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Items: 7


Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21.


CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.

Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE, Stone E, Callaghan J, Chandler S, Clark VL, Kirwin-Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood LM, Eccles SA, Bone EA, Ayscough A, Drummond AH.

Cancer Res. 2008 Aug 15;68(16):6669-79. doi: 10.1158/0008-5472.CAN-07-6627.


Inhibition of tumour growth by marimastat in a human xenograft model of gastric cancer: relationship with levels of circulating CEA.

Watson SA, Morris TM, Collins HM, Bawden LJ, Hawkins K, Bone EA.

Br J Cancer. 1999 Sep;81(1):19-23.


Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor.

Chirivi RG, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R.

Int J Cancer. 1994 Aug 1;58(3):460-4.


Purification and analysis of proteinase-resistant mutants of recombinant platelet-derived growth factor-BB exhibiting improved biological activity.

Cook AL, Kirwin PM, Craig S, Bawden LJ, Green DR, Price MJ, Richardson SJ, Fallon A, Drummond AH, Edwards RM, et al.

Biochem J. 1992 Jan 1;281 ( Pt 1):57-65.


Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.

Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR, et al.

EMBO J. 1991 Dec;10(13):4113-20.


The antiproliferative activity of interferons assayed by measuring growth medium color changes related to cell number.

Dawson KM, Bawden LJ, Featherstone DA.

J Interferon Res. 1986 Apr;6(2):137-42.


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