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Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model.

Chen W, Wasnik S, Fu Y, Aranda L, Rundle CH, Lau KW, Baylink DJ, Zhang X.

Bone Rep. 2019 Dec 11;12:100236. doi: 10.1016/j.bonr.2019.100236. eCollection 2020 Jun.


Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis.

Li CH, Tang X, Wasnik S, Wang X, Zhang J, Xu Y, Lau KW, Nguyen HB, Baylink DJ.

BMC Infect Dis. 2019 Dec 2;19(1):1020. doi: 10.1186/s12879-019-4529-7.


Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules.

Wasnik S, Baylink DJ, Leavenworth J, Liu C, Bi H, Tang X.

Int J Mol Sci. 2019 Sep 28;20(19). pii: E4829. doi: 10.3390/ijms20194829. Review.


Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90+ skeletal stem cells in fracture sites.

Wasnik S, Lakhan R, Baylink DJ, Rundle CH, Xu Y, Zhang J, Qin X, Lau KW, Carreon EE, Tang X.

Sci Adv. 2019 Jul 31;5(7):eaaw2108. doi: 10.1126/sciadv.aaw2108. eCollection 2019 Jul.


In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis.

Xu Y, Cheng Y, Baylink DJ, Wasnik S, Goel G, Huang M, Cao H, Qin X, Lau KW, Chan C, Koch A, Pham LH, Zhang J, Li CH, Wang X, Berumen EC, Smith J, Tang X.

J Immunol. 2019 Jun 15;202(12):3447-3457. doi: 10.4049/jimmunol.1800018. Epub 2019 May 3.


1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites.

Wasnik S, Rundle CH, Baylink DJ, Yazdi MS, Carreon EE, Xu Y, Qin X, Lau KW, Tang X.

JCI Insight. 2018 Sep 6;3(17). pii: 98773. doi: 10.1172/jci.insight.98773. eCollection 2018 Sep 6.


Detection of dinitrosyl iron complexes by ozone-based chemiluminescence.

Mukosera GT, Liu T, Ishtiaq Ahmed AS, Li Q, Sheng MH, Tipple TE, Baylink DJ, Power GG, Blood AB.

Nitric Oxide. 2018 Sep 1;79:57-67. doi: 10.1016/j.niox.2018.07.005. Epub 2018 Jul 27.


Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice.

Choudry M, Tang X, Santorian T, Wasnik S, Xiao J, Xing W, Lau KW, Mohan S, Baylink DJ, Qin X.

Immunology. 2018 Sep;155(1):85-98. doi: 10.1111/imm.12926. Epub 2018 Apr 16.


Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein.

Xu Y, Wasnik S, Baylink DJ, Berumen EC, Tang X.

J Vis Exp. 2017 Dec 20;(130). doi: 10.3791/56401.


Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis.

Li CH, Zhang J, Baylink DJ, Wang X, Goparaju NB, Xu Y, Wasnik S, Cheng Y, Berumen EC, Qin X, Lau KW, Tang X.

FASEB J. 2017 Jul;31(7):2996-3006. doi: 10.1096/fj.201601243R. Epub 2017 Mar 31.


Unique Regenerative Mechanism to Replace Bone Lost During Dietary Bone Depletion in Weanling Mice.

Sheng MH, Lau KW, Lakhan R, Ahmed ASI, Rundle CH, Biswanath P, Baylink DJ.

Endocrinology. 2017 Apr 1;158(4):714-729. doi: 10.1210/en.2016-1379.


Effect of aging on stem cells.

Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW.

World J Exp Med. 2017 Feb 20;7(1):1-10. doi: 10.5493/wjem.v7.i1.1. eCollection 2017 Feb 20. Review.


Application of vitamin D and vitamin D analogs in acute myelogenous leukemia.

Cao H, Xu Y, de Necochea-Campion R, Baylink DJ, Payne KJ, Tang X, Ratanatharathorn C, Ji Y, Mirshahidi S, Chen CS.

Exp Hematol. 2017 Jun;50:1-12. doi: 10.1016/j.exphem.2017.01.007. Epub 2017 Feb 4. Review.


Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis.

Wang X, Zhang J, Baylink DJ, Li CH, Watts DM, Xu Y, Qin X, Walter MH, Tang X.

Sci Rep. 2016 Oct 31;6:36064. doi: 10.1038/srep36064.


Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice.

Lau KW, Rundle CH, Zhou XD, Baylink DJ, Sheng MH.

Bone. 2016 Nov;92:18-28. doi: 10.1016/j.bone.2016.08.005. Epub 2016 Aug 9.


Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia.

Goyal R, Billings TL, Mansour T, Martin C, Baylink DJ, Longo LD, Pearce WJ, Mata-Greenwood E.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1062-71. doi: 10.1152/ajpendo.00494.2015. Epub 2016 May 3.


MicroRNA223 promotes pathogenic T-cell development and autoimmune inflammation in central nervous system in mice.

Satoorian T, Li B, Tang X, Xiao J, Xing W, Shi W, Lau KH, Baylink DJ, Qin X.

Immunology. 2016 Aug;148(4):326-38. doi: 10.1111/imm.12611. Epub 2016 Jun 29.


Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration.

Hu J, Wang Y, Jiao J, Liu Z, Zhao C, Zhou Z, Zhang Z, Forde K, Wang L, Wang J, Baylink DJ, Zhang XB, Gao S, Yang B, Chen YE, Ma PX.

Biomaterials. 2015 Dec;73:51-9. doi: 10.1016/j.biomaterials.2015.09.008. Epub 2015 Sep 11.


PDGFB-based stem cell gene therapy increases bone strength in the mouse.

Chen W, Baylink DJ, Brier-Jones J, Neises A, Kiroyan JB, Rundle CH, Lau KH, Zhang XB.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3893-900. doi: 10.1073/pnas.1501759112. Epub 2015 Jul 6.


Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming.

Chen W, Baylink DJ, Lau KH, Zhang XB.

Curr Stem Cell Res Ther. 2016;11(2):114-21.


Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice.

Lakhan R, Baylink DJ, Lau KH, Tang X, Sheng MH, Rundle CH, Qin X.

Gene Ther. 2015 Sep;22(9):721-8. doi: 10.1038/gt.2015.40. Epub 2015 Apr 28.


Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice.

Lau KH, Baylink DJ, Sheng MH.

PLoS One. 2015 Jan 30;10(1):e0115897. doi: 10.1371/journal.pone.0115897. eCollection 2015.


Targeted 25-hydroxyvitamin D3 1α-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice.

Li B, Baylink DJ, Walter MH, Lau KH, Meng X, Wang J, Cherkas A, Tang X, Qin X.

Mol Ther. 2015 Feb;23(2):339-51. doi: 10.1038/mt.2014.201. Epub 2014 Oct 20.


Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.

Sheng MH, Lau KH, Baylink DJ.

J Bone Metab. 2014 Feb;21(1):41-54. doi: 10.11005/jbm.2014.21.1.41. Epub 2014 Feb 28. Review.


Characterization of an animal model of pregnancy-induced vitamin D deficiency due to metabolic gene dysregulation.

Goyal R, Zhang L, Blood AB, Baylink DJ, Longo LD, Oshiro B, Mata-Greenwood E.

Am J Physiol Endocrinol Metab. 2014 Feb;306(3):E256-66. doi: 10.1152/ajpendo.00528.2013. Epub 2013 Dec 10.


ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size.

Edderkaoui B, Kesavan C, Baylink DJ, Wergedal JE, Srivastava AK, Mohan S.

Physiol Genomics. 2013 Dec 15;45(24):1222-8. doi: 10.1152/physiolgenomics.00142.2013. Epub 2013 Oct 22.


Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.

Lau KH, Baylink DJ, Zhou XD, Rodriguez D, Bonewald LF, Li Z, Ruffoni D, Müller R, Kesavan C, Sheng MH.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E271-81. doi: 10.1152/ajpendo.00092.2013. Epub 2013 May 28.


Efficient generation of integration-free ips cells from human adult peripheral blood using BCL-XL together with Yamanaka factors.

Su RJ, Baylink DJ, Neises A, Kiroyan JB, Meng X, Payne KJ, Tschudy-Seney B, Duan Y, Appleby N, Kearns-Jonker M, Gridley DS, Wang J, Lau KH, Zhang XB.

PLoS One. 2013 May 21;8(5):e64496. doi: 10.1371/journal.pone.0064496. Print 2013.


1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo.

Li B, Baylink DJ, Deb C, Zannetti C, Rajaallah F, Xing W, Walter MH, Lau KH, Qin X.

PLoS One. 2013;8(3):e58808. doi: 10.1371/journal.pone.0058808. Epub 2013 Mar 14.


Rapid and efficient reprogramming of human fetal and adult blood CD34+ cells into mesenchymal stem cells with a single factor.

Meng X, Su RJ, Baylink DJ, Neises A, Kiroyan JB, Lee WY, Payne KJ, Gridley DS, Wang J, Lau KH, Li G, Zhang XB.

Cell Res. 2013 May;23(5):658-72. doi: 10.1038/cr.2013.40. Epub 2013 Mar 12.


Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures.

Lau KH, Kothari V, Das A, Zhang XB, Baylink DJ.

Bone. 2013 Apr;53(2):369-81. doi: 10.1016/j.bone.2013.01.003. Epub 2013 Jan 11.


Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice.

Sheng MH, Zhou XD, Bonewald LF, Baylink DJ, Lau KH.

Bone. 2013 Jan;52(1):133-44. doi: 10.1016/j.bone.2012.09.027. Epub 2012 Sep 29.


Transgenic overexpression of pregnancy-associated plasma protein-A in skeletal muscle of mice increases myofiber size and central nucleation in sedentary muscle and promotes muscle regeneration in the injured muscle.

Deb C, Li B, Baylink DJ, Xing W, Zhang W, Chen M, Wergedal JE, Mohan S, Qin X.

Growth Horm IGF Res. 2012 Oct;22(5):173-9. doi: 10.1016/j.ghir.2012.05.003. Epub 2012 Jun 17.


Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation.

Meng X, Baylink DJ, Sheng M, Wang H, Gridley DS, Lau KH, Zhang XB.

PLoS One. 2012;7(5):e37569. doi: 10.1371/journal.pone.0037569. Epub 2012 May 18.


Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

Sheng MH, Wergedal JE, Mohan S, Amoui M, Baylink DJ, Lau KH.

PLoS One. 2012;7(4):e35280. doi: 10.1371/journal.pone.0035280. Epub 2012 Apr 20.


Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 alone.

Meng X, Neises A, Su RJ, Payne KJ, Ritter L, Gridley DS, Wang J, Sheng M, Lau KH, Baylink DJ, Zhang XB.

Mol Ther. 2012 Feb;20(2):408-16. doi: 10.1038/mt.2011.258. Epub 2011 Nov 22.


Prevention of colorectal cancer with vitamin D.

Rheem DS, Baylink DJ, Olafsson S, Jackson CS, Walter MH.

Scand J Gastroenterol. 2010 Aug;45(7-8):775-84. doi: 10.3109/00365521003734125. Review.


Mapping of the chromosome 17 BMD QTL in the F(2) male mice of MRL/MpJ x SJL/J.

Yu H, Edderkaoui B, Cortez A, Davidson HM, Wergedal JE, Baylink DJ, Mohan S.

Genetica. 2009 Jan;135(1):59-66. doi: 10.1007/s10709-008-9258-6. Epub 2008 Mar 11.


Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.

Rundle CH, Strong DD, Chen ST, Linkhart TA, Sheng MH, Wergedal JE, Lau KH, Baylink DJ.

J Gene Med. 2008 Mar;10(3):229-41.


A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways.

Mohan S, Baylink DJ, Srivastava AK.

Bone. 2008 Feb;42(2):388-95. Epub 2007 Oct 28.


Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: congenic analysis and fine mapping.

Yu H, Baylink DJ, Masinde GL, Li R, Nguyen B, Davidson HM, Xu S, Mohan S.

Wound Repair Regen. 2007 Nov-Dec;15(6):922-7.


Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion.

Govoni KE, Wergedal JE, Florin L, Angel P, Baylink DJ, Mohan S.

Endocrinology. 2007 Dec;148(12):5706-15. Epub 2007 Aug 23.


Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice.

Hall SL, Lau KH, Chen ST, Wergedal JE, Srivastava A, Klamut H, Sheng MH, Gridley DS, Mohan S, Baylink DJ.

Mol Ther. 2007 Oct;15(10):1881-9. Epub 2007 Jul 17.


Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice.

Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Wergedal JE, Mohan S.

Bone. 2007 Sep;41(3):340-5. Epub 2007 Jun 6.


Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.

Kesavan C, Baylink DJ, Kapoor S, Mohan S.

Bone. 2007 Aug;41(2):223-30. Epub 2007 Apr 27.


Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice.

Govoni KE, Lee SK, Chung YS, Behringer RR, Wergedal JE, Baylink DJ, Mohan S.

Physiol Genomics. 2007 Aug 20;30(3):354-62. Epub 2007 May 22.


Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.

Xing W, Singgih A, Kapoor A, Alarcon CM, Baylink DJ, Mohan S.

J Biol Chem. 2007 Jul 27;282(30):22052-61. Epub 2007 May 17.


Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.

Wergedal JE, Ackert-Bicknell CL, Beamer WG, Mohan S, Baylink DJ, Srivastava AK.

J Lipid Res. 2007 Aug;48(8):1724-34. Epub 2007 May 13.

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