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Items: 1 to 50 of 201

1.

Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Ritov VB, Kochanek PM, Balasubramani GK, Kenny E, Sharma M, Viegas M, Callaway C, Kagan VE, Bayír H.

Pediatr Crit Care Med. 2019 Jul 11. doi: 10.1097/PCC.0000000000002036. [Epub ahead of print]

PMID:
31305328
2.

Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing.

Artyukhova MA, Tyurina YY, Chu CT, Zharikova TM, Bayır H, Kagan VE, Timashev PS.

Free Radic Biol Med. 2019 Jun 12. pii: S0891-5849(19)30251-5. doi: 10.1016/j.freeradbiomed.2019.06.007. [Epub ahead of print] Review.

PMID:
31201850
3.

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.

Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE.

J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. Epub 2019 May 9. Review.

4.

Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow.

Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayir H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS.

In Vivo. 2019 May-Jun;33(3):675-688. doi: 10.21873/invivo.11526.

5.

Detection of brain specific cardiolipins in plasma after experimental pediatric head injury.

Anthonymuthu TS, Kenny EM, Hier ZE, Clark RSB, Kochanek PM, Kagan VE, Bayır H.

Exp Neurol. 2019 Jun;316:63-73. doi: 10.1016/j.expneurol.2019.04.007. Epub 2019 Apr 11.

PMID:
30981805
6.

"Redox lipidomics technology: Looking for a needle in a haystack".

Tyurina YY, Tyurin VA, Anthonymuthu T, Amoscato AA, Sparvero LJ, Nesterova AM, Baynard ML, Sun W, He R, Khaitovich P, Vladimirov YA, Gabrilovich DI, Bayır H, Kagan VE.

Chem Phys Lipids. 2019 Jul;221:93-107. doi: 10.1016/j.chemphyslip.2019.03.012. Epub 2019 Mar 27. Review.

7.

Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest.

Anthonymuthu TS, Kenny EM, Lamade AM, Gidwani H, Krehel NM, Misse A, Gao X, Amoscato AA, Straub AC, Kagan VE, Dezfulian C, Bayır H.

Crit Care Med. 2019 Apr;47(4):e292-e300. doi: 10.1097/CCM.0000000000003636.

PMID:
30855329
8.

Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.

Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I.

J Chem Inf Model. 2019 May 28;59(5):2496-2508. doi: 10.1021/acs.jcim.9b00006. Epub 2019 Feb 28.

9.

Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level.

Tian H, Sparvero LJ, Blenkinsopp P, Amoscato AA, Watkins SC, Bayır H, Kagan VE, Winograd N.

Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. doi: 10.1002/anie.201814256. Epub 2019 Feb 14.

PMID:
30680861
10.

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury.

Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J.

J Neurosci. 2019 Mar 6;39(10):1930-1943. doi: 10.1523/JNEUROSCI.3415-17.2018. Epub 2019 Jan 9.

11.

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury.

Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H.

Crit Care Med. 2019 Mar;47(3):410-418. doi: 10.1097/CCM.0000000000003555.

PMID:
30531185
12.

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE.

Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H.

J Am Chem Soc. 2018 Dec 26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. Epub 2018 Dec 17.

PMID:
30525572
13.

Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.

Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.

J Neurotrauma. 2019 Feb 1. doi: 10.1089/neu.2018.6203. [Epub ahead of print]

PMID:
30520681
14.

Extracorporeal Membrane Oxygenation and Hemolysis-Still a Challenge.

Kim-Campbell N, Bayir H.

Pediatr Crit Care Med. 2018 Nov;19(11):1089-1090. doi: 10.1097/PCC.0000000000001728. No abstract available.

PMID:
30395113
15.

Disentangling oxidation/hydrolysis reactions of brain mitochondrial cardiolipins in pathogenesis of traumatic injury.

Chao H, Anthonymuthu TS, Kenny EM, Amoscato AA, Cole LK, Hatch GM, Ji J, Kagan VE, Bayır H.

JCI Insight. 2018 Nov 2;3(21). pii: 97677. doi: 10.1172/jci.insight.97677.

16.

Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin.

Wolf MS, Chen Y, Simon DW, Alexander H, Ross M, Gibson GA, Manole MD, Bayır H, Kochanek PM, Clark RSB.

J Neurosci Methods. 2019 Jan 1;311:436-441. doi: 10.1016/j.jneumeth.2018.09.031. Epub 2018 Oct 5.

PMID:
30292824
17.

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O, Jadhav S, Bolevich SB, Kozlov AV, Vladimirov YA, Shvedova AA, Philpott CC, Bayir H, Kagan VE.

Free Radic Biol Med. 2019 Mar;133:153-161. doi: 10.1016/j.freeradbiomed.2018.09.008. Epub 2018 Sep 12. Review.

PMID:
30217775
18.

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE.

J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10.

19.

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB.

ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. Epub 2018 Sep 14.

PMID:
30184433
20.

Aiming for the target: Mitochondrial drug delivery in traumatic brain injury.

Lamade AM, Kenny EM, Anthonymuthu TS, Soysal E, Clark RSB, Kagan VE, Bayır H.

Neuropharmacology. 2019 Feb;145(Pt B):209-219. doi: 10.1016/j.neuropharm.2018.07.014. Epub 2018 Jul 30. Review.

PMID:
30009835
21.

Oxidized phospholipid signaling in traumatic brain injury.

Anthonymuthu TS, Kenny EM, Lamade AM, Kagan VE, Bayır H.

Free Radic Biol Med. 2018 Aug 20;124:493-503. doi: 10.1016/j.freeradbiomed.2018.06.031. Epub 2018 Jun 30. Review.

22.

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.

Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T.

J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. Epub 2018 Jun 25.

23.

Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation.

Lou W, Ting HC, Reynolds CA, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayır H, Kagan VE, Greenberg ML.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1354-1368. doi: 10.1016/j.bbalip.2018.06.016. Epub 2018 Jun 20.

24.

Regulation of lipid peroxidation and ferroptosis in diverse species.

Conrad M, Kagan VE, Bayir H, Pagnussat GC, Head B, Traber MG, Stockwell BR.

Genes Dev. 2018 May 1;32(9-10):602-619. doi: 10.1101/gad.314674.118. Review.

25.

Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RSB.

Crit Care Med. 2018 Sep;46(9):1471-1479. doi: 10.1097/CCM.0000000000003203.

26.

Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.

Fidan E, Foley LM, New LA, Alexander H, Kochanek PM, Hitchens TK, Bayır H.

ASN Neuro. 2018 Jan-Dec;10:1759091418770543. doi: 10.1177/1759091418770543.

27.

The role of autophagy in acute brain injury: A state of flux?

Wolf MS, Bayır H, Kochanek PM, Clark RSB.

Neurobiol Dis. 2019 Feb;122:9-15. doi: 10.1016/j.nbd.2018.04.018. Epub 2018 Apr 26. Review.

PMID:
29704549
28.

Quantitative assessment of cell fate decision between autophagy and apoptosis.

Liu B, Oltvai ZN, Bayır H, Silverman GA, Pak SC, Perlmutter DH, Bahar I.

Sci Rep. 2017 Dec 14;7(1):17605. doi: 10.1038/s41598-017-18001-w.

29.

Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned.

Kochanek PM, Wallisch JS, Bayır H, Clark RSB.

Childs Nerv Syst. 2017 Oct;33(10):1693-1701. doi: 10.1007/s00381-017-3474-2. Epub 2017 Sep 6. Review.

30.

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.

Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS.

Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. Epub 2017 Nov 15.

31.

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.

Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044.

32.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD.

Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review.

33.

Evaluation of encapsulated sodium butyrate on growth performance, energy digestibility, gut development, and Salmonella colonization in broilers.

Liu JD, Bayir HO, Cosby DE, Cox NA, Williams SM, Fowler J.

Poult Sci. 2017 Oct 1;96(10):3638-3644. doi: 10.3382/ps/pex174.

PMID:
28938774
34.

Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek PM, Maul T, Wearden P, Sharma M, Viegas M, Munoz R, Gladwin MT, Bayir H.

Crit Care Med. 2017 Nov;45(11):e1123-e1130. doi: 10.1097/CCM.0000000000002703.

35.

"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions.

Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE.

Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. Epub 2017 Oct 16. Review.

PMID:
28835115
36.

The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RSB, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Sep;13(9):572. doi: 10.1038/nrneurol.2017.116. Epub 2017 Aug 4.

PMID:
28776601
37.

Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

Simon DW, Aneja RK, Alexander H, Bell MJ, Bayır H, Kochanek PM, Clark RSB.

J Neurotrauma. 2018 Jan 1;35(1):130-138. doi: 10.1089/neu.2017.5093. Epub 2017 Aug 22.

38.

Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.

Clark RSB, Empey PE, Bayır H, Rosario BL, Poloyac SM, Kochanek PM, Nolin TD, Au AK, Horvat CM, Wisniewski SR, Bell MJ.

PLoS One. 2017 Jul 7;12(7):e0180280. doi: 10.1371/journal.pone.0180280. eCollection 2017.

39.

Oxidative lipidomics: applications in critical care.

Anthonymuthu TS, Kim-Campbell N, Bayır H.

Curr Opin Crit Care. 2017 Aug;23(4):251-256. doi: 10.1097/MCC.0000000000000419. Review.

40.

Titrating the Dose of Oxygen after Severe Traumatic Brain Injury in the Era of Precision Medicine.

Kochanek PM, Bayır H.

J Neurotrauma. 2017 Nov 15;34(22):3067-3069. doi: 10.1089/neu.2017.5159. Epub 2017 Jul 21. No abstract available.

PMID:
28537530
41.

Role of Ultrasonography in Detecting the Localisation of the Nasoenteric Tube.

Dağlı R, Bayır H, Dadalı Y, Tokmak TT, Erbesler ZA.

Turk J Anaesthesiol Reanim. 2017 Apr;45(2):103-107. doi: 10.5152/TJAR.2017.80269. Epub 2017 Apr 1.

42.

Global assessment of oxidized free fatty acids in brain reveals an enzymatic predominance to oxidative signaling after trauma.

Anthonymuthu TS, Kenny EM, Amoscato AA, Lewis J, Kochanek PM, Kagan VE, Bayır H.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2601-2613. doi: 10.1016/j.bbadis.2017.03.015. Epub 2017 Mar 25.

43.

Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury.

Tian H, Sparvero LJ, Amoscato AA, Bloom A, Bayır H, Kagan VE, Winograd N.

Anal Chem. 2017 Apr 18;89(8):4611-4619. doi: 10.1021/acs.analchem.7b00164. Epub 2017 Mar 29.

44.

Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids.

Kagan VE, Bayır H, Tyurina YY, Bolevich SB, Maguire JJ, Fadeel B, Balasubramanian K.

Biochem Biophys Res Commun. 2017 Jan 15;482(3):482-490. doi: 10.1016/j.bbrc.2016.11.005. Epub 2017 Feb 3. Review.

45.

The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Mar;13(3):171-191. doi: 10.1038/nrneurol.2017.13. Epub 2017 Feb 10. Review. Erratum in: Nat Rev Neurol. 2017 Aug 04;:.

46.

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children.

Wallisch JS, Simon DW, Bayır H, Bell MJ, Kochanek PM, Clark RSB.

Neurocrit Care. 2017 Aug;27(1):44-50. doi: 10.1007/s12028-017-0378-7.

47.

α-Tocopherol transfer protein mediates protective hypercapnia in murine ventilator-induced lung injury.

Otulakowski G, Engelberts D, Arima H, Hirate H, Bayir H, Post M, Kavanagh BP.

Thorax. 2017 Jun;72(6):538-549. doi: 10.1136/thoraxjnl-2016-209501. Epub 2017 Feb 3.

PMID:
28159772
48.

Achalasia case detected during endoscopy application accompanied by anaesthesia.

Dağlı R, Bayır H, Ergül B, Kocaoğlu N, Erbesler ZA.

Prz Gastroenterol. 2016;11(4):302-303. doi: 10.5114/pg.2016.61476. Epub 2016 Jul 22. No abstract available.

49.

Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury.

Au AK, Aneja RK, Bayır H, Bell MJ, Janesko-Feldman K, Kochanek PM, Clark RSB.

Neurocrit Care. 2017 Jun;26(3):348-355. doi: 10.1007/s12028-016-0351-x.

PMID:
28000126
50.

Magic angle spinning 31P NMR spectroscopy reveals two essentially identical ionization states for the cardiolipin phosphates in phospholipid liposomes.

Kooijman EE, Swim LA, Graber ZT, Tyurina YY, Bayır H, Kagan VE.

Biochim Biophys Acta Biomembr. 2017 Jan;1859(1):61-68. doi: 10.1016/j.bbamem.2016.10.013. Epub 2016 Oct 27.

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