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Items: 1 to 50 of 164

1.

Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB.

Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, Kish SJ, Boileau I.

Neuropsychopharmacology. 2020 Jan 7. doi: 10.1038/s41386-020-0606-2. [Epub ahead of print]

PMID:
31910433
2.

Erratum: Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

J Lipid Res. 2019 Dec;60(12):2102. doi: 10.1194/jlr.ERR119000440. No abstract available.

3.

Interlaboratory Assessment of Dried Blood Spot Fatty Acid Compositions.

Metherel AH, Harris WS, Ge L, Gibson RA, Chouinard-Watkins R, Bazinet RP, Liu L, Brenna JT, Aristizabal-Henao JJ, Stark KD, Block RC.

Lipids. 2019 Nov;54(11-12):755-761. doi: 10.1002/lipd.12203. Epub 2019 Nov 29.

PMID:
31782523
4.

The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus.

Alashmali SM, Lin L, Trépanier MO, Cisbani G, Bazinet RP.

J Neuroinflammation. 2019 Nov 27;16(1):237. doi: 10.1186/s12974-019-1615-0.

5.

Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis.

Lacombe RJS, Lee CC, Bazinet RP.

J Lipid Res. 2020 Jan;61(1):116-126. doi: 10.1194/jlr.D119000518. Epub 2019 Nov 11.

PMID:
31712249
6.

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids.

Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY.

Lipids. 2020 Jan;55(1):7-22. doi: 10.1002/lipd.12197. Epub 2019 Nov 6.

PMID:
31691988
7.

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion.

Metherel AH, Bazinet RP.

Prog Lipid Res. 2019 Oct;76:101008. doi: 10.1016/j.plipres.2019.101008. Epub 2019 Oct 15. Review.

PMID:
31626820
8.

EPA and DHA have divergent effects on serum triglycerides and lipogenesis, but similar effects on lipoprotein lipase activity: a randomized controlled trial.

Klingel SL, Metherel AH, Irfan M, Rajna A, Chabowski A, Bazinet RP, Mutch DM.

Am J Clin Nutr. 2019 Dec 1;110(6):1502-1509. doi: 10.1093/ajcn/nqz234.

PMID:
31535138
9.

Projected declines in global DHA availability for human consumption as a result of global warming.

Colombo SM, Rodgers TFM, Diamond ML, Bazinet RP, Arts MT.

Ambio. 2020 Apr;49(4):865-880. doi: 10.1007/s13280-019-01234-6. Epub 2019 Sep 12.

PMID:
31512173
10.

The Distribution of Fatty Acid Biomarkers of Dairy Intake across Serum Lipid Fractions: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort.

Santaren ID, Bazinet RP, Liu Z, Johnston LW, Sievenpiper JL, Giacca A, Retnakaran R, Harris SB, Zinman B, Hanley AJ.

Lipids. 2019 Oct;54(10):617-627. doi: 10.1002/lipd.12185. Epub 2019 Aug 19.

PMID:
31429083
11.

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression.

Bazinet RP, Metherel AH, Chen CT, Shaikh SR, Nadjar A, Joffre C, Layé S.

Brain Behav Immun. 2019 Jul 3. pii: S0889-1591(19)30302-2. doi: 10.1016/j.bbi.2019.07.001. [Epub ahead of print] Review.

PMID:
31278982
12.

Clinical Efficacy and Biological Regulations of ω-3 PUFA-Derived Endocannabinoids in Major Depressive Disorder.

Yang B, Lin L, Bazinet RP, Chien YC, Chang JP, Satyanarayanan SK, Su H, Su KP.

Psychother Psychosom. 2019;88(4):215-224. doi: 10.1159/000501158. Epub 2019 Jul 3.

PMID:
31269506
13.

Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial.

Metherel AH, Irfan M, Klingel SL, Mutch DM, Bazinet RP.

Am J Clin Nutr. 2019 Oct 1;110(4):823-831. doi: 10.1093/ajcn/nqz097.

PMID:
31204771
14.

The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.

Seneviratne AK, Xu M, Aristizabal Henao JJ, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD.

Cell Stem Cell. 2019 Jun 6;24(6):1007. doi: 10.1016/j.stem.2019.04.020. No abstract available.

PMID:
31173706
15.

Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males.

Schwartz A, Hunschede S, Lacombe RJS, Chatterjee D, Sánchez-Hernández D, Kubant R, Bazinet RP, Hamilton JK, Anderson GH.

Clin Endocrinol (Oxf). 2019 Aug;91(2):295-303. doi: 10.1111/cen.14005. Epub 2019 May 16.

PMID:
31055857
16.

Oxylipin concentration, but not fatty acid composition, is altered in human donor milk pasteurised using both thermal and non-thermal techniques.

Pitino MA, Alashmali SM, Hopperton KE, Unger S, Pouliot Y, Doyen A, O'Connor DL, Bazinet RP.

Br J Nutr. 2019 Jul 14;122(1):47-55. doi: 10.1017/S0007114519000916. Epub 2019 Jun 20.

PMID:
31006410
17.

The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.

Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD.

Cell Stem Cell. 2019 Apr 4;24(4):621-636.e16. doi: 10.1016/j.stem.2019.02.020. Epub 2019 Mar 28. Erratum in: Cell Stem Cell. 2019 Jun 6;24(6):1007.

PMID:
30930145
18.

Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats.

Taha AY, Trepanier MO, Coibanu FA, Saxena A, Jeffrey MA, Taha NMY, Burnham WM, Bazinet RP.

Front Neurol. 2019 Feb 5;9:1188. doi: 10.3389/fneur.2018.01188. eCollection 2018.

19.

How the plasma lysophospholipid and unesterified fatty acid pools supply the brain with docosahexaenoic acid.

Bazinet RP, Bernoud-Hubac N, Lagarde M.

Prostaglandins Leukot Essent Fatty Acids. 2019 Mar;142:1-3. doi: 10.1016/j.plefa.2018.12.003. Epub 2018 Dec 25. Review.

PMID:
30773208
20.

DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol.

Chouinard-Watkins R, Lacombe RJS, Metherel AH, Masoodi M, Bazinet RP.

Mol Nutr Food Res. 2019 May;63(9):e1801224. doi: 10.1002/mnfr.201801224. Epub 2019 Feb 27.

PMID:
30768751
21.

DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats.

Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP.

J Nutr. 2019 Apr 1;149(4):586-595. doi: 10.1093/jn/nxy282.

PMID:
30715388
22.

Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

J Lipid Res. 2019 Feb;60(2):412-420. doi: 10.1194/jlr.M090373. Epub 2018 Dec 20. Erratum in: J Lipid Res. 2019 Dec;60(12):2102.

23.

Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time.

Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY.

J Lipid Res. 2019 Mar;60(3):671-682. doi: 10.1194/jlr.D084228. Epub 2018 Nov 21.

PMID:
30463986
24.

ACSL6 is critical for maintaining brain DHA levels.

Chouinard-Watkins R, Bazinet RP.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12343-12345. doi: 10.1073/pnas.1817557115. Epub 2018 Nov 16. No abstract available.

25.

Dietary fatty acids augment tissue levels of n-acylethanolamines in n-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout mice.

Lin L, Metherel AH, Kitson AP, Alashmali SM, Hopperton KE, Trépanier MO, Jones PJ, Bazinet RP.

J Nutr Biochem. 2018 Dec;62:134-142. doi: 10.1016/j.jnutbio.2018.08.015. Epub 2018 Sep 5.

PMID:
30290332
26.

Applying stable carbon isotopic analysis at the natural abundance level to determine the origin of docosahexaenoic acid in the brain of the fat-1 mouse.

Giuliano V, Lacombe RJS, Hopperton KE, Bazinet RP.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov;1863(11):1388-1398. doi: 10.1016/j.bbalip.2018.07.014. Epub 2018 Jul 31.

PMID:
30075211
27.

Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State.

Lin YH, Hibbeln JR, Domenichiello AF, Ramsden CE, Salem NM, Chen CT, Jin H, Courville AB, Majchrzak-Hong SF, Rapoport SI, Bazinet RP, Miller BV 3rd.

Lipids. 2018 May;53(5):547-558. doi: 10.1002/lipd.12055. Epub 2018 Aug 3.

28.

Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation.

Metherel AH, Lacombe RJS, Aristizabal Henao JJ, Morin-Rivron D, Kitson AP, Hopperton KE, Chalil D, Masoodi M, Stark KD, Bazinet RP.

J Nutr Biochem. 2018 Oct;60:24-34. doi: 10.1016/j.jnutbio.2018.07.002. Epub 2018 Jul 5.

PMID:
30041049
29.

Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes.

Johnston LW, Liu Z, Retnakaran R, Zinman B, Giacca A, Harris SB, Bazinet RP, Hanley AJ.

J Lipid Res. 2018 Sep;59(9):1751-1762. doi: 10.1194/jlr.P084970. Epub 2018 Jul 9.

30.

Natural Abundance Carbon Isotopic Analysis Indicates the Equal Contribution of Local Synthesis and Plasma Uptake to Palmitate Levels in the Mouse Brain.

Lacombe RJS, Giuliano V, Chouinard-Watkins R, Bazinet RP.

Lipids. 2018 May;53(5):481-490. doi: 10.1002/lipd.12046. Epub 2018 Jun 20.

PMID:
29923600
31.

Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection.

Trépanier MO, Hopperton KE, Giuliano V, Masoodi M, Bazinet RP.

Neurochem Int. 2018 Sep;118:115-126. doi: 10.1016/j.neuint.2018.05.010. Epub 2018 May 22.

PMID:
29792954
32.

Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.

Trépanier MO, Hildebrand KD, Nyamoya SD, Amor S, Bazinet RP, Kipp M.

J Neurochem. 2018 Jun;145(6):504-515. doi: 10.1111/jnc.14335. Epub 2018 Jun 10.

33.

Alterations in peripheral fatty acid composition in bipolar and unipolar depression.

Scola G, Versace A, Metherel AH, Monsalve-Castro LA, Phillips ML, Bazinet RP, Andreazza AC.

J Affect Disord. 2018 Jun;233:86-91. doi: 10.1016/j.jad.2017.12.025. Epub 2018 Jan 6.

PMID:
29336895
34.

Brain docosahexaenoic acid uptake and metabolism.

Lacombe RJS, Chouinard-Watkins R, Bazinet RP.

Mol Aspects Med. 2018 Dec;64:109-134. doi: 10.1016/j.mam.2017.12.004. Epub 2018 Feb 9. Review.

35.

Association of NEFA composition with insulin sensitivity and beta cell function in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort.

Johnston LW, Harris SB, Retnakaran R, Giacca A, Liu Z, Bazinet RP, Hanley AJ.

Diabetologia. 2018 Apr;61(4):821-830. doi: 10.1007/s00125-017-4534-6. Epub 2017 Dec 24.

PMID:
29275428
36.

Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.

Hopperton KE, Mohammad D, Trépanier MO, Giuliano V, Bazinet RP.

Mol Psychiatry. 2018 Feb;23(2):177-198. doi: 10.1038/mp.2017.246. Epub 2017 Dec 12.

37.

Complete assessment of whole-body n-3 and n-6 PUFA synthesis-secretion kinetics and DHA turnover in a rodent model.

Metherel AH, Lacombe RJS, Chouinard-Watkins R, Hopperton KE, Bazinet RP.

J Lipid Res. 2018 Feb;59(2):357-367. doi: 10.1194/jlr.M081380. Epub 2017 Dec 11.

38.

Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology.

Layé S, Nadjar A, Joffre C, Bazinet RP.

Pharmacol Rev. 2018 Jan;70(1):12-38. doi: 10.1124/pr.117.014092. Review.

PMID:
29217656
39.

Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver.

Metherel AH, Chouinard-Watkins R, Trépanier MO, Lacombe RJS, Bazinet RP.

Nutr Metab (Lond). 2017 Nov 28;14:75. doi: 10.1186/s12986-017-0230-2. eCollection 2017.

40.

Mechanisms regulating brain docosahexaenoic acid uptake: what is the recent evidence?

Chouinard-Watkins R, Lacombe RJS, Bazinet RP.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):71-77. doi: 10.1097/MCO.0000000000000440. Review.

PMID:
29206690
41.

Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-β 1-40 in mice.

Hopperton KE, James NCE, Mohammad D, Irfan M, Bazinet RP.

Nutr Neurosci. 2019 Jun;22(6):418-424. doi: 10.1080/1028415X.2017.1396068. Epub 2017 Nov 7.

PMID:
29113539
42.

Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease.

Hopperton KE, Trépanier MO, James NCE, Chouinard-Watkins R, Bazinet RP.

Brain Behav Immun. 2018 Mar;69:74-90. doi: 10.1016/j.bbi.2017.11.002. Epub 2017 Nov 3.

PMID:
29109025
43.

Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.

Rao JS, Ertley RN, Lee HJ, Rapoport SI, Bazinet RP.

Pharmacogenomics J. 2017 Dec;17(6):563. doi: 10.1038/tpj.2017.42. Epub 2017 Oct 17.

PMID:
29053139
44.

Docosahexaenoic acid (DHA) accretion in the placenta but not the fetus is matched by plasma unesterified DHA uptake rates in pregnant Long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

Placenta. 2017 Oct;58:90-97. doi: 10.1016/j.placenta.2017.08.072. Epub 2017 Sep 1.

PMID:
28962703
45.

Retraction Note: n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

Rao JS, Ertley RN, Lee HJ, DeMar JC, Arnold JT, Rapoport SI, Bazinet RP.

Mol Psychiatry. 2018 Sep;23(9):1968. doi: 10.1038/mp.2017.199.

PMID:
28948969
46.

Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study.

Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Festa A, Bazinet RP, Hanley AJ.

J Lipid Res. 2017 Nov;58(11):2171-2179. doi: 10.1194/jlr.P076836. Epub 2017 Sep 19.

47.

Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus.

Alashmali SM, Kitson AP, Lin L, Lacombe RJS, Bazinet RP.

Nutr Neurosci. 2019 Apr;22(4):223-234. doi: 10.1080/1028415X.2017.1372160. Epub 2017 Sep 13.

PMID:
28903622
48.

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Desai HR, Sivasubramaniyam T, Revelo XS, Schroer SA, Luk CT, Rikkala PR, Metherel AH, Dodington DW, Park YJ, Kim MJ, Rapps JA, Besla R, Robbins CS, Wagner KU, Bazinet RP, Winer DA, Woo M.

Sci Rep. 2017 Aug 9;7(1):7653. doi: 10.1038/s41598-017-07923-0.

49.

Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion.

Chouinard-Watkins R, Chen CT, Metherel AH, Lacombe RJS, Thies F, Masoodi M, Bazinet RP.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt A):1092-1098. doi: 10.1016/j.bbalip.2017.07.013. Epub 2017 Jul 28.

PMID:
28760485
50.

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M.

JCI Insight. 2017 Jul 20;2(14). pii: 93735. doi: 10.1172/jci.insight.93735. eCollection 2017 Jul 20.

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