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Items: 1 to 50 of 139

1.

Applying stable carbon isotopic analysis at the natural abundance level to determine the origin of docosahexaenoic acid in the brain of the fat-1 mouse.

Giuliano V, Scott Lacombe RJ, Hopperton KE, Bazinet RP.

Biochim Biophys Acta. 2018 Jul 31. pii: S1388-1981(18)30188-4. doi: 10.1016/j.bbalip.2018.07.014. [Epub ahead of print]

PMID:
30075211
2.

Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State.

Lin YH, Hibbeln JR, Domenichiello AF, Ramsden CE, Salem NM, Chen CT, Jin H, Courville AB, Majchrzak-Hong SF, Rapoport SI, Bazinet RP, Miller BV 3rd.

Lipids. 2018 Aug 3. doi: 10.1002/lipd.12055. [Epub ahead of print]

PMID:
30074625
3.

Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation.

Metherel AH, Lacombe RJS, Aristizabal Henao JJ, Morin-Rivron D, Kitson AP, Hopperton KE, Chalil D, Masoodi M, Stark KD, Bazinet RP.

J Nutr Biochem. 2018 Jul 5;60:24-34. doi: 10.1016/j.jnutbio.2018.07.002. [Epub ahead of print]

PMID:
30041049
4.

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes.

Johnston LW, Liu Z, Retnakaran R, Zinman B, Giacca A, Harris SB, Bazinet RP, Hanley AJ.

J Lipid Res. 2018 Jul 9. pii: jlr.P084970. doi: 10.1194/jlr.P084970. [Epub ahead of print]

5.

Natural Abundance Carbon Isotopic Analysis Indicates the Equal Contribution of Local Synthesis and Plasma Uptake to Palmitate Levels in the Mouse Brain.

Lacombe RJS, Giuliano V, Chouinard-Watkins R, Bazinet RP.

Lipids. 2018 Jun 20. doi: 10.1002/lipd.12046. [Epub ahead of print]

PMID:
29923600
6.

Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection.

Trépanier MO, Hopperton KE, Giuliano V, Masoodi M, Bazinet RP.

Neurochem Int. 2018 Sep;118:115-126. doi: 10.1016/j.neuint.2018.05.010. Epub 2018 May 22.

PMID:
29792954
7.

Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.

Trépanier MO, Hildebrand KD, Nyamoya SD, Amor S, Bazinet RP, Kipp M.

J Neurochem. 2018 Jun;145(6):504-515. doi: 10.1111/jnc.14335. Epub 2018 Jun 10.

PMID:
29574981
8.

Alterations in peripheral fatty acid composition in bipolar and unipolar depression.

Scola G, Versace A, Metherel AH, Monsalve-Castro LA, Phillips ML, Bazinet RP, Andreazza AC.

J Affect Disord. 2018 Jun;233:86-91. doi: 10.1016/j.jad.2017.12.025. Epub 2018 Jan 6.

PMID:
29336895
9.

Brain docosahexaenoic acid uptake and metabolism.

Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

Mol Aspects Med. 2018 Feb 8. pii: S0098-2997(17)30135-8. doi: 10.1016/j.mam.2017.12.004. [Epub ahead of print] Review.

10.

Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.

Johnston LW, Harris SB, Retnakaran R, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

Diabetologia. 2018 Apr;61(4):821-830. doi: 10.1007/s00125-017-4534-6. Epub 2017 Dec 24.

PMID:
29275428
11.

Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.

Hopperton KE, Mohammad D, Trépanier MO, Giuliano V, Bazinet RP.

Mol Psychiatry. 2018 Feb;23(2):177-198. doi: 10.1038/mp.2017.246. Epub 2017 Dec 12. Review.

12.

Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Hopperton KE, Bazinet RP.

J Lipid Res. 2018 Feb;59(2):357-367. doi: 10.1194/jlr.M081380. Epub 2017 Dec 11.

PMID:
29229739
13.

Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology.

Layé S, Nadjar A, Joffre C, Bazinet RP.

Pharmacol Rev. 2018 Jan;70(1):12-38. doi: 10.1124/pr.117.014092. Review.

PMID:
29217656
14.

Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver.

Metherel AH, Chouinard-Watkins R, Trépanier MO, Lacombe RJS, Bazinet RP.

Nutr Metab (Lond). 2017 Nov 28;14:75. doi: 10.1186/s12986-017-0230-2. eCollection 2017.

15.

Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?

Chouinard-Watkins R, Lacombe RJS, Bazinet RP.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):71-77. doi: 10.1097/MCO.0000000000000440.

PMID:
29206690
16.

Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-β 1-40 in mice.

Hopperton KE, James NCE, Mohammad D, Irfan M, Bazinet RP.

Nutr Neurosci. 2017 Nov 7:1-7. doi: 10.1080/1028415X.2017.1396068. [Epub ahead of print]

PMID:
29113539
17.

Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease.

Hopperton KE, Trépanier MO, James NCE, Chouinard-Watkins R, Bazinet RP.

Brain Behav Immun. 2018 Mar;69:74-90. doi: 10.1016/j.bbi.2017.11.002. Epub 2017 Nov 3.

PMID:
29109025
18.

Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.

Rao JS, Ertley RN, Lee HJ, Rapoport SI, Bazinet RP.

Pharmacogenomics J. 2017 Dec;17(6):563. doi: 10.1038/tpj.2017.42. Epub 2017 Oct 17.

PMID:
29053139
19.

Docosahexaenoic acid (DHA) accretion in the placenta but not the fetus is matched by plasma unesterified DHA uptake rates in pregnant Long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

Placenta. 2017 Oct;58:90-97. doi: 10.1016/j.placenta.2017.08.072. Epub 2017 Sep 1.

PMID:
28962703
20.

n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

Rao JS, Ertley RN, Lee HJ, DeMar JC Jr, Arnold JT, Rapoport SI, Bazinet RP.

Mol Psychiatry. 2017 Sep 26. doi: 10.1038/mp.2017.199. [Epub ahead of print] No abstract available.

PMID:
28948969
21.

Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study.

Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Festa A, Bazinet RP, Hanley AJ.

J Lipid Res. 2017 Nov;58(11):2171-2179. doi: 10.1194/jlr.P076836. Epub 2017 Sep 19.

PMID:
28928169
22.

Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus.

Alashmali SM, Kitson AP, Lin L, Lacombe RJS, Bazinet RP.

Nutr Neurosci. 2017 Sep 13:1-12. doi: 10.1080/1028415X.2017.1372160. [Epub ahead of print]

PMID:
28903622
23.

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Desai HR, Sivasubramaniyam T, Revelo XS, Schroer SA, Luk CT, Rikkala PR, Metherel AH, Dodington DW, Park YJ, Kim MJ, Rapps JA, Besla R, Robbins CS, Wagner KU, Bazinet RP, Winer DA, Woo M.

Sci Rep. 2017 Aug 9;7(1):7653. doi: 10.1038/s41598-017-07923-0.

24.

Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion.

Chouinard-Watkins R, Chen CT, Metherel AH, Lacombe RJS, Thies F, Masoodi M, Bazinet RP.

Biochim Biophys Acta. 2017 Oct;1862(10 Pt A):1092-1098. doi: 10.1016/j.bbalip.2017.07.013. Epub 2017 Jul 28.

PMID:
28760485
25.

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M.

JCI Insight. 2017 Jul 20;2(14). pii: 93735. doi: 10.1172/jci.insight.93735. [Epub ahead of print]

26.

Compound-specific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain.

Lacombe RJS, Giuliano V, Colombo SM, Arts MT, Bazinet RP.

J Lipid Res. 2017 Oct;58(10):2071-2081. doi: 10.1194/jlr.D077990. Epub 2017 Jul 10.

PMID:
28694298
27.

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission.

Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KSS, Hammock BD, Zhang L, Bazinet RP, Taha AY.

Sci Rep. 2017 Jun 28;7(1):4342. doi: 10.1038/s41598-017-02914-7.

28.

Maternal liver docosahexaenoic acid (DHA) stores are increased via higher serum unesterified DHA uptake in pregnant long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

J Nutr Biochem. 2017 Aug;46:143-150. doi: 10.1016/j.jnutbio.2017.05.011. Epub 2017 Jun 1.

PMID:
28628798
29.

Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction.

Islam R, Trépanier MO, Milenkovic M, Horsfall W, Salahpour A, Bazinet RP, Ramsey AJ.

NPJ Schizophr. 2017 Mar 22;3:12. doi: 10.1038/s41537-017-0014-8. eCollection 2017.

30.

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

Lewis EJH, Perkins BA, Lovblom LE, Bazinet RP, Wolever TMS, Bril V.

Neurology. 2017 Jun 13;88(24):2294-2301. doi: 10.1212/WNL.0000000000004033. Epub 2017 May 17.

31.

Fatty acid amide hydrolase (FAAH) regulates hypercapnia/ischemia-induced increases in n-acylethanolamines in mouse brain.

Lin L, Metherel AH, Jones PJ, Bazinet RP.

J Neurochem. 2017 Sep;142(5):662-671. doi: 10.1111/jnc.14067. Epub 2017 Jul 25.

PMID:
28488728
32.

Using in vivo corneal confocal microscopy to identify diabetic sensorimotor polyneuropathy risk profiles in patients with type 1 diabetes.

Lewis EJ, Perkins BA, Lovblom LE, Bazinet RP, Wolever TM, Bril V.

BMJ Open Diabetes Res Care. 2017 Feb 16;5(1):e000251. doi: 10.1136/bmjdrc-2016-000251. eCollection 2017.

33.

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

Shi SY, Luk CT, Schroer SA, Kim MJ, Dodington DW, Sivasubramaniyam T, Lin L, Cai EP, Lu SY, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.

34.

Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial.

Vuksan V, Jenkins AL, Brissette C, Choleva L, Jovanovski E, Gibbs AL, Bazinet RP, Au-Yeung F, Zurbau A, Ho HV, Duvnjak L, Sievenpiper JL, Josse RG, Hanna A.

Nutr Metab Cardiovasc Dis. 2017 Feb;27(2):138-146. doi: 10.1016/j.numecd.2016.11.124. Epub 2016 Dec 9.

PMID:
28089080
35.

Serum n-3 Tetracosapentaenoic Acid and Tetracosahexaenoic Acid Increase Following Higher Dietary α-Linolenic Acid but not Docosahexaenoic Acid.

Metherel AH, Domenichiello AF, Kitson AP, Lin YH, Bazinet RP.

Lipids. 2017 Feb;52(2):167-172. doi: 10.1007/s11745-016-4223-0. Epub 2016 Dec 22.

PMID:
28005226
36.

High-resolution lipidomics coupled with rapid fixation reveals novel ischemia-induced signaling in the rat neurolipidome.

Trépanier MO, Eiden M, Morin-Rivron D, Bazinet RP, Masoodi M.

J Neurochem. 2017 Mar;140(5):766-775. doi: 10.1111/jnc.13934. Epub 2017 Feb 8.

37.

Retraction note to: Chronic fluoxetine increases cytosolic phospholipase A2 activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat.

Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP.

Psychopharmacology (Berl). 2017 Feb;234(3):523. doi: 10.1007/s00213-016-4499-z. No abstract available.

PMID:
27999922
38.

Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes.

Domenichiello AF, Kitson AP, Metherel AH, Chen CT, Hopperton KE, Stavro PM, Bazinet RP.

J Nutr. 2017 Jan;147(1):37-44. doi: 10.3945/jn.116.232074. Epub 2016 Nov 16.

PMID:
27852871
39.
40.

Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [18F]FEPPA.

Hafizi S, Tseng HH, Rao N, Selvanathan T, Kenk M, Bazinet RP, Suridjan I, Wilson AA, Meyer JH, Remington G, Houle S, Rusjan PM, Mizrahi R.

Am J Psychiatry. 2017 Feb 1;174(2):118-124. doi: 10.1176/appi.ajp.2016.16020171. Epub 2016 Sep 9.

41.

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.

Trépanier MO, Hopperton KE, Mizrahi R, Mechawar N, Bazinet RP.

Mol Psychiatry. 2016 Aug;21(8):1009-26. doi: 10.1038/mp.2016.90. Epub 2016 Jun 7. Review.

42.

Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat.

Metherel AH, Domenichiello AF, Kitson AP, Hopperton KE, Bazinet RP.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):997-1004. doi: 10.1016/j.bbalip.2016.05.014. Epub 2016 Jun 2.

43.

Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes.

Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

J Clin Endocrinol Metab. 2016 Jun;101(6):2536-44. doi: 10.1210/jc.2015-4267. Epub 2016 May 4.

PMID:
27144932
44.

Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion.

Kitson AP, Metherel AH, Chen CT, Domenichiello AF, Trépanier MO, Berger A, Bazinet RP.

J Nutr Biochem. 2016 Jul;33:91-102. doi: 10.1016/j.jnutbio.2016.02.009. Epub 2016 Mar 21.

45.

The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP.

J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12.

46.

Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids.

Alashmali SM, Hopperton KE, Bazinet RP.

Curr Opin Lipidol. 2016 Feb;27(1):54-66. doi: 10.1097/MOL.0000000000000255.

PMID:
26709472
47.

A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.

Kubant R, Poon AN, Sánchez-Hernández D, Domenichiello AF, Huot PS, Pannia E, Cho CE, Hunschede S, Bazinet RP, Anderson GH.

Nutr Diabetes. 2015 Dec 14;5:e188. doi: 10.1038/nutd.2015.40.

48.

Effect of Replacing Animal Protein with Plant Protein on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Viguiliouk E, Stewart SE, Jayalath VH, Ng AP, Mirrahimi A, de Souza RJ, Hanley AJ, Bazinet RP, Blanco Mejia S, Leiter LA, Josse RG, Kendall CW, Jenkins DJ, Sievenpiper JL.

Nutrients. 2015 Dec 1;7(12):9804-24. doi: 10.3390/nu7125509. Review.

49.

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain.

Chen CT, Kitson AP, Hopperton KE, Domenichiello AF, Trépanier MO, Lin LE, Ermini L, Post M, Thies F, Bazinet RP.

Sci Rep. 2015 Oct 29;5:15791. doi: 10.1038/srep15791.

50.

High vitamin A intake during pregnancy modifies dopaminergic reward system and decreases preference for sucrose in Wistar rat offspring.

Sánchez-Hernández D, Poon AN, Kubant R, Kim H, Huot PS, Cho CE, Pannia E, Reza-López SA, Pausova Z, Bazinet RP, Anderson GH.

J Nutr Biochem. 2016 Jan;27:104-11. doi: 10.1016/j.jnutbio.2015.08.020. Epub 2015 Aug 28.

PMID:
26456562

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