty M, Nagar M, Atkinson L, Legay CM, Derksen DJ, Bearne SL.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):390-3. doi: 10.1016/j.bmcl.2013.10.061. Epub 2013 Nov 4.

PMID:
24314397
21.

Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron.

Lietzan AD, Nagar M, Pellmann EA, Bourque JR, Bearne SL, St Maurice M.

Biochemistry. 2012 Feb 14;51(6):1160-70. doi: 10.1021/bi2018514. Epub 2012 Feb 3.

22.

Redefining the minimal substrate tolerance of mandelate racemase. Racemization of trifluorolactate.

Nagar M, Narmandakh A, Khalak Y, Bearne SL.

Biochemistry. 2011 Oct 18;50(41):8846-52. doi: 10.1021/bi201188j. Epub 2011 Sep 21.

PMID:
21894901
23.

Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.

Steeves CH, Bearne SL.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5188-90. doi: 10.1016/j.bmcl.2011.07.054. Epub 2011 Jul 23.

PMID:
21840216
24.

Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum.

Steeves CH, Potrykus J, Barnett DA, Bearne SL.

Proteomics. 2011 May;11(10):2027-37. doi: 10.1002/pmic.201000631.

PMID:
21563313
25.

Interrogation of the active site of OMP decarboxylase from Escherichia coli with a substrate analogue bearing an anionic group at C6.

Thirumalairajan S, Mahaney B, Bearne SL.

Chem Commun (Camb). 2010 May 14;46(18):3158-60. doi: 10.1039/b926894d. Epub 2010 Mar 12.

PMID:
20424759
26.

Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.

Roy AC, Lunn FA, Bearne SL.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):141-4. doi: 10.1016/j.bmcl.2009.11.017. Epub 2009 Nov 12.

PMID:
20004571
27.

A continuous assay for alpha-methylacyl-coenzyme A racemase using circular dichroism.

Ouazia D, Bearne SL.

Anal Biochem. 2010 Mar 1;398(1):45-51. doi: 10.1016/j.ab.2009.10.039. Epub 2009 Oct 23.

PMID:
19854148
28.

Kinetic characterization and quaternary structure of glutamate racemase from the periodontal anaerobe Fusobacterium nucleatum.

Potrykus J, Flemming J, Bearne SL.

Arch Biochem Biophys. 2009 Nov;491(1-2):16-24. doi: 10.1016/j.abb.2009.09.009. Epub 2009 Sep 20. Erratum in: Arch Biochem Biophys. 2010 Jan 15;493(2):251.

PMID:
19772853
29.

Purification of recombinant mandelate racemase: improved catalytic activity.

Narmandakh A, Bearne SL.

Protein Expr Purif. 2010 Jan;69(1):39-46. doi: 10.1016/j.pep.2009.06.022. Epub 2009 Jul 7.

PMID:
19589387
30.

Ground state, intermediate, and multivalent nucleotide analogue inhibitors of cytidine 5'-triphosphate synthase.

Taylor SD, Lunn FA, Bearne SL.

ChemMedChem. 2008 Dec;3(12):1853-7. doi: 10.1002/cmdc.200800236. No abstract available.

PMID:
18988211
31.

Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium.

Potrykus J, White RL, Bearne SL.

Proteomics. 2008 Jul;8(13):2691-703. doi: 10.1002/pmic.200700437.

PMID:
18546150
32.
33.

Bismethylene triphosphate nucleotides of uridine 4-phosphate analogues: a new class of anionic pyrimidine nucleotide analogues.

Taylor SD, Mirzaei F, Bearne SL.

J Org Chem. 2008 Feb 15;73(4):1403-12. doi: 10.1021/jo702249j. Epub 2008 Jan 24.

PMID:
18215061
34.

Mutational analysis of the active site flap (20s loop) of mandelate racemase.

Bourque JR, Bearne SL.

Biochemistry. 2008 Jan 15;47(2):566-78. Epub 2007 Dec 20.

PMID:
18092808
35.
36.

Proteomic investigation of glucose metabolism in the butyrate-producing gut anaerobe Fusobacterium varium.

Potrykus J, Mahaney B, White RL, Bearne SL.

Proteomics. 2007 Jun;7(11):1839-53.

PMID:
17464938
37.

Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate.

Taylor SD, Mirzaei F, Sharifi A, Bearne SL.

J Org Chem. 2006 Dec 8;71(25):9420-30.

PMID:
17137369
38.

Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron.

Bourque JR, Burley RK, Bearne SL.

Bioorg Med Chem Lett. 2007 Jan 1;17(1):105-8. Epub 2006 Sep 30. Erratum in: Bioorg Med Chem Lett. 2007 May 1;17(9):2664.

PMID:
17055725
39.

An unsymmetrical approach to the synthesis of bismethylene triphosphate analogues.

Taylor SD, Mirzaei F, Bearne SL.

Org Lett. 2006 Sep 14;8(19):4243-6.

PMID:
16956197
40.
41.
42.

Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis.

Siddiqi F, Bourque JR, Jiang H, Gardner M, St Maurice M, Blouin C, Bearne SL.

Biochemistry. 2005 Jun 28;44(25):9013-21.

PMID:
15966725
43.

Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.

O'Malley PG, Sangster SM, Abdelmagid SA, Bearne SL, Too CK.

Biochem J. 2005 Sep 15;390(Pt 3):665-73.

44.

Reduction of intrinsic kinetic and thermodynamic barriers for enzyme-catalysed proton transfers from carbon acid substrates.

Bearne SL, Spiteri RJ.

J Theor Biol. 2005 Apr 21;233(4):563-71. Epub 2004 Dec 25.

PMID:
15748916
46.

Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP.

MacDonnell JE, Lunn FA, Bearne SL.

Biochim Biophys Acta. 2004 Jun 1;1699(1-2):213-20.

PMID:
15158730
47.

Hydrophobic nature of the active site of mandelate racemase.

St Maurice M, Bearne SL.

Biochemistry. 2004 Mar 9;43(9):2524-32.

PMID:
14992589
48.

Inhibition of mandelate racemase by alpha-fluorobenzylphosphonates.

St Maurice M, Bearne SL, Lu W, Taylor SD.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2041-4.

PMID:
12781191
50.

An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.

Iyengar A, Bearne SL.

Anal Biochem. 2002 Sep 15;308(2):396-400. No abstract available.

PMID:
12419356

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