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Items: 1 to 50 of 146

1.

How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid.

Bazinet RP, Bernoud-Hubac N, Lagarde M.

Prostaglandins Leukot Essent Fatty Acids. 2019 Mar;142:1-3. doi: 10.1016/j.plefa.2018.12.003. Epub 2018 Dec 25. Review.

PMID:
30773208
2.

DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol.

Chouinard-Watkins R, Lacombe RJS, Metherel AH, Masoodi M, Bazinet RP.

Mol Nutr Food Res. 2019 Feb 15:e1801224. doi: 10.1002/mnfr.201801224. [Epub ahead of print]

PMID:
30768751
3.

DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats.

Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP.

J Nutr. 2019 Feb 2. doi: 10.1093/jn/nxy282. [Epub ahead of print]

PMID:
30715388
4.

Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

J Lipid Res. 2019 Feb;60(2):412-420. doi: 10.1194/jlr.M090373. Epub 2018 Dec 20.

PMID:
30573561
5.

Brain oxylipin concentrations following hypercapnia / ischemia: effects of brain dissection and dissection time.

Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY.

J Lipid Res. 2018 Nov 21. pii: jlr.D084228. doi: 10.1194/jlr.D084228. [Epub ahead of print]

6.

ACSL6 is critical for maintaining brain DHA levels.

Chouinard-Watkins R, Bazinet RP.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12343-12345. doi: 10.1073/pnas.1817557115. Epub 2018 Nov 16. No abstract available.

PMID:
30446610
7.

Dietary fatty acids augment tissue levels of n-acylethanolamines in n-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout mice.

Lin L, Metherel AH, Kitson AP, Alashmali SM, Hopperton KE, Trépanier MO, Jones PJ, Bazinet RP.

J Nutr Biochem. 2018 Dec;62:134-142. doi: 10.1016/j.jnutbio.2018.08.015. Epub 2018 Sep 5.

PMID:
30290332
8.

Applying stable carbon isotopic analysis at the natural abundance level to determine the origin of docosahexaenoic acid in the brain of the fat-1 mouse.

Giuliano V, Lacombe RJS, Hopperton KE, Bazinet RP.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov;1863(11):1388-1398. doi: 10.1016/j.bbalip.2018.07.014. Epub 2018 Jul 31.

PMID:
30075211
9.

Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State.

Lin YH, Hibbeln JR, Domenichiello AF, Ramsden CE, Salem NM, Chen CT, Jin H, Courville AB, Majchrzak-Hong SF, Rapoport SI, Bazinet RP, Miller BV 3rd.

Lipids. 2018 May;53(5):547-558. doi: 10.1002/lipd.12055. Epub 2018 Aug 3.

PMID:
30074625
10.

Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation.

Metherel AH, Lacombe RJS, Aristizabal Henao JJ, Morin-Rivron D, Kitson AP, Hopperton KE, Chalil D, Masoodi M, Stark KD, Bazinet RP.

J Nutr Biochem. 2018 Oct;60:24-34. doi: 10.1016/j.jnutbio.2018.07.002. Epub 2018 Jul 5.

PMID:
30041049
11.

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes.

Johnston LW, Liu Z, Retnakaran R, Zinman B, Giacca A, Harris SB, Bazinet RP, Hanley AJ.

J Lipid Res. 2018 Sep;59(9):1751-1762. doi: 10.1194/jlr.P084970. Epub 2018 Jul 9.

PMID:
29986954
12.

Natural Abundance Carbon Isotopic Analysis Indicates the Equal Contribution of Local Synthesis and Plasma Uptake to Palmitate Levels in the Mouse Brain.

Lacombe RJS, Giuliano V, Chouinard-Watkins R, Bazinet RP.

Lipids. 2018 May;53(5):481-490. doi: 10.1002/lipd.12046. Epub 2018 Jun 20.

PMID:
29923600
13.

Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection.

Trépanier MO, Hopperton KE, Giuliano V, Masoodi M, Bazinet RP.

Neurochem Int. 2018 Sep;118:115-126. doi: 10.1016/j.neuint.2018.05.010. Epub 2018 May 22.

PMID:
29792954
14.

Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.

Trépanier MO, Hildebrand KD, Nyamoya SD, Amor S, Bazinet RP, Kipp M.

J Neurochem. 2018 Jun;145(6):504-515. doi: 10.1111/jnc.14335. Epub 2018 Jun 10.

PMID:
29574981
15.

Alterations in peripheral fatty acid composition in bipolar and unipolar depression.

Scola G, Versace A, Metherel AH, Monsalve-Castro LA, Phillips ML, Bazinet RP, Andreazza AC.

J Affect Disord. 2018 Jun;233:86-91. doi: 10.1016/j.jad.2017.12.025. Epub 2018 Jan 6.

PMID:
29336895
16.

Brain docosahexaenoic acid uptake and metabolism.

Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

Mol Aspects Med. 2018 Dec;64:109-134. doi: 10.1016/j.mam.2017.12.004. Epub 2018 Feb 9. Review.

17.

Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.

Johnston LW, Harris SB, Retnakaran R, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

Diabetologia. 2018 Apr;61(4):821-830. doi: 10.1007/s00125-017-4534-6. Epub 2017 Dec 24.

PMID:
29275428
18.

Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.

Hopperton KE, Mohammad D, Trépanier MO, Giuliano V, Bazinet RP.

Mol Psychiatry. 2018 Feb;23(2):177-198. doi: 10.1038/mp.2017.246. Epub 2017 Dec 12. Review.

19.

Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Hopperton KE, Bazinet RP.

J Lipid Res. 2018 Feb;59(2):357-367. doi: 10.1194/jlr.M081380. Epub 2017 Dec 11.

20.

Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology.

Layé S, Nadjar A, Joffre C, Bazinet RP.

Pharmacol Rev. 2018 Jan;70(1):12-38. doi: 10.1124/pr.117.014092. Review.

PMID:
29217656
21.

Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver.

Metherel AH, Chouinard-Watkins R, Trépanier MO, Lacombe RJS, Bazinet RP.

Nutr Metab (Lond). 2017 Nov 28;14:75. doi: 10.1186/s12986-017-0230-2. eCollection 2017.

22.

Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?

Chouinard-Watkins R, Lacombe RJS, Bazinet RP.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):71-77. doi: 10.1097/MCO.0000000000000440.

PMID:
29206690
23.

Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-β 1-40 in mice.

Hopperton KE, James NCE, Mohammad D, Irfan M, Bazinet RP.

Nutr Neurosci. 2017 Nov 7:1-7. doi: 10.1080/1028415X.2017.1396068. [Epub ahead of print]

PMID:
29113539
24.

Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease.

Hopperton KE, Trépanier MO, James NCE, Chouinard-Watkins R, Bazinet RP.

Brain Behav Immun. 2018 Mar;69:74-90. doi: 10.1016/j.bbi.2017.11.002. Epub 2017 Nov 3.

PMID:
29109025
25.

Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.

Rao JS, Ertley RN, Lee HJ, Rapoport SI, Bazinet RP.

Pharmacogenomics J. 2017 Dec;17(6):563. doi: 10.1038/tpj.2017.42. Epub 2017 Oct 17.

PMID:
29053139
26.

Docosahexaenoic acid (DHA) accretion in the placenta but not the fetus is matched by plasma unesterified DHA uptake rates in pregnant Long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

Placenta. 2017 Oct;58:90-97. doi: 10.1016/j.placenta.2017.08.072. Epub 2017 Sep 1.

PMID:
28962703
27.

Retraction Note: n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

Rao JS, Ertley RN, Lee HJ, DeMar JC, Arnold JT, Rapoport SI, Bazinet RP.

Mol Psychiatry. 2018 Sep;23(9):1. doi: 10.1038/mp.2017.199.

PMID:
28948969
28.

Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study.

Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Festa A, Bazinet RP, Hanley AJ.

J Lipid Res. 2017 Nov;58(11):2171-2179. doi: 10.1194/jlr.P076836. Epub 2017 Sep 19.

29.

Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus.

Alashmali SM, Kitson AP, Lin L, Lacombe RJS, Bazinet RP.

Nutr Neurosci. 2017 Sep 13:1-12. doi: 10.1080/1028415X.2017.1372160. [Epub ahead of print]

PMID:
28903622
30.

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Desai HR, Sivasubramaniyam T, Revelo XS, Schroer SA, Luk CT, Rikkala PR, Metherel AH, Dodington DW, Park YJ, Kim MJ, Rapps JA, Besla R, Robbins CS, Wagner KU, Bazinet RP, Winer DA, Woo M.

Sci Rep. 2017 Aug 9;7(1):7653. doi: 10.1038/s41598-017-07923-0.

31.

Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion.

Chouinard-Watkins R, Chen CT, Metherel AH, Lacombe RJS, Thies F, Masoodi M, Bazinet RP.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt A):1092-1098. doi: 10.1016/j.bbalip.2017.07.013. Epub 2017 Jul 28.

PMID:
28760485
32.

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M.

JCI Insight. 2017 Jul 20;2(14). pii: 93735. doi: 10.1172/jci.insight.93735. [Epub ahead of print]

33.

Compound-specific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain.

Lacombe RJS, Giuliano V, Colombo SM, Arts MT, Bazinet RP.

J Lipid Res. 2017 Oct;58(10):2071-2081. doi: 10.1194/jlr.D077990. Epub 2017 Jul 10.

34.

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission.

Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KSS, Hammock BD, Zhang L, Bazinet RP, Taha AY.

Sci Rep. 2017 Jun 28;7(1):4342. doi: 10.1038/s41598-017-02914-7.

35.

Maternal liver docosahexaenoic acid (DHA) stores are increased via higher serum unesterified DHA uptake in pregnant long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

J Nutr Biochem. 2017 Aug;46:143-150. doi: 10.1016/j.jnutbio.2017.05.011. Epub 2017 Jun 1.

PMID:
28628798
36.

Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction.

Islam R, Trépanier MO, Milenkovic M, Horsfall W, Salahpour A, Bazinet RP, Ramsey AJ.

NPJ Schizophr. 2017 Mar 22;3:12. doi: 10.1038/s41537-017-0014-8. eCollection 2017.

37.

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

Lewis EJH, Perkins BA, Lovblom LE, Bazinet RP, Wolever TMS, Bril V.

Neurology. 2017 Jun 13;88(24):2294-2301. doi: 10.1212/WNL.0000000000004033. Epub 2017 May 17.

38.

Fatty acid amide hydrolase (FAAH) regulates hypercapnia/ischemia-induced increases in n-acylethanolamines in mouse brain.

Lin L, Metherel AH, Jones PJ, Bazinet RP.

J Neurochem. 2017 Sep;142(5):662-671. doi: 10.1111/jnc.14067. Epub 2017 Jul 25.

39.

Using in vivo corneal confocal microscopy to identify diabetic sensorimotor polyneuropathy risk profiles in patients with type 1 diabetes.

Lewis EJ, Perkins BA, Lovblom LE, Bazinet RP, Wolever TM, Bril V.

BMJ Open Diabetes Res Care. 2017 Feb 16;5(1):e000251. doi: 10.1136/bmjdrc-2016-000251. eCollection 2017.

40.

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

Shi SY, Luk CT, Schroer SA, Kim MJ, Dodington DW, Sivasubramaniyam T, Lin L, Cai EP, Lu SY, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.

41.

Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial.

Vuksan V, Jenkins AL, Brissette C, Choleva L, Jovanovski E, Gibbs AL, Bazinet RP, Au-Yeung F, Zurbau A, Ho HV, Duvnjak L, Sievenpiper JL, Josse RG, Hanna A.

Nutr Metab Cardiovasc Dis. 2017 Feb;27(2):138-146. doi: 10.1016/j.numecd.2016.11.124. Epub 2016 Dec 9.

PMID:
28089080
42.

Serum n-3 Tetracosapentaenoic Acid and Tetracosahexaenoic Acid Increase Following Higher Dietary α-Linolenic Acid but not Docosahexaenoic Acid.

Metherel AH, Domenichiello AF, Kitson AP, Lin YH, Bazinet RP.

Lipids. 2017 Feb;52(2):167-172. doi: 10.1007/s11745-016-4223-0. Epub 2016 Dec 22.

PMID:
28005226
43.

High-resolution lipidomics coupled with rapid fixation reveals novel ischemia-induced signaling in the rat neurolipidome.

Trépanier MO, Eiden M, Morin-Rivron D, Bazinet RP, Masoodi M.

J Neurochem. 2017 Mar;140(5):766-775. doi: 10.1111/jnc.13934. Epub 2017 Feb 8.

44.

Retraction note to: Chronic fluoxetine increases cytosolic phospholipase A2 activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat.

Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP.

Psychopharmacology (Berl). 2017 Feb;234(3):523. doi: 10.1007/s00213-016-4499-z. No abstract available.

PMID:
27999922
45.

Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes.

Domenichiello AF, Kitson AP, Metherel AH, Chen CT, Hopperton KE, Stavro PM, Bazinet RP.

J Nutr. 2017 Jan;147(1):37-44. doi: 10.3945/jn.116.232074. Epub 2016 Nov 16.

PMID:
27852871
46.
47.

Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA.

Hafizi S, Tseng HH, Rao N, Selvanathan T, Kenk M, Bazinet RP, Suridjan I, Wilson AA, Meyer JH, Remington G, Houle S, Rusjan PM, Mizrahi R.

Am J Psychiatry. 2017 Feb 1;174(2):118-124. doi: 10.1176/appi.ajp.2016.16020171. Epub 2016 Sep 9.

48.

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.

Trépanier MO, Hopperton KE, Mizrahi R, Mechawar N, Bazinet RP.

Mol Psychiatry. 2016 Aug;21(8):1009-26. doi: 10.1038/mp.2016.90. Epub 2016 Jun 7. Review.

49.

Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat.

Metherel AH, Domenichiello AF, Kitson AP, Hopperton KE, Bazinet RP.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):997-1004. doi: 10.1016/j.bbalip.2016.05.014. Epub 2016 Jun 2.

50.

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes.

Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

J Clin Endocrinol Metab. 2016 Jun;101(6):2536-44. doi: 10.1210/jc.2015-4267. Epub 2016 May 4.

PMID:
27144932

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