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Items: 1 to 50 of 103

1.

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.

Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC.

Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4.

2.

Designs on a curve.

Bazan JF, Kajava AV.

Nat Struct Mol Biol. 2015 Feb;22(2):103-5. doi: 10.1038/nsmb.2966. No abstract available.

PMID:
25650904
3.

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.

Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D, Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson DC, van Raaij MJ, Rohwer F, Segall A, Seguritan V, Zeth K, Schwede T.

Proteins. 2014 Feb;82 Suppl 2:26-42. doi: 10.1002/prot.24489. Erratum in: Proteins. 2015 Jun;83(6):1198.

4.

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA.

Dev Cell. 2013 Aug 26;26(4):346-57. doi: 10.1016/j.devcel.2013.07.015. Epub 2013 Aug 15.

5.

The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?

Bazan JF, Macdonald BT, He X.

Dev Cell. 2013 May 13;25(3):225-7. doi: 10.1016/j.devcel.2013.04.019.

6.

Polo boxes come out of the crypt: a new view of PLK function and evolution.

Jana SC, Bazan JF, Bettencourt-Dias M.

Structure. 2012 Nov 7;20(11):1801-4. doi: 10.1016/j.str.2012.10.008. Erratum in: Structure. 2012 Dec 5;20(12):2191. Bettencourt Dias, Mónica [corrected to Bettencourt-Dias, Mónica].

7.

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.

Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL.

Open Biol. 2012 Aug;2(8):120071. doi: 10.1098/rsob.120071.

8.

Structural architecture and functional evolution of Wnts.

Bazan JF, Janda CY, Garcia KC.

Dev Cell. 2012 Aug 14;23(2):227-32. doi: 10.1016/j.devcel.2012.07.011.

9.

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K.

Troutman TD, Bazan JF, Pasare C.

Cell Cycle. 2012 Oct 1;11(19):3559-67. doi: 10.4161/cc.21572. Epub 2012 Aug 16. Review.

10.

Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.

Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, Wu Y, Martin F, Bazan JF, Starovasnik MA.

Structure. 2012 Apr 4;20(4):676-87. doi: 10.1016/j.str.2012.02.010. Epub 2012 Apr 3.

11.

Structure of the activating IL-1 receptor signaling complex.

Thomas C, Bazan JF, Garcia KC.

Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260.

12.

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.

Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.

13.

Novel C16orf57 mutations in patients with Poikiloderma with Neutropenia: bioinformatic analysis of the protein and predicted effects of all reported mutations.

Colombo EA, Bazan JF, Negri G, Gervasini C, Elcioglu NH, Yucelten D, Altunay I, Cetincelik U, Teti A, Del Fattore A, Luciani M, Sullivan SK, Yan AC, Volpi L, Larizza L.

Orphanet J Rare Dis. 2012 Jan 23;7:7. doi: 10.1186/1750-1172-7-7.

14.

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.

Troutman TD, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan JF, Pasare C.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):273-8. doi: 10.1073/pnas.1118579109. Epub 2011 Dec 20.

15.

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.

Rousseau F, Pan B, Fairbrother WJ, Bazan JF, Lingel A.

J Mol Biol. 2012 Jan 6;415(1):22-8. doi: 10.1016/j.jmb.2011.10.048. Epub 2011 Nov 4.

PMID:
22079049
16.

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.

Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T.

Proteins. 2011;79 Suppl 10:6-20. doi: 10.1002/prot.23196. Epub 2011 Oct 21.

17.

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK.

Cell. 2011 May 13;145(4):513-28. doi: 10.1016/j.cell.2011.04.019.

18.

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.

Lobito AA, Ramani SR, Tom I, Bazan JF, Luis E, Fairbrother WJ, Ouyang W, Gonzalez LC.

J Biol Chem. 2011 May 27;286(21):18969-81. doi: 10.1074/jbc.M111.224626. Epub 2011 Mar 31.

19.

Functional characterization of putative cilia genes by high-content analysis.

Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ.

Mol Biol Cell. 2011 Apr;22(7):1104-19. doi: 10.1091/mbc.E10-07-0596. Epub 2011 Feb 2.

20.

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV.

Cell. 2010 Jun 25;141(7):1208-19. doi: 10.1016/j.cell.2010.05.015.

21.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.

22.

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.

Lingel A, Weiss TM, Niebuhr M, Pan B, Appleton BA, Wiesmann C, Bazan JF, Fairbrother WJ.

Structure. 2009 Oct 14;17(10):1398-410. doi: 10.1016/j.str.2009.08.009.

23.

Structural ties between cholesterol transport and morphogen signaling.

Bazan JF, de Sauvage FJ.

Cell. 2009 Sep 18;138(6):1055-6. doi: 10.1016/j.cell.2009.09.006. No abstract available.

24.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.

Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2.

25.

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA.

Nat Struct Mol Biol. 2009 Jul;16(7):691-7. doi: 10.1038/nsmb.1632. Epub 2009 Jun 28.

PMID:
19561609
26.

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV.

Dev Cell. 2008 Dec;15(6):854-65. doi: 10.1016/j.devcel.2008.11.001.

27.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.

PMID:
18939944
28.

An old HAT in human p300/CBP and yeast Rtt109.

Bazan JF.

Cell Cycle. 2008 Jun 15;7(12):1884-6. Epub 2008 Jun 8.

PMID:
18583929
29.

DUBA: a deubiquitinase that regulates type I interferon production.

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM.

Science. 2007 Dec 7;318(5856):1628-32. Epub 2007 Nov 8.

30.

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.

Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, Mortara K, Bowman KK, Elliott JM, Desmarais W, Bazan JF, Bagri A, Tessier-Lavigne M, Koch AW, Wu Y, Watts RJ, Wiesmann C.

EMBO J. 2007 Nov 28;26(23):4902-12. Epub 2007 Nov 8.

31.

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.

32.

Distinguishing cancer-associated missense mutations from common polymorphisms.

Kaminker JS, Zhang Y, Waugh A, Haverty PM, Peters B, Sebisanovic D, Stinson J, Forrest WF, Bazan JF, Seshagiri S, Zhang Z.

Cancer Res. 2007 Jan 15;67(2):465-73.

33.

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.

McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ.

Biochemistry. 2006 Oct 3;45(39):11974-82.

PMID:
17002296
34.

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA.

Immunity. 2005 Nov;23(5):479-90.

35.

Pathogen recognition: TLRs throw us a curve.

Kirk P, Bazan JF.

Immunity. 2005 Oct;23(4):347-50. Review.

36.

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.

Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.

J Immunol. 2004 Feb 15;172(4):2225-31.

37.

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.

He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC.

Neuron. 2003 Apr 24;38(2):177-85.

38.

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.

Immunity. 2002 Jun;16(6):779-90.

39.

A new nomenclature for IL-1-family genes.

Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR.

Trends Immunol. 2001 Oct;22(10):536-7. No abstract available.

PMID:
11574262
40.

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.

Neighbors M, Xu X, Barrat FJ, Ruuls SR, Churakova T, Debets R, Bazan JF, Kastelein RA, Abrams JS, O'Garra A.

J Exp Med. 2001 Aug 6;194(3):343-54.

41.

Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.

Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA.

J Immunol. 2001 Aug 1;167(3):1440-6.

42.

Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.

Reche PA, Soumelis V, Gorman DM, Clifford T, Liu Mr, Travis M, Zurawski SM, Johnston J, Liu YJ, Spits H, de Waal Malefyt R, Kastelein RA, Bazan JF.

J Immunol. 2001 Jul 1;167(1):336-43.

43.

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.

Wiekowski MT, Leach MW, Evans EW, Sullivan L, Chen SC, Vassileva G, Bazan JF, Gorman DM, Kastelein RA, Narula S, Lira SA.

J Immunol. 2001 Jun 15;166(12):7563-70.

44.

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.

Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1.

45.

A genomic view of immunology.

Fahrer AM, Bazan JF, Papathanasiou P, Nelms KA, Goodnow CC.

Nature. 2001 Feb 15;409(6822):836-8.

PMID:
11237003
46.

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA.

Immunity. 2000 Nov;13(5):715-25.

47.

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R, Moore KW, Abrams JS, O'Garra A, Bazan JF, Kastelein RA.

J Immunol. 2000 Nov 1;165(9):4950-6.

49.

Patient mutations in doublecortin define a repeated tubulin-binding domain.

Taylor KR, Holzer AK, Bazan JF, Walsh CA, Gleeson JG.

J Biol Chem. 2000 Nov 3;275(44):34442-50.

50.

OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA.

J Biol Chem. 1999 Aug 6;274(32):22729-38. Erratum in: J Biol Chem 1999 Sep 24;274(39):28058.

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