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Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.

J Gene Med. 2018 Oct;20(10-11):e3050. doi: 10.1002/jgm.3050. Epub 2018 Oct 1.


Creation of zebularine-resistant human cytidine deaminase mutants to enhance the chemoprotection of hematopoietic stem cells.

Ruan H, Qiu S, Beard BC, Black ME.

Protein Eng Des Sel. 2016 Dec;29(12):573-582. Epub 2016 May 8.


VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.

BMC Bioinformatics. 2015 Jul 7;16:212. doi: 10.1186/s12859-015-0653-6.


(211)Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy.

Burtner CR, Chandrasekaran D, Santos EB, Beard BC, Adair JE, Hamlin DK, Wilbur DS, Sandmaier BM, Kiem HP.

Hum Gene Ther. 2015 Jun;26(6):399-406. doi: 10.1089/hum.2015.021.


Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.

Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL, Bridge CA, Hawkins-Daarud A, Gori JL, Born DE, Gonzalez-Cuyar LF, Silbergeld DL, Rockne RC, Storer BE, Rockhill JK, Swanson KR, Kiem HP.

J Clin Invest. 2014 Sep;124(9):4082-92. doi: 10.1172/JCI76739. Epub 2014 Aug 8.


High-throughput genomic mapping of vector integration sites in gene therapy studies.

Beard BC, Adair JE, Trobridge GD, Kiem HP.

Methods Mol Biol. 2014;1185:321-44. doi: 10.1007/978-1-4939-1133-2_22.


No evidence of clonal dominance after transplant of HOXB4-expanded cord blood cells in a nonhuman primate model.

Watts KL, Beard BC, Wood BL, Trobridge GD, Humphries RK, Adams AB, Nelson V, Kiem HP.

Exp Hematol. 2014 Jul;42(7):497-504. doi: 10.1016/j.exphem.2014.03.007. Epub 2014 Apr 2.


Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP.

Blood. 2014 Jun 5;123(23):3578-84. doi: 10.1182/blood-2013-11-538926. Epub 2014 Mar 18.


Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.

Wurm M, Kowalski J, Heckl D, Zhang XB, Nelson V, Beard BC, Kiem HP.

Exp Hematol. 2014 Feb;42(2):114-25.e4. doi: 10.1016/j.exphem.2013.10.004. Epub 2013 Oct 26.


Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.

Kiem HP, Arumugam PI, Burtner CR, Fox CF, Beard BC, Dexheimer P, Adair JE, Malik P.

Mol Ther Methods Clin Dev. 2014 Dec 17;1:14055. doi: 10.1038/mtm.2014.55. eCollection 2014.


Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model.

Younan PM, Polacino P, Kowalski JP, Peterson CW, Maurice NJ, Williams NP, Ho O, Trobridge GD, Von Laer D, Prlic M, Beard BC, DeRosa S, Hu SL, Kiem HP.

Blood. 2013 Jul 11;122(2):179-87. doi: 10.1182/blood-2013-01-482224. Epub 2013 May 29.


In vivo protection of activated Tyr22-dihydrofolate reductase gene-modified canine T lymphocytes from methotrexate.

Gori JL, Beard BC, Williams NP, Ironside C, Swanson D, Scott McIvor R, Kiem HP.

J Gene Med. 2013 Jun-Jul;15(6-7):233-41. doi: 10.1002/jgm.2713.


CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model.

Watts KL, Delaney C, Nelson V, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Mol Ther. 2013 Jun;21(6):1270-8. doi: 10.1038/mt.2013.40. Epub 2013 Apr 16.


Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques.

Berger C, Berger M, Beard BC, Kiem HP, Gooley TA, Riddell SR.

PLoS One. 2013;8(2):e56268. doi: 10.1371/journal.pone.0056268. Epub 2013 Feb 13.


Large animal models for foamy virus vector gene therapy.

Trobridge GD, Horn PA, Beard BC, Kiem HP.

Viruses. 2012 Dec 7;4(12):3572-88. doi: 10.3390/v4123572. Review.


Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.

Trobridge GD, Beard BC, Wu RA, Ironside C, Malik P, Kiem HP.

PLoS One. 2012;7(9):e45173. doi: 10.1371/journal.pone.0045173. Epub 2012 Sep 13. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/90f278b2-f474-42ec-8645-435f7006018c.


Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.

Gori JL, Chandrasekaran D, Kowalski JP, Adair JE, Beard BC, D'Souza SL, Kiem HP.

Blood. 2012 Sep 27;120(13):e35-44. Epub 2012 Aug 16.


Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities.

Adair JE, Zhao X, Chien S, Fang M, Wohlfahrt ME, Trobridge GD, Taylor JA, Beard BC, Kiem HP, Becker PS.

J Mol Med (Berl). 2012 Nov;90(11):1283-94. doi: 10.1007/s00109-012-0905-0. Epub 2012 Jun 3.


In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model.

Gori JL, Beard BC, Ironside C, Karponi G, Kiem HP.

Cancer Gene Ther. 2012 Aug;19(8):523-9. doi: 10.1038/cgt.2012.25. Epub 2012 May 25.


Extended survival of glioblastoma patients after chemoprotective HSC gene therapy.

Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL, Mrugala MM, Kiem HP.

Sci Transl Med. 2012 May 9;4(133):133ra57. doi: 10.1126/scitranslmed.3003425.


Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.

Watts KL, Nelson V, Wood BL, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Exp Hematol. 2012 Mar;40(3):187-96. doi: 10.1016/j.exphem.2011.11.009. Epub 2011 Dec 8.


Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.

Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP.

Nucleic Acids Res. 2012 Jan;40(2):e14. doi: 10.1093/nar/gkr897. Epub 2011 Nov 21.


Corrigendum to "Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs".

Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Torok-Storb B, Kiem HP, Blau CA.

Mol Ther. 2011 Nov;19(11):2102. doi: 10.1038/mt.2011.180. Epub 2016 Dec 6. No abstract available.


Differential effects of HOXB4 and NUP98-HOXA10hd on hematopoietic repopulating cells in a nonhuman primate model.

Watts KL, Zhang X, Beard BC, Chiu SY, Trobridge GD, Humphries RK, Kiem HP.

Hum Gene Ther. 2011 Dec;22(12):1475-82. doi: 10.1089/hum.2011.100. Epub 2011 Sep 6.


Long-term regulation of genetically modified primary hematopoietic cells in dogs.

Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Torok-Storb B, Kiem HP, Blau CA.

Mol Ther. 2011 Jul;19(7):1287-94. doi: 10.1038/mt.2011.8. Epub 2011 Feb 15. Erratum in: Mol Ther. 2011 Nov;19(11):2102. Torok-Storb, Beverly [added].


Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.

Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem HP.

J Clin Invest. 2010 Jul;120(7):2345-54. doi: 10.1172/JCI40767. Epub 2010 Jun 14.


Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector.

Becker PS, Taylor JA, Trobridge GD, Zhao X, Beard BC, Chien S, Adair J, Kohn DB, Wagner JE, Shimamura A, Kiem HP.

Gene Ther. 2010 Oct;17(10):1244-52. doi: 10.1038/gt.2010.62. Epub 2010 May 20.


A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells.

Kiem HP, Ironside C, Beard BC, Trobridge GD.

Exp Hematol. 2010 Sep;38(9):819-22, 822.e1-3. doi: 10.1016/j.exphem.2010.04.014. Epub 2010 Apr 29.


Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells.

Trobridge GD, Wu RA, Hansen M, Ironside C, Watts KL, Olsen P, Beard BC, Kiem HP.

Mol Ther. 2010 Apr;18(4):725-33. doi: 10.1038/mt.2009.282. Epub 2009 Dec 8.


Stable marking and transgene expression without progression to monoclonality in canine long-term hematopoietic repopulating cells transduced with lentiviral vectors.

Enssle J, Trobridge GD, Keyser KA, Ironside C, Beard BC, Kiem HP.

Hum Gene Ther. 2010 Apr;21(4):397-403. doi: 10.1089/hum.2009.076.


Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.

Trobridge GD, Wu RA, Beard BC, Chiu SY, Muñoz NM, von Laer D, Rossi JJ, Kiem HP.

PLoS One. 2009 Nov 2;4(11):e7693. doi: 10.1371/journal.pone.0007693.


Myeloablative irradiation in non-human primates.

Watts KL, Beard BC, Wood BL, Kiem HP.

J Med Primatol. 2009 Dec;38(6):425-32. doi: 10.1111/j.1600-0684.2009.00368.x. Epub 2009 Jul 22.


Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model.

Thakar MS, Zhang XB, Beard BC, Sale GE, Santos EB, Peterson L, Kiem HP, Sandmaier BM.

Exp Hematol. 2009 Oct;37(10):1157-66. doi: 10.1016/j.exphem.2009.07.004. Epub 2009 Jul 17.


Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients.

Beard BC, Sud R, Keyser KA, Ironside C, Neff T, Gerull S, Trobridge GD, Kiem HP.

Blood. 2009 May 21;113(21):5094-103. doi: 10.1182/blood-2008-09-176412. Epub 2009 Mar 31.


Canine models of gene-modified hematopoiesis.

Beard BC, Kiem HP.

Methods Mol Biol. 2009;506:341-61. doi: 10.1007/978-1-59745-409-4_23.


NOD/SCID repopulating cells contribute only to short-term repopulation in the baboon.

Mezquita P, Beard BC, Kiem HP.

Gene Ther. 2008 Nov;15(21):1460-2. doi: 10.1038/gt.2008.108. Epub 2008 Jun 19.


Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors.

Trobridge GD, Beard BC, Gooch C, Wohlfahrt M, Olsen P, Fletcher J, Malik P, Kiem HP.

Blood. 2008 Jun 15;111(12):5537-43. doi: 10.1182/blood-2007-09-115022. Epub 2008 Apr 3.


High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector.

Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK, Kiem HP.

J Clin Invest. 2008 Apr;118(4):1502-10. doi: 10.1172/JCI34371.


Hematopoietic stem cell engraftment: a direct comparison between intramarrow and intravenous injection in nonhuman primates.

Jung CW, Beard BC, Morris JC, Neff T, Beebe K, Storer BE, Kiem HP.

Exp Hematol. 2007 Jul;35(7):1132-9.


Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus.

Beard BC, Keyser KA, Trobridge GD, Peterson LJ, Miller DG, Jacobs M, Kaul R, Kiem HP.

Hum Gene Ther. 2007 May;18(5):423-34.


Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells.

Beard BC, Dickerson D, Beebe K, Gooch C, Fletcher J, Okbinoglu T, Miller DG, Jacobs MA, Kaul R, Kiem HP, Trobridge GD.

Mol Ther. 2007 Jul;15(7):1356-65. Epub 2007 Apr 17.


Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells.

Zhang XB, Beard BC, Beebe K, Storer B, Humphries RK, Kiem HP.

PLoS Med. 2006 May;3(5):e173. Epub 2006 May 2.


Hematopoietic stem cell transduction and amplification in large animal models.

Trobridge G, Beard BC, Kiem HP.

Hum Gene Ther. 2005 Dec;16(12):1355-66.


Survival of the fittest: in vivo selection and stem cell gene therapy.

Neff T, Beard BC, Kiem HP.

Blood. 2006 Mar 1;107(5):1751-60. Epub 2005 Nov 3. Review.


Electron spectroscopy and microscopy applied to chemical and structural analysis of hair.

Beard BC, Johnson A, Cambria FM, Trinh PN.

J Cosmet Sci. 2005 Jan-Feb;56(1):65-77.


Base excision repair in nucleosomes lacking histone tails.

Beard BC, Stevenson JJ, Wilson SH, Smerdon MJ.

DNA Repair (Amst). 2005 Feb 3;4(2):203-9.


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