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Items: 19

1.

Longitudinal study revealed motor, cognitive and behavioral decline in transgenic minipig model of Huntington's disease.

Baxa M, Levinska B, Skrivankova M, Pokorny M, Juhasova J, Klima J, Klempir J, Juhas S, Ellederova Z.

Dis Model Mech. 2019 Nov 8. pii: dmm.041293. doi: 10.1242/dmm.041293. [Epub ahead of print]

2.

Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration.

Ardan T, Baxa M, Levinská B, Sedláčková M, Nguyen TD, Klíma J, Juhás Š, Juhásová J, Šmatlíková P, Vochozková P, Motlík J, Ellederová Z.

Dis Model Mech. 2019 Oct 23. pii: dmm.041319. doi: 10.1242/dmm.041319. [Epub ahead of print]

3.

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies.

Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L.

Dis Model Mech. 2018 Oct 24;11(10). pii: dmm035949. doi: 10.1242/dmm.035949.

4.

Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age.

Vidinská D, Vochozková P, Šmatlíková P, Ardan T, Klíma J, Juhás Š, Juhásová J, Bohuslavová B, Baxa M, Valeková I, Motlík J, Ellederová Z.

Neurodegener Dis. 2018;18(2-3):107-119. doi: 10.1159/000488592. Epub 2018 Jun 5.

PMID:
29870995
5.

Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core.

Gates ZP, Baxa MC, Yu W, Riback JA, Li H, Roux B, Kent SB, Sosnick TR.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2241-2246. doi: 10.1073/pnas.1609579114. Epub 2017 Feb 13.

6.

Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.

Yu W, Baxa MC, Gagnon I, Freed KF, Sosnick TR.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4747-52. doi: 10.1073/pnas.1522500113. Epub 2016 Apr 13.

7.

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Talkowski M, Gusella JF, Howland DS, DiFiglia M, Motlik J.

Neurodegener Dis. 2016;16(3-4):245-59. doi: 10.1159/000443665. Epub 2016 Mar 10.

PMID:
26959244
8.

Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar.

Baxa MC, Yu W, Adhikari AN, Ge L, Xia Z, Zhou R, Freed KF, Sosnick TR.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8302-7. doi: 10.1073/pnas.1503613112. Epub 2015 Jun 22.

9.

Benchmarking all-atom simulations using hydrogen exchange.

Skinner JJ, Yu W, Gichana EK, Baxa MC, Hinshaw JR, Freed KF, Sosnick TR.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15975-80. doi: 10.1073/pnas.1404213111. Epub 2014 Oct 27.

10.

Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations.

Baxa MC, Haddadian EJ, Jumper JM, Freed KF, Sosnick TR.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15396-401. doi: 10.1073/pnas.1407768111. Epub 2014 Oct 13.

11.

Revealing what gets buried first in protein folding.

Sosnick TR, Baxa MC.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16704-5. doi: 10.1073/pnas.1316158110. Epub 2013 Oct 4. No abstract available.

12.

A transgenic minipig model of Huntington's Disease.

Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J.

J Huntingtons Dis. 2013;2(1):47-68. doi: 10.3233/JHD-130001.

PMID:
25063429
13.

Context and force field dependence of the loss of protein backbone entropy upon folding using realistic denatured and native state ensembles.

Baxa MC, Haddadian EJ, Jha AK, Freed KF, Sosnick TR.

J Am Chem Soc. 2012 Sep 26;134(38):15929-36. Epub 2012 Sep 14.

14.

A "Link-Psi" strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable.

Shandiz AT, Baxa MC, Sosnick TR.

Protein Sci. 2012 Jun;21(6):819-27. doi: 10.1002/pro.2065. Epub 2012 Apr 23.

15.
16.

Metal binding kinetics of bi-histidine sites used in psi analysis: evidence of high-energy protein folding intermediates.

Bosco GL, Baxa M, Sosnick TR.

Biochemistry. 2009 Apr 7;48(13):2950-9. doi: 10.1021/bi802072u.

17.

Quantifying the structural requirements of the folding transition state of protein A and other systems.

Baxa MC, Freed KF, Sosnick TR.

J Mol Biol. 2008 Sep 19;381(5):1362-81. doi: 10.1016/j.jmb.2008.06.067. Epub 2008 Jul 1.

18.

Characterizing the protein folding transition state using psi analysis.

Sosnick TR, Krantz BA, Dothager RS, Baxa M.

Chem Rev. 2006 May;106(5):1862-76. Review. No abstract available.

PMID:
16683758

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