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Dependency of Coxiella burnetii Type 4B Secretion on the Chaperone IcmS.

Larson CL, Beare PA, Heinzen RA.

J Bacteriol. 2019 Nov 5;201(23). pii: e00431-19. doi: 10.1128/JB.00431-19. Print 2019 Dec 1.


Comparative virulence of diverse Coxiella burnetii strains.

Long CM, Beare PA, Cockrell DC, Larson CL, Heinzen RA.

Virulence. 2019 Dec;10(1):133-150. doi: 10.1080/21505594.2019.1575715.


Coxiella burnetii RpoS Regulates Genes Involved in Morphological Differentiation and Intracellular Growth.

Moormeier DE, Sandoz KM, Beare PA, Sturdevant DE, Nair V, Cockrell DC, Miller HE, Heinzen RA.

J Bacteriol. 2019 Mar 26;201(8). pii: e00009-19. doi: 10.1128/JB.00009-19. Print 2019 Apr 15.


Immunological Responses to the Relapsing Fever Spirochete Borrelia turicatae in Infected Rhesus Macaques: Implications for Pathogenesis and Diagnosis.

Embers ME, Krishnavajhala A, Armstrong BA, Curtis MW, Pahar B, Wilder HK, Allen MS, Beare PA, Hasenkampf NR, Lopez JE.

Infect Immun. 2019 Mar 25;87(4). pii: e00900-18. doi: 10.1128/IAI.00900-18. Print 2019 Apr.


A Coxiella burnetii phospholipase A homolog pldA is required for optimal growth in macrophages and developmental form lipid remodeling.

Stead CM, Cockrell DC, Beare PA, Miller HE, Heinzen RA.

BMC Microbiol. 2018 Apr 16;18(1):33. doi: 10.1186/s12866-018-1181-0.


Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation.

Beare PA, Jeffrey BM, Long CM, Martens CM, Heinzen RA.

PLoS Pathog. 2018 Feb 26;14(3):e1006922. doi: 10.1371/journal.ppat.1006922. eCollection 2018 Mar.


Draft Genome Sequences of Historical Strains of Coxiella burnetii Isolated from Cow's Milk and a Goat Placenta.

Beare PA, Jeffrey BM, Martens CA, Pearson T, Heinzen RA.

Genome Announc. 2017 Sep 28;5(39). pii: e00985-17. doi: 10.1128/genomeA.00985-17.


Draft Genome Sequences of the Avirulent Coxiella burnetii Dugway 7D77-80 and Dugway 7E65-68 Strains Isolated from Rodents in Dugway, Utah.

Beare PA, Jeffrey BM, Martens CA, Heinzen RA.

Genome Announc. 2017 Sep 28;5(39). pii: e00984-17. doi: 10.1128/genomeA.00984-17.


Draft Genome Sequences of Three Coxiella burnetii Strains Isolated from Q Fever Patients.

Beare PA, Jeffrey BM, Martens CA, Heinzen RA.

Genome Announc. 2017 Sep 21;5(38). pii: e00986-17. doi: 10.1128/genomeA.00986-17.


Whole-Genome Sequence of Coxiella burnetii Nine Mile RSA439 (Phase II, Clone 4), a Laboratory Workhorse Strain.

Millar JA, Beare PA, Moses AS, Martens CA, Heinzen RA, Raghavan R.

Genome Announc. 2017 Jun 8;5(23). pii: e00471-17. doi: 10.1128/genomeA.00471-17.


Horizontally Acquired Biosynthesis Genes Boost Coxiella burnetii's Physiology.

Moses AS, Millar JA, Bonazzi M, Beare PA, Raghavan R.

Front Cell Infect Microbiol. 2017 May 10;7:174. doi: 10.3389/fcimb.2017.00174. eCollection 2017.


Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages.

Cockrell DC, Long CM, Robertson SJ, Shannon JG, Miller HE, Myers L, Larson CL, Starr T, Beare PA, Heinzen RA.

PLoS One. 2017 Mar 9;12(3):e0173528. doi: 10.1371/journal.pone.0173528. eCollection 2017.


Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages.

Colonne PM, Winchell CG, Graham JG, Onyilagha FI, MacDonald LJ, Doeppler HR, Storz P, Kurten RC, Beare PA, Heinzen RA, Voth DE.

PLoS Pathog. 2016 Oct 6;12(10):e1005915. doi: 10.1371/journal.ppat.1005915. eCollection 2016 Oct.


Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions.

Larson CL, Martinez E, Beare PA, Jeffrey B, Heinzen RA, Bonazzi M.

Future Microbiol. 2016 Jul;11:919-39. doi: 10.2217/fmb-2016-0044. Epub 2016 Jul 15. Review.


Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L.

Justis AV, Hansen B, Beare PA, King KB, Heinzen RA, Gilk SD.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12637. Epub 2016 Jul 15.


Correction for Sandoz et al., Complementation of Arginine Auxotrophy for Genetic Transformation of Coxiella burnetii by Use of a Defined Axenic Medium.

Sandoz KM, Beare PA, Cockrell DC, Heinzen RA.

Appl Environ Microbiol. 2016 May 31;82(12):3695. doi: 10.1128/AEM.01212-16. Print 2016 Jun 15. No abstract available.


Complementation of Arginine Auxotrophy for Genetic Transformation of Coxiella burnetii by Use of a Defined Axenic Medium.

Sandoz KM, Beare PA, Cockrell DC, Heinzen RA.

Appl Environ Microbiol. 2016 May 2;82(10):3042-51. doi: 10.1128/AEM.00261-16. Print 2016 May 15. Erratum in: Appl Environ Microbiol. 2016 Jun 15;82(12):3695.


Transcriptional Profiling of Coxiella burnetii Reveals Extensive Cell Wall Remodeling in the Small Cell Variant Developmental Form.

Sandoz KM, Popham DL, Beare PA, Sturdevant DE, Hansen B, Nair V, Heinzen RA.

PLoS One. 2016 Feb 24;11(2):e0149957. doi: 10.1371/journal.pone.0149957. eCollection 2016.


Chlamydial Lytic Exit from Host Cells Is Plasmid Regulated.

Yang C, Starr T, Song L, Carlson JH, Sturdevant GL, Beare PA, Whitmire WM, Caldwell HD.

MBio. 2015 Nov 10;6(6):e01648-15. doi: 10.1128/mBio.01648-15.


Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that traffic to the host cell endoplasmic reticulum.

VieBrock L, Evans SM, Beyer AR, Larson CL, Beare PA, Ge H, Singh S, Rodino KG, Heinzen RA, Richards AL, Carlyon JA.

Front Cell Infect Microbiol. 2015 Feb 3;4:186. doi: 10.3389/fcimb.2014.00186. eCollection 2014.


Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication.

Larson CL, Beare PA, Voth DE, Howe D, Cockrell DC, Bastidas RJ, Valdivia RH, Heinzen RA.

Infect Immun. 2015 Feb;83(2):661-70. doi: 10.1128/IAI.02763-14. Epub 2014 Nov 24.


Gene inactivation in Coxiella burnetii.

Beare PA, Heinzen RA.

Methods Mol Biol. 2014;1197:329-45. doi: 10.1007/978-1-4939-1261-2_19.


Essential role for the response regulator PmrA in Coxiella burnetii type 4B secretion and colonization of mammalian host cells.

Beare PA, Sandoz KM, Larson CL, Howe D, Kronmiller B, Heinzen RA.

J Bacteriol. 2014 Jun;196(11):1925-40. doi: 10.1128/JB.01532-14. Epub 2014 Mar 7.


Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis.

Larson CL, Beare PA, Howe D, Heinzen RA.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4770-9. doi: 10.1073/pnas.1309195110. Epub 2013 Nov 18.


Development of genetic system to inactivate a Borrelia turicatae surface protein selectively produced within the salivary glands of the arthropod vector.

Lopez JE, Wilder HK, Hargrove R, Brooks CP, Peterson KE, Beare PA, Sturdevant DE, Nagarajan V, Raffel SJ, Schwan TG.

PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2514. doi: 10.1371/journal.pntd.0002514. eCollection 2013.


Sec-mediated secretion by Coxiella burnetii.

Stead CM, Omsland A, Beare PA, Sandoz KM, Heinzen RA.

BMC Microbiol. 2013 Oct 5;13:222. doi: 10.1186/1471-2180-13-222.


Genetic manipulation of Coxiella burnetii.

Beare PA.

Adv Exp Med Biol. 2012;984:249-71. doi: 10.1007/978-94-007-4315-1_13. Review.


Two systems for targeted gene deletion in Coxiella burnetii.

Beare PA, Larson CL, Gilk SD, Heinzen RA.

Appl Environ Microbiol. 2012 Jul;78(13):4580-9. doi: 10.1128/AEM.00881-12. Epub 2012 Apr 20.


Identification of Anaplasma marginale type IV secretion system effector proteins.

Lockwood S, Voth DE, Brayton KA, Beare PA, Brown WC, Heinzen RA, Broschat SL.

PLoS One. 2011;6(11):e27724. doi: 10.1371/journal.pone.0027724. Epub 2011 Nov 28.


Differential proteolysis of sigma regulators controls cell-surface signalling in Pseudomonas aeruginosa.

Draper RC, Martin LW, Beare PA, Lamont IL.

Mol Microbiol. 2011 Dec;82(6):1444-53. doi: 10.1111/j.1365-2958.2011.07901.x. Epub 2011 Nov 13.


Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages.

Beare PA, Gilk SD, Larson CL, Hill J, Stead CM, Omsland A, Cockrell DC, Howe D, Voth DE, Heinzen RA.

MBio. 2011 Sep 1;2(4):e00175-11. doi: 10.1128/mBio.00175-11. Print 2011.


Advances in genetic manipulation of obligate intracellular bacterial pathogens.

Beare PA, Sandoz KM, Omsland A, Rockey DD, Heinzen RA.

Front Microbiol. 2011 May 2;2:97. doi: 10.3389/fmicb.2011.00097. eCollection 2011.


Isolation from animal tissue and genetic transformation of Coxiella burnetii are facilitated by an improved axenic growth medium.

Omsland A, Beare PA, Hill J, Cockrell DC, Howe D, Hansen B, Samuel JE, Heinzen RA.

Appl Environ Microbiol. 2011 Jun;77(11):3720-5. doi: 10.1128/AEM.02826-10. Epub 2011 Apr 8.


The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates.

Voth DE, Beare PA, Howe D, Sharma UM, Samoilis G, Cockrell DC, Omsland A, Heinzen RA.

J Bacteriol. 2011 Apr;193(7):1493-503. doi: 10.1128/JB.01359-10. Epub 2011 Jan 7.


Coxiella burnetii expresses a functional Δ24 sterol reductase.

Gilk SD, Beare PA, Heinzen RA.

J Bacteriol. 2010 Dec;192(23):6154-9. doi: 10.1128/JB.00818-10. Epub 2010 Sep 24.


Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics.

Sturdevant DE, Virtaneva K, Martens C, Bozinov D, Ogundare O, Castro N, Kanakabandi K, Beare PA, Omsland A, Carlson JH, Kennedy AD, Heinzen RA, Celli J, Greenberg DE, DeLeo FR, Porcella SF.

Future Microbiol. 2010 Feb;5(2):205-19. doi: 10.2217/fmb.09.125. Review. Erratum in: Future Microbiol. 2010 Mar;5(3):526. Ohmsland, Anders [corrected to Omsland, Anders].


Anaplasma marginale type IV secretion system proteins VirB2, VirB7, VirB11, and VirD4 are immunogenic components of a protective bacterial membrane vaccine.

Sutten EL, Norimine J, Beare PA, Heinzen RA, Lopez JE, Morse K, Brayton KA, Gillespie JJ, Brown WC.

Infect Immun. 2010 Mar;78(3):1314-25. doi: 10.1128/IAI.01207-09. Epub 2010 Jan 11.


The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion.

Voth DE, Howe D, Beare PA, Vogel JP, Unsworth N, Samuel JE, Heinzen RA.

J Bacteriol. 2009 Jul;191(13):4232-42. doi: 10.1128/JB.01656-08. Epub 2009 May 1.


A systematic approach to evaluate humoral and cellular immune responses to Coxiella burnetii immunoreactive antigens.

Chen C, Bouman TJ, Beare PA, Mertens K, Zhang GQ, Russell-Lodrigue KE, Hogaboam JP, Peters B, Felgner PL, Brown WC, Heinzen RA, Hendrix LR, Samuel JE.

Clin Microbiol Infect. 2009 Dec;15 Suppl 2:156-7. doi: 10.1111/j.1469-0691.2008.02206.x. Epub 2009 Mar 11. No abstract available.


Characterization of a Coxiella burnetii ftsZ mutant generated by Himar1 transposon mutagenesis.

Beare PA, Howe D, Cockrell DC, Omsland A, Hansen B, Heinzen RA.

J Bacteriol. 2009 Mar;191(5):1369-81. doi: 10.1128/JB.01580-08. Epub 2008 Dec 29.


Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella.

Beare PA, Unsworth N, Andoh M, Voth DE, Omsland A, Gilk SD, Williams KP, Sobral BW, Kupko JJ 3rd, Porcella SF, Samuel JE, Heinzen RA.

Infect Immun. 2009 Feb;77(2):642-56. doi: 10.1128/IAI.01141-08. Epub 2008 Dec 1.


Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray.

Beare PA, Chen C, Bouman T, Pablo J, Unal B, Cockrell DC, Brown WC, Barbian KD, Porcella SF, Samuel JE, Felgner PL, Heinzen RA.

Clin Vaccine Immunol. 2008 Dec;15(12):1771-9. doi: 10.1128/CVI.00300-08. Epub 2008 Oct 8.


Role of cell surface signaling in proteolysis of an alternative sigma factor in Pseudomonas aeruginosa.

Spencer MR, Beare PA, Lamont IL.

J Bacteriol. 2008 Jul;190(14):4865-9. doi: 10.1128/JB.01998-07. Epub 2008 May 23.


High-throughput identification of T-lymphocyte antigens from Anaplasma marginale expressed using in vitro transcription and translation.

Lopez JE, Beare PA, Heinzen RA, Norimine J, Lahmers KK, Palmer GH, Brown WC.

J Immunol Methods. 2008 Mar 20;332(1-2):129-41. doi: 10.1016/j.jim.2007.12.018. Epub 2008 Jan 28.


A method for purifying obligate intracellular Coxiella burnetii that employs digitonin lysis of host cells.

Cockrell DC, Beare PA, Fischer ER, Howe D, Heinzen RA.

J Microbiol Methods. 2008 Mar;72(3):321-5. doi: 10.1016/j.mimet.2007.12.015. Epub 2008 Jan 12.


Efficient method of cloning the obligate intracellular bacterium Coxiella burnetii.

Beare PA, Howe D, Cockrell DC, Heinzen RA.

Appl Environ Microbiol. 2007 Jun;73(12):4048-54. Epub 2007 Apr 27.


Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons.

Beare PA, Samuel JE, Howe D, Virtaneva K, Porcella SF, Heinzen RA.

J Bacteriol. 2006 Apr;188(7):2309-24.


Preliminary assessment of genome differences between the reference Nine Mile isolate and two human endocarditis isolates of Coxiella burnetii.

Beare PA, Porcella SF, Seshadri R, Samuel JE, Heinzen RA.

Ann N Y Acad Sci. 2005 Dec;1063:64-7.


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