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Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis.

Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D.

Circ Res. 2019 Dec 9. doi: 10.1161/CIRCRESAHA.119.315644. [Epub ahead of print]


NINJA trial: should the nail plate be replaced or discarded after nail bed repair in children? Protocol for a multicentre randomised control trial.

Jain A, Jones A, Gardiner MD, Cooper C, Sierakowski A, Dritsaki M, Png ME, Stokes JR, Shirkey B, Cook J, Beard D, Greig AVH.

BMJ Open. 2019 Dec 4;9(12):e031552. doi: 10.1136/bmjopen-2019-031552.


The Heart by Numbers.

Campbell KS, Beard DA, Qu Z.

Biophys J. 2019 Nov 29. pii: S0006-3495(19)30933-6. doi: 10.1016/j.bpj.2019.11.010. [Epub ahead of print] No abstract available.


Determining responsiveness and meaningful changes for the Musculoskeletal Health Questionnaire (MSK-HQ) for use across musculoskeletal care pathways.

Price AJ, Ogollah R, Kang S, Hay E, Barker KL, Benedetto E, Smith S, Smith J, Galloway JB, Ellis B, Rees J, Glyn-Jones S, Beard D, Fitzpatrick R, Hill JC.

BMJ Open. 2019 Oct 3;9(10):e025357. doi: 10.1136/bmjopen-2018-025357.


Long-term rates of knee arthroplasty in a cohort of 834 393 patients with a history of arthroscopic partial meniscectomy.

Abram SGF, Judge A, Beard DJ, Carr AJ, Price AJ.

Bone Joint J. 2019 Sep;101-B(9):1071-1080. doi: 10.1302/0301-620X.101B9.BJJ-2019-0335.R1.


Longitudinal study of use and cost of subacromial decompression surgery: the need for effective evaluation of surgical procedures to prevent overtreatment and wasted resources.

Jones T, Carr AJ, Beard D, Linton MJ, Rooshenas L, Donovan J, Hollingworth W.

BMJ Open. 2019 Aug 28;9(8):e030229. doi: 10.1136/bmjopen-2019-030229.


Systematic Review of the Use of Patient Reported Outcome Measures in Studies of Electively-Managed Hand Conditions.

Lloyd-Hughes H, Geoghegan L, Rodrigues J, Peters M, Beard D, Price A, Jain A.

J Hand Surg Asian Pac Vol. 2019 Sep;24(3):329-341. doi: 10.1142/S2424835519500425.


Predictors of the effects of treatment for shoulder pain: protocol of an individual participant data meta-analysis.

van der Windt DA, Burke DL, Babatunde O, Hattle M, McRobert C, Littlewood C, Wynne-Jones G, Chesterton L, van der Heijden GJMG, Winters JC, Rhon DI, Bennell K, Roddy E, Heneghan C, Beard D, Rees JL, Riley RD.

Diagn Progn Res. 2019 Aug 8;3:15. doi: 10.1186/s41512-019-0061-x. eCollection 2019.


Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging.

Gao X, Jakovljevic DG, Beard DA.

Biophys J. 2019 Jul 2. pii: S0006-3495(19)30515-6. doi: 10.1016/j.bpj.2019.06.026. [Epub ahead of print]


Rates of Adverse Outcomes and Revision Surgery After Anterior Cruciate Ligament Reconstruction: A Study of 104,255 Procedures Using the National Hospital Episode Statistics Database for England, UK.

Abram SGF, Judge A, Beard DJ, Price AJ.

Am J Sports Med. 2019 Sep;47(11):2533-2542. doi: 10.1177/0363546519861393. Epub 2019 Jul 26.


The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial.

Beard DJ, Davies LJ, Cook JA, MacLennan G, Price A, Kent S, Hudson J, Carr A, Leal J, Campbell H, Fitzpatrick R, Arden N, Murray D, Campbell MK; TOPKAT Study Group.

Lancet. 2019 Aug 31;394(10200):746-756. doi: 10.1016/S0140-6736(19)31281-4. Epub 2019 Jul 17.


Surgical interventions for symptomatic mild to moderate knee osteoarthritis.

Palmer JS, Monk AP, Hopewell S, Bayliss LE, Jackson W, Beard DJ, Price AJ.

Cochrane Database Syst Rev. 2019 Jul 19;7:CD012128. doi: 10.1002/14651858.CD012128.pub2.


Rates of knee arthroplasty in anterior cruciate ligament reconstructed patients: a longitudinal cohort study of 111,212 procedures over 20 years.

Abram SGF, Judge A, Khan T, Beard DJ, Price AJ.

Acta Orthop. 2019 Dec;90(6):568-574. doi: 10.1080/17453674.2019.1639360. Epub 2019 Jul 10.


The Arthroplasty Candidacy Help Engine tool to select candidates for hip and knee replacement surgery: development and economic modelling.

Price A, Smith J, Dakin H, Kang S, Eibich P, Cook J, Gray A, Harris K, Middleton R, Gibbons E, Benedetto E, Smith S, Dawson J, Fitzpatrick R, Sayers A, Miller L, Marques E, Gooberman-Hill R, Blom A, Judge A, Arden N, Murray D, Glyn-Jones S, Barker K, Carr A, Beard D.

Health Technol Assess. 2019 Jun;23(32):1-216. doi: 10.3310/hta23320.


Arthroscopic meniscal surgery: a national society treatment guideline and consensus statement.

Abram SGF, Beard DJ, Price AJ; BASK Meniscal Working Group.

Bone Joint J. 2019 Jun;101-B(6):652-659. doi: 10.1302/0301-620X.101B6.BJJ-2019-0126.R1.


New guidelines for the use of arthroscopic meniscal knee surgery.

Price AJ, Haddad FS, Beard DJ.

Bone Joint J. 2019 Jun;101-B(6):625-626. doi: 10.1302/0301-620X.101B6.BJJ-2019-0550. No abstract available.


Evidence update: A summary of new evidence to inform treatment decisions for patients with meniscal lesions.

Abram SGF, Beard DJ, Hing CB, Price AJ.

Knee. 2019 Jun;26(3):521-523. doi: 10.1016/j.knee.2019.04.017. Epub 2019 May 23. No abstract available.


Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia.

Hadley G, Beard DJ, Alexopoulou Z, Sutherland BA, Buchan AM.

Neurosci Lett. 2019 Jul 27;706:223-230. doi: 10.1016/j.neulet.2019.05.023. Epub 2019 May 14.


Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

Philpott C, le Conte S, Beard D, Cook J, Sones W, Morris S, Clarke CS, Thomas M, Little P, Vennik J, Lund V, Blackshaw H, Schilder A, Durham S, Denaxas S, Carpenter J, Boardman J, Hopkins C; MACRO programme team.

Trials. 2019 Apr 29;20(1):246. doi: 10.1186/s13063-019-3314-7.


Rates of knee arthroplasty within one-year of undergoing arthroscopic partial meniscectomy in England: temporal trends, regional and age-group variation in conversion rates.

Abram SGF, Judge A, Beard DJ, Price AJ.

Osteoarthritis Cartilage. 2019 Oct;27(10):1420-1429. doi: 10.1016/j.joca.2019.03.009. Epub 2019 Apr 26.


Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme).

Blackshaw H, Vennik J, Philpott C, Thomas M, Eyles C, Carpenter J, Clarke CS, Morris S, Schilder A, Lund V, Little P, Durham S, Denaxas S, Williamson E, Beard D, Cook J, Le Conte S, Airey K, Boardman J, Hopkins C.

Trials. 2019 Apr 23;20(1):230. doi: 10.1186/s13063-019-3318-3.


Adherence monitoring of rehabilitation exercise with inertial sensors: A clinical validation study.

Bavan L, Surmacz K, Beard D, Mellon S, Rees J.

Gait Posture. 2019 May;70:211-217. doi: 10.1016/j.gaitpost.2019.03.008. Epub 2019 Mar 16.


Arthroscopic partial meniscectomy for meniscal tears of the knee: a systematic review and meta-analysis.

Abram SGF, Hopewell S, Monk AP, Bayliss LE, Beard DJ, Price AJ.

Br J Sports Med. 2019 Feb 22. pii: bjsports-2018-100223. doi: 10.1136/bjsports-2018-100223. [Epub ahead of print] Review.


Exploring variation in patient access of post-discharge physiotherapy following total hip and knee arthroplasty under a choice based system in the UK: an observational cohort study.

Hamilton DF, Loth FC, MacDonald DJ, MacFarlane GJ, Beard DJ, Simpson AHR, Patton JT, Howie CR.

BMJ Open. 2019 Feb 20;9(2):e021614. doi: 10.1136/bmjopen-2018-021614.


SUcceSS, SUrgery for Spinal Stenosis: protocol of a randomised, placebo-controlled trial.

Anderson DB, Ferreira ML, Harris IA, Davis GA, Stanford R, Beard D, Li Q, Jan S, Mobbs RJ, Maher CG, Yong R, Zammit T, Latimer J, Buchbinder R.

BMJ Open. 2019 Feb 13;9(2):e024944. doi: 10.1136/bmjopen-2018-024944.


Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial.

Palmer AJR, Ayyar Gupta V, Fernquest S, Rombach I, Dutton SJ, Mansour R, Wood S, Khanduja V, Pollard TCB, McCaskie AW, Barker KL, Andrade TJMD, Carr AJ, Beard DJ, Glyn-Jones S; FAIT Study Group.

BMJ. 2019 Feb 7;364:l185. doi: 10.1136/bmj.l185.


Anterior cruciate ligament (ACL) reconstruction and meniscal repair rates have both increased in the past 20 years in England: hospital statistics from 1997 to 2017.

Abram SGF, Price AJ, Judge A, Beard DJ.

Br J Sports Med. 2019 Jan 19. pii: bjsports-2018-100195. doi: 10.1136/bjsports-2018-100195. [Epub ahead of print]


Cost-effectiveness analysis of a placebo-controlled randomized trial evaluating the effectiveness of arthroscopic subacromial decompression in patients with subacromial shoulder pain.

Rombach I, Merritt N, Shirkey BA, Rees JL, Cook JA, Cooper C, Carr AJ, Beard DJ, Gray AM.

Bone Joint J. 2019 Jan;101-B(1):55-62. doi: 10.1302/0301-620X.101B1.BJJ-2018-0555.R1.


Patch-augmented rotator cuff surgery (PARCS) study-protocol for a feasibility study.

Cook JA, Merritt N, Rees JL, Crocker JC, Hopewell S, Dritsaki M, Beard DJ, Rangan A, Cooper C, Kottam L, Farrar-Hockley D, Thomas M, Earle R, Carr AJ.

Pilot Feasibility Stud. 2018 Dec 21;4:188. doi: 10.1186/s40814-018-0380-7. eCollection 2018.


Assessing the Validity and Utility of the Guyton Model of Arterial Blood Pressure Control.

Beard DA.

Hypertension. 2018 Dec;72(6):1272-1273. doi: 10.1161/HYPERTENSIONAHA.118.11998. No abstract available.


Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture.

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD.

PLoS One. 2018 Nov 29;13(11):e0207803. doi: 10.1371/journal.pone.0207803. eCollection 2018.


Knee replacement.

Price AJ, Alvand A, Troelsen A, Katz JN, Hooper G, Gray A, Carr A, Beard D.

Lancet. 2018 Nov 3;392(10158):1672-1682. doi: 10.1016/S0140-6736(18)32344-4. Review.


The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.

Beard DJ, Hadley G, Thurley N, Howells DW, Sutherland BA, Buchan AM.

Int J Stroke. 2019 Feb;14(2):137-145. doi: 10.1177/1747493018816503. Epub 2018 Nov 29.


High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.

Allen LA, Schmidt JR, Thompson CT, Carlson BE, Beard DA, Lombard JH.

Microcirculation. 2019 Apr;26(3):e12518. doi: 10.1111/micc.12518. Epub 2019 Jan 15.


Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics.

Kasper JD, Meyer RA, Beard DA, Wiseman RW.

Am J Physiol Regul Integr Comp Physiol. 2019 Jan 1;316(1):R76-R86. doi: 10.1152/ajpregu.00321.2018. Epub 2018 Nov 21.


Systematic review of the surgical management of rotator cuff repair with an augmentative patch: a feasibility study protocol.

Greenall G, Carr A, Beard D, Rees J, Rangan A, Merritt N, Dritsaki M, Nagra NS, Baldwin M, Hopewell S, Cook JA.

Syst Rev. 2018 Nov 13;7(1):187. doi: 10.1186/s13643-018-0851-1.


The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.

Rooshenas L, Scott LJ, Blazeby JM, Rogers CA, Tilling KM, Husbands S, Conefrey C, Mills N, Stein RC, Metcalfe C, Carr AJ, Beard DJ, Davis T, Paramasivan S, Jepson M, Avery K, Elliott D, Wilson C, Donovan JL; By-Band-Sleeve study group; CSAW study group; HAND-1 study group; Optima prelim study group; Romio feasibility study group.

J Clin Epidemiol. 2019 Feb;106:108-120. doi: 10.1016/j.jclinepi.2018.10.004. Epub 2018 Oct 16.


Rapamycin in ischemic stroke: Old drug, new tricks?

Hadley G, Beard DJ, Couch Y, Neuhaus AA, Adriaanse BA, DeLuca GC, Sutherland BA, Buchan AM.

J Cereb Blood Flow Metab. 2019 Jan;39(1):20-35. doi: 10.1177/0271678X18807309. Epub 2018 Oct 18. Review.


Temporal trends and regional variation in the rate of arthroscopic knee surgery in England: analysis of over 1.7 million procedures between 1997 and 2017. Has practice changed in response to new evidence?

Abram SGF, Judge A, Beard DJ, Wilson HA, Price AJ.

Br J Sports Med. 2019 Dec;53(24):1533-1538. doi: 10.1136/bjsports-2018-099414. Epub 2018 Oct 2.


Adverse outcomes after arthroscopic partial meniscectomy: a study of 700 000 procedures in the national Hospital Episode Statistics database for England.

Abram SGF, Judge A, Beard DJ, Price AJ.

Lancet. 2018 Nov 17;392(10160):2194-2202. doi: 10.1016/S0140-6736(18)31771-9. Epub 2018 Sep 24.


Computational model-based assessment of baroreflex function from response to Valsalva maneuver.

Kosinski SA, Carlson BE, Hummel SL, Brook RD, Beard DA.

J Appl Physiol (1985). 2018 Dec 1;125(6):1944-1967. doi: 10.1152/japplphysiol.00095.2018. Epub 2018 Sep 20.


Do computers dream of electric glomeruli?

Bukowy JD, Dayton A, Cloutier D, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

Kidney Int. 2018 Sep;94(3):635. doi: 10.1016/j.kint.2018.02.011. No abstract available.


Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.

Watt FE, Corp N, Kingsbury SR, Frobell R, Englund M, Felson DT, Levesque M, Majumdar S, Wilson C, Beard DJ, Lohmander LS, Kraus VB, Roemer F, Conaghan PG, Mason DJ; Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group.

Osteoarthritis Cartilage. 2019 Jan;27(1):23-33. doi: 10.1016/j.joca.2018.08.001. Epub 2018 Aug 18.


Can Shoulder Arthroscopy Work? (CSAW) trial - Authors' reply.

Beard DJ, Carr AJ, Cook JA.

Lancet. 2018 Jul 28;392(10144):281-282. doi: 10.1016/S0140-6736(18)30773-6. No abstract available.


Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition.

Hashimoto T, Kim GE, Tunin RS, Adesiyun T, Hsu S, Nakagawa R, Zhu G, O'Brien JJ, Hendrick JP, Davis RE, Yao W, Beard D, Hoxie HR, Wennogle LP, Lee DI, Kass DA.

Circulation. 2018 Oct 30;138(18):1974-1987. doi: 10.1161/CIRCULATIONAHA.117.030490.


Water treatment residuals as soil amendments: Examining element extractability, soil porewater concentrations and effects on earthworm behaviour and survival.

Howells AP, Lewis SJ, Beard DB, Oliver IW.

Ecotoxicol Environ Saf. 2018 Oct 30;162:334-340. doi: 10.1016/j.ecoenv.2018.06.087. Epub 2018 Jul 11.


Multiscale Computational Analysis of Right Ventricular Mechanoenergetics.

Pewowaruk RJ, Philip JL, Tewari SG, Chen CS, Nyaeme MS, Wang Z, Tabima DM, Baker AJ, Beard DA, Chesler NC.

J Biomech Eng. 2018 Aug 1;140(8). doi: 10.1115/1.4040044.


Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions.

Philip JL, Pewowaruk RJ, Chen CS, Tabima DM, Beard DA, Baker AJ, Chesler NC.

Front Physiol. 2018 Jun 27;9:731. doi: 10.3389/fphys.2018.00731. eCollection 2018.


National consensus on the definition, investigation, and classification of meniscal lesions of the knee.

Abram SGF, Beard DJ, Price AJ; BASK Meniscal Working Group.

Knee. 2018 Oct;25(5):834-840. doi: 10.1016/j.knee.2018.06.001. Epub 2018 Jul 6.


Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections.

Bukowy JD, Dayton A, Cloutier D, Manis AD, Staruschenko A, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.

J Am Soc Nephrol. 2018 Aug;29(8):2081-2088. doi: 10.1681/ASN.2017111210. Epub 2018 Jun 19.

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