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Items: 23


Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N.

Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6.


Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y.

Dis Model Mech. 2018 Sep 27;11(9). pii: dmm035634. doi: 10.1242/dmm.035634.


A practical multi-step synthesis of ethyl N-functionalized [Formula: see text]-amino benzimidazole acrylate derivatives as promising cytotoxic agents.

Ambeu CN, Le Guével R, Corlu A, Mamyrbekova JA, Bazureau JP.

Mol Divers. 2018 Aug;22(3):685-708. doi: 10.1007/s11030-018-9824-5. Epub 2018 Apr 5.


Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors.

Dago CD, Maux PL, Roisnel T, Brigaudeau C, Bekro YA, Mignen O, Bazureau JP.

Int J Mol Sci. 2018 Mar 14;19(3). pii: E856. doi: 10.3390/ijms19030856.


Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, Davis RA, Alencar A, Roué M, Bourguet-Kondracki ML, Proksch P, Limanton E, Guiheneuf S, Carreaux F, Bazureau JP, Klautau M, Meijer L.

Mar Drugs. 2017 Oct 17;15(10). pii: E316. doi: 10.3390/md15100316. Review.


Evolution of DMSP (dimethylsulfoniopropionate) biosynthesis pathway: Origin and phylogenetic distribution in polyploid Spartina (Poaceae, Chloridoideae).

Rousseau H, Rousseau-Gueutin M, Dauvergne X, Boutte J, Simon G, Marnet N, Bouchereau A, Guiheneuf S, Bazureau JP, Morice J, Ravanel S, Cabello-Hurtado F, Ainouche A, Salmon A, Wendel JF, Ainouche ML.

Mol Phylogenet Evol. 2017 Sep;114:401-414. doi: 10.1016/j.ympev.2017.07.003. Epub 2017 Jul 8.


Sample preparation for an optimized extraction of localized metabolites in lichens: Application to Pseudevernia furfuracea.

Komaty S, Letertre M, Dang HD, Jungnickel H, Laux P, Luch A, Carrié D, Merdrignac-Conanec O, Bazureau JP, Gauffre F, Tomasi S, Paquin L.

Talanta. 2016 Apr 1;150:525-30. doi: 10.1016/j.talanta.2015.12.081. Epub 2015 Dec 31.


Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice.

Naert G, Ferré V, Meunier J, Keller E, Malmström S, Givalois L, Carreaux F, Bazureau JP, Maurice T.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82. doi: 10.1016/j.euroneuro.2015.03.018. Epub 2015 Apr 10.


Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases.

Dago CD, Ambeu CN, Coulibaly WK, Békro YA, Mamyrbékova J, Defontaine A, Baratte B, Bach S, Ruchaud S, Guével RL, Ravache M, Corlu A, Bazureau JP.

Molecules. 2015 Jul 8;20(7):12412-35. doi: 10.3390/molecules200712412.


Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.

Brun E, Safer A, Carreaux F, Bourahla K, L'helgoua'ch JM, Bazureau JP, Villalgordo JM.

Molecules. 2015 Jun 23;20(6):11617-31. doi: 10.3390/molecules200611617.


New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Guiheneuf S, Paquin L, Carreaux F, Durieu E, Roisnel T, Meijer L, Bazureau JP.

Mol Divers. 2014 May;18(2):375-88. doi: 10.1007/s11030-014-9509-7. Epub 2014 Mar 2.


cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L.

Mol Pharmacol. 2014 Mar;85(3):441-50. doi: 10.1124/mol.113.090837. Epub 2013 Dec 23.


Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.

Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP.

Eur J Med Chem. 2013 Apr;62:728-37. doi: 10.1016/j.ejmech.2013.01.035. Epub 2013 Feb 6.


Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation.

Coulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP.

Sci Pharm. 2012 Oct-Dec;80(4):825-36. doi: 10.3797/scipharm.1206-04. Epub 2012 Sep 16.


Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases.

Coulibaly WK, Paquin L, Bénie A, Bekro YA, Durieu E, Meijer L, Bazureau JP.

Eur J Med Chem. 2012 Dec;58:581-90. doi: 10.1016/j.ejmech.2012.08.044. Epub 2012 Sep 7.


Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L.

J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8.


An efficient approach to dispacamide A and its derivatives.

Guihéneuf S, Paquin L, Carreaux F, Durieu E, Meijer L, Bazureau JP.

Org Biomol Chem. 2012 Feb 7;10(5):978-87. doi: 10.1039/c1ob06161e. Epub 2011 Dec 8.


A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives.

Bourahla K, Paquin L, Lozach O, Meijer L, Carreaux F, Bazureau JP.

Molecules. 2011 Aug 30;16(9):7377-90. doi: 10.3390/molecules16097377.


Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP.

J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26.


Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.

Debdab M, Renault S, Lozach O, Meijer L, Paquin L, Carreaux F, Bazureau JP.

Eur J Med Chem. 2010 Feb;45(2):805-10. doi: 10.1016/j.ejmech.2009.10.009. Epub 2009 Oct 12.


Parallel solution-phase synthesis of 2-alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by one-pot three-component domino reaction.

Renault S, Bertrand S, Carreaux F, Bazureau JP.

J Comb Chem. 2007 Nov-Dec;9(6):935-42. Epub 2007 Sep 7.


Liquid-phase synthesis of polyhydroquinoline using task-specific ionic liquid technology.

Legeay JC, Goujon JY, Vanden Eynde JJ, Toupet L, Bazureau JP.

J Comb Chem. 2006 Nov-Dec;8(6):829-33.


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