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Items: 1 to 50 of 318


Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering.

Koo S, Cheley S, Bayley H.

ACS Cent Sci. 2019 Apr 24;5(4):629-639. doi: 10.1021/acscentsci.8b00910. Epub 2019 Mar 25.


Single-Molecule Kinetics of Growth and Degradation of Cell-Penetrating Poly(disulfide)s.

Pulcu GS, Galenkamp NS, Qing Y, Gasparini G, Mikhailova E, Matile S, Bayley H.

J Am Chem Soc. 2019 May 6. doi: 10.1021/jacs.9b00387. [Epub ahead of print]


Single-Molecule Protein Phosphorylation and Dephosphorylation by Nanopore Enzymology.

Harrington L, Alexander LT, Knapp S, Bayley H.

ACS Nano. 2019 Jan 22;13(1):633-641. doi: 10.1021/acsnano.8b07697. Epub 2019 Jan 4.


Single-Molecule Observation of the Intermediates in a Catalytic Cycle.

Ramsay WJ, Bell NAW, Qing Y, Bayley H.

J Am Chem Soc. 2018 Dec 19;140(50):17538-17546. doi: 10.1021/jacs.8b09282. Epub 2018 Dec 10.


Directional control of a processive molecular hopper.

Qing Y, Ionescu SA, Pulcu GS, Bayley H.

Science. 2018 Aug 31;361(6405):908-912. doi: 10.1126/science.aat3872.


Correction to "Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm".

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Sep 4;57(35):5270. doi: 10.1021/acs.biochem.8b00864. Epub 2018 Aug 23. No abstract available.


Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm.

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Jul 24;57(29):4374-4381. doi: 10.1021/acs.biochem.8b00621. Epub 2018 Jul 6. Erratum in: Biochemistry. 2018 Sep 4;57(35):5270.


Lipid binding attenuates channel closure of the outer membrane protein OmpF.

Liko I, Degiacomi MT, Lee S, Newport TD, Gault J, Reading E, Hopper JTS, Housden NG, White P, Colledge M, Sula A, Wallace BA, Kleanthous C, Stansfeld PJ, Bayley H, Benesch JLP, Allison TM, Robinson CV.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6691-6696. doi: 10.1073/pnas.1721152115. Epub 2018 Jun 11.


DNA scaffolds support stable and uniform peptide nanopores.

Spruijt E, Tusk SE, Bayley H.

Nat Nanotechnol. 2018 Aug;13(8):739-745. doi: 10.1038/s41565-018-0139-6. Epub 2018 May 28.


Single-Molecule Determination of the Isomers of d-Glucose and d-Fructose that Bind to Boronic Acids.

Ramsay WJ, Bayley H.

Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2841-2845. doi: 10.1002/anie.201712740. Epub 2018 Feb 13.


Bioorthogonal Cycloadditions with Sub-Millisecond Intermediates.

Qing Y, Pulcu GS, Bell NAW, Bayley H.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1218-1221. doi: 10.1002/anie.201710262. Epub 2018 Jan 5.


Single-molecule DNA sequencing: Getting to the bottom of the well.

Bayley H.

Nat Nanotechnol. 2017 Dec;12(12):1116-1117. doi: 10.1038/nnano.2017.205. Epub 2017 Sep 25. No abstract available.


Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines.

Lakshminarayanan A, Vijayakrishnan B, Bayley H, Davis BG.

Methods Enzymol. 2017;597:335-357. doi: 10.1016/bs.mie.2017.06.008. Epub 2017 Sep 8.


Light-patterning of synthetic tissues with single droplet resolution.

Booth MJ, Restrepo Schild V, Box SJ, Bayley H.

Sci Rep. 2017 Aug 24;7(1):9315. doi: 10.1038/s41598-017-09394-9.


A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis.

Rouse SL, Hawthorne WJ, Berry JL, Chorev DS, Ionescu SA, Lambert S, Stylianou F, Ewert W, Mackie U, Morgan RML, Otzen D, Herbst FA, Nielsen PH, Dueholm M, Bayley H, Robinson CV, Hare S, Matthews S.

Nat Commun. 2017 Aug 15;8(1):263. doi: 10.1038/s41467-017-00361-6.


Functional aqueous droplet networks.

Booth MJ, Restrepo Schild V, Downs FG, Bayley H.

Mol Biosyst. 2017 Aug 22;13(9):1658-1691. doi: 10.1039/c7mb00192d. Review.


High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing.

Graham AD, Olof SN, Burke MJ, Armstrong JPK, Mikhailova EA, Nicholson JG, Box SJ, Szele FG, Perriman AW, Bayley H.

Sci Rep. 2017 Aug 1;7(1):7004. doi: 10.1038/s41598-017-06358-x.


Membrane pores: from structure and assembly, to medicine and technology.

Gilbert RJC, Bayley H, Anderluh G.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160208. doi: 10.1098/rstb.2016.0208. No abstract available.


A monodisperse transmembrane α-helical peptide barrel.

Mahendran KR, Niitsu A, Kong L, Thomson AR, Sessions RB, Woolfson DN, Bayley H.

Nat Chem. 2017 May;9(5):411-419. doi: 10.1038/nchem.2647. Epub 2016 Nov 14.


Light-Patterned Current Generation in a Droplet Bilayer Array.

Restrepo Schild V, Booth MJ, Box SJ, Olof SN, Mahendran KR, Bayley H.

Sci Rep. 2017 Apr 18;7:46585. doi: 10.1038/srep46585.


Multi-compartment encapsulation of communicating droplets and droplet networks in hydrogel as a model for artificial cells.

Bayoumi M, Bayley H, Maglia G, Sapra KT.

Sci Rep. 2017 Apr 3;7:45167. doi: 10.1038/srep45167.


Orientation of the OmpF Porin in Planar Lipid Bilayers.

Ionescu SA, Lee S, Housden NG, Kaminska R, Kleanthous C, Bayley H.

Chembiochem. 2017 Mar 16;18(6):554-562. doi: 10.1002/cbic.201600644. Epub 2017 Feb 28.


Engineered transmembrane pores.

Ayub M, Bayley H.

Curr Opin Chem Biol. 2016 Oct;34:117-126. doi: 10.1016/j.cbpa.2016.08.005. Epub 2016 Sep 20. Review.


Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry.

Lee J, Boersma AJ, Boudreau MA, Cheley S, Daltrop O, Li J, Tamagaki H, Bayley H.

ACS Nano. 2016 Sep 27;10(9):8843-50. doi: 10.1021/acsnano.6b04663. Epub 2016 Aug 30.


Chemical polyglycosylation and nanolitre detection enables single-molecule recapitulation of bacterial sugar export.

Kong L, Almond A, Bayley H, Davis BG.

Nat Chem. 2016 May;8(5):461-9. doi: 10.1038/nchem.2487. Epub 2016 Apr 18.


Light-activated communication in synthetic tissues.

Booth MJ, Schild VR, Graham AD, Olof SN, Bayley H.

Sci Adv. 2016 Apr 1;2(4):e1600056. doi: 10.1126/sciadv.1600056. eCollection 2016 Apr.


The role of lipids in mechanosensation.

Pliotas C, Dahl AC, Rasmussen T, Mahendran KR, Smith TK, Marius P, Gault J, Banda T, Rasmussen A, Miller S, Robinson CV, Bayley H, Sansom MS, Booth IR, Naismith JH.

Nat Struct Mol Biol. 2015 Dec;22(12):991-8. doi: 10.1038/nsmb.3120. Epub 2015 Nov 9.


New technologies for DNA analysis--a review of the READNA Project.

McGinn S, Bauer D, Brefort T, Dong L, El-Sagheer A, Elsharawy A, Evans G, Falk-Sörqvist E, Forster M, Fredriksson S, Freeman P, Freitag C, Fritzsche J, Gibson S, Gullberg M, Gut M, Heath S, Heath-Brun I, Heron AJ, Hohlbein J, Ke R, Lancaster O, Le Reste L, Maglia G, Marie R, Mauger F, Mertes F, Mignardi M, Moens L, Oostmeijer J, Out R, Pedersen JN, Persson F, Picaud V, Rotem D, Schracke N, Sengenes J, Stähler PF, Stade B, Stoddart D, Teng X, Veal CD, Zahra N, Bayley H, Beier M, Brown T, Dekker C, Ekström B, Flyvbjerg H, Franke A, Guenther S, Kapanidis AN, Kaye J, Kristensen A, Lehrach H, Mangion J, Sauer S, Schyns E, Tost J, van Helvoort JM, van der Zaag PJ, Tegenfeldt JO, Brookes AJ, Mir K, Nilsson M, Willcocks JP, Gut IG.

N Biotechnol. 2016 May 25;33(3):311-30. doi: 10.1016/j.nbt.2015.10.003. Epub 2015 Oct 26. Review.


Semisynthetic protein nanoreactor for single-molecule chemistry.

Lee J, Bayley H.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13768-73. doi: 10.1073/pnas.1510565112. Epub 2015 Oct 26.


High-throughput optical sensing of nucleic acids in a nanopore array.

Huang S, Romero-Ruiz M, Castell OK, Bayley H, Wallace MI.

Nat Nanotechnol. 2015 Nov;10(11):986-91. doi: 10.1038/nnano.2015.189. Epub 2015 Aug 31.


Nucleobase Recognition by Truncated α-Hemolysin Pores.

Ayub M, Stoddart D, Bayley H.

ACS Nano. 2015 Aug 25;9(8):7895-903. doi: 10.1021/nn5060317. Epub 2015 Jul 28.


Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor.

Harrington L, Alexander LT, Knapp S, Bayley H.

Angew Chem Int Ed Engl. 2015 Jul 6;54(28):8154-9. doi: 10.1002/anie.201503141. Epub 2015 Jun 8.


DNA stretching and optimization of nucleobase recognition in enzymatic nanopore sequencing.

Stoddart D, Franceschini L, Heron A, Bayley H, Maglia G.

Nanotechnology. 2015 Feb 27;26(8):084002. doi: 10.1088/0957-4484/26/8/084002. Epub 2015 Feb 3.


Continuous observation of the stochastic motion of an individual small-molecule walker.

Pulcu GS, Mikhailova E, Choi LS, Bayley H.

Nat Nanotechnol. 2015 Jan;10(1):76-83. doi: 10.1038/nnano.2014.264. Epub 2014 Dec 8.


Nanopore sequencing: from imagination to reality.

Bayley H.

Clin Chem. 2015 Jan;61(1):25-31. doi: 10.1373/clinchem.2014.223016. Epub 2014 Dec 4. No abstract available.


A droplet microfluidic system for sequential generation of lipid bilayers and transmembrane electrical recordings.

Czekalska MA, Kaminski TS, Jakiela S, Tanuj Sapra K, Bayley H, Garstecki P.

Lab Chip. 2015 Jan 21;15(2):541-8. doi: 10.1039/c4lc00985a.


Designing a hydrophobic barrier within biomimetic nanopores.

Trick JL, Wallace EJ, Bayley H, Sansom MS.

ACS Nano. 2014 Nov 25;8(11):11268-79. doi: 10.1021/nn503930p. Epub 2014 Oct 20.


Protein co-translocational unfolding depends on the direction of pulling.

Rodriguez-Larrea D, Bayley H.

Nat Commun. 2014 Sep 8;5:4841. doi: 10.1038/ncomms5841.


Single-molecule analysis of chirality in a multicomponent reaction network.

Steffensen MB, Rotem D, Bayley H.

Nat Chem. 2014 Jul;6(7):603-7. doi: 10.1038/nchem.1949. Epub 2014 May 18.


Functional truncated membrane pores.

Stoddart D, Ayub M, Höfler L, Raychaudhuri P, Klingelhoefer JW, Maglia G, Heron A, Bayley H.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2425-30. doi: 10.1073/pnas.1312976111. Epub 2014 Jan 27.


Single-molecule site-specific detection of protein phosphorylation with a nanopore.

Rosen CB, Rodriguez-Larrea D, Bayley H.

Nat Biotechnol. 2014 Feb;32(2):179-81. doi: 10.1038/nbt.2799. Epub 2014 Jan 19.


Detection of 3'-end RNA uridylation with a protein nanopore.

Clamer M, Höfler L, Mikhailova E, Viero G, Bayley H.

ACS Nano. 2014 Feb 25;8(2):1364-74. doi: 10.1021/nn4050479. Epub 2013 Dec 31.


Construction and manipulation of functional three-dimensional droplet networks.

Wauer T, Gerlach H, Mantri S, Hill J, Bayley H, Sapra KT.

ACS Nano. 2014 Jan 28;8(1):771-9. doi: 10.1021/nn405433y. Epub 2014 Jan 6.


Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate.

Harrington L, Cheley S, Alexander LT, Knapp S, Bayley H.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4417-26. doi: 10.1073/pnas.1312739110. Epub 2013 Nov 5.


Nanopore-based identification of individual nucleotides for direct RNA sequencing.

Ayub M, Hardwick SW, Luisi BF, Bayley H.

Nano Lett. 2013;13(12):6144-50. doi: 10.1021/nl403469r. Epub 2013 Nov 13.


Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor.

Kong L, Harrington L, Li Q, Cheley S, Davis BG, Bayley H.

Nat Chem. 2013 Aug;5(8):651-9. doi: 10.1038/nchem.1695. Epub 2013 Jun 30.


Rates and stoichiometries of metal ion probes of cysteine residues within ion channels.

Choi LS, Mach T, Bayley H.

Biophys J. 2013 Jul 16;105(2):356-64. doi: 10.1016/j.bpj.2013.04.046.


Porphyrins for probing electrical potential across lipid bilayer membranes by second harmonic generation.

Reeve JE, Corbett AD, Boczarow I, Kaluza W, Barford W, Bayley H, Wilson T, Anderson HL.

Angew Chem Int Ed Engl. 2013 Aug 19;52(34):9044-8. doi: 10.1002/anie.201304515. Epub 2013 Jul 16. No abstract available.


Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF.

Housden NG, Hopper JT, Lukoyanova N, Rodriguez-Larrea D, Wojdyla JA, Klein A, Kaminska R, Bayley H, Saibil HR, Robinson CV, Kleanthous C.

Science. 2013 Jun 28;340(6140):1570-4. doi: 10.1126/science.1237864.


Translocating kilobase RNA through the Staphylococcal α-hemolysin nanopore.

Cracknell JA, Japrung D, Bayley H.

Nano Lett. 2013 Jun 12;13(6):2500-5. doi: 10.1021/nl400560r. Epub 2013 May 23.

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