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Items: 1 to 50 of 86

1.

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL.

Genome Biol. 2015 Sep 17;16:194. doi: 10.1186/s13059-015-0748-4.

2.

Cellular senescence mediated by p16INK4A-coupled miRNA pathways.

Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH, Bishop CL.

Nucleic Acids Res. 2014 Feb;42(3):1606-18. doi: 10.1093/nar/gkt1096. Epub 2013 Nov 11.

3.

The villain team-up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert.

Fichorova RN, Buck OR, Yamamoto HS, Fashemi T, Dawood HY, Fashemi B, Hayes GR, Beach DH, Takagi Y, Delaney ML, Nibert ML, Singh BN, Onderdonk AB.

Sex Transm Infect. 2013 Sep;89(6):460-6. doi: 10.1136/sextrans-2013-051052. Epub 2013 Jul 31.

4.

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.

Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE.

Cell. 2013 Jan 17;152(1-2):340-51. doi: 10.1016/j.cell.2012.12.010.

5.

Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy.

Fichorova RN, Lee Y, Yamamoto HS, Takagi Y, Hayes GR, Goodman RP, Chepa-Lotrea X, Buck OR, Murray R, Kula T, Beach DH, Singh BN, Nibert ML.

PLoS One. 2012;7(11):e48418. doi: 10.1371/journal.pone.0048418. Epub 2012 Nov 7.

6.

A whole genome screen for HIV restriction factors.

Liu L, Oliveira NM, Cheney KM, Pade C, Dreja H, Bergin AM, Borgdorff V, Beach DH, Bishop CL, Dittmar MT, McKnight A.

Retrovirology. 2011 Nov 14;8:94. doi: 10.1186/1742-4690-8-94.

7.

Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae).

Goodman RP, Freret TS, Kula T, Geller AM, Talkington MW, Tang-Fernandez V, Suciu O, Demidenko AA, Ghabrial SA, Beach DH, Singh BN, Fichorova RN, Nibert ML.

J Virol. 2011 May;85(9):4258-70. doi: 10.1128/JVI.00220-11. Epub 2011 Feb 23.

8.

Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).

Bishop CL, Bergin AM, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J, Beach DH.

Mol Cell. 2010 Nov 24;40(4):533-47. doi: 10.1016/j.molcel.2010.10.027.

9.

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1).

Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG, Beach DH.

Oncogene. 2010 Apr 15;29(15):2262-71. doi: 10.1038/onc.2009.497. Epub 2010 Jan 25.

PMID:
20101223
10.

Induction of human host cell apoptosis by Trichomonas vaginalis cysteine proteases is modulated by parasite exposure to iron.

Kummer S, Hayes GR, Gilbert RO, Beach DH, Lucas JJ, Singh BN.

Microb Pathog. 2008 Mar;44(3):197-203. Epub 2007 Oct 6.

PMID:
18024074
11.

Cellular senescence bypass screen identifies new putative tumor suppressor genes.

Leal JF, Fominaya J, Cascón A, Guijarro MV, Blanco-Aparicio C, Lleonart M, Castro ME, Ramon Y Cajal S, Robledo M, Beach DH, Carnero A.

Oncogene. 2008 Mar 27;27(14):1961-70. Epub 2007 Oct 29.

PMID:
17968325
12.

EMX homeobox genes regulate microphthalmia and alter melanocyte biology.

Bordogna W, Hudson JD, Buddle J, Bennett DC, Beach DH, Carnero A.

Exp Cell Res. 2005 Nov 15;311(1):27-38. Epub 2005 Sep 27.

PMID:
16197942
13.

In vitro cytopathic effects of a cysteine protease of Tritrichomonas foetus on cultured bovine uterine epithelial cells.

Singh BN, Hayes GR, Lucas JJ, Beach DH, Gilbert RO.

Am J Vet Res. 2005 Jul;66(7):1181-6.

PMID:
16111156
14.

Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells.

Sommer U, Costello CE, Hayes GR, Beach DH, Gilbert RO, Lucas JJ, Singh BN.

J Biol Chem. 2005 Jun 24;280(25):23853-60. Epub 2005 Apr 20.

15.

Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells.

Singh BN, Lucas JJ, Hayes GR, Kumar I, Beach DH, Frajblat M, Gilbert RO, Sommer U, Costello CE.

Infect Immun. 2004 Jul;72(7):4151-8.

16.
17.

Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT.

Worsham DN, Basselin M, Smulian AG, Beach DH, Kaneshiro ES.

J Eukaryot Microbiol. 2003;50 Suppl:678-9. No abstract available.

PMID:
14736216
18.

Myc confers androgen-independent prostate cancer cell growth.

Bernard D, Pourtier-Manzanedo A, Gil J, Beach DH.

J Clin Invest. 2003 Dec;112(11):1724-31.

19.

Comprehensive and definitive structural identities of Pneumocystis carinii sterols.

Giner JL, Zhao H, Beach DH, Parish EJ, Jayasimhulu K, Kaneshiro ES.

J Lipid Res. 2002 Jul;43(7):1114-24.

20.

Definitive structural identities of 42 sterol components in Pneumocystis carinii.

Giner JL, Beach DH, Parish EJ, Jayasimhulu K, Kaneshiro ES.

J Eukaryot Microbiol. 2001;Suppl:142S-143S. No abstract available.

PMID:
11906032
21.

Acidic glycerol lipids of Trichomonas vaginalis and Tritrichomonas foetus.

Costello CE, Beach DH, Singh BN.

Biol Chem. 2001 Feb;382(2):275-82.

PMID:
11308025
22.

Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

Carnero A, Hudson JD, Hannon GJ, Beach DH.

Nucleic Acids Res. 2000 Jun 1;28(11):2234-41.

23.

Risky immortalization by telomerase.

Wang J, Hannon GJ, Beach DH.

Nature. 2000 Jun 15;405(6788):755-6. No abstract available.

PMID:
10866187
24.

Cytopathogenic effect of Trichomonas vaginalis on human vaginal epithelial cells cultured in vitro.

Gilbert RO, Elia G, Beach DH, Klaessig S, Singh BN.

Infect Immun. 2000 Jul;68(7):4200-6.

25.

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization.

Carnero A, Hudson JD, Price CM, Beach DH.

Nat Cell Biol. 2000 Mar;2(3):148-55.

PMID:
10707085
26.

A proinflammatory cytokine inhibits p53 tumor suppressor activity.

Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, Beach DH.

J Exp Med. 1999 Nov 15;190(10):1375-82.

27.

Twist is a potential oncogene that inhibits apoptosis.

Maestro R, Dei Tos AP, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L, Doglioni C, Beach DH, Hannon GJ.

Genes Dev. 1999 Sep 1;13(17):2207-17.

28.

Adhesion of Tritrichomonas foetus to bovine vaginal epithelial cells.

Singh BN, Lucas JJ, Beach DH, Shin ST, Gilbert RO.

Infect Immun. 1999 Aug;67(8):3847-54.

29.

Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis.

Kaneshiro ES, Amit Z, Swonger MM, Kreishman GP, Brooks EE, Kreishman M, Jayasimhulu K, Parish EJ, Sun H, Kizito SA, Beach DH.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):97-102.

30.

Characterizations of Pneumocystis carinii and rat lung lipids: glyceryl ethers and fatty alcohols.

Kaneshiro ES, Guo Z, Sul D, Kallam KA, Jayasimhulu K, Beach DH.

J Lipid Res. 1998 Oct;39(10):1907-17.

31.

Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator.

Perkins ND, Felzien LK, Betts JC, Leung K, Beach DH, Nabel GJ.

Science. 1997 Jan 24;275(5299):523-7.

32.

Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii.

Beach DH, Chen F, Cushion MT, Macomber RS, Krudy GA, Wyder MA, Kaneshiro ES.

Antimicrob Agents Chemother. 1997 Jan;41(1):162-8.

33.

Identification of C31 and C32 sterols in Pneumocystis carinii hominis-infected human lungs.

Kaneshiro ES, Swonger M, Kreishman G, Brooks E, Jayasimhulu K, Parish EJ, Beach DH.

J Eukaryot Microbiol. 1996 Sep-Oct;43(5):36S.

PMID:
8822839
35.

Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22.

Demetrick DJ, Zhang H, Beach DH.

Cytogenet Cell Genet. 1996;73(3):250-4.

PMID:
8697818
36.
37.

Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).

Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH.

Cytogenet Cell Genet. 1995;69(3-4):190-2.

PMID:
7698009
38.

Mutations and altered expression of p16INK4 in human cancer.

Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH, et al.

Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11045-9.

39.

Expression of a novel cell surface lipophosphoglycan-like glycoconjugate in Trypanosoma cruzi epimastigotes.

Singh BN, Lucas JJ, Beach DH, Costello CE.

J Biol Chem. 1994 Sep 2;269(35):21972-82.

40.

Isoprenoid metabolism in Pneumocystis carinii.

Kaneshiro ES, Ellis JE, Zhou LH, Rudney H, Gupta A, Jayasimhulu K, Setchell KD, Beach DH.

J Eukaryot Microbiol. 1994 Sep-Oct;41(5):93S. No abstract available.

PMID:
7804289
41.
42.

Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.

Demetrick DJ, Zhang H, Beach DH.

Cytogenet Cell Genet. 1994;66(1):72-4.

PMID:
8275715
43.

Evidence for the presence of "metabolic sterols" in Pneumocystis: identification and initial characterization of Pneumocystis carinii sterols.

Kaneshiro ES, Ellis JE, Jayasimhulu K, Beach DH.

J Eukaryot Microbiol. 1994 Jan-Feb;41(1):78-85.

PMID:
8124270
44.

Chromosome mapping of human CDC25A and CDC25B phosphatases.

Demetrick DJ, Beach DH.

Genomics. 1993 Oct;18(1):144-7.

PMID:
8276402
45.

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

Jans DA, Ackermann MJ, Bischoff JR, Beach DH, Peters R.

J Cell Biol. 1991 Dec;115(5):1203-12.

46.

Structures of glycophosphosphingolipids of Tritrichomonas foetus: a novel glycophosphosphingolipid.

Singh BN, Costello CE, Beach DH.

Arch Biochem Biophys. 1991 May 1;286(2):409-18.

PMID:
1897966
47.

Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats.

Yamauchi S, Linscheer WG, Beach DH.

Am J Physiol. 1991 Apr;260(4 Pt 1):G625-30.

PMID:
2018137
48.

Phospholipid metabolism of cultured Trichomonas vaginalis and Tritrichomonas foetus.

Beach DH, Holz GG Jr, Singh BN, Lindmark DG.

Mol Biochem Parasitol. 1991 Jan;44(1):97-108.

PMID:
2011157
50.

Fatty acid and sterol metabolism of cultured Trichomonas vaginalis and Tritrichomonas foetus.

Beach DH, Holz GG Jr, Singh BN, Lindmark DG.

Mol Biochem Parasitol. 1990 Jan 15;38(2):175-90.

PMID:
2325705

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