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Genetic and biochemical analysis of CodY-mediated cell aggregation in Staphylococcus aureus reveals an interaction between eDNA and polysaccharide in the extracellular matrix.

Mlynek KD, Bulock LL, Stone CJ, Curran LJ, Sadykov MR, Bayles KW, Brinsmade SR.

J Bacteriol. 2020 Feb 3. pii: JB.00593-19. doi: 10.1128/JB.00593-19. [Epub ahead of print]


Fluorescent Sensor Arrays Can Predict and Quantify the Composition of Multicomponent Bacterial Samples.

Svechkarev D, Sadykov MR, Houser LJ, Bayles KW, Mohs AM.

Front Chem. 2020 Jan 15;7:916. doi: 10.3389/fchem.2019.00916. eCollection 2019.


An integrated computational and experimental study to investigate Staphylococcus aureus metabolism.

Mazharul Islam M, Thomas VC, Van Beek M, Ahn JS, Alqarzaee AA, Zhou C, Fey PD, Bayles KW, Saha R.

NPJ Syst Biol Appl. 2020 Jan 30;6(1):3. doi: 10.1038/s41540-019-0122-3.


Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS.

DelMain EA, Moormeier DE, Endres JL, Hodges RE, Sadykov MR, Horswill AR, Bayles KW.

mBio. 2020 Jan 14;11(1). pii: e03081-19. doi: 10.1128/mBio.03081-19.


CidR and CcpA Synergistically Regulate Staphylococcus aureus cidABC Expression.

Sadykov MR, Windham IH, Widhelm TJ, Yajjala VK, Watson SM, Endres JL, Bavari AI, Thomas VC, Bose JL, Bayles KW.

J Bacteriol. 2019 Nov 5;201(23). pii: e00371-19. doi: 10.1128/JB.00371-19. Print 2019 Dec 1.


Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix.

Kavanaugh JS, Flack CE, Lister J, Ricker EB, Ibberson CB, Jenul C, Moormeier DE, Delmain EA, Bayles KW, Horswill AR.

mBio. 2019 Jun 25;10(3). pii: e01137-19. doi: 10.1128/mBio.01137-19.


Construction of a Sequence-Defined Transposon Mutant Library in Staphylococcus aureus.

Endres JL, Yajjala VK, Fey PD, Bayles KW.

Methods Mol Biol. 2019;2016:29-37. doi: 10.1007/978-1-4939-9570-7_3.


Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.

King AN, Borkar SA, Samuels DJ, Batz Z, Bulock LL, Sadykov MR, Bayles KW, Brinsmade SR.

J Bacteriol. 2018 Jun 25;200(14). pii: e00136-18. doi: 10.1128/JB.00136-18. Print 2018 Jul 15.


Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis.

Svechkarev D, Sadykov MR, Bayles KW, Mohs AM.

ACS Sens. 2018 Mar 23;3(3):700-708. doi: 10.1021/acssensors.8b00025. Epub 2018 Mar 9.


Nutritional Regulation of the Sae Two-Component System by CodY in Staphylococcus aureus.

Mlynek KD, Sause WE, Moormeier DE, Sadykov MR, Hill KR, Torres VJ, Bayles KW, Brinsmade SR.

J Bacteriol. 2018 Mar 26;200(8). pii: e00012-18. doi: 10.1128/JB.00012-18. Print 2018 Apr 15.


Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase.

Zhang X, Bayles KW, Luca S.

Biochemistry. 2017 Sep 12;56(36):4819-4829. doi: 10.1021/acs.biochem.7b00570. Epub 2017 Aug 25.


Poly(3-hydroxybutyrate) fuels the tricarboxylic acid cycle and de novo lipid biosynthesis during Bacillus anthracis sporulation.

Sadykov MR, Ahn JS, Widhelm TJ, Eckrich VM, Endres JL, Driks A, Rutkowski GE, Wingerd KL, Bayles KW.

Mol Microbiol. 2017 Jun;104(5):793-803. doi: 10.1111/mmi.13665. Epub 2017 Mar 30.


Staphylococcus aureus biofilm: a complex developmental organism.

Moormeier DE, Bayles KW.

Mol Microbiol. 2017 May;104(3):365-376. doi: 10.1111/mmi.13634. Epub 2017 Mar 8. Review.


Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents.

Udumula V, Endres JL, Harper CN, Jaramillo L, Zhong HA, Bayles KW, Conda-Sheridan M.

Eur J Med Chem. 2017 Jan 5;125:710-721. doi: 10.1016/j.ejmech.2016.09.079. Epub 2016 Sep 28.


Identification of inhibitors for single-stranded DNA-binding proteins in eubacteria.

Glanzer JG, Endres JL, Byrne BM, Liu S, Bayles KW, Oakley GG.

J Antimicrob Chemother. 2016 Dec;71(12):3432-3440. Epub 2016 Sep 8.


Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities.

Yang Z, Liu Y, Ahn J, Qiao Z, Endres JL, Gautam N, Huang Y, Li J, Zheng J, Alnouti Y, Bayles KW, Li R.

Eur J Med Chem. 2016 Nov 29;124:129-137. doi: 10.1016/j.ejmech.2016.08.017. Epub 2016 Aug 12.


Potassium Uptake Modulates Staphylococcus aureus Metabolism.

Gries CM, Sadykov MR, Bulock LL, Chaudhari SS, Thomas VC, Bose JL, Bayles KW.

mSphere. 2016 Jun 15;1(3). pii: e00125-16. doi: 10.1128/mSphere.00125-16. eCollection 2016 May-Jun.


The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus.

Chaudhari SS, Thomas VC, Sadykov MR, Bose JL, Ahn DJ, Zimmerman MC, Bayles KW.

Mol Microbiol. 2016 Sep;101(6):942-53. doi: 10.1111/mmi.13433. Epub 2016 Jul 4.


Electron Paramagnetic Resonance (EPR) Spectroscopy to Detect Reactive Oxygen Species in Staphylococcus aureus.

Thomas VC, Chaudhari SS, Jones J, Zimmerman MC, Bayles KW.

Bio Protoc. 2015 Sep 5;5(17). pii: e1586.


Resistance to Acute Macrophage Killing Promotes Airway Fitness of Prevalent Community-Acquired Staphylococcus aureus Strains.

Yajjala VK, Thomas VC, Bauer C, Scherr TD, Fischer KJ, Fey PD, Bayles KW, Kielian T, Sun K.

J Immunol. 2016 May 15;196(10):4196-203. doi: 10.4049/jimmunol.1600081. Epub 2016 Apr 6.


The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model.

McCarthy H, Waters EM, Bose JL, Foster S, Bayles KW, O'Neill E, Fey PD, O'Gara JP.

FEMS Microbiol Lett. 2016 May;363(9). pii: fnw087. doi: 10.1093/femsle/fnw087. Epub 2016 Apr 3.


Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus.

Marshall DD, Sadykov MR, Thomas VC, Bayles KW, Powers R.

J Proteome Res. 2016 Apr 1;15(4):1205-12. doi: 10.1021/acs.jproteome.5b01089. Epub 2016 Mar 24.


Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms.

Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, Kaplan JB.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2639-51. doi: 10.1128/AAC.02070-15. Print 2016 May.


SrrAB Modulates Staphylococcus aureus Cell Death through Regulation of cidABC Transcription.

Windham IH, Chaudhari SS, Bose JL, Thomas VC, Bayles KW.

J Bacteriol. 2016 Jan 25;198(7):1114-22. doi: 10.1128/JB.00954-15.


Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.

Scherr TD, Hanke ML, Huang O, James DB, Horswill AR, Bayles KW, Fey PD, Torres VJ, Kielian T.

mBio. 2015 Aug 25;6(4). pii: e01021-15. doi: 10.1128/mBio.01021-15.


Generation of a Transposon Mutant Library in Staphylococcus aureus and Staphylococcus epidermidis Using bursa aurealis.

Yajjala VK, Widhelm TJ, Endres JL, Fey PD, Bayles KW.

Methods Mol Biol. 2016;1373:103-10. doi: 10.1007/7651_2014_189.


Examination of the Staphylococcus aureus nitric oxide reductase (saNOR) reveals its contribution to modulating intracellular NO levels and cellular respiration.

Lewis AM, Matzdorf SS, Endres JL, Windham IH, Bayles KW, Rice KC.

Mol Microbiol. 2015 May;96(3):651-69. doi: 10.1111/mmi.12962. Epub 2015 Mar 16.


Allelic Exchange.

Lehman MK, Bose JL, Bayles KW.

Methods Mol Biol. 2016;1373:89-96. doi: 10.1007/7651_2014_187.


Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression.

Lehman MK, Bose JL, Sharma-Kuinkel BK, Moormeier DE, Endres JL, Sadykov MR, Biswas I, Bayles KW.

Mol Microbiol. 2015 Feb;95(4):723-37. doi: 10.1111/mmi.12902. Epub 2015 Jan 16.


Temporal and stochastic control of Staphylococcus aureus biofilm development.

Moormeier DE, Bose JL, Horswill AR, Bayles KW.

mBio. 2014 Oct 14;5(5):e01341-14. doi: 10.1128/mBio.01341-14.


Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds.

Wang G, Hanke ML, Mishra B, Lushnikova T, Heim CE, Chittezham Thomas V, Bayles KW, Kielian T.

ACS Chem Biol. 2014 Sep 19;9(9):1997-2002. doi: 10.1021/cb500475y. Epub 2014 Jul 30.


A central role for carbon-overflow pathways in the modulation of bacterial cell death.

Thomas VC, Sadykov MR, Chaudhari SS, Jones J, Endres JL, Widhelm TJ, Ahn JS, Jawa RS, Zimmerman MC, Bayles KW.

PLoS Pathog. 2014 Jun 19;10(6):e1004205. doi: 10.1371/journal.ppat.1004205. eCollection 2014 Jun.


The development of drug-free therapy for prevention of dental caries.

Chen F, Jia Z, Rice KC, Reinhardt RA, Bayles KW, Wang D.

Pharm Res. 2014 Nov;31(11):3031-7. doi: 10.1007/s11095-014-1396-1. Epub 2014 May 15.


Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis.

Lindgren JK, Thomas VC, Olson ME, Chaudhari SS, Nuxoll AS, Schaeffer CR, Lindgren KE, Jones J, Zimmerman MC, Dunman PM, Bayles KW, Fey PD.

J Bacteriol. 2014 Jun;196(12):2277-89. doi: 10.1128/JB.00051-14. Epub 2014 Apr 11.


Predicting the virulence of MRSA from its genome sequence.

Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, Yajjala VK, Widhelm T, Hawkins E, Lewis K, Parfett S, Scowen L, Peacock SJ, Holden M, Wilson D, Read TD, van den Elsen J, Priest NK, Feil EJ, Hurst LD, Josefsson E, Massey RC.

Genome Res. 2014 May;24(5):839-49. doi: 10.1101/gr.165415.113. Epub 2014 Apr 9.


Identification of the Staphylococcus aureus vfrAB operon, a novel virulence factor regulatory locus.

Bose JL, Daly SM, Hall PR, Bayles KW.

Infect Immun. 2014 May;82(5):1813-22. doi: 10.1128/IAI.01655-13. Epub 2014 Feb 18.


Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus.

Abdelhady W, Bayer AS, Seidl K, Moormeier DE, Bayles KW, Cheung A, Yeaman MR, Xiong YQ.

J Infect Dis. 2014 Apr 15;209(8):1231-40. doi: 10.1093/infdis/jiu007. Epub 2014 Jan 7.


Bacterial programmed cell death: making sense of a paradox.

Bayles KW.

Nat Rev Microbiol. 2014 Jan;12(1):63-9. doi: 10.1038/nrmicro3136. Review.


Examination of Staphylococcus epidermidis biofilms using flow-cell technology.

Moormeier DE, Bayles KW.

Methods Mol Biol. 2014;1106:143-55. doi: 10.1007/978-1-62703-736-5_13.


Methods to generate a sequence-defined transposon mutant library in Staphylococcus epidermidis strain 1457.

Widhelm TJ, Yajjala VK, Endres JL, Fey PD, Bayles KW.

Methods Mol Biol. 2014;1106:135-42. doi: 10.1007/978-1-62703-736-5_12.


A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during β-lactam stress.

Thomas VC, Kinkead LC, Janssen A, Schaeffer CR, Woods KM, Lindgren JK, Peaster JM, Chaudhari SS, Sadykov M, Jones J, AbdelGhani SM, Zimmerman MC, Bayles KW, Somerville GA, Fey PD.

mBio. 2013 Aug 20;4(4). pii: e00437-13. doi: 10.1128/mBio.00437-13. Erratum in: MBio. 2014;5(3):e01307-14. Chittezham Thomas, Vinai [corrected to Thomas, Vinai C].


The Ktr potassium transport system in Staphylococcus aureus and its role in cell physiology, antimicrobial resistance and pathogenesis.

Gries CM, Bose JL, Nuxoll AS, Fey PD, Bayles KW.

Mol Microbiol. 2013 Aug;89(4):760-73. doi: 10.1111/mmi.12312. Epub 2013 Jul 17.


The development of dentotropic micelles with biodegradable tooth-binding moieties.

Chen F, Jia Z, Rice KC, Reinhardt RA, Bayles KW, Wang D.

Pharm Res. 2013 Nov;30(11):2808-17. doi: 10.1007/s11095-013-1105-5. Epub 2013 Jun 14.


Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus.

Yang SJ, Xiong YQ, Yeaman MR, Bayles KW, Abdelhady W, Bayer AS.

Antimicrob Agents Chemother. 2013 Aug;57(8):3875-82. doi: 10.1128/AAC.00412-13. Epub 2013 Jun 3.


Inactivation of the Pta-AckA pathway causes cell death in Staphylococcus aureus.

Sadykov MR, Thomas VC, Marshall DD, Wenstrom CJ, Moormeier DE, Widhelm TJ, Nuxoll AS, Powers R, Bayles KW.

J Bacteriol. 2013 Jul;195(13):3035-44. doi: 10.1128/JB.00042-13. Epub 2013 Apr 26.


Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches.

Moormeier DE, Endres JL, Mann EE, Sadykov MR, Horswill AR, Rice KC, Fey PD, Bayles KW.

Appl Environ Microbiol. 2013 Jun;79(11):3413-24. doi: 10.1128/AEM.00395-13. Epub 2013 Mar 22.


A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes.

Fey PD, Endres JL, Yajjala VK, Widhelm TJ, Boissy RJ, Bose JL, Bayles KW.

mBio. 2013 Feb 12;4(1):e00537-12. doi: 10.1128/mBio.00537-12.


Genetic tools to enhance the study of gene function and regulation in Staphylococcus aureus.

Bose JL, Fey PD, Bayles KW.

Appl Environ Microbiol. 2013 Apr;79(7):2218-24. doi: 10.1128/AEM.00136-13. Epub 2013 Jan 25.


CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism.

Nuxoll AS, Halouska SM, Sadykov MR, Hanke ML, Bayles KW, Kielian T, Powers R, Fey PD.

PLoS Pathog. 2012;8(11):e1003033. doi: 10.1371/journal.ppat.1003033. Epub 2012 Nov 29.


Programmed cell death in plants: lessons from bacteria?

Wang J, Bayles KW.

Trends Plant Sci. 2013 Mar;18(3):133-9. doi: 10.1016/j.tplants.2012.09.004. Epub 2012 Oct 16.

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