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Items: 1 to 50 of 137

1.

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging.

Gao X, Jakovljevic DG, Beard DA.

Biophys J. 2019 Jul 2. pii: S0006-3495(19)30515-6. doi: 10.1016/j.bpj.2019.06.026. [Epub ahead of print]

PMID:
31395314
2.

Assessing the Validity and Utility of the Guyton Model of Arterial Blood Pressure Control.

Beard DA.

Hypertension. 2018 Dec;72(6):1272-1273. doi: 10.1161/HYPERTENSIONAHA.118.11998. No abstract available.

PMID:
30571241
3.

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture.

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD.

PLoS One. 2018 Nov 29;13(11):e0207803. doi: 10.1371/journal.pone.0207803. eCollection 2018.

4.

High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.

Allen LA, Schmidt JR, Thompson CT, Carlson BE, Beard DA, Lombard JH.

Microcirculation. 2019 Apr;26(3):e12518. doi: 10.1111/micc.12518. Epub 2019 Jan 15.

PMID:
30481399
5.

Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics.

Kasper JD, Meyer RA, Beard DA, Wiseman RW.

Am J Physiol Regul Integr Comp Physiol. 2019 Jan 1;316(1):R76-R86. doi: 10.1152/ajpregu.00321.2018. Epub 2018 Nov 21.

PMID:
30462525
6.

Computational model-based assessment of baroreflex function from response to Valsalva maneuver.

Kosinski SA, Carlson BE, Hummel SL, Brook RD, Beard DA.

J Appl Physiol (1985). 2018 Dec 1;125(6):1944-1967. doi: 10.1152/japplphysiol.00095.2018. Epub 2018 Sep 20.

PMID:
30236047
7.

Do computers dream of electric glomeruli?

Bukowy JD, Dayton A, Cloutier D, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

Kidney Int. 2018 Sep;94(3):635. doi: 10.1016/j.kint.2018.02.011. No abstract available.

8.

Multiscale Computational Analysis of Right Ventricular Mechanoenergetics.

Pewowaruk RJ, Philip JL, Tewari SG, Chen CS, Nyaeme MS, Wang Z, Tabima DM, Baker AJ, Beard DA, Chesler NC.

J Biomech Eng. 2018 Aug 1;140(8). doi: 10.1115/1.4040044.

9.

Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions.

Philip JL, Pewowaruk RJ, Chen CS, Tabima DM, Beard DA, Baker AJ, Chesler NC.

Front Physiol. 2018 Jun 27;9:731. doi: 10.3389/fphys.2018.00731. eCollection 2018.

10.

Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections.

Bukowy JD, Dayton A, Cloutier D, Manis AD, Staruschenko A, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

J Am Soc Nephrol. 2018 Aug;29(8):2081-2088. doi: 10.1681/ASN.2017111210. Epub 2018 Jun 19.

11.

Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats.

Moxley MA, Vinnakota KC, Bazil JN, Qi NR, Beard DA.

PLoS Comput Biol. 2018 Feb 23;14(2):e1005982. doi: 10.1371/journal.pcbi.1005982. eCollection 2018 Feb.

12.

Human Cardiac 31P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise.

Bakermans AJ, Bazil JN, Nederveen AJ, Strijkers GJ, Boekholdt SM, Beard DA, Jeneson JAL.

Front Physiol. 2017 Nov 27;8:939. doi: 10.3389/fphys.2017.00939. eCollection 2017.

13.

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform.

Marshall-Colon A, Long SP, Allen DK, Allen G, Beard DA, Benes B, von Caemmerer S, Christensen AJ, Cox DJ, Hart JC, Hirst PM, Kannan K, Katz DS, Lynch JP, Millar AJ, Panneerselvam B, Price ND, Prusinkiewicz P, Raila D, Shekar RG, Shrivastava S, Shukla D, Srinivasan V, Stitt M, Turk MJ, Voit EO, Wang Y, Yin X, Zhu XG.

Front Plant Sci. 2017 May 15;8:786. doi: 10.3389/fpls.2017.00786. eCollection 2017.

14.

Tautological Nature of Guyton's Theory of Blood Pressure Control.

Beard DA.

Am J Hypertens. 2017 Jul 1;30(7):e5. doi: 10.1093/ajh/hpx038. No abstract available.

PMID:
28407085
15.

The feasibility of genome-scale biological network inference using Graphics Processing Units.

Thiagarajan R, Alavi A, Podichetty JT, Bazil JN, Beard DA.

Algorithms Mol Biol. 2017 Mar 20;12:8. doi: 10.1186/s13015-017-0100-5. eCollection 2017.

16.

Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension.

Liu A, Philip J, Vinnakota KC, Van den Bergh F, Tabima DM, Hacker T, Beard DA, Chesler NC.

Physiol Rep. 2017 Mar;5(6). pii: e13157. doi: 10.14814/phy2.13157.

17.

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure.

Tewari SG, Bugenhagen SM, Vinnakota KC, Rice JJ, Janssen PML, Beard DA.

J Mol Cell Cardiol. 2016 May;94:162-175. doi: 10.1016/j.yjmcc.2016.04.003. Epub 2016 Apr 13.

18.

Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.

Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, Beard DA, Efimov IR.

FASEB J. 2016 Aug;30(8):2698-707. doi: 10.1096/fj.201500118R. Epub 2016 Apr 13.

19.

Improving the physiological realism of experimental models.

Vinnakota KC, Cha CY, Rorsman P, Balaban RS, La Gerche A, Wade-Martins R, Beard DA, Jeneson JA.

Interface Focus. 2016 Apr 6;6(2):20150076. doi: 10.1098/rsfs.2015.0076. Review.

20.

Open-loop (feed-forward) and feedback control of coronary blood flow during exercise, cardiac pacing, and pressure changes.

Pradhan RK, Feigl EO, Gorman MW, Brengelmann GL, Beard DA.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1683-94. doi: 10.1152/ajpheart.00663.2015. Epub 2016 Apr 1.

21.

Feedback Regulation and Time Hierarchy of Oxidative Phosphorylation in Cardiac Mitochondria.

Vinnakota KC, Bazil JN, Van den Bergh F, Wiseman RW, Beard DA.

Biophys J. 2016 Feb 23;110(4):972-80. doi: 10.1016/j.bpj.2016.01.003.

22.

Catalytic Coupling of Oxidative Phosphorylation, ATP Demand, and Reactive Oxygen Species Generation.

Bazil JN, Beard DA, Vinnakota KC.

Biophys J. 2016 Feb 23;110(4):962-71. doi: 10.1016/j.bpj.2015.09.036.

23.

Open-Loop Control of Oxidative Phosphorylation in Skeletal and Cardiac Muscle Mitochondria by Ca(2.).

Vinnakota KC, Singhal A, Van den Bergh F, Bagher-Oskouei M, Wiseman RW, Beard DA.

Biophys J. 2016 Feb 23;110(4):954-61. doi: 10.1016/j.bpj.2015.12.018.

24.

Heterogeneous mechanics of the mouse pulmonary arterial network.

Lee P, Carlson BE, Chesler N, Olufsen MS, Qureshi MU, Smith NP, Sochi T, Beard DA.

Biomech Model Mechanobiol. 2016 Oct;15(5):1245-61. doi: 10.1007/s10237-015-0757-y. Epub 2016 Jan 20.

25.

The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.

Bassingthwaighte JB, Raymond GM, Dash RK, Beard DA, Nolan M.

Adv Exp Med Biol. 2016;876:103-110. doi: 10.1007/978-1-4939-3023-4_13.

26.

Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum.

Moxley MA, Beard DA, Bazil JN.

J Biol Chem. 2016 Feb 5;291(6):2712-30. doi: 10.1074/jbc.M115.676619. Epub 2015 Dec 7.

27.

Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli.

Fan F, Chen CC, Zhang J, Schreck CM, Roman EA, Williams JM, Hirata T, Sharma M, Beard DA, Savin VJ, Roman RJ.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1049-59. doi: 10.1152/ajprenal.00311.2015. Epub 2015 Oct 7.

28.

Computational analysis of the regulation of Ca(2+) dynamics in rat ventricular myocytes.

Bugenhagen SM, Beard DA.

Phys Biol. 2015 Sep 11;12(5):056008. doi: 10.1088/1478-3975/12/5/056008.

29.

Big Data Analytics in Healthcare.

Belle A, Thiagarajan R, Soroushmehr SM, Navidi F, Beard DA, Najarian K.

Biomed Res Int. 2015;2015:370194. doi: 10.1155/2015/370194. Epub 2015 Jul 2. Review.

30.

Letter to the Editor: Mitochondrial cytochrome c oxidase: mechanism of action and role in regulating oxidative phosphorylation.

Pannala VR, Beard DA, Dash RK.

J Appl Physiol (1985). 2015 Jul 15;119(2):157. doi: 10.1152/japplphysiol.00290.2015. No abstract available.

31.

Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle.

Tewari SG, Bugenhagen SM, Palmer BM, Beard DA.

J Mol Cell Cardiol. 2016 Jul;96:11-25. doi: 10.1016/j.yjmcc.2015.02.006. Epub 2015 Feb 11.

32.

Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics.

Tewari SG, Zhou Y, Otto BJ, Dash RK, Kwok WM, Beard DA.

Front Physiol. 2015 Jan 13;5:513. doi: 10.3389/fphys.2014.00513. eCollection 2014.

33.

Characterization of the kinetics of cardiac cytosolic malate dehydrogenase and comparative analysis of cytosolic and mitochondrial isoforms.

Dasika SK, Vinnakota KC, Beard DA.

Biophys J. 2015 Jan 20;108(2):420-30. doi: 10.1016/j.bpj.2014.11.3466.

34.

Determination of the catalytic mechanism for mitochondrial malate dehydrogenase.

Dasika SK, Vinnakota KC, Beard DA.

Biophys J. 2015 Jan 20;108(2):408-19. doi: 10.1016/j.bpj.2014.11.3467.

35.

A pH-dependent kinetic model of dihydrolipoamide dehydrogenase from multiple organisms.

Moxley MA, Beard DA, Bazil JN.

Biophys J. 2014 Dec 16;107(12):2993-3007. doi: 10.1016/j.bpj.2014.09.025.

36.

Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase.

Bazil JN, Pannala VR, Dash RK, Beard DA.

Free Radic Biol Med. 2014 Dec;77:121-9. doi: 10.1016/j.freeradbiomed.2014.08.023. Epub 2014 Sep 16.

37.

The inferred cardiogenic gene regulatory network in the mammalian heart.

Bazil JN, Stamm KD, Li X, Thiagarajan R, Nelson TJ, Tomita-Mitchell A, Beard DA.

PLoS One. 2014 Jun 27;9(6):e100842. doi: 10.1371/journal.pone.0100842. eCollection 2014.

38.

Arterial stiffening provides sufficient explanation for primary hypertension.

Pettersen KH, Bugenhagen SM, Nauman J, Beard DA, Omholt SW.

PLoS Comput Biol. 2014 May 22;10(5):e1003634. doi: 10.1371/journal.pcbi.1003634. eCollection 2014 May.

39.

A computational analysis of the long-term regulation of arterial pressure.

Beard DA, Pettersen KH, Carlson BE, Omholt SW, Bugenhagen SM.

Version 2. F1000Res. 2013 Oct 8 [revised 2013 Jan 1];2:208. doi: 10.12688/f1000research.2-208.v2. eCollection 2013.

40.

Analysis of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice.

Tewari SG, Bugenhagen SM, Wang Z, Schreier DA, Carlson BE, Chesler NC, Beard DA.

Front Physiol. 2013 Dec 11;4:355. doi: 10.3389/fphys.2013.00355. eCollection 2013.

41.

Rebuttal from Daniel Beard and Eric Feigl.

Beard DA, Feigl EO.

J Physiol. 2013 Dec 1;591(23):5801. doi: 10.1113/jphysiol.2013.264663. No abstract available.

42.

CrossTalk opposing view: Guyton's venous return curves should not be taught.

Beard DA, Feigl EO.

J Physiol. 2013 Dec 1;591(23):5795-7. doi: 10.1113/jphysiol.2013.260034. No abstract available.

43.

Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats.

Menzies RI, Unwin RJ, Dash RK, Beard DA, Cowley AW Jr, Carlson BE, Mullins JJ, Bailey MA.

Front Physiol. 2013 Oct 25;4:305. doi: 10.3389/fphys.2013.00305. eCollection 2013.

44.

Tautology vs. physiology in the etiology of hypertension.

Beard DA.

Physiology (Bethesda). 2013 Sep;28(5):270-1. doi: 10.1152/physiol.00038.2013. No abstract available.

45.

Analysis of the kinetics and bistability of ubiquinol:cytochrome c oxidoreductase.

Bazil JN, Vinnakota KC, Wu F, Beard DA.

Biophys J. 2013 Jul 16;105(2):343-55. doi: 10.1016/j.bpj.2013.05.033.

46.

Bridging the genotype-phenotype gap: what does it take?

Gjuvsland AB, Vik JO, Beard DA, Hunter PJ, Omholt SW.

J Physiol. 2013 Apr 15;591(8):2055-66. doi: 10.1113/jphysiol.2012.248864. Epub 2013 Feb 11. Review.

47.

Reply to "letter to the editor: a return to the venous return controversy: a visual aid for combatants'".

Beard DA, Feigl EO.

Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H489. doi: 10.1152/ajpheart.00886.2012. No abstract available.

48.

Identification of the kinetic mechanism of succinyl-CoA synthetase.

Li X, Wu F, Beard DA.

Biosci Rep. 2013 Jan 18;33(1):145-63. doi: 10.1042/BSR20120069.

49.

Specification, construction, and exact reduction of state transition system models of biochemical processes.

Bugenhagen SM, Beard DA.

J Chem Phys. 2012 Oct 21;137(15):154108. doi: 10.1063/1.4758074.

50.

A biophysical model of the mitochondrial ATP-Mg/P(i) carrier.

Tewari SG, Dash RK, Beard DA, Bazil JN.

Biophys J. 2012 Oct 3;103(7):1616-25. doi: 10.1016/j.bpj.2012.08.050. Epub 2012 Oct 2.

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