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Items: 1 to 50 of 71

1.

Large deletions induced by Cas9 cleavage.

Adikusuma F, Piltz S, Corbett MA, Turvey M, McColl SR, Helbig KJ, Beard MR, Hughes J, Pomerantz RT, Thomas PQ.

Nature. 2018 Aug;560(7717):E8-E9. doi: 10.1038/s41586-018-0380-z. Epub 2018 Aug 8. No abstract available.

PMID:
30089922
2.

Interferon-Stimulated Genes as Enhancers of Antiviral Innate Immune Signaling.

Crosse KM, Monson EA, Beard MR, Helbig KJ.

J Innate Immun. 2018;10(2):85-93. doi: 10.1159/000484258. Epub 2017 Nov 30.

3.

Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses.

Eyre NS, Johnson SM, Eltahla AA, Aloi M, Aloia AL, McDevitt CA, Bull RA, Beard MR.

J Virol. 2017 Nov 14;91(23). pii: e01455-17. doi: 10.1128/JVI.01455-17. Print 2017 Dec 1.

4.

Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages.

Nasr N, Alshehri AA, Wright TK, Shahid M, Heiner BM, Harman AN, Botting RA, Helbig KJ, Beard MR, Suzuki K, Kelleher AD, Hertzog P, Cunningham AL.

J Virol. 2017 Sep 27;91(20). pii: e00744-17. doi: 10.1128/JVI.00744-17. Print 2017 Oct 15.

5.

Viperin is an important host restriction factor in control of Zika virus infection.

Van der Hoek KH, Eyre NS, Shue B, Khantisitthiporn O, Glab-Ampi K, Carr JM, Gartner MJ, Jolly LA, Thomas PQ, Adikusuma F, Jankovic-Karasoulos T, Roberts CT, Helbig KJ, Beard MR.

Sci Rep. 2017 Jun 30;7(1):4475. doi: 10.1038/s41598-017-04138-1.

6.

Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus NS5A protein into the extracellular environment.

Eyre NS, Aloia AL, Joyce MA, Chulanetra M, Tyrrell DL, Beard MR.

Virology. 2017 Jul;507:20-31. doi: 10.1016/j.virol.2017.04.003. Epub 2017 Apr 7.

7.

Calsyntenin-1 mediates hepatitis C virus replication.

Awan Z, Tay ES, Eyre NS, Wu LE, Beard MR, Boo I, Drummer HE, George J, Douglas MW.

J Gen Virol. 2016 Aug;97(8):1877-87. doi: 10.1099/jgv.0.000511. Epub 2016 May 24.

PMID:
27221318
8.

HCV RNA traffic and association with NS5A in living cells.

Fiches GN, Eyre NS, Aloia AL, Van Der Hoek K, Betz-Stablein B, Luciani F, Chopra A, Beard MR.

Virology. 2016 Jun;493:60-74. doi: 10.1016/j.virol.2016.02.016. Epub 2016 Mar 19.

9.

Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation.

Eyre NS, Hampton-Smith RJ, Aloia AL, Eddes JS, Simpson KJ, Hoffmann P, Beard MR.

Virology. 2016 Apr;491:27-44. doi: 10.1016/j.virol.2016.01.018. Epub 2016 Feb 10.

10.

Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.

Clarke JN, Davies LK, Calvert JK, Gliddon BL, Al Shujari WH, Aloia AL, Helbig KJ, Beard MR, Pitson SM, Carr JM.

J Gen Virol. 2016 Jan;97(1):95-109. doi: 10.1099/jgv.0.000334. Epub 2015 Nov 5.

PMID:
26541871
11.

Oyster viperin retains direct antiviral activity and its transcription occurs via a signalling pathway involving a heat-stable haemolymph protein.

Green TJ, Speck P, Geng L, Raftos D, Beard MR, Helbig KJ.

J Gen Virol. 2015 Dec;96(12):3587-97.

PMID:
26407968
12.

The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.

Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR.

J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9.

13.

Dengue Virus Infection of Primary Endothelial Cells Induces Innate Immune Responses, Changes in Endothelial Cells Function and Is Restricted by Interferon-Stimulated Responses.

Calvert JK, Helbig KJ, Dimasi D, Cockshell M, Beard MR, Pitson SM, Bonder CS, Carr JM.

J Interferon Cytokine Res. 2015 Aug;35(8):654-65. doi: 10.1089/jir.2014.0195. Epub 2015 Apr 22.

PMID:
25902155
14.

Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus).

Milic NL, Davis S, Carr JM, Isberg S, Beard MR, Helbig KJ.

Dev Comp Immunol. 2015 Jul;51(1):108-15. doi: 10.1016/j.dci.2015.03.001. Epub 2015 Mar 9.

PMID:
25766282
15.

Resistance to hepatitis C virus: potential genetic and immunological determinants.

Mina MM, Luciani F, Cameron B, Bull RA, Beard MR, Booth D, Lloyd AR.

Lancet Infect Dis. 2015 Apr;15(4):451-60. doi: 10.1016/S1473-3099(14)70965-X. Epub 2015 Feb 19. Review.

PMID:
25703062
16.

Fatty Acids Induce a Pro-Inflammatory Gene Expression Profile in Huh-7 Cells That Attenuates the Anti-HCV Action of Interferon.

Tse E, Helbig KJ, Van der Hoek K, McCartney EM, Van der Hoek M, George J, Beard MR.

J Interferon Cytokine Res. 2015 May;35(5):392-400. doi: 10.1089/jir.2014.0165. Epub 2015 Jan 14.

PMID:
25588104
17.

HCV NS5A inhibitors disrupt replication factory formation: a novel mechanism of antiviral action.

Eyre NS, Beard MR.

Gastroenterology. 2014 Nov;147(5):959-62. doi: 10.1053/j.gastro.2014.09.024. Epub 2014 Sep 27. No abstract available.

PMID:
25265576
18.

Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations.

Aloia AL, Eyre NS, Black S, Bent SJ, Gaeguta A, Guo Z, Narayana SK, Chase R, Locarnini S, Carr JM, Howe JA, Beard MR.

Antivir Ther. 2015;20(3):271-80. doi: 10.3851/IMP2850. Epub 2014 Sep 15.

PMID:
25222708
19.

A summary of the 20th International Symposium on Hepatitis C Virus and Related Viruses.

Beard MR, Ffrench R, Gowans EJ, Helbig KJ, Eyre NM, Douglas MM, Grebely J, Ahlenstiel G, Locarnini S, George J, Shackel NA, White PA, Thompson AJ, Drummer HE.

Gastroenterology. 2014 Jul;147(1):e1-4. doi: 10.1053/j.gastro.2014.05.022. Epub 2014 May 23. No abstract available.

PMID:
24861641
20.

Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection.

Eyre NS, Fiches GN, Aloia AL, Helbig KJ, McCartney EM, McErlean CS, Li K, Aggarwal A, Turville SG, Beard MR.

J Virol. 2014 Apr;88(7):3636-52. doi: 10.1128/JVI.02490-13. Epub 2014 Jan 15.

21.

The role of viperin in the innate antiviral response.

Helbig KJ, Beard MR.

J Mol Biol. 2014 Mar 20;426(6):1210-9. doi: 10.1016/j.jmb.2013.10.019. Epub 2013 Oct 22. Review.

22.

Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA.

Carr JM, Kua T, Clarke JN, Calvert JK, Zebol JR, Beard MR, Pitson SM.

J Gen Virol. 2013 Nov;94(Pt 11):2437-48. doi: 10.1099/vir.0.055616-0. Epub 2013 Aug 12.

PMID:
23939980
23.

Bioinformatics methods for the analysis of hepatitis viruses.

Moriconi F, Beard MR, Yuen LK.

Antivir Ther. 2013;18(3 Pt B):531-9. doi: 10.3851/IMP2613. Epub 2013 Jun 21. Review.

PMID:
23792814
24.

Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus.

McCartney EM, Helbig KJ, Narayana SK, Eyre NS, Aloia AL, Beard MR.

Hepatology. 2013 Nov;58(5):1558-68. doi: 10.1002/hep.26496. Epub 2013 Oct 1.

PMID:
23703790
25.

Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.

Helbig KJ, Carr JM, Calvert JK, Wati S, Clarke JN, Eyre NS, Narayana SK, Fiches GN, McCartney EM, Beard MR.

PLoS Negl Trop Dis. 2013 Apr 18;7(4):e2178. doi: 10.1371/journal.pntd.0002178. Print 2013.

26.

Antiviral resistance and direct-acting antiviral agents for HCV.

Aloia AL, Locarnini S, Beard MR.

Antivir Ther. 2012;17(6 Pt B):1147-62. doi: 10.3851/IMP2426. Epub 2012 Oct 5. Review.

PMID:
23188771
27.

Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner.

Phillips RJ, Helbig KJ, Van der Hoek KH, Seth D, Beard MR.

World J Gastroenterol. 2012 Jul 14;18(26):3389-99. doi: 10.3748/wjg.v18.i26.3389.

28.

HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.

Nasr N, Maddocks S, Turville SG, Harman AN, Woolger N, Helbig KJ, Wilkinson J, Bye CR, Wright TK, Rambukwelle D, Donaghy H, Beard MR, Cunningham AL.

Blood. 2012 Jul 26;120(4):778-88. doi: 10.1182/blood-2012-01-407395. Epub 2012 Jun 7.

29.

The interferon signaling pathway genes as biomarkers of hepatitis C virus disease progression and response to treatment.

Helbig KJ, Beard MR.

Biomark Med. 2012 Apr;6(2):141-50. doi: 10.2217/BMM.12.9. Review.

PMID:
22448788
30.

Resistance to anti-HCV protease inhibitors.

Thompson AJ, Locarnini SA, Beard MR.

Curr Opin Virol. 2011 Dec;1(6):599-606. doi: 10.1016/j.coviro.2011.10.001. Epub 2011 Oct 28. Review.

PMID:
22440917
31.

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.

Helbig KJ, Eyre NS, Yip E, Narayana S, Li K, Fiches G, McCartney EM, Jangra RK, Lemon SM, Beard MR.

Hepatology. 2011 Nov;54(5):1506-17. doi: 10.1002/hep.24542.

32.

Border patrol intensifies for hepatitis C virus entry.

McCartney EM, Eyre NS, Beard MR.

Hepatology. 2011 Oct;54(4):1472-5. doi: 10.1002/hep.24586. No abstract available.

PMID:
21956707
33.

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific.

Suzuki K, Ishida T, Yamagishi M, Ahlenstiel C, Swaminathan S, Marks K, Murray D, McCartney EM, Beard MR, Alexander M, Purcell DF, Cooper DA, Watanabe T, Kelleher AD.

RNA Biol. 2011 Nov-Dec;8(6):1035-46. doi: 10.4161/rna.8.6.16264. Epub 2011 Nov 1.

34.

Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease.

Berzsenyi MD, Woollard DJ, McLean CA, Preiss S, Perreau VM, Beard MR, Scott Bowden D, Cowie BC, Li S, Mijch AM, Roberts SK.

J Hepatol. 2011 Sep;55(3):536-544. doi: 10.1016/j.jhep.2010.12.021. Epub 2011 Jan 23.

PMID:
21266183
35.

Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity.

Wati S, Rawlinson SM, Ivanov RA, Dorstyn L, Beard MR, Jans DA, Pitson SM, Burrell CJ, Li P, Carr JM.

J Gen Virol. 2011 Apr;92(Pt 4):807-18. doi: 10.1099/vir.0.028159-0. Epub 2010 Dec 9.

PMID:
21148274
36.

Hepatic TLR2 & TLR4 expression correlates with hepatic inflammation and TNF-α in HCV & HCV/HIV infection.

Berzsenyi MD, Roberts SK, Preiss S, Woollard DJ, Beard MR, Skinner NA, Bowden DS, Visvanathan K.

J Viral Hepat. 2011 Dec;18(12):852-60. doi: 10.1111/j.1365-2893.2010.01390.x. Epub 2010 Nov 3.

PMID:
21050341
37.

The SR-BI partner PDZK1 facilitates hepatitis C virus entry.

Eyre NS, Drummer HE, Beard MR.

PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130.

38.

Hepatitis C virus infection in living color.

Eyre NS, Beard MR.

Hepatology. 2010 May;51(5):1852-5. doi: 10.1002/hep.23695. No abstract available.

PMID:
20432262
39.

Impact of alcohol on hepatitis C virus replication and interferon signaling.

McCartney EM, Beard MR.

World J Gastroenterol. 2010 Mar 21;16(11):1337-43. Review.

40.

Impaired methylation as a novel mechanism for proteasome suppression in liver cells.

Osna NA, White RL, Donohue TM Jr, Beard MR, Tuma DJ, Kharbanda KK.

Biochem Biophys Res Commun. 2010 Jan 8;391(2):1291-6. doi: 10.1016/j.bbrc.2009.12.074. Epub 2009 Dec 21.

41.

Hepatitis B virus and hepatitis C virus interaction in Huh-7 cells.

Eyre NS, Phillips RJ, Bowden S, Yip E, Dewar B, Locarnini SA, Beard MR.

J Hepatol. 2009 Sep;51(3):446-57. doi: 10.1016/j.jhep.2009.04.025. Epub 2009 Jun 3.

PMID:
19596477
42.

Closing the gap: the tight junction protein occludin and hepatitis C virus entry.

Eyre NS, Baumert TF, Beard MR.

Hepatology. 2009 May;49(5):1770-2. doi: 10.1002/hep.22935. No abstract available.

PMID:
19402114
43.

Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro.

Helbig KJ, Ruszkiewicz A, Lanford RE, Berzsenyi MD, Harley HA, McColl SR, Beard MR.

J Virol. 2009 Jan;83(2):836-46. doi: 10.1128/JVI.01388-08. Epub 2008 Nov 5.

44.

Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon.

McCartney EM, Semendric L, Helbig KJ, Hinze S, Jones B, Weinman SA, Beard MR.

J Infect Dis. 2008 Dec 15;198(12):1766-75. doi: 10.1086/593216.

PMID:
18956976
45.

Control of HCV replication: when size does not matter.

Beard MR, Helbig KJ.

Hepatology. 2008 Mar;47(3):1092-4. doi: 10.1002/hep.22267. No abstract available.

PMID:
18302297
46.

A screening method for identifying disruptions in interferon signaling reveals HCV NS3/4a disrupts Stat-1 phosphorylation.

Helbig KJ, Yip E, McCartney EM, Eyre NS, Beard MR.

Antiviral Res. 2008 Mar;77(3):169-76. doi: 10.1016/j.antiviral.2007.11.008. Epub 2007 Dec 26.

PMID:
18190974
47.

Claudin-1, a new junction in the hepatitis C virus entry pathway.

Beard MR, Warner FJ.

Hepatology. 2007 Jul;46(1):277-9. No abstract available.

PMID:
17596888
48.

Readers' responses to "the cost of marginal medicine is too high".

Beard MR.

MedGenMed. 2006;8(2):44; author reply 43. No abstract available.

PMID:
17048327
49.

Genomics of hepatitis B and C infections: diagnostic and therapeutic applications of microarray profiling.

Berzsenyi MD, Roberts SK, Beard MR.

Antivir Ther. 2006;11(5):541-52. Review.

PMID:
16964821
50.

Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.

Helbig KJ, Lau DT, Semendric L, Harley HA, Beard MR.

Hepatology. 2005 Sep;42(3):702-10.

PMID:
16108059

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