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Stress- and ubiquitylation-dependent phase separation of the proteasome.

Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernández-Busnadiego R, Tanaka K, Saeki Y.

Nature. 2020 Feb;578(7794):296-300. doi: 10.1038/s41586-020-1982-9. Epub 2020 Feb 5.


Author Correction: Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms.

Martinez-Sanchez A, Kochovski Z, Laugks U, Meyer Zum Alten Borgloh J, Chakraborty S, Pfeffer S, Baumeister W, Lučić V.

Nat Methods. 2020 Feb;17(2):240. doi: 10.1038/s41592-020-0763-6.


Author Correction: Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms.

Martinez-Sanchez A, Kochovski Z, Laugks U, Meyer Zum Alten Borgloh J, Chakraborty S, Pfeffer S, Baumeister W, Lučić V.

Nat Methods. 2020 Feb;17(2):240. doi: 10.1038/s41592-020-0747-6.


Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms.

Martinez-Sanchez A, Kochovski Z, Laugks U, Meyer Zum Alten Borgloh J, Chakraborty S, Pfeffer S, Baumeister W, Lučić V.

Nat Methods. 2020 Feb;17(2):209-216. doi: 10.1038/s41592-019-0675-5. Epub 2020 Jan 6. Erratum in: Nat Methods. 2020 Jan 22;:. Nat Methods. 2020 Jan 27;:.


Direct visualization of degradation microcompartments at the ER membrane.

Albert S, Wietrzynski W, Lee CW, Schaffer M, Beck F, Schuller JM, Salomé PA, Plitzko JM, Baumeister W, Engel BD.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1069-1080. doi: 10.1073/pnas.1905641117. Epub 2019 Dec 27.


Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.

Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martínez-Sánchez A, Baumeister W, Stefan CJ, Fernández-Busnadiego R.

Dev Cell. 2019 Nov 18;51(4):476-487.e7. doi: 10.1016/j.devcel.2019.10.018.


The persuasive power of Ernesto Carafoli.

Baumeister W.

Biochem Biophys Res Commun. 2019 Dec 17;520(4):657-658. doi: 10.1016/j.bbrc.2019.10.171. Epub 2019 Nov 1. No abstract available.


Proteasomes: unfoldase-assisted protein degradation machines.

Majumder P, Baumeister W.

Biol Chem. 2019 Dec 18;401(1):183-199. doi: 10.1515/hsz-2019-0344. Review.


An integrated workflow for crosslinking mass spectrometry.

Mendes ML, Fischer L, Chen ZA, Barbon M, O'Reilly FJ, Giese SH, Bohlke-Schneider M, Belsom A, Dau T, Combe CW, Graham M, Eisele MR, Baumeister W, Speck C, Rappsilber J.

Mol Syst Biol. 2019 Sep;15(9):e8994. doi: 10.15252/msb.20198994.


Cryo-EM structure of the native rhodopsin dimer in nanodiscs.

Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K.

J Biol Chem. 2019 Sep 27;294(39):14215-14230. doi: 10.1074/jbc.RA119.010089. Epub 2019 Aug 9.


Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.

Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM, Baumeister W.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16866-16871. doi: 10.1073/pnas.1903642116. Epub 2019 Aug 2.


A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue.

Schaffer M, Pfeffer S, Mahamid J, Kleindiek S, Laugks T, Albert S, Engel BD, Rummel A, Smith AJ, Baumeister W, Plitzko JM.

Nat Methods. 2019 Aug;16(8):757-762. doi: 10.1038/s41592-019-0497-5. Epub 2019 Jul 29.


The Architecture of Traveling Actin Waves Revealed by Cryo-Electron Tomography.

Jasnin M, Beck F, Ecke M, Fukuda Y, Martinez-Sanchez A, Baumeister W, Gerisch G.

Structure. 2019 Aug 6;27(8):1211-1223.e5. doi: 10.1016/j.str.2019.05.009. Epub 2019 Jun 20.


Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.

Majumder P, Rudack T, Beck F, Danev R, Pfeifer G, Nagy I, Baumeister W.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):534-539. doi: 10.1073/pnas.1817752116. Epub 2018 Dec 17.


Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species.

Zinzula L, Nagy I, Orsini M, Weyher-Stingl E, Bracher A, Baumeister W.

Structure. 2019 Jan 2;27(1):39-54.e6. doi: 10.1016/j.str.2018.09.009. Epub 2018 Oct 25.


Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.

Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM.

Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12.


Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.

Eisele MR, Reed RG, Rudack T, Schweitzer A, Beck F, Nagy I, Pfeifer G, Plitzko JM, Baumeister W, Tomko RJ Jr, Sakata E.

Cell Rep. 2018 Jul 31;24(5):1301-1315.e5. doi: 10.1016/j.celrep.2018.07.004.


Connectivity of centermost chromatophores in Rhodobacter sphaeroides bacteria.

Noble JM, Lubieniecki J, Savitzky BH, Plitzko J, Engelhardt H, Baumeister W, Kourkoutis LF.

Mol Microbiol. 2018 Sep;109(6):812-825. doi: 10.1111/mmi.14077. Epub 2018 Sep 15.


Structure of the adenosine-bound human adenosine A1 receptor-Gi complex.

Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A.

Nature. 2018 Jun;558(7711):559-563. doi: 10.1038/s41586-018-0236-6. Epub 2018 Jun 20.


In situ architecture of the algal nuclear pore complex.

Mosalaganti S, Kosinski J, Albert S, Schaffer M, Strenkert D, Salomé PA, Merchant SS, Plitzko JM, Baumeister W, Engel BD, Beck M.

Nat Commun. 2018 Jun 18;9(1):2361. doi: 10.1038/s41467-018-04739-y.


Pleomorphic linkers as ubiquitous structural organizers of vesicles in axons.

Schrod N, Vanhecke D, Laugks U, Stein V, Fukuda Y, Schaffer M, Baumeister W, Lucic V.

PLoS One. 2018 Jun 4;13(6):e0197886. doi: 10.1371/journal.pone.0197886. eCollection 2018.


Molecular and structural architecture of polyQ aggregates in yeast.

Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. Epub 2018 Mar 26.


The cryo-electron microscopy structure of huntingtin.

Guo Q, Bin Huang, Cheng J, Seefelder M, Engler T, Pfeifer G, Oeckl P, Otto M, Moser F, Maurer M, Pautsch A, Baumeister W, Fernández-Busnadiego R, Kochanek S.

Nature. 2018 Mar 1;555(7694):117-120. doi: 10.1038/nature25502. Epub 2018 Feb 21.


Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D.

Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21.


In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R.

Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.


Phase separation of a yeast prion protein promotes cellular fitness.

Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S.

Science. 2018 Jan 5;359(6371). pii: eaao5654. doi: 10.1126/science.aao5654.


Proteasomes tether to two distinct sites at the nuclear pore complex.

Albert S, Schaffer M, Beck F, Mosalaganti S, Asano S, Thomas HF, Plitzko JM, Beck M, Baumeister W, Engel BD.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13726-13731. doi: 10.1073/pnas.1716305114. Epub 2017 Dec 11.


The structure of the COPI coat determined within the cell.

Bykov YS, Schaffer M, Dodonova SO, Albert S, Plitzko JM, Baumeister W, Engel BD, Briggs JA.

Elife. 2017 Nov 17;6. pii: e32493. doi: 10.7554/eLife.32493.


In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R.

Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7.


Isolation and Characterization of Metallosphaera Turreted Icosahedral Virus, a Founding Member of a New Family of Archaeal Viruses.

Wagner C, Reddy V, Asturias F, Khoshouei M, Johnson JE, Manrique P, Munson-McGee J, Baumeister W, Lawrence CM, Young MJ.

J Virol. 2017 Sep 27;91(20). pii: e00925-17. doi: 10.1128/JVI.00925-17. Print 2017 Oct 15.


Morphologies of synaptic protein membrane fusion interfaces.

Gipson P, Fukuda Y, Danev R, Lai Y, Chen DH, Baumeister W, Brunger AT.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9110-9115. doi: 10.1073/pnas.1708492114. Epub 2017 Jul 24.


Revisiting the Structure of Hemoglobin and Myoglobin with Cryo-Electron Microscopy.

Khoshouei M, Danev R, Plitzko JM, Baumeister W.

J Mol Biol. 2017 Aug 18;429(17):2611-2618. doi: 10.1016/j.jmb.2017.07.004. Epub 2017 Jul 8. Review.


Expanding the boundaries of cryo-EM with phase plates.

Danev R, Baumeister W.

Curr Opin Struct Biol. 2017 Oct;46:87-94. doi: 10.1016/ Epub 2017 Jul 1. Review.


Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate.

Khoshouei M, Radjainia M, Baumeister W, Danev R.

Nat Commun. 2017 Jun 30;8:16099. doi: 10.1038/ncomms16099.


Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM.

Nature. 2017 Jun 1;546(7656):118-123. doi: 10.1038/nature22327. Epub 2017 Apr 24.


In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes.

Fukuda Y, Beck F, Plitzko JM, Baumeister W.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4412-4417. doi: 10.1073/pnas.1701367114. Epub 2017 Apr 10.


Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L.

Mol Cell Proteomics. 2017 May;16(5):840-854. doi: 10.1074/mcp.M116.065326. Epub 2017 Mar 14.


Challenges of Integrating Stochastic Dynamics and Cryo-Electron Tomograms in Whole-Cell Simulations.

Earnest TM, Watanabe R, Stone JE, Mahamid J, Baumeister W, Villa E, Luthey-Schulten Z.

J Phys Chem B. 2017 Apr 20;121(15):3871-3881. doi: 10.1021/acs.jpcb.7b00672. Epub 2017 Mar 30.


Dissecting the molecular organization of the translocon-associated protein complex.

Pfeffer S, Dudek J, Schaffer M, Ng BG, Albert S, Plitzko JM, Baumeister W, Zimmermann R, Freeze HH, Engel BD, Förster F.

Nat Commun. 2017 Feb 20;8:14516. doi: 10.1038/ncomms14516.


Structural insights into the functional cycle of the ATPase module of the 26S proteasome.

Wehmer M, Rudack T, Beck F, Aufderheide A, Pfeifer G, Plitzko JM, Förster F, Schulten K, Baumeister W, Sakata E.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1305-1310. doi: 10.1073/pnas.1621129114. Epub 2017 Jan 23.


Using the Volta phase plate with defocus for cryo-EM single particle analysis.

Danev R, Tegunov D, Baumeister W.

Elife. 2017 Jan 21;6. pii: e23006. doi: 10.7554/eLife.23006.


Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

Beck M, Baumeister W.

Trends Cell Biol. 2016 Nov;26(11):825-837. doi: 10.1016/j.tcb.2016.08.006. Epub 2016 Sep 23. Review.


Hierarchical detection and analysis of macromolecular complexes in cryo-electron tomograms using Pyto software.

Lučić V, Fernández-Busnadiego R, Laugks U, Baumeister W.

J Struct Biol. 2016 Dec;196(3):503-514. doi: 10.1016/j.jsb.2016.10.004. Epub 2016 Oct 11.


Optimized cryo-focused ion beam sample preparation aimed at in situ structural studies of membrane proteins.

Schaffer M, Mahamid J, Engel BD, Laugks T, Baumeister W, Plitzko JM.

J Struct Biol. 2017 Feb;197(2):73-82. doi: 10.1016/j.jsb.2016.07.010. Epub 2016 Jul 19.


Lipoprotein-like particles in a prokaryote: quinone droplets of Thermoplasma acidophilum.

Nagy I, Knispel RW, Kofler C, Orsini M, Boicu M, Varga S, Weyher-Stingl E, Sun N, Fernandez-Busnadiego R, Kukolya J, Nickell S, Baumeister W.

FEMS Microbiol Lett. 2016 Sep;363(18). pii: fnw169. doi: 10.1093/femsle/fnw169. Epub 2016 Jul 11.


Structure of the human 26S proteasome at a resolution of 3.9 Å.

Schweitzer A, Aufderheide A, Rudack T, Beck F, Pfeifer G, Plitzko JM, Sakata E, Schulten K, Förster F, Baumeister W.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7816-21. doi: 10.1073/pnas.1608050113. Epub 2016 Jun 24.


Actin Organization in Cells Responding to a Perforated Surface, Revealed by Live Imaging and Cryo-Electron Tomography.

Jasnin M, Ecke M, Baumeister W, Gerisch G.

Structure. 2016 Jul 6;24(7):1031-43. doi: 10.1016/j.str.2016.05.004. Epub 2016 Jun 16.


Cryo-focused Ion Beam Sample Preparation for Imaging Vitreous Cells by Cryo-electron Tomography.

Schaffer M, Engel BD, Laugks T, Mahamid J, Plitzko JM, Baumeister W.

Bio Protoc. 2015 Sep 5;5(17). pii: e1575.


Subtomogram analysis using the Volta phase plate.

Khoshouei M, Pfeffer S, Baumeister W, Förster F, Danev R.

J Struct Biol. 2017 Feb;197(2):94-101. doi: 10.1016/j.jsb.2016.05.009. Epub 2016 May 25.


Cryo-EM single particle analysis with the Volta phase plate.

Danev R, Baumeister W.

Elife. 2016 Mar 7;5. pii: e13046. doi: 10.7554/eLife.13046.

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