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Lidocaine binding enhances inhibition of Nav1.7 channels by the sulfonamide PF-05089771.

Jo S, Bean BP.

Mol Pharmacol. 2020 Mar 19. pii: mol.119.118380. doi: 10.1124/mol.119.118380. [Epub ahead of print]


Vagal sensory neurons drive mucous cell metaplasia.

Talbot S, Doyle B, Huang J, Wang JC, Ahmadi M, Roberson DP, Yekkirala A, Foster SL, Browne LE, Bean BP, Levy BD, Woolf CJ.

J Allergy Clin Immunol. 2020 Jan 16. pii: S0091-6749(20)30037-3. doi: 10.1016/j.jaci.2020.01.003. [Epub ahead of print] No abstract available.


Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.

Lee S, Jo S, Talbot S, Zhang HB, Kotoda M, Andrews NA, Puopolo M, Liu PW, Jacquemont T, Pascal M, Heckman LM, Jain A, Lee J, Woolf CJ, Bean BP.

Elife. 2019 Nov 25;8. pii: e48118. doi: 10.7554/eLife.48118.


Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.

Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD.

Neuron. 2019 Aug 21;103(4):598-616.e7. doi: 10.1016/j.neuron.2019.05.039. Epub 2019 Jun 24.


The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.

Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG.

Cell Rep. 2019 Feb 26;26(9):2289-2297.e3. doi: 10.1016/j.celrep.2019.01.114.


Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons.

Hu W, Bean BP.

Neuron. 2018 Sep 19;99(6):1355. doi: 10.1016/j.neuron.2018.08.042. No abstract available.


Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons.

Hu W, Bean BP.

Neuron. 2018 Mar 21;97(6):1315-1326.e3. doi: 10.1016/j.neuron.2018.02.016. Epub 2018 Mar 8. Erratum in: Neuron. 2018 Sep 19;99(6):1355.


Breaking barriers to novel analgesic drug development.

Yekkirala AS, Roberson DP, Bean BP, Woolf CJ.

Nat Rev Drug Discov. 2017 Nov;16(11):810. doi: 10.1038/nrd.2017.202. Epub 2017 Oct 6.


Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.

Liu PW, Blair NT, Bean BP.

J Neurosci. 2017 Oct 4;37(40):9705-9714. doi: 10.1523/JNEUROSCI.1703-17.2017. Epub 2017 Sep 6.


Breaking barriers to novel analgesic drug development.

Yekkirala AS, Roberson DP, Bean BP, Woolf CJ.

Nat Rev Drug Discov. 2017 Aug;16(8):545-564. doi: 10.1038/nrd.2017.87. Epub 2017 Jun 9. Review. Erratum in: Nat Rev Drug Discov. 2017 Oct 06;:.


Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling.

Gantz SC, Bean BP.

Neuron. 2017 Mar 22;93(6):1375-1387.e2. doi: 10.1016/j.neuron.2017.02.025. Epub 2017 Mar 2.


Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States.

Jo S, Bean BP.

Mol Pharmacol. 2017 Apr;91(4):277-286. doi: 10.1124/mol.116.106401. Epub 2017 Jan 24.


Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.

Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R.

Elife. 2016 Apr 13;5. pii: e15751. doi: 10.7554/eLife.15751.


Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons.

Kimm T, Khaliq ZM, Bean BP.

J Neurosci. 2015 Dec 16;35(50):16404-17. doi: 10.1523/JNEUROSCI.5291-14.2015.


Pore dilation reconsidered.

Bean BP.

Nat Neurosci. 2015 Nov;18(11):1534-5. doi: 10.1038/nn.4148. No abstract available.


Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.

Yamada-Hanff J, Bean BP.

J Neurophysiol. 2015 Oct;114(4):2376-89. doi: 10.1152/jn.00489.2015. Epub 2015 Aug 19.


Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ.

Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.


Inhibition of A-type potassium current by the peptide toxin SNX-482.

Kimm T, Bean BP.

J Neurosci. 2014 Jul 9;34(28):9182-9. doi: 10.1523/JNEUROSCI.0339-14.2014.


Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ.

Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3.


Sidedness of carbamazepine accessibility to voltage-gated sodium channels.

Jo S, Bean BP.

Mol Pharmacol. 2014 Feb;85(2):381-7. doi: 10.1124/mol.113.090472. Epub 2013 Dec 6.


Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.

Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466.


Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation.

Yamada-Hanff J, Bean BP.

J Neurosci. 2013 Sep 18;33(38):15011-21. doi: 10.1523/JNEUROSCI.0577-13.2013.


Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.

Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ.

Nat Neurosci. 2013 Jul;16(7):910-8. doi: 10.1038/nn.3404. Epub 2013 May 19.


Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.

Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP.

J Neurophysiol. 2013 Apr;109(7):1704-12. doi: 10.1152/jn.00012.2013. Epub 2013 Jan 9.


Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

J Neurosci. 2013 Jan 2;33(1):315-26. doi: 10.1523/JNEUROSCI.2804-12.2013.


Transient sodium current at subthreshold voltages: activation by EPSP waveforms.

Carter BC, Giessel AJ, Sabatini BL, Bean BP.

Neuron. 2012 Sep 20;75(6):1081-93. doi: 10.1016/j.neuron.2012.08.033. Erratum in: Neuron. 2015 Aug 19;87(4):906.


Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.

Liu P, Jo S, Bean BP.

J Neurophysiol. 2012 Jun;107(11):3155-67. doi: 10.1152/jn.00785.2011. Epub 2012 Mar 21.


Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors.

Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ.

J Gen Physiol. 2011 Jul;138(1):59-72. doi: 10.1085/jgp.201110614. Epub 2011 Jun 13.


Inhibition of neuronal voltage-gated sodium channels by brilliant blue G.

Jo S, Bean BP.

Mol Pharmacol. 2011 Aug;80(2):247-57. doi: 10.1124/mol.110.070276. Epub 2011 May 2.


Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.

Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ.

Br J Pharmacol. 2011 Sep;164(1):48-58. doi: 10.1111/j.1476-5381.2011.01391.x.


Incomplete inactivation and rapid recovery of voltage-dependent sodium channels during high-frequency firing in cerebellar Purkinje neurons.

Carter BC, Bean BP.

J Neurophysiol. 2011 Feb;105(2):860-71. doi: 10.1152/jn.01056.2010. Epub 2010 Dec 15.


Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse.

Milescu LS, Bean BP, Smith JC.

J Neurosci. 2010 Jun 2;30(22):7740-8. doi: 10.1523/JNEUROSCI.6136-09.2010.


Selectively targeting pain in the trigeminal system.

Kim HY, Kim K, Li HY, Chung G, Park CK, Kim JS, Jung SJ, Lee MK, Ahn DK, Hwang SJ, Kang Y, Binshtok AM, Bean BP, Woolf CJ, Oh SB.

Pain. 2010 Jul;150(1):29-40. doi: 10.1016/j.pain.2010.02.016. Epub 2010 Mar 16.


Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies.

Cannon SC, Bean BP.

J Clin Invest. 2010 Jan;120(1):80-3. doi: 10.1172/JCI41340. Epub 2009 Dec 28.


Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.

Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ.

Anesthesiology. 2009 Jul;111(1):127-37. doi: 10.1097/ALN.0b013e3181a915e7.


Inhibition by an excitatory conductance: a paradox explained.

Bean BP.

Nat Neurosci. 2009 May;12(5):530-2. doi: 10.1038/nn0509-530. No abstract available.


Nociceptors are interleukin-1beta sensors.

Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA.

J Neurosci. 2008 Dec 24;28(52):14062-73. doi: 10.1523/JNEUROSCI.3795-08.2008.


Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve.

Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK.

Anesthesiology. 2008 Nov;109(5):872-8. doi: 10.1097/ALN.0b013e31818958f7.


Dynamic, nonlinear feedback regulation of slow pacemaking by A-type potassium current in ventral tegmental area neurons.

Khaliq ZM, Bean BP.

J Neurosci. 2008 Oct 22;28(43):10905-17. doi: 10.1523/JNEUROSCI.2237-08.2008.


Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Binshtok AM, Bean BP, Woolf CJ.

Nature. 2007 Oct 4;449(7162):607-10.


Neurophysiology: stressful pacemaking.

Bean BP.

Nature. 2007 Jun 28;447(7148):1059-60. No abstract available.


The action potential in mammalian central neurons.

Bean BP.

Nat Rev Neurosci. 2007 Jun;8(6):451-65. Review.


Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin.

Martina M, Metz AE, Bean BP.

J Neurophysiol. 2007 Jan;97(1):563-71. Epub 2006 Oct 25.


Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb.

Puopolo M, Bean BP, Raviola E.

J Neurophysiol. 2005 Nov;94(5):3618-27. Epub 2005 Jul 20.

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