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Items: 1 to 50 of 51

1.

Calcineurin Silencing in Dictyostelium discoideum Leads to Cellular Alterations Affecting Mitochondria, Gene Expression, and Oxidative Stress Response.

Kobel-Höller K, Gley K, Jochinke J, Heider K, Fritsch VN, Nguyen HVD, Lischke T, Radek R, Baumgrass R, Mutzel R, Thewes S.

Protist. 2018 Aug;169(4):584-602. doi: 10.1016/j.protis.2018.04.004. Epub 2018 Apr 21.

PMID:
29960931
2.

Dataset on the activation of Müller cells through macrophages upon hypoxia in the retina.

Nürnberg C, Kociok N, Brockmann C, Lischke T, Crespo-Garcia S, Reichhart N, Wolf S, Baumgrass R, Eming SA, Beer-Hammer S, Joussen AM.

Data Brief. 2017 Nov 22;16:489-500. doi: 10.1016/j.dib.2017.11.062. eCollection 2018 Feb.

3.

Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells.

Nürnberg C, Kociok N, Brockmann C, Lischke T, Crespo-Garcia S, Reichhart N, Wolf S, Baumgrass R, Eming SA, Beer-Hammer S, Joussen AM.

Exp Eye Res. 2018 Jan;166:56-69. doi: 10.1016/j.exer.2017.10.011. Epub 2017 Oct 14.

PMID:
29042140
4.

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model.

Fuhrmann F, Lischke T, Gross F, Scheel T, Bauer L, Kalim KW, Radbruch A, Herzel H, Hutloff A, Baumgrass R.

Elife. 2016 Dec 30;5. pii: e20616. doi: 10.7554/eLife.20616.

5.

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.

Gabriel CH, Gross F, Karl M, Stephanowitz H, Hennig AF, Weber M, Gryzik S, Bachmann I, Hecklau K, Wienands J, Schuchhardt J, Herzel H, Radbruch A, Krause E, Baumgrass R.

J Biol Chem. 2016 Nov 11;291(46):24172-24187. Epub 2016 Sep 16.

6.

Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.

Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U.

J Immunol. 2016 Oct 15;197(8):3406-3414. Epub 2016 Sep 2.

7.

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions.

Jargosch M, Kröger S, Gralinska E, Klotz U, Fang Z, Chen W, Leser U, Selbig J, Groth D, Baumgrass R.

Genet Mol Res. 2016 Jun 24;15(2). doi: 10.4238/gmr.15028493.

8.

Transcription factor co-occupied regions in the murine genome constitute T-helper-cell subtype-specific enhancers.

Fang Z, Hecklau K, Gross F, Bachmann I, Venzke M, Karl M, Schuchhardt J, Radbruch A, Herzel H, Baumgrass R.

Eur J Immunol. 2015 Nov;45(11):3150-7. doi: 10.1002/eji.201545713. Epub 2015 Sep 21.

9.

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF.

Eur J Immunol. 2015 Apr;45(4):1192-205. doi: 10.1002/eji.201444633. Epub 2015 Jan 22.

10.

Nuclear factor of activated T cells regulates the expression of interleukin-4 in Th2 cells in an all-or-none fashion.

Köck J, Kreher S, Lehmann K, Riedel R, Bardua M, Lischke T, Jargosch M, Haftmann C, Bendfeldt H, Hatam F, Mashreghi MF, Baumgrass R, Radbruch A, Chang HD.

J Biol Chem. 2014 Sep 26;289(39):26752-61. doi: 10.1074/jbc.M114.587865. Epub 2014 Jul 17.

11.

Impaired T cell activation and cytokine production by calcitriol-primed human B cells.

Drozdenko G, Scheel T, Heine G, Baumgrass R, Worm M.

Clin Exp Immunol. 2014 Nov;178(2):364-72. doi: 10.1111/cei.12406.

12.

NK cells gain higher IFN-γ competence during terminal differentiation.

Luetke-Eversloh M, Cicek BB, Siracusa F, Thom JT, Hamann A, Frischbutter S, Baumgrass R, Chang HD, Thiel A, Dong J, Romagnani C.

Eur J Immunol. 2014 Jul;44(7):2074-84. doi: 10.1002/eji.201344072. Epub 2014 May 19.

13.

Interferon-α suppresses cAMP to disarm human regulatory T cells.

Bacher N, Raker V, Hofmann C, Graulich E, Schwenk M, Baumgrass R, Bopp T, Zechner U, Merten L, Becker C, Steinbrink K.

Cancer Res. 2013 Sep 15;73(18):5647-56. doi: 10.1158/0008-5472.CAN-12-3788. Epub 2013 Jul 22.

14.

Mechanisms and rescue strategies of calcineurin inhibitor mediated tolerance abrogation induced by anti-CD4 mAb treatment.

Siepert A, Brösel S, Vogt K, Ahrlich S, Schmitt-Knosalla I, Loddenkemper C, Kühl A, Baumgrass R, Gerstmayer B, Tomiuk S, Tiedge M, Viklický O, Brabcova I, Nizze H, Lehmann M, Volk HD, Sawitzki B.

Am J Transplant. 2013 Sep;13(9):2308-21. doi: 10.1111/ajt.12352. Epub 2013 Jul 15.

15.

Comment on "constitutive nuclear localization of NFAT in Foxp3(+) regulatory T cells independent of calcineurin activity".

Scheel T, Abajyan A, Baumgrass R.

J Immunol. 2012 Nov 15;189(10):4703; author reply 4703-4. doi: 10.4049/jimmunol.1290068. No abstract available.

16.
17.

Evaluation of calcineurin/NFAT inhibitor selectivity in primary human Th cells using bar-coding and phospho-flow cytometry.

Frischbutter S, Schultheis K, Pätzel M, Radbruch A, Baumgrass R.

Cytometry A. 2012 Nov;81(11):1005-11. doi: 10.1002/cyto.a.22204. Epub 2012 Sep 20.

18.

IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of  T Cell Activation.

Bendfeldt H, Benary M, Scheel T, Steinbrink K, Radbruch A, Herzel H, Baumgrass R.

Front Immunol. 2012 Aug 27;3:264. doi: 10.3389/fimmu.2012.00264. eCollection 2012.

19.

The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines.

Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A.

J Mol Med (Berl). 2012 Nov;90(11):1295-309. doi: 10.1007/s00109-012-0907-y. Epub 2012 May 19.

PMID:
22610275
20.

Stable IL-2 decision making by endogenous c-Fos amounts in peripheral memory T-helper cells.

Bendfeldt H, Benary M, Scheel T, Frischbutter S, Abajyan A, Radbruch A, Herzel H, Baumgrass R.

J Biol Chem. 2012 May 25;287(22):18386-97. doi: 10.1074/jbc.M112.358853. Epub 2012 Apr 3.

21.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.

Schmidt A, Oberle N, Weiss EM, Vobis D, Frischbutter S, Baumgrass R, Falk CS, Haag M, Brügger B, Lin H, Mayr GW, Reichardt P, Gunzer M, Suri-Payer E, Krammer PH.

Sci Signal. 2011 Dec 20;4(204):ra90. doi: 10.1126/scisignal.2002179.

PMID:
22375050
22.

Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells.

Klein M, Vaeth M, Scheel T, Grabbe S, Baumgrass R, Berberich-Siebelt F, Bopp T, Schmitt E, Becker C.

J Immunol. 2012 Feb 1;188(3):1091-7. doi: 10.4049/jimmunol.1102045. Epub 2011 Dec 21.

23.

Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.

Frischbutter S, Gabriel C, Bendfeldt H, Radbruch A, Baumgrass R.

Eur J Immunol. 2011 Aug;41(8):2349-57. doi: 10.1002/eji.201041052. Epub 2011 Jul 4.

24.

1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells.

Geldmeyer-Hilt K, Heine G, Hartmann B, Baumgrass R, Radbruch A, Worm M.

Biochem Biophys Res Commun. 2011 Apr 22;407(4):699-702. doi: 10.1016/j.bbrc.2011.03.078. Epub 2011 Mar 21.

PMID:
21420936
25.

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.

Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF.

Nat Immunol. 2010 Nov;11(11):1057-62. doi: 10.1038/ni.1945. Epub 2010 Oct 10.

PMID:
20935646
26.

Defining TNF-α- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease.

Smiljanovic B, Grün JR, Steinbrich-Zöllner M, Stuhlmüller B, Häupl T, Burmester GR, Radbruch A, Grützkau A, Baumgrass R.

J Mol Med (Berl). 2010 Oct;88(10):1065-79. doi: 10.1007/s00109-010-0648-8. Epub 2010 Jul 17.

PMID:
20640394
27.

Whole blood flow cytometric measurement of NFATc1 and IL-2 expression to analyze cyclosporine A-mediated effects in T cells.

Brandt C, Liman P, Bendfeldt H, Mueller K, Reinke P, Radbruch A, Worm M, Baumgrass R.

Cytometry A. 2010 Jul;77(7):607-13. doi: 10.1002/cyto.a.20928.

28.

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.

Polansky JK, Schreiber L, Thelemann C, Ludwig L, Krüger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J.

J Mol Med (Berl). 2010 Oct;88(10):1029-40. doi: 10.1007/s00109-010-0642-1. Epub 2010 Jun 24.

29.

Low-dose, but not high-dose, cyclosporin A promotes regulatory T-cell induction, expansion, or both.

Baumgrass R, Brandt C, Wegner F, Abdollahnia M, Worm M.

J Allergy Clin Immunol. 2010 Jul;126(1):183-4; author reply 184. doi: 10.1016/j.jaci.2010.04.032. Epub 2010 Jun 12. No abstract available.

PMID:
20542321
30.

Prediction of regulatory transcription factors in T helper cell differentiation and maintenance.

Lee YH, Benary M, Baumgrass R, Herzel H.

Genome Inform. 2010 Jan;22:84-94.

PMID:
20238421
31.

Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology.

Entschladen F, Altschmied J, Baumgrass R, Behrmann I, Giehl K, Hermanns H, Huber O, Kieser A, Klotz LO, Kubatzky KF, Hass R, Janssen O, Friedrich K.

Cell Commun Signal. 2010 Feb 11;8:2. doi: 10.1186/1478-811X-8-2.

32.

The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells.

Erdmann F, Weiwad M, Kilka S, Karanik M, Pätzel M, Baumgrass R, Liebscher J, Fischer G.

J Biol Chem. 2010 Jan 15;285(3):1888-98. doi: 10.1074/jbc.M109.024844. Epub 2009 Nov 18.

33.

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Sieber M, Baumgrass R.

Cell Commun Signal. 2009 Oct 27;7:25. doi: 10.1186/1478-811X-7-25.

34.

[Biological switches: the 'all-or-none' principle in T-cell activation].

Kimmig S, Baumgrass R.

Z Rheumatol. 2009 Sep;68(7):560, 562-5. doi: 10.1007/s00393-009-0495-6. Review. German.

PMID:
19585132
35.

Low-dose cyclosporine A therapy increases the regulatory T cell population in patients with atopic dermatitis.

Brandt C, Pavlovic V, Radbruch A, Worm M, Baumgrass R.

Allergy. 2009 Nov;64(11):1588-96. doi: 10.1111/j.1398-9995.2009.02054.x. Epub 2009 Apr 29.

PMID:
19432936
36.

TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.

Aliahmadi E, Gramlich R, Grützkau A, Hitzler M, Krüger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M.

Eur J Immunol. 2009 May;39(5):1221-30. doi: 10.1002/eji.200838742.

37.

SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data.

Menssen A, Edinger G, Grün JR, Haase U, Baumgrass R, Grützkau A, Radbruch A, Burmester GR, Häupl T.

BMC Genomics. 2009 Mar 5;10:98. doi: 10.1186/1471-2164-10-98.

38.

Interactions of T helper cells with fibroblast-like synoviocytes: up-regulation of matrix metalloproteinases by macrophage migration inhibitory factor from both Th1 and Th2 cells.

Schurigt U, Pfirschke C, Irmler IM, Hückel M, Gajda M, Janik T, Baumgrass R, Bernhagen J, Bräuer R.

Arthritis Rheum. 2008 Oct;58(10):3030-40. doi: 10.1002/art.23904.

39.

Autoregulation of Th1-mediated inflammation by twist1.

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A.

J Exp Med. 2008 Aug 4;205(8):1889-901. doi: 10.1084/jem.20072468. Epub 2008 Jul 28.

40.

Modeling IL-2 gene expression in human regulatory T cells.

Benary M, Bendfeldt H, Baumgrass R, Herzel H.

Genome Inform. 2008;20:222-30.

PMID:
19425136
41.

A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema.

Schulz F, Marenholz I, Fölster-Holst R, Chen C, Sternjak A, Baumgrass R, Esparza-Gordillo J, Grüber C, Nickel R, Schreiber S, Stoll M, Kurek M, Rüschendorf F, Hubner N, Wahn U, Lee YA.

J Allergy Clin Immunol. 2007 Nov;120(5):1097-102. Epub 2007 Sep 27.

PMID:
17900679
42.

Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression.

Podtschaske M, Benary U, Zwinger S, Höfer T, Radbruch A, Baumgrass R.

PLoS One. 2007 Sep 26;2(9):e935.

43.

Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3.

Sieber M, Karanik M, Brandt C, Blex C, Podtschaske M, Erdmann F, Rost R, Serfling E, Liebscher J, Pätzel M, Radbruch A, Fischer G, Baumgrass R.

Eur J Immunol. 2007 Sep;37(9):2617-26.

44.

Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression.

Zhang Y, Erdmann F, Baumgrass R, Schutkowski M, Fischer G.

J Biol Chem. 2005 Feb 11;280(6):4842-50. Epub 2004 Nov 30.

45.

Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.

Zhang Y, Baumgrass R, Schutkowski M, Fischer G.

Chembiochem. 2004 Jul 5;5(7):1006-9. No abstract available. Erratum in: Chembiochem. 2004 Sep 6;5(9):1169. Raumgrass, Ria [corrected to Baumgrass, Ria].

PMID:
15239062
46.

Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression.

Baumgrass R, Zhang Y, Erdmann F, Thiel A, Weiwad M, Radbruch A, Fischer G.

J Biol Chem. 2004 Jan 23;279(4):2470-9. Epub 2003 Oct 28.

47.

The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin.

Klettner A, Baumgrass R, Zhang Y, Fischer G, Bürger E, Herdegen T, Mielke K.

Brain Res Mol Brain Res. 2001 Dec 16;97(1):21-31.

PMID:
11744159
48.

Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol.

Baumgrass R, Weiwad M, Erdmann F, Liu JO, Wunderlich D, Grabley S, Fischer G.

J Biol Chem. 2001 Dec 21;276(51):47914-21. Epub 2001 Oct 11.

49.

Improved in vitro stability of serum osteocalcin by using a new commercially available antiproteolytic compound.

Baumgrass R, Daenzer M, Felsenberg D.

Clin Chim Acta. 1999 Mar;281(1-2):47-55.

PMID:
10217626

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